Yamane Daisuke 山根大典

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YAMANE Daisuke 山根大典

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Researcher Number	60782761
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 感染症医学研究センター, 副参事研究員 2025: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主席研究員
Affiliation (based on the past Project Information) *help	2019 – 2025: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主席研究員 2016 – 2023: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Virology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 42020:Veterinary medical science-related
Keywords	Principal Investigator ウイルス / 感染症 / RNAウイルス / 肝炎ウイルス / インターフェロン制御因子 / 自然免疫 / 宿主因子 / 小胞体膜 / 脂肪酸 / 脂質代謝 … More / 複製複合体 / 脂質 / 免疫学 / シグナル伝達 / ウィルス / 肝細胞 / ウイルス複製 / 先天性免疫応答 … More Except Principal Investigator 肝炎ウイルス / 肝炎ウイルイス / miRISC / 宿主因子 / C型肝炎ウイルス / 肝癌 / マイクロRNA / III型IFN / 腸管 / 自然免疫 / I・III型IFN受容体遺伝子欠損マウス / A型肝炎ウイルス / 経口感染 / マウスモデル / A型肝炎 Less

転写因子間相互作用を介した恒常的抗ウイルス防御層の制御機構の解明Principal Investigator
- Principal Investigator
  
  山根大典
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
基底レベルの感染防御を担うウイルス抑制シグナルの解明Principal Investigator
- Principal Investigator
  
  山根大典
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Hepatitis virus-induced dysfunction of tumor-suppressive microRNAs and its molecular mechanisms
- Principal Investigator
  
  政木隆博
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Jikei University School of Medicine
Intestinal innate immune response to enterically transmitted hepatitis virus
- Principal Investigator
  
  Hirai-Yuki Asuka
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  National Institute of Infectious Diseases
Host lipids that regulate the function of replication factories of RNA virusesPrincipal Investigator
- Principal Investigator
  
  YAMANE Daisuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Virology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
肝炎ウイルス複製の抑制に関わる内在性シグナル経路についての比較ウイルス学的解析Principal Investigator
- Principal Investigator
  
  山根大典
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Virology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] SNK2B modulates IRF1 binding to functional DNA elements and promotes basal and agonist-induced antiviral signaling2023
- Author(s)
  Matsumoto M, Modliszewski JL, Shinozaki K, Maezawa R, Perez VM, Ishikawa Y, Suzuki R, McKnight KL, Masaki T, Hirai-Yuki A, Kohara M, Lemon SM, Selitsky SR, Yamane D
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 9 Pages: 4451-4466
- DOI
  10.1093/nar/gkad298
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08342, KAKENHI-PROJECT-23K21382
[Journal Article] Phospholipase A and acyltransferase 4/retinoic acid receptor responder 3 at the intersection of tumor suppression and pathogen restriction2023
- Author(s)
  Zhao Jian-Yong、Yuan Xiang-Kun、Luo Rui-Zhen、Wang Li-Xin、Gu Wei、Yamane Daisuke、Feng Hui
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1107239-1107239
- DOI
  10.3389/fimmu.2023.1107239
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21382
[Journal Article] Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder2023
- Author(s)
  Yamaji Kenzaburo、Iwabuchi Sadahiro、Tokunaga Yuko、Hashimoto Shinichi、Yamane Daisuke、Toyama Sakiko、Kono Risa、Kitab Bouchra、Tsukiyama-Kohara Kyoko、Osawa Yosuke、Hayashi Yukiko、Hishima Tsunekazu、Tateno Chise、Kimura Kiminori、Okanoue Takeshi、Kohara Michinori
- Journal Title
  
  Biomedicine Pharmacotherapy
  
  Volume: 166 Pages: 115379-115379
- DOI
  10.1016/j.biopha.2023.115379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06981, KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-20H03164, KAKENHI-PROJECT-23K21382
[Journal Article] FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication2022
- Author(s)
  D. Yamane, Y. Hayashi, M. Matsumoto, H. Nakanishi, H. Imagawa, M. Kohara, SM. Lemon, I. Ichi
- Journal Title
  
  Cell Chem Biol
  
  Volume: 29 Issue: 5 Pages: 1-12
- DOI
  10.1016/j.chembiol.2021.07.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K02383, KAKENHI-PROJECT-23K21382
[Journal Article] Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses2021
- Author(s)
  Feng Hui、Zhang Yi-Bing、Gui Jian-Fang、Lemon Stanley M.、Yamane Daisuke
- Journal Title
  
  PLOS Pathogens
  
  Volume: 17 Issue: 1 Pages: e1009220-e1009220
- DOI
  10.1371/journal.ppat.1009220
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05070, KAKENHI-PROJECT-23K21382
[Journal Article] Development and Characterization of a Highly Sensitive NanoLuciferase-Based Immunoprecipitation System for the Detection of Anti-Influenza Virus HA Antibodies.2021
- Author(s)
  Honda T, Gomi S, Yamane D, Yasui F, Yamamoto T, Munakata T, Itoh Y, Ogasawara K, Sanada T, Yamaji K, Yasutomi Y, Tsukiyama-Kohara K, Kohara M.
- Journal Title
  
  mSphere
  
  Volume: 12 Issue: 3
- DOI
  10.1128/msphere.01342-20
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03164, KAKENHI-PROJECT-20K07531, KAKENHI-PROJECT-19K16680, KAKENHI-PROJECT-23K21382
[Journal Article] Longer poly(U) stretches in the 3′UTR are essential for replication of the hepatitis C virus genotype 4a clone in in vitro and in vivo.2021
- Author(s)
  Asako Takagi, Yutaka Amako, Daisuke, Yamane, Bouchra Kitab, Yuko Tokunaga, Ahmed El-Gohary, Michinori Kohara, Kyoko Tsukiyama-Kohara
- Journal Title
  
  Front. Microbiol.
  
  Volume: 12 Pages: 76816-76816
- DOI
  10.3389/fmicb.2021.764816
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03164, KAKENHI-PROJECT-23K21382
[Journal Article] Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors2020
- Author(s)
  Dultz Georg、Shimakami Tetsuro、Schneider Markus、Murai Kazuhisa、Yamane Daisuke、Marion Antoine、Zeitler Tobias M.、Stross Claudia、Grimm Christian、Richter Rebecca M.、B?umer Katrin、Yi MinKyung、Biondi Ricardo M.、Zeuzem Stefan、Tamp? Robert、Antes Iris、Lange Christian M.、Welsch Christoph
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 40 Pages: 13862-13874
- DOI
  10.1074/jbc.ra120.013898
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05070
[Journal Article] Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models2020
- Author(s)
  Saito, M Itoh Y, Yasui F, Munakata T, Yamane D, Ozawa M, Ito R, Katoh T, Ishigaki H, Nakayama M, Shichinohe S, Yamaji K, Yamamoto N, Ikejiri A, Honda T, Sanada T, Sakoda Y, Kida H, Le TH, Kawaoka Y, Ogasawara Tsukiyama-Kohara T, Suga H, & Kohara M
- Journal Title
  
  Nature Comunications
  
  Volume: - Issue: 1 Pages: 2654-2654
- DOI
  10.1038/s41467-021-22964-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03164, KAKENHI-PROJECT-18H02080, KAKENHI-PROJECT-23K21382
[Journal Article] Stearoyl-CoA desaturase-1 is required for flavivirus RNA replication2019
- Author(s)
  Hishiki Takayuki、Kato Fumihiro、Nio Yasunori、Watanabe Satoru、Wen Tan Nicole Wei、Yamane Daisuke、Miyazaki Yasuyuki、Lin Chun-Chieh、Suzuki Rieko、Tajima Shigeru、Lim Chang-Kweng、Saijo Masayuki、Hijikata Makoto、Vasudevan Subhash G.、Takasaki Tomohiko
- Journal Title
  
  Antiviral Research
  
  Volume: 165 Pages: 42-46
- DOI
  10.1016/j.antiviral.2019.03.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08870, KAKENHI-PROJECT-17H05070, KAKENHI-PROJECT-16K09957
[Journal Article] Hepatovirus 3ABC proteases and evolution of mitochondrial antiviral signaling protein (MAVS)2019
- Author(s)
  Feng Hui、Sander Anna-Lena、Moreira-Soto Andr?s、Yamane Daisuke、Felix Drexler Jan、Lemon Stanley M.
- Journal Title
  
  Journal of Hepatology
  
  Volume: in press Issue: 1 Pages: 25-34
- DOI
  10.1016/j.jhep.2019.02.020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05070
[Journal Article] Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses2019
- Author(s)
  Yamane D, Feng H, Rivera-Serrano EE, Selitsky SR, Hirai-Yuki A, Das A, McKnight KL, Misumi I, Hensley L, Lovell W, González-López O, Suzuki R, Matsuda M, Nakanishi H, Ohto-Nakanishi T, Hishiki T, Wauthier E, Oikawa T, Morita K, Reid LM, Sethupathy P, Kohara M, Whitmire JK, Lemon SM
- Journal Title
  
  Nature Microbiology
  
  Volume: 印刷中 Issue: 7 Pages: 1096-1104
- DOI
  10.1038/s41564-019-0425-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05987, KAKENHI-PROJECT-17H05070, KAKENHI-PROJECT-17K07194, KAKENHI-PROJECT-17K08870
[Journal Article] NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.2017
- Author(s)
  Benzine T, Brandt R, Lovell WC, Yamane D, Neddermann P, De Francesco R, Lemon SM, Perelson AS, Ke R, McGivern DR.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 13 Issue: 6 Pages: e1006343-e1006343
- DOI
  10.1371/journal.ppat.1006343
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05070
[Journal Article] Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3' variants.2017
- Author(s)
  Yamane D, Selitsky SR, Shimakami T, Li Y, Zhou M, Honda M, Sethupathy P, Lemon SM.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: - Pages: 4743-4755
- DOI
  10.1093/nar/gkw1332
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H07462, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-15K08492
[Journal Article] NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.2017
- Author(s)
  Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, Gonzalez-Lopez O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM.
- Journal Title
  
  Nat Immunol.
  
  Volume: 18 Issue: 12 Pages: 1299-1309
- DOI
  10.1038/ni.3853
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05070
[Presentation] フェロトーシスを介した C 型肝炎ウイルスの持続感染の制御2024
- Author(s)
  山根大典
- Organizer
  レドックスR&D戦略委員会第4回春のシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] 抗HAVヒト抗体の単離および動物モデルを使った抗HAV効果の検討2023
- Author(s)
  鄭シン、平井-結城明香、寺原和孝、渡邉則幸、塩田智之、小谷治、山根大典、深野顕人、大崎恵理子、小野寺大志、安達悠、若江亨祥、滝本一広、永田典代、加藤孝宣、相崎英樹、上田啓次、鈴木亮介、高橋宜聖、村松正道
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] ビタミン Eを介した肝細胞の脂質過酸化とC型肝炎ウイルスの持続感染の制御2023
- Author(s)
  山根大典
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] 動物モデルにおけるヒトモノクロ抗HAV抗体の感染阻止効果の検討2023
- Author(s)
  鄭シン、平井-結城明香、寺原和孝、渡邉則幸、塩田智之、小谷治、山根大典、深野顕人、大崎恵理子、小野寺大志、安達悠、佐藤由子、大園誠也、若江亨祥、滝本一広、永田典代、加藤孝宣、相崎英樹、上田啓次、鈴木亮介、高橋宜聖、村松正道
- Organizer
  第31回日本抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] RNAウイルスの複製を抑制する宿主因子とその仕組みを模倣した創薬の試み2023
- Author(s)
  山根大典
- Organizer
  東京大学医科学研究所・学友会セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] A CBP/Β-CATENIN SIGNALING INHIBITOR, PRI-724 AMELIORATES NASH-INDUCED LIVER FIBROSIS AND DISORDER2022
- Author(s)
  Kenzaburo Yamaji, Yuko Tokunaga, Sadahiro Iwabuchi, Shinichi Hashimoto, Daisuke Yamane, Sakiko Toyama, Bouchra Kitab, Kiminori Kimura, Kyoko Tsukiyama-Kohara, Michinori Kohara
- Organizer
  AASLD2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] 肝炎ウイルス複製を抑制する肝細胞内シグナル伝達の解析と創薬への応用2022
- Author(s)
  山根大典、結城明香
- Organizer
  TOBIRA第10回研究交流フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] C 型肝炎ウイルス（遺伝子型 4a)の3'UTR 内 poly(U)配列の複製制御における役割2022
- Author(s)
  高木朝子、尼子豊、山根大典、キタブブシュラ、徳永優子、アームドエルゴハリー、小原道法、小原恭子
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] 脂肪酸不飽和化酵素を介したC型肝炎ウイルス複製とフェロトーシスの制御2022
- Author(s)
  山根大典
- Organizer
  第374回脂溶性ビタミン総合研究委員会
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] レポーター遺伝子を持つ組換えA型肝炎ウイルスを用いた抗ウイルス低分子化合物の探索2021
- Author(s)
  鈴木亮介、松田麻未、西山直子、小林さくら、鈴木祐成、清原知子、結城（平井）明香、山根大典、村松正道
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] NASH肝線維化モデルマウスに対するβ-catenin/CBP選択的阻害剤 PRI-724の脱線維化に寄与する細胞集団の同定2021
- Author(s)
  山地賢三郎、徳永優子、岩淵貞弘、山根大典、橋本真一、小原道法
- Organizer
  第28回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] 多価不飽和脂肪酸の代謝を介した脂質過酸化の制御とC型肝炎ウイルス複製2021
- Author(s)
  山根大典
- Organizer
  第６３回日本脂質生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] 脂溶性ビタミンを介した肝炎ウイルス複製制御機構2020
- Author(s)
  山根大典
- Organizer
  第364回脂溶性ビタミン総合研究委員会
- Invited
- Data Source
  KAKENHI-PROJECT-17H05070
[Presentation] 肝細胞に内在するRNA ウイルス抑制シグナルとその制御機構2020
- Author(s)
  山根大典
- Organizer
  第65回肝炎ウイルスセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17H05070
[Presentation] RARRES3 mediates interferon regulatory factor 1-induced suppression of hepatitis A virus replication through modulation of the mTOR activity.2019
- Author(s)
  Daisuke Yamane, Asuka Hirai-Yuki, Michinori Kohara, and Stanley M. Lemon.
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K05987
[Presentation] RARRES3 mediates interferon regulatory factor 1-induced suppression of hepatitis A virus replication through modulation of the mTOR activity.2019
- Author(s)
  Daisuke Yamane, Asuka Hirai-Yuki, Michinori Kohara, Stanley M. Lemon
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05070
[Presentation] MAVS-independent activity of interferon regulatory factor 1 restricts replication of hepatotropic RNA viruses.2018
- Author(s)
  Daisuke Yamane，Asuka Hirai-Yuki，Michinori Kohara，Stanley M Lemon.
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K05987
[Presentation] MAVS-independent activity of interferon regulatory factor 1 restricts hepatotropic RNA virus infections2018
- Author(s)
  Daisuke Yamane, Asuka Hirai-Yuki, Ichiro Misumi, Michinori Kohara, Jason K Whitmire, and Stanley M Lemon
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05070
[Presentation] Efficient replication of non-adapted hepatitis C virus isolates in cell culture2017
- Author(s)
  Daisuke Yamane, Michinori Kohara
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05070
[Presentation] C型肝炎ウイルス持続感染における脂質過酸化とビタミンEの役割2017
- Author(s)
  山根大典
- Organizer
  第354回脂溶性ビタミン総合研究委員会
- Place of Presentation
  お茶の水女子大学（東京都文京区）
- Year and Date
  2017-03-10
- Invited
- Data Source
  KAKENHI-PROJECT-16H07462
[Presentation] Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3' variants.2016
- Author(s)
  Yamane D, Selitsky SR, Shimakami T, Li Y, Honda M, Sethupathy P, Lemon SM.
- Organizer
  23rd International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-10-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07462
[Presentation] Roles of Iron and Fatty Acid Desaturase in the Restriction of Lipid Peroxidation-sensitive Hepatitis C Viruses.2016
- Author(s)
  Yamane D, Lemon SM, Kohara M.
- Organizer
  The 15th Awaji International Forum on Infection and Immunity.
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県淡路市）
- Year and Date
  2016-09-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07462

1. Hirai-Yuki Asuka (50450557)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 政木隆博 (60535657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. HISHIKI Takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. HIRAI Asuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
5. ICHI Ikuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 迫田義博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 小原恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 本多政夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 島上哲朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 小原道法

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamane Daisuke 山根 大典

YAMANE Daisuke 山根 大典

Research Projects

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転写因子間相互作用を介した恒常的抗ウイルス防御層の制御機構の解明Principal Investigator

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基底レベルの感染防御を担うウイルス抑制シグナルの解明Principal Investigator

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Hepatitis virus-induced dysfunction of tumor-suppressive microRNAs and its molecular mechanisms

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Intestinal innate immune response to enterically transmitted hepatitis virus

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Host lipids that regulate the function of replication factories of RNA virusesPrincipal Investigator

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肝炎ウイルス複製の抑制に関わる内在性シグナル経路についての比較ウイルス学的解析Principal Investigator

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[Journal Article] SNK2B modulates IRF1 binding to functional DNA elements and promotes basal and agonist-induced antiviral signaling2023

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[Journal Article] Phospholipase A and acyltransferase 4/retinoic acid receptor responder 3 at the intersection of tumor suppression and pathogen restriction2023

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[Journal Article] Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder2023

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[Journal Article] FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication2022

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[Journal Article] Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses2021

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[Journal Article] Development and Characterization of a Highly Sensitive NanoLuciferase-Based Immunoprecipitation System for the Detection of Anti-Influenza Virus HA Antibodies.2021

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[Journal Article] Longer poly(U) stretches in the 3′UTR are essential for replication of the hepatitis C virus genotype 4a clone in in vitro and in vivo.2021

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[Journal Article] Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors2020

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Yamane Daisuke 山根大典

YAMANE Daisuke 山根大典