HAMAMOTO Akie 濱本明恵

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Hamamoto Akie 濱本明恵

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Researcher Number	60784197
Other IDs
Affiliation (Current)	2025: 広島大学, 統合生命科学研究科(総), 助教 2025: 久留米大学, 付置研究所, 研究員
Affiliation (based on the past Project Information) *help	2025: 広島大学, 統合生命科学研究科(総), 特任助教 2023: 広島大学, 統合生命科学研究科(総), 研究員 2019 – 2023: 岐阜大学, 工学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields
Keywords	Principal Investigator 摂食 / メラニン凝集ホルモン受容体 / Gタンパク質共役型受容体 / 摂食行動 / メラニン凝集ホルモン受容体1 / エクソソーム / 拒食症 / GPCR / エピジェネティクス / メラニン凝集ホルモン / 摂食障害 / ヒストン脱アセチル化酵素 … More Except Principal Investigator … More 慢性閉塞性肺疾患（COPD） / ヌマダイコン / COPD / ヒドロキシカウレン酸 Less

細胞アンテナ由来の小胞は肥満に関係するのかー小胞を介した新規情報伝達様式の提唱Principal Investigator
- Principal Investigator
  
  濱本明恵
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hiroshima University
Analysis of feeding mechanisms regulated by exosomes and development of novel therapeutic approachesPrincipal Investigator
- Principal Investigator
  
  Hamamoto Akie
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hiroshima University
  Gifu University
Development new materials for pneumonia
- Principal Investigator
  
  纐纈守
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Gifu University
Correlation between epigenetic control and GPCR focusing on feeding disordersPrincipal Investigator
- Principal Investigator
  
  Hamamoto Akie
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gifu University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Melanin-concentrating hormone receptor 1 is discarded by exosomes after internalization.2024
- Author(s)
  Yamada R, Michimae M, Hamamoto A, Takemori H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 710 Pages: 149917-149917
- DOI
  10.1016/j.bbrc.2024.149917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08867, KAKENHI-PROJECT-23K07972, KAKENHI-PROJECT-21K17638
[Journal Article] Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities2023
- Author(s)
  Takahashi M, Hamamoto A, Oh-Hashi K, Takemori H, Furuta K, Hirata Y.
- Journal Title
  
  ACS Chem Neurosci.
  
  Volume: － Issue: 10 Pages: 1826-1833
- DOI
  10.1021/acschemneuro.3c00042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K17638, KAKENHI-PROJECT-22K11824, KAKENHI-PROJECT-23K04504
[Journal Article] Adenostemmoic acid B suppresses NO production by downregulating the expression and inhibiting the enzymatic activity of iNOS2022
- Author(s)
  Kobayashi Takahiro、Tanaka Norika、Suzuki Mayu、Maeda Miwa、Batubara Irmanida、Iswantini Dyah、Koketsu Mamoru、Hamamoto Akie、Takemori Hiroshi
- Journal Title
  
  Phytochemistry Letters
  
  Volume: 49 Pages: 131-137
- DOI
  10.1016/j.phytol.2022.03.024
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0125, KAKENHI-PROJECT-20K05703
[Journal Article] Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan2022
- Author(s)
  Maeda Miwa、Suzuki Mayu、Fuchino Hiroyuki、Tanaka Norika、Kobayashi Takahiro、Isogai Ryosuke、Batubara Irmanida、Iswantini Dyah、Matsuno Michiyo、Kawahara Nobuo、Koketsu Mamoru、Hamamoto Akie、Takemori Hiroshi
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 76 Issue: 1 Pages: 132-143
- DOI
  10.1007/s11418-021-01565-3
- NAID
  40022800336
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0125
[Journal Article] Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones.2022
- Author(s)
  Hasegawa Y, Motoyama M, Hamamoto A, Kimura S, Kamatari YO, Kamishina H, Oh-Hashi K, Furuta K, Hirata Y
- Journal Title
  
  ACS Chem Neurosci.
  
  Volume: Apr 6;13(7) Issue: 7 Pages: 1055-1064
- DOI
  10.1021/acschemneuro.2c00064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06390, KAKENHI-PROJECT-21K17638
[Journal Article] Thioxothiazolidin derivative, 4‐OST, inhibits melanogenesis by enhancing the specific recruitment of tyrosinase‐containing vesicles to lysosome2021
- Author(s)
  Isogawa Kenta、Asano Masataka、Hayazaki Masumi、Koga Kenichi、Watanabe Miyu、Suzuki Keiichi、Kobayashi Takahiro、Kawaguchi Kyoka、Ishizuka Akane、Kato Shinya、Ito Hironari、Hamamoto Akie、Koyama Hiroko、Furuta Kyoji、Takemori Hiroshi
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: in press Issue: 6 Pages: 667-678
- DOI
  10.1002/jcb.29895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05703, KAKENHI-PROJECT-19K20143
[Journal Article] The Antiaging Effect of Active Fractions and Ent-11α-Hydroxy-15-Oxo-Kaur-16-En-19-Oic Acid Isolated from Adenostemma lavenia (L.) O. Kuntze at the Cellular Level2020
- Author(s)
  Irmanida Batubara, Rika Indri Astuti, Muhammad Eka Prastya, Auliya Ilmiawati, Miwa Maeda, Mayu Suzuki, Akie Hamamoto, Hiroshi Takemori
- Journal Title
  
  Antioxidants (Basel)
  
  Volume: 9 Issue: 8 Pages: 719-719
- DOI
  10.3390/antiox9080719
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20143
[Journal Article] High Content of 11αOH-Kaurenoic Acid in AdenostemmA. lavenia (L.) O. Kuntze Leaf Extract.2020
- Author(s)
  Hamamoto A, Isogai R, Maeda M, Hayazaki M, Horiyama E, Takashima S, Koketsu M, Takemori H.
- Journal Title
  
  Foods
  
  Volume: 9 Issue: 1 Pages: 73-73
- DOI
  10.3390/foods9010073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20143
[Journal Article] Mouse Model of Metformin-Induced Diarrhea.2020
- Author(s)
  Takemori H, Hamamoto A, Isogawa K, Ito M, Takagi M, Morino H, Miura T, Oshida K, Shibata T.
- Journal Title
  
  BMJ Open Diabetes Res Care.
  
  Volume: 8 Issue: 1 Pages: e000898-e000898
- DOI
  10.1136/bmjdrc-2019-000898
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20143
[Journal Article] Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode2020
- Author(s)
  Shiimura Yuki、Horita Shoichiro、Hamamoto Akie、Asada Hidetsugu、Hirata Kunio、Tanaka Misuzu、Mori Kenji、Uemura Tomoko、Kobayashi Takuya、Iwata So、Kojima Masayasu
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1-9
- DOI
  10.1038/s41467-020-17554-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06531, KAKENHI-PROJECT-18K16217, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-18K08497, KAKENHI-PROJECT-19K20143, KAKENHI-PLANNED-19H05777
[Journal Article] Analysis of ciliary status via G protein-coupled receptor localized in primary cilia.2020
- Author(s)
  Kobayashi Y, Hamamoto A, Saito Y
- Journal Title
  
  Microscopy
  
  Volume: 69 Issue: 5 Pages: 277-285
- DOI
  10.1093/jmicro/dfaa035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06739, KAKENHI-PROJECT-19K20143
[Journal Article] New Deletions in the Hermansky-Pudlak Syndrome Type 5 Gene in a Japanese Patient.2019
- Author(s)
  Kato S, Aoe T, Hamamoto A, Takemori H, Nishikubo T.
- Journal Title
  
  Reports
  
  Volume: 2 Issue: 2 Pages: 15-15
- DOI
  10.3390/reports2020015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20143, KAKENHI-PROJECT-16K10103
[Journal Article] Selective signaling pathway via feeding-related ciliary GPCR, melanin-concentrating hormone receptor 12019
- Author(s)
  Saito Y, Hamamoto A, Kobayashi Y.
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 154 Issue: 4 Pages: 179-185
- DOI
  10.1254/fpj.154.179
- NAID
  130007726233
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K20143
[Journal Article] Azepine derivative T4FAT, a new copper chelator, inhibits tyrosinase.2019
- Author(s)
  Okajima S, Hamamoto A, Asano M, Isogawa K, Ito H, Kato S, Hirata Y, Furuta K, Takemori H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 509 Issue: 1 Pages: 209-215
- DOI
  10.1016/j.bbrc.2018.12.105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 拘束ストレス負荷に伴うマウスの1次繊毛動態と情動行動の変化2024
- Author(s)
  髙橋凜太朗、濱本明恵、斎藤祐見子、小林勇喜
- Organizer
  令和5年度日本動物学会中国四国支部広島県例会
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] 細胞外小胞エクソソームに発現するGPCRの機能解析2024
- Author(s)
  濱本明恵、斎藤祐見子、小林勇喜
- Organizer
  令和5年度日本動物学会中国四国支部広島県例会
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] 拘束ストレスにより誘導したうつ様表現型を示すマウスの脳内一次繊毛解析2023
- Author(s)
  髙橋凜太朗、濱本明恵、斎藤祐見子、小林勇喜
- Organizer
  日本動物学会第94回大会
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] 一次繊毛長は繊毛におけるシグナル受容能を調節する2023
- Author(s)
  斎藤祐見子、濱本明恵、小林勇喜
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] 一次繊毛におけるドーパミン受容体5のシグナル依存的排出2023
- Author(s)
  濱本明恵、斎藤祐見子、德永優希、小林勇喜
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] エクソソームおけるGPCRの発現及び機能解析2022
- Author(s)
  山田凌平、道前桃花、竹森洋、濱本明恵
- Organizer
  第95回日本生化学会
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] Zebrafish could be useful as animal models to evaluate chemical-induced leukoderma.2022
- Author(s)
  Akie Hamamoto，Masumi Hayazaki，Osamu Hatano，Hiroshi Takemori
- Organizer
  第31回日本色素細胞学会学術大会
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] 摂食関連受容体と細胞から分泌されるナノ粒子2022
- Author(s)
  濱本明恵
- Organizer
  SPIRITS生物-無機-有機融合化学セミナー
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] エクソソームを介したメラニン凝集ホルモン受容体(MCHR1)のシグナル伝達2022
- Author(s)
  道前桃花、山田凌平、竹森洋、濱本明恵
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] エクソソームにおける摂食関連GPCRの発現と機能2021
- Author(s)
  山田凌平、道前桃花、竹森洋、濱本明恵
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] エクソソームによるGタンパク質共役型受容体（GPCR)の伝達機構2021
- Author(s)
  道前桃花、山田凌平、竹森洋、濱本明恵
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-21K17638
[Presentation] 11αOHカウレン酸の標的検索を目的とした修飾法の開発2020
- Author(s)
  前田美和、鈴木麻由、濱本明恵、竹森洋
- Organizer
  第84回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 11αOHカウレン酸における抗炎症作用機序の解析2020
- Author(s)
  小林卓広、磯貝亮介、濱本明恵、竹森洋
- Organizer
  第84回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] メラニン凝集ホルモン受容体１シグナル伝達経路におけるHDAＣの機能2020
- Author(s)
  道前桃花、溝口桃加、竹森洋、濱本明恵
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 11αOHカウレン酸及びその誘導体によるマウスでの癌免疫亢進作用2020
- Author(s)
  田中紀花、小林卓広、濱本明恵、竹森洋
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] ゼブラフィッシュに対する白斑誘発性化合物の影響2020
- Author(s)
  早﨑真純、秦野修、竹森洋、濱本明恵
- Organizer
  第84回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] ヌマダイコンに含まれる抗炎症成分11αOH カウレン酸と転写因子NFκB との関係の解析2020
- Author(s)
  磯貝亮介、濱本明恵、竹森洋
- Organizer
  第84回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 摂食亢進GPCRを介したヒストン脱アセチル化酵素の制御2020
- Author(s)
  濱本明恵、青山瑠里子、竹森洋
- Organizer
  第84回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 摂食亢進GPCR を介したヒストン脱アセチル化酵素の制御2020
- Author(s)
  濱本明恵、青山瑠里子、竹森洋
- Organizer
  第84回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 新規DDS開発のためのメラニン合成制御剤の探索2020
- Author(s)
  渡邉実夢、中村優介、濱本明恵、古田享史、竹森洋
- Organizer
  第84回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] CLEM imagings of rhododendrol-induced vitiligo in Danio rerio and catalytic oxidation of Japanese cedar wood.2020
- Author(s)
  61.Hatano O, Hayazaki M, Hamamoto A, Takemori H, Takaya H, Shano T, Isozaki K, Ohnishi K, Nakamura M
- Organizer
  ABiS Symposium: Forefront and Future of Electron Microscopic Imaging
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 新規DDS 開発のためのメラニン合成制御剤の探索2020
- Author(s)
  渡邉実夢、中村優介、濱本明恵、古田享史、竹森洋
- Organizer
  第84回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 摂食関連GPCRとHDACの機能相関関係2019
- Author(s)
  青山瑠里子、竹森洋、濱本明恵
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] ゼブラフィッシュを利用した白斑評価2019
- Author(s)
  濱本明恵、島林沙樹、竹森洋
- Organizer
  第90回動物学会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] ゼブラフィッシュにおける白斑化現象2019
- Author(s)
  早崎真純、竹森洋、濱本明恵
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 化合物HCOQによるメラニン合成抑制機構の解明2019
- Author(s)
  加藤慎也、濱本明恵、竹森洋
- Organizer
  第83回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 薬物輸送システム開発にためのホワイトメラノソームの作成2019
- Author(s)
  渡邉実夢、中村優介、岡島沙也花、濱本明恵、古田享史、竹森洋
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] メトホルミン誘導性下痢のマウスモデルにおける木クレオソートの止瀉効果2019
- Author(s)
  竹森洋、濱本明恵、五十川健太、伊藤雅文、高木優憲、森野博文、三浦孝典、押田恭一、柴田高
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 11αOHカウレン酸のメラニン合成酵素遺伝子発現抑制における構造活性相関2019
- Author(s)
  前田美和、伊藤弘成、濱本明恵、竹森洋
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 11αOHカウレン酸誘導体による一酸化窒素(NO)産出抑制作用2019
- Author(s)
  小林卓広、磯貝亮介、濱本明恵、竹森洋
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K20143
[Presentation] 11αOHカウレン酸誘導体のメラニン形成抑制及び抗炎症作用2019
- Author(s)
  磯貝亮介、濱本明恵、竹森洋
- Organizer
  第83回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-19K20143

1. 纐纈守 (50178208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 竹森洋 (90273672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 平島一輝 (50826633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 二ノ宮真之 (90557638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 古田享史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 椎村祐樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 児島将康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 斎藤祐見子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 鎌足雄司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAMAMOTO Akie 濱本 明恵

Hamamoto Akie 濱本 明恵

Research Projects

Research Products

Co-Researchers

細胞アンテナ由来の小胞は肥満に関係するのかー小胞を介した新規情報伝達様式の提唱Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of feeding mechanisms regulated by exosomes and development of novel therapeutic approachesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development new materials for pneumonia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Correlation between epigenetic control and GPCR focusing on feeding disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Melanin-concentrating hormone receptor 1 is discarded by exosomes after internalization.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adenostemmoic acid B suppresses NO production by downregulating the expression and inhibiting the enzymatic activity of iNOS2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones.2022

Author(s)

Journal Title

DOI

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HAMAMOTO Akie 濱本明恵

Hamamoto Akie 濱本明恵