Shimizu Tomohiro 清水智弘

Researcher Number	60784246
Other IDs
Affiliation (Current)	2025: 北海道大学, 大学病院, 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 北海道大学, 大学病院, 助教 2023: 北海道大学, 大学病院, 講師 2017: 北海道大学, 医学研究院, 客員研究員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator 特発性大腿骨頭壊死症 / 腸内細菌叢 / 自然免疫 / 多発骨壊死 / 自然免疫異常 / 好中球トラップ / 全身MRI / 好中球 / 細胞・組織 / テリパラチド … More / ビスフォスフォネート / CKD / 骨質異常 / ラット動物モデル / 骨質 / 慢性腎臓病 / 骨脆弱性 … More Except Principal Investigator 骨折 / マクロファージ / 偽関節 / 骨折治癒 / 骨リモデリング / 骨マクロファージ / 免疫異常 / 慢性炎症 / 大腿骨頭軟骨下脆弱性骨折 / 急速破壊型股関節症 / 関節破壊 / 抗RANKL抗体 / 炎症収束性貪食細胞由来細胞外小胞 / 関節炎 / 軟骨細胞 / 好中球由来細胞小胞 / 軟骨 / 細胞外小胞 / 好中球 / 抗炎症性マクロファージ / 遺伝子プロファイル / 制御性T細胞 / M2マクロファージ / 骨細胞 / インターフェロンシグナル / 破骨細胞 / 骨粗鬆症 Less

マクロファージ応答に着目した抗RANKL抗体のリバウンドのメカニズム解明とその対策
- Principal Investigator
  
  浅野毅
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Exploring functional roles of osteal macrophages in bone metabolism for the development of osteoporosis therapeutics
- Principal Investigator
  
  照川アラー
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Research on the effect of anti-inflammatory macrophage transplantation on fracture healing
- Principal Investigator
  
  高橋大介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
特発性大腿骨頭壊死症における多発骨壊死発生とマイクロバイオーム異常の関連性Principal Investigator
- Principal Investigator
  
  清水智弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Elucidation of innate immune disorders that regulate joint destruction and joint degeneration after fracture
- Principal Investigator
  
  宮崎拓自
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Exploration of novel mechanism of osteoporosis focusing on resolving macrophage-derived factors.
- Principal Investigator
  
  Takahashi Daisuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Resolving mechanism of arthritis induced by extracellular vesicles derived from resolving neutrophil
- Principal Investigator
  
  Asano Tsuyoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Association of innate immune abnormalities with the development and collapse of idiopathic osteonecrosis of the femoral head.Principal Investigator
- Principal Investigator
  
  Shimizu Tomohiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Bone fragility induced by tissue disoreder of mineral crystals and collargen in chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Shimizu Tomohiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hokkaido University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Methylprednisolone pulse-enhanced neutrophil extracellular trap formation in mice with imiquimod-induced lupus-like disease, resulting in ischaemia of the femoral head cartilage2023
- Author(s)
  Ogawa Hodaka、Yokota Shunichi、Hosoi Yumeka、Shindo Ayano、Ogawa Naho、Yamamura Ryodai、Shimizu Tomohiro、Nakade Issei、Arai Suishin、Taniguchi Mai、Nishibata Yuka、Masuda Sakiko、Nakazawa Daigo、Tomaru Utano、Iwasaki Norimasa、Ishizu Akihiro
- Journal Title
  
  Lupus Science & Medicine
  
  Volume: 10 Issue: 2 Pages: e001042-e001042
- DOI
  10.1136/lupus-2023-001042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16337, KAKENHI-PROJECT-23K08689, KAKENHI-PROJECT-21H02958
[Journal Article] Inflammasome Activation in the Hip Synovium of Rapidly Destructive Coxopathy Patients and Its Relationship with the Development of Synovitis and Bone Loss2022
- Author(s)
  Yokota Shunichi、Shimizu Tomohiro、Matsumae Gen、Ebata Taku、Alhasan Hend、Takahashi Daisuke、Terkawi Mohamad Alaa、Iwasaki Norimasa
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 192 Issue: 5 Pages: 794-804
- DOI
  10.1016/j.ajpath.2022.02.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09298, KAKENHI-PROJECT-20K17984
[Journal Article] Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis2021
- Author(s)
  Ebata Taku、Terkawi Mohamad Alaa、Hamasaki Masanari、Matsumae Gen、Onodera Tomohiro、Aly Mahmoud Khamis、Yokota Shunichi、Alhasan Hend、Shimizu Tomohiro、Takahashi Daisuke、Homan Kentaro、Kadoya Ken、Iwasaki Norimasa
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 6 Pages: 102643-102643
- DOI
  10.1016/j.isci.2021.102643
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18516, KAKENHI-PROJECT-20K09471
[Journal Article] Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates excessive bone loss and osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.2021
- Author(s)
  Shunichi Yokota, Gen Matsumae, Tomohiro Shimizu, Tomoka Hasegawa, Taku Ebata, Daisuke Takahashi, Cai Heguo, Yuan Tian, Hend Alhasan, Masahiko Takahata, Ken Kadoya, Alaa Terkawi, Norimasa Iwasaki
- Journal Title
  
  Bone
  
  Volume: 153 Pages: 116140-116140
- DOI
  10.1016/j.bone.2021.116140
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09425, KAKENHI-PROJECT-21K19585
[Journal Article] Evaluation of whole-body modalities for diagnosis of multifocal osteonecrosis?a pilot study2021
- Author(s)
  Yokota Shunichi、Sakamoto Keita、Shimizu Yukie、Asano Tsuyoshi、Takahashi Daisuke、Kudo Kohsuke、Iwasaki Norimasa、Shimizu Tomohiro
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 23 Issue: 1 Pages: 83-83
- DOI
  10.1186/s13075-021-02473-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17984
[Journal Article] Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles2020
- Author(s)
  Tian Yuan、Terkawi Mohamad Alaa、Onodera Tomohiro、Alhasan Hend、Matsumae Gen、Takahashi Daisuke、Hamasaki Masanari、Ebata Taku、Aly Mahmoud Khamis、Kida Hiroaki、Shimizu Tomohiro、Uetsuki Keita、Kadoya Ken、Iwasaki Norimasa
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 1720-1720
- DOI
  10.3389/fimmu.2020.01720
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09425, KAKENHI-PROJECT-20H03558
[Journal Article] Ten years change in post-fracture care for hip fracture patients.2020
- Author(s)
  Shimodan S, Sato D, Takahashi K, Nakamura Y, Hyakkan R, Watanabe T, Hishimura R, Ota M, Shimizu H, Hojo Y, Hasegawa Y, Chubachi T, Yasui K, Tsujimoto T, Tsukuda Y, Asano T, Takahashi D, Takahata M, Iwasaki N, Shimizu T.
- Journal Title
  
  J Bone Miner Metab.
  
  Volume: 38(2) Pages: 222-229
- NAID
  120006980047
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16670
[Journal Article] Association of Neutrophil Extracellular Traps with the Development of Idiopathic Osteonecrosis of the Femoral Head2020
- Author(s)
  Nonokawa Mayu、Shimizu Tomohiro、Yoshinari Miku、Hashimoto Yamato、Nakamura Yusuke、Takahashi Daisuke、Asano Tsuyoshi、Nishibata Yuka、Masuda Sakiko、Nakazawa Daigo、Tanaka Satoshi、Tomaru Utano、Iwasaki Norimasa、Ishizu Akihiro
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 190 Issue: 11 Pages: 2282-2289
- DOI
  10.1016/j.ajpath.2020.07.008
- NAID
  120007168180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21512, KAKENHI-PROJECT-20K17984, KAKENHI-PROJECT-18H02629
[Journal Article] Potential association with early changes in serum calcium level after starting or switching to denosumab combined with eldecalcitol.2019
- Author(s)
  Asano T, Shimizu T, Takahashi D, Ota M, Sato D, Hamano H, Hiratsuka S, Takahata M, Iwasaki N.
- Journal Title
  
  J Bone Miner Metab.
  
  Volume: 37(2) Pages: 351-357
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16670
[Journal Article] Optimal administration frequency and dose of teriparatide for acceleration of biomechanical healing of long-bone fracture in a mouse model2018
- Author(s)
  Ota Masahiro、Takahata Masahiko、Shimizu Tomohiro、Momma Daisuke、Hamano Hiroki、Hiratsuka Shigeto、Amizuka Norio、Hasegawa Tomoka、Iwasaki Norimasa
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 37 Issue: 2 Pages: 256-263
- DOI
  10.1007/s00774-018-0930-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16670
[Journal Article] Potential association with early changes in serum calcium level after starting or switching to denosumab combined with eldecalcitol2018
- Author(s)
  Asano Tsuyoshi、Shimizu Tomohiro、Takahashi Daisuke、Ota Masahiro、Sato Dai、Hamano Hiroki、Hiratsuka Shigeto、Takahata Masahiko、Iwasaki Norimasa
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 37 Issue: 2 Pages: 351-357
- DOI
  10.1007/s00774-018-0928-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16670
[Journal Article] Efficacy and safety of osteoporosis medications in a rat model of late-stage chronic kidney disease accompanied by secondary hyperparathyroidism and hyperphosphatemia.2017
- Author(s)
  Ota M, Takahata M, Shimizu T, Kanehira Y, Kimura-Suda H, Kameda Y, Hamano H, Hiratsuka S, Sato D, Iwasaki N.
- Journal Title
  
  Osteoporosis International
  
  Volume: 28 Issue: 4 Pages: 1481-1490
- DOI
  10.1007/s00198-016-3861-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16670, KAKENHI-PROJECT-15H02207
[Presentation] Extracellular Vesicles Derived From Neutrophils Suppress Catabolic Process Induced By Il-1β Stimulation In Chondrocytes.2023
- Author(s)
  北原圭太 ,江畑拓 ,照川アラー ,西田善郎, ヘンドアルハサン,横田隼一, 塩田惇喜, 徳廣泰貴, 遠藤努 ,清水智弘 ,髙橋大介 , 浅野毅, 岩崎倫政
- Organizer
  Orthopaedic Research Society 2023 ANNUAL MEETING
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09471
[Presentation] CLCF1投与によるインターフェロンシグナルの活性化を介した骨粗鬆症モデルマウスの骨量減少抑制効果について2022
- Author(s)
  横田隼一, 松前元, 江畑拓, 照川ヘンド, 清水智弘, 髙橋大介, 照川アラー, 岩崎倫政
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09425
[Presentation] 骨リモデリング調節におけるアネキシンA1の機能解析2022
- Author(s)
  西田善郎, 松前元, 江畑拓, 横田隼一, 照川ヘンド, 塩田惇喜, 北原圭太, 清水智弘, 髙橋大介, 照川アラー, 岩崎倫政
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09425
[Presentation] 炎症収束型好中球由来細胞外小胞による軟骨細胞抗異化作用の検討2022
- Author(s)
  北原圭太 ,江畑拓 ,照川アラー ,清水智弘 ,遠藤努 ,浅野毅,髙橋大介 ,角家健 ,岩崎倫政
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09471
[Presentation] Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates excessive bone loss and osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.2022
- Author(s)
  Shunichi Yokota, Gen Matsumae, Tomohiro Shimizu, Taku Ebata, Hend Alhasan, Daisuke Takahashi, M Alaa Terkawi, Norimasa Iwasaki
- Organizer
  ORS 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09425
[Presentation] 新規骨粗鬆症治療薬が骨粗鬆症性骨脆弱性骨折に及ぼす影響の検討：10年2747例の検討2018
- Author(s)
  佐藤大，清水智弘，菱村亮介，高橋要，太田昌博，辻本武尊，佃幸憲，髙橋大介，高畑雅彦，岩崎倫政
- Organizer
  第20回日本骨粗鬆症学会，長崎市，2018年10月26日-28日
- Data Source
  KAKENHI-PROJECT-17K16670
[Presentation] 手術加療を施行した脆弱性骨折における術後骨粗鬆症検査・治療介入率の検証－北海道10年多施設後ろ向きコホート－2018
- Author(s)
  太田昌博, 清水智弘，菱村亮介, 高橋要, 佐藤大, 辻本武尊, 岸本隆史, 林晴久, 宮本守孝, 佃幸憲, 髙橋大介, 高畑雅彦, 岩崎倫政
- Organizer
  第20回日本骨粗鬆症学会
- Data Source
  KAKENHI-PROJECT-17K16670

1. 照川アラー (00723074)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. Takahashi Daisuke (90528845)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. Asano Tsuyoshi (50722493)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 長谷川智香 (50739349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 宮崎拓自 (70908194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 市川聡 (60333621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HOMAN Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. テルカウィアラー

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
9. 益田紗季子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 外丸詩野

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Tomohiro 清水 智弘

Research Projects

Research Products

Co-Researchers

マクロファージ応答に着目した抗RANKL抗体のリバウンドのメカニズム解明とその対策

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring functional roles of osteal macrophages in bone metabolism for the development of osteoporosis therapeutics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on the effect of anti-inflammatory macrophage transplantation on fracture healing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

特発性大腿骨頭壊死症における多発骨壊死発生とマイクロバイオーム異常の関連性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of innate immune disorders that regulate joint destruction and joint degeneration after fracture

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of novel mechanism of osteoporosis focusing on resolving macrophage-derived factors.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Resolving mechanism of arthritis induced by extracellular vesicles derived from resolving neutrophil

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Association of innate immune abnormalities with the development and collapse of idiopathic osteonecrosis of the femoral head.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Bone fragility induced by tissue disoreder of mineral crystals and collargen in chronic kidney diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Methylprednisolone pulse-enhanced neutrophil extracellular trap formation in mice with imiquimod-induced lupus-like disease, resulting in ischaemia of the femoral head cartilage2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inflammasome Activation in the Hip Synovium of Rapidly Destructive Coxopathy Patients and Its Relationship with the Development of Synovitis and Bone Loss2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates excessive bone loss and osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of whole-body modalities for diagnosis of multifocal osteonecrosis?a pilot study2021

Author(s)

Shimizu Tomohiro 清水智弘

[Presentation] 手術加療を施行した脆弱性骨折における術後骨粗鬆症検査・治療介入率の検証－北海道10年多施設後ろ向きコホート－2018