tanabe aki 田部亜季

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Tanabe Aki 田部亜季

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Researcher Number	60786367
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所エイズ研究センター, 研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 国立感染症研究所, エイズ研究センター, 研究員 2019 – 2022: 東京大学, 大学院工学系研究科(工学部), 特任助教 2018: 東京大学, 大学院工学系研究科(工学部), 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / 0403:Biomedical engineering and related fields Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 62010:Life, health and medical informatics-related
Keywords	Principal Investigator 成人T細胞白血病リンパ腫 / 抗体薬物複合体 / 抗体-薬物複合体 / 抗体工学 / 成人T細胞白血病 / 抗体 / HTLV-1 / ATL / 抗体エンジニアリング / 血液悪性腫瘍 … More / 自己免疫疾患 / 蛋白質間相互作用解析 / Drug Delivery / チオストレオプトン / 成人T細胞性白血病/リンパ腫 / CADM1 / 成人T細胞白血病/リンパ腫 / ドラッグデリバリー / 成人T細胞白血病リンパ腫(ATLL) / ファージディスプレイ … More Except Principal Investigator ウイルスタンパク質機能 / 疫学研究 / 疫学調査 / 細胞外微小環境 / ウイルスタンパク質 / HTLV-1関連疾患 / HTLV-1 a/c / リモート診療 / オーストラリア先住民 / HTLV-1ｃ / 気管支拡張症 / HU / HAM / ATL / オーストラリア / HTLV-1c / 日本 / HTLV-1a / 凝集性 / 熱安定性 / タンパク質工学 / シミュレーション / 蛋白質工学 / Supercharging / 単ドメイン抗体 / 分子デザイン / 機能計測 / 物性計測 / ペプチド / 抗体 / 抗体工学 / 分子設計 / 安定性 / 親和性成熟 / 機械学習 / 分子シミュレーション / ペプチド設計 / 抗体設計 Less

成人T細胞白血病リンパ腫に対する新規治療法の開発Principal Investigator
- Principal Investigator
  
  田部亜季
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institute of Infectious Diseases
Japan-Australia joint study for epidemiological survey of HTLV-1 a/c subtypes and elucidation of their unique pathogenic mechanims
- Principal Investigator
  
  中野和民
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  The University of Tokyo
Development of novel antibody-drug conjugate for refractory hematological malignancy and autoimmune diseasePrincipal Investigator
- Principal Investigator
  
  Tanabe Aki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institute of Infectious Diseases
  The University of Tokyo
Molecular design of real proteins in virtual space
- Principal Investigator
  
  Kuroda Daisuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  National Institute of Infectious Diseases
  The University of Tokyo
Thiostrepton Antibody-Drug Conjugate Targeting CADM1 for Adult T-Cell Leukemia/Lymphoma TherapyPrincipal Investigator
- Principal Investigator
  
  Tanabe Aki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0403:Biomedical engineering and related fields
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Analytical Method for Experimental Validation of Computer-Designed Antibody2022
- Author(s)
  Tanabe Aki、Tsumoto Kouhei
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2552 Pages: 409-433
- DOI
  10.1007/978-1-0716-2609-2_23
- ISBN
  9781071626085, 9781071626092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02531, KAKENHI-PLANNED-19H05766, KAKENHI-PROJECT-22K15598
[Journal Article] Thrombophlebitis Migrans As the Prodrome of Adult T-Cell Leukemia-Lymphoma2022
- Author(s)
  Matsuda-Hirose Haruna、Nashimoto Yuko、Tanabe Aki、Ogata Masao、Iwao Masao、Mizukami Kazuhiro、Nishida Haruto、Hatano Yutaka
- Journal Title
  
  Annals of Dermatology
  
  Volume: 34 Issue: 4 Pages: 312-312
- DOI
  10.5021/ad.20.184
- Data Source
  KAKENHI-PROJECT-22K15598
[Journal Article] Elucidation of the mechanism of host NMD suppression by HTLV-1 Rex: Dissection of Rex to identify the NMD inhibitory domain2022
- Author(s)
  Nakano, K., Karasawa N., Hashizume M., Tanaka, Y, Ohsugi, T., Uchimaru. K. and Watanabe, T.
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 2 Pages: 344-344
- DOI
  10.3390/v14020344
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-19K07573, KAKENHI-PROJECT-20KK0181
[Journal Article] Tuning Rex rules HTLV-1 pathogenesis2022
- Author(s)
  Kazumi Nakano and Toshiki Watanabe
- Journal Title
  
  Frontiers Immunology
  
  Volume: 13 Pages: 959962-959962
- DOI
  10.3389/fimmu.2022.959962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0181
[Journal Article] Exploring New Functional Aspects of HTLV-1 RNA-Binding Protein Rex: How Does Rex Control Viral Replication?2022
- Author(s)
  Kazumi Nakano(corresponding author), Koichi Yokoyama, Shuichi Shin, Koki Uchida, Kazuki Tsuji, Marie Tanaka, Kaoru Uchimaru, and Toshiki Watanabe
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 2 Pages: 407-407
- DOI
  10.3390/v14020407
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07573, KAKENHI-PROJECT-20KK0181
[Journal Article] Extracellular matrix-inspired hydrogel of hyaluronan and gelatin crosslinked via a Link module with a transglutaminase reactive sequence2022
- Author(s)
  Okawa Masashi、Tanabe Aki、Ohta Seiichi、Nagatoishi Satoru、Tsumoto Kouhei、Ito Taichi
- Journal Title
  
  Communications Materials
  
  Volume: 3 Issue: 1 Pages: 1-11
- DOI
  10.1038/s43246-022-00309-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15598, KAKENHI-PROJECT-20H02530, KAKENHI-PLANNED-21H05092, KAKENHI-PROJECT-21J12834
[Journal Article] Correction: Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis2022
- Author(s)
  Yokoo Takanori、Tanabe Aki、Yoshida Yoko、Caaveiro Jose M.M.、Nakakido Makoto、Ikeda Yoichiro、Fujimura Yoshihiro、Matsumoto Masaneori、Entzminger Kevin、Maruyama Toshiaki、Okumura C.J.、Nangaku Masaomi、Tsumoto Kouhei
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 8 Pages: 102262-102262
- DOI
  10.1016/j.jbc.2022.102262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15598, KAKENHI-PROJECT-20H02531
[Journal Article] Overexpression of aberrant Wnt5a and its effect on acquisition of malignant phenotypes in adult T-cell leukemia/lymphoma (ATL) cells.2021
- Author(s)
  Nakano K., Chihara Y., Kobayashi S., Iwanaga M., Utsunomiya A., Watanabe T., and Uchimaru K.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 4114-4114
- DOI
  10.1038/s41598-021-83613-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07573, KAKENHI-PROJECT-20KK0181, KAKENHI-PROJECT-16H06277
[Journal Article] Anion solvation enhanced by positive supercharging mutations preserves thermal stability of an antibody in a wide pH range2021
- Author(s)
  Kasahara Keisuke、Kuroda Daisuke、Tanabe Aki、Kawade Raiji、Nagatoishi Satoru、Tsumoto Kouhei
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 563 Pages: 54-59
- DOI
  10.1016/j.bbrc.2021.05.053
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05425, KAKENHI-PROJECT-19H03522, KAKENHI-PROJECT-20H02531, KAKENHI-PLANNED-19H05766, KAKENHI-PROJECT-19H04202
[Journal Article] Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysis2020
- Author(s)
  Chiba Shuntaro、Tanabe Aki、Nakakido Makoto、Okuno Yasushi、Tsumoto Kouhei、Ohta Masateru
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 17590-17590
- DOI
  10.1038/s41598-020-74545-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02531, KAKENHI-PROJECT-20K16377
[Journal Article] A Peptoid with Ectended Shape in Water2019
- Author(s)
  Morimoto J, Fukuda Y, Kuroda D, Watanabe T, Yoshida F, Asada M, Nakamura T, Senoo A, Nagatoishi S, Tsumoto K, *Sando S
- Journal Title
  
  J Am Chem Soc.
  
  Volume: 141 Issue: 37 Pages: 14612-14623
- DOI
  10.1021/jacs.9b04371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02082, KAKENHI-PROJECT-19H03522, KAKENHI-PROJECT-19H04202
[Patent] 抗CADM1抗体2022
- Inventor(s)
  田部亜季、高橋良明、中野和民、渡邉俊樹、津本浩平
- Industrial Property Rights Holder
  田部亜季、高橋良明、中野和民、渡邉俊樹、津本浩平
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-22K15598
[Patent] 抗CADM1抗体2021
- Inventor(s)
  中野和民、高橋良明、田部亜季、渡邉俊樹、津本浩平
- Industrial Property Rights Holder
  中野和民、高橋良明、田部亜季、渡邉俊樹、津本浩平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-080133
- Filing Date
  2021
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-20KK0181
[Presentation] 成人T細胞白血病リンパ腫を標的とする抗CADM1scFvの機能解析2023
- Author(s)
  田部亜季、高橋良明、中野和民、由井杏奈、中木戸誠、久世望、中村碧、石井洋、立川愛、俣野哲郎、渡邉俊樹、津本浩平
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15598
[Presentation] 新規抗CADM1抗体を用いた抗体薬物複合体の生体内動体と効果の検討2023
- Author(s)
  中野和民、田部亜季、高橋良明、由井杏奈、中木戸誠、内丸薫、渡邉俊樹、津本浩平
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15598
[Presentation] HTLV-1 type-aとtype-cのウイルス特性と病原性の違いに関する研究：ウイルス学的比較解析の試み2023
- Author(s)
  中野和民、田部亜季、佐藤知雄、鴨居功樹、宇都宮與、Lloyd Einseadel、渡邉俊樹、
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15598
[Presentation] 新規CADM1抗体-FoxM1阻害剤複合体によるATL細胞への標的治療の試み2022
- Author(s)
  中野和民、田部亜季、高橋良明、山本奈央佳、津本浩平、渡邉俊樹、内丸薫
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15598
[Presentation] 抗CADM1抗体を用いた成人T細胞白血病・リンパ腫細胞に対する抗体薬物複合体の開発2022
- Author(s)
  田部亜季、高橋良明、那須智博、由井杏奈、中木戸誠、内丸薫、渡邉俊樹、津本浩平、中野和民
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15598
[Presentation] 新規抗CADM1モノクローナル抗体の作製：CloneYTH-W-2C22022
- Author(s)
  高橋良明、田部亜季、中野和民、渡邉俊樹、津本浩平
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15598
[Presentation] 新規抗CADM１抗体を用いた成人T細胞白血病・リンパ腫細胞に対する抗体薬物複合体の開発2022
- Author(s)
  田部亜季、高橋良明、那須智博、由井杏奈、中木戸誠、内丸薫、渡邉俊樹、津本浩平、中野和民
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-20KK0181
[Presentation] 新規CADM1抗体-FoxM1阻害剤複合体によるATL細胞への標的治療の試み2022
- Author(s)
  中野和民、田部亜季、高橋良明、山本菜央佳、津本浩平、渡邉俊樹、内丸薫
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-20KK0181
[Presentation] The mechanism by which positive supercharging mutations confer pH-independent thermal stability of an antibody2021
- Author(s)
  笠原慶亮・黒田大祐・河出来時・田部亜季・長門石曉・津本浩平
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-19H04202
[Presentation] 計算デザイン Supercharging 抗体の物性機能解析2020
- Author(s)
  笠原慶亮、黒田大祐、河出来時、田部亜季、長門石曉、津本浩平
- Organizer
  第48回　構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-20K16377
[Presentation] 成人T細胞白血病・リンパ腫（ATL)細胞に対する新規治療薬Darinaparsinの効果の検討とその作用機序解明の試み2020
- Author(s)
  那須　智博、田部　亜季、渡邉　俊樹、内丸　薫、中野　和民
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16377
[Presentation] 抗OX40抗体の受容体機能制御に関わる分子メカニズム解明2020
- Author(s)
  氏家寛、田部亜季、伊村明浩、広瀬茂久、津本浩平
- Organizer
  第43回日本分子生物学会年、オンライン開催、2020年12月2日-4日
- Data Source
  KAKENHI-PROJECT-20K16377
[Presentation] aHUSに関連する補体抑制因子CFHと特異的抗体の機能解析2020
- Author(s)
  横尾尚典、田部亜季、中木戸誠、長門石曉、吉田瑶子、池田洋一郎、南学正臣、津本浩平
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16377
[Presentation] Production of rhTSG-6 using Expi293 expression system2019
- Author(s)
  Masashi Okawa, Aki Tanabe, Satoru Nagatoishi, Seiichi Ohta, Kohei Tsumoto, Taichi Ito
- Organizer
  The 14th Asian Congress on Biotechnology, July 1-4, 2019, Taiwan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21113
[Presentation] 成人T細胞白血病(ATL)を標的としたPhage display法による抗CADM1 scFvの取得2019
- Author(s)
  田部亜季
- Organizer
  蛋白質科学会
- Data Source
  KAKENHI-PROJECT-19K21113
[Presentation] 成人T細胞白血病(ATL)を標的としたPhage display法による抗CADM1 scFvの取得2019
- Author(s)
  田部亜季、中木戸誠、山本菜央佳、中野和民、内丸薫、津本浩平
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-19K21113

1. Kuroda Daisuke (60756732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 森本淳平 (70754935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 中野和民 (60549591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 渡邉俊樹 (30182934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 佐藤知雄 (30387063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 鴨居功樹 (40451942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 宇都宮與 (40511663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAGATOISHI Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 津本浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 大杉剛生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 渡辺俊樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 中木戸誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

tanabe aki 田部 亜季

Tanabe Aki 田部 亜季

Research Projects

Research Products

Co-Researchers

成人T細胞白血病リンパ腫に対する新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Japan-Australia joint study for epidemiological survey of HTLV-1 a/c subtypes and elucidation of their unique pathogenic mechanims

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel antibody-drug conjugate for refractory hematological malignancy and autoimmune diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular design of real proteins in virtual space

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Thiostrepton Antibody-Drug Conjugate Targeting CADM1 for Adult T-Cell Leukemia/Lymphoma TherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Analytical Method for Experimental Validation of Computer-Designed Antibody2022

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Thrombophlebitis Migrans As the Prodrome of Adult T-Cell Leukemia-Lymphoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elucidation of the mechanism of host NMD suppression by HTLV-1 Rex: Dissection of Rex to identify the NMD inhibitory domain2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tuning Rex rules HTLV-1 pathogenesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring New Functional Aspects of HTLV-1 RNA-Binding Protein Rex: How Does Rex Control Viral Replication?2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular matrix-inspired hydrogel of hyaluronan and gelatin crosslinked via a Link module with a transglutaminase reactive sequence2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correction: Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of aberrant Wnt5a and its effect on acquisition of malignant phenotypes in adult T-cell leukemia/lymphoma (ATL) cells.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anion solvation enhanced by positive supercharging mutations preserves thermal stability of an antibody in a wide pH range2021

Author(s)

Journal Title

DOI

tanabe aki 田部亜季

Tanabe Aki 田部亜季