Kume Tsutomu 久米努

Researcher Number	60786474
Other IDs
Affiliation (Current)	2025: 熊本大学, 生命資源研究・支援センター, 客員教授
Affiliation (based on the past Project Information) *help	2018 – 2022: 熊本大学, 生命資源研究・支援センター, 客員教授
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator 遺伝子改変モデルマウス / ゲノムワイド解析 / Fox転写因子 / リンパ管新生 / Foxc 転写因子 / RasGAP / Foxc転写因子 / 転写ネットワーク / がん微小環境 / share stress … More / GATA / FOXC / 血管新生 / リンパ弁 / リンパ管内凝固 / 虚血性腸疾患 / 小腸虚血再灌流障害モデル / VEGF-C / リンパ管 Less

Physiological and pathological analysis of intestinal mucosa lymphatic endothelial cells.Principal Investigator
- Principal Investigator
  
  Kume Tsutomu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kumamoto University
Foundation of anti-lymphangiogenesis and metastasis method via Foxc network analysisPrincipal Investigator
- Principal Investigator
  
  Kume Tsutomu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University

All 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation2022
- Author(s)
  Ujiie Naoto、Kume Tsutomu
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 13
- DOI
  10.3389/fphys.2022.1066460
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665
[Journal Article] <i>Foxc1</i> and <i>Foxc2</i> are indispensable for the maintenance of nephron and stromal progenitors in the developing kidney2022
- Author(s)
  Motojima Masaru、Tanaka Masayuki、Kume Tsutomu
- Journal Title
  
  Journal of Cell Science
  
  Volume: 135 Issue: 19
- DOI
  10.1242/jcs.260356
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08364, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-19K22665
[Journal Article] Cell lineage‐ and expression‐based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development2021
- Author(s)
  Takenoshita Manami、Takechi Masaki、Vu Hoang Tri、Furutera Toshiko、Akagawa Chisaki、Namangkalakul Worachat、Aoto Kazushi、Kume Tsutomu、Miyashin Michiyo、Iwamoto Tsutomu、Iseki Sachiko
- Journal Title
  
  Developmental Dynamics
  
  Volume: - Issue: 8 Pages: 1-10
- DOI
  10.1002/dvdy.324
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06821, KAKENHI-PROJECT-20K07243, KAKENHI-PROJECT-19K22665, KAKENHI-PROJECT-18H02682, KAKENHI-PROJECT-17K08513, KAKENHI-PROJECT-21H03098
[Journal Article] Molecular Mechanisms Controlling Lymphatic Endothelial Junction Integrity2021
- Author(s)
  Norden Pieter R.、Kume Tsutomu
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 8 Pages: 627647-627647
- DOI
  10.3389/fcell.2020.627647
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665, KAKENHI-PROJECT-18H02682
[Journal Article] Escape of hair follicle stem cells causes stem cell exhaustion during aging2021
- Author(s)
  Zhang Chi、Wang Dongmei、Wang Jingjing、Wang Li、Qiu Wenli、Kume Tsutomu、Dowell Robin、Yi Rui
- Journal Title
  
  Nature Aging
  
  Volume: 1 Issue: 10 Pages: 889-903
- DOI
  10.1038/s43587-021-00103-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665
[Journal Article] Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes2021
- Author(s)
  Yang Jingping、Zhang Difei、Motojima Masaru、Kume Tsutomu、Hou Qing、Pan Yu、Duan Aiping、Zhang Mingchao、Jiang Song、Hou Jinhua、Shi Jingsong、Qin Zhaohui、Liu Zhihong
- Journal Title
  
  Journal of the American Society of Nephrology
  
  Volume: 32 Issue: 6 Pages: 1323-1337
- DOI
  10.1681/asn.2020081177
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665
[Journal Article] Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation2020
- Author(s)
  Norden Pieter R、Sabine Am?lie、Wang Ying、Demir Cansaran Saygili、Liu Ting、Petrova Tatiana V、Kume Tsutomu
- Journal Title
  
  eLife
  
  Volume: 9 Pages: 9-9
- DOI
  10.7554/elife.53814
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665, KAKENHI-PROJECT-18H02682
[Journal Article] In Vivo Imaging of Schlemm's Canal and Limbal Vascular Network in Mouse Using Visible-Light OCT2020
- Author(s)
  Zhang Xian、Beckmann Lisa、Miller David A.、Shao Guangbin、Cai Zhen、Sun Cheng、Sheibani Nader、Liu Xiaorong、Schuman Joel、Johnson Mark、Kume Tsutomu、Zhang Hao F.
- Journal Title
  
  Investigative Opthalmology & Visual Science
  
  Volume: 61 Issue: 2 Pages: 23-23
- DOI
  10.1167/iovs.61.2.23
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665, KAKENHI-PROJECT-18H02682
[Journal Article] Conditional inactivation of Foxc1 and Foxc2 in neural crest cells leads to cardiac abnormalities2020
- Author(s)
  Sanchez Joshua、Miyake Risa、Cheng Andrew、Liu Ting、Iseki Sachiko、Kume Tsutomu
- Journal Title
  
  genesis
  
  Volume: 58 Issue: 7 Pages: 7-7
- DOI
  10.1002/dvg.23364
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665, KAKENHI-PROJECT-18H02682
[Journal Article] The Role of Lymphangiogenesis and Lymphatic Collecting Vessel Function in Metabolic Disorders.2020
- Author(s)
  Norden Pieter, Kume Tsutomu
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 11 Pages: 404-404
- DOI
  10.3389/fphys.2020.00404
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665, KAKENHI-PROJECT-18H02682
[Journal Article] Organ/Tissue-Specific Vascular Endothelial Cell Heterogeneity in Health and Disease2019
- Author(s)
  Minami Takashi、Muramatsu Masashi、Kume Tsutomu
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 10 Pages: 1609-1619
- DOI
  10.1248/bpb.b19-00531
- NAID
  130007722463
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-10-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0026, KAKENHI-PROJECT-19K22665, KAKENHI-PUBLICLY-19H04972, KAKENHI-PROJECT-17H03580, KAKENHI-PROJECT-18H02682
[Journal Article] リンパ管の発生・弁形成の分子制御機構2018
- Author(s)
  久米努
- Journal Title
  
  リンパ学
  
  Volume: 41(2) Pages: 67-70
- Data Source
  KAKENHI-PROJECT-18H02682
[Presentation] Foxc1 and Foxc2 are required in blood and lymphatic vasculatures for small intestinal mucosal repair after ischemia/reperfusion injury2020
- Author(s)
  Can Tan, Ting Liu, and Tsutomu Kume
- Organizer
  Gordon Research Conference on Lymphatics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665
[Presentation] Neural-crest derived Foxc2 expression is required for proper morphogenesis of the Schlemm’s Canal2020
- Author(s)
  Pieter R. Norden, Lisa J. Beckmann, Zhen Cai, Xian Zhang, Hao F. Zhang, and Tsutomu Kume
- Organizer
  Gordon Research Conference on Lymphatics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665
[Presentation] Neural-crest derived Foxc2 expression is required for proper morphogenesis of the Schlemm’s Canal2020
- Author(s)
  Pieter R. Norden, Lisa J. Beckmann, Zhen Cai, Xian Zhang, Hao F. Zhang, and Tsutomu Kume
- Organizer
  Gordon Research Conference on Lymphatics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02682
[Presentation] Foxc Transcription Factors in Organ-Specific Lymphatic Function2020
- Author(s)
  Tsutomu Kume
- Organizer
  Gordon Research Conference on Lymphatics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02682
[Presentation] Foxc Transcription Factors in Organ-Specific Lymphatic Function2020
- Author(s)
  Tsutomu Kume
- Organizer
  Gordon Research Conference on Lymphatics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665
[Presentation] Foxc1 and Foxc2 are required in blood and lymphatic vasculatures for small intestinal mucosal repair after ischemia/reperfusion injury2020
- Author(s)
  Can Tan, Ting Liu, and Tsutomu Kume
- Organizer
  Gordon Research Conference on Lymphatics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02682
[Presentation] Foxc1/Foxc2 regulation of RHO/ROCK activation in postnatal lymphatic valve maturation2019
- Author(s)
  Pieter R. Norden, Amélie Sabine, Ying Wang, Ting Liu, Tatiana V. Petrova, and Tsutomu Kume
- Organizer
  Lymphatic Forum 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22665
[Presentation] Foxc1/Foxc2 regulation of RHO/ROCK activation in postnatal lymphatic valve maturation2019
- Author(s)
  Pieter R. Norden, Amélie Sabine, Ying Wang, Ting Liu, Tatiana V. Petrova, and Tsutomu Kume
- Organizer
  Lymphatic Forum 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02682

1. 南敬 (00345141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. TAKECHI Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. MOTOJIMA Masaru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 井関祥子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kume Tsutomu 久米 努

Research Projects

Research Products

Co-Researchers

Physiological and pathological analysis of intestinal mucosa lymphatic endothelial cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Foundation of anti-lymphangiogenesis and metastasis method via Foxc network analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <i>Foxc1</i> and <i>Foxc2</i> are indispensable for the maintenance of nephron and stromal progenitors in the developing kidney2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell lineage‐ and expression‐based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Mechanisms Controlling Lymphatic Endothelial Junction Integrity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Escape of hair follicle stem cells causes stem cell exhaustion during aging2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In Vivo Imaging of Schlemm's Canal and Limbal Vascular Network in Mouse Using Visible-Light OCT2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conditional inactivation of Foxc1 and Foxc2 in neural crest cells leads to cardiac abnormalities2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Role of Lymphangiogenesis and Lymphatic Collecting Vessel Function in Metabolic Disorders.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Organ/Tissue-Specific Vascular Endothelial Cell Heterogeneity in Health and Disease2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] リンパ管の発生・弁形成の分子制御機構2018

Author(s)

Journal Title

Data Source

[Presentation] Foxc1 and Foxc2 are required in blood and lymphatic vasculatures for small intestinal mucosal repair after ischemia/reperfusion injury2020

Kume Tsutomu 久米努