Shiheido Yuka 始平堂由佳

Researcher Number	60791853
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2022: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / Periodontology
Keywords	Principal Investigator 歯周病 / 歯周病原細菌 / 心肥大 / オートファジー / 心筋障害 / 心筋梗塞 / 糖尿病 / 選択的オートファジー / 糖尿病性心筋障害

Effect of periodontal infection on cardiac hypertrophy through dysregulation of autophagy and its mechanism.Principal Investigator
- Principal Investigator
  
  Shiheido Yuka
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of the influence of periodontal pathogen infection on the association between diabetic myocardial disease and selective autophagyPrincipal Investigator
- Principal Investigator
  
  Shiheido Yuka
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Tokyo Medical and Dental University

All 2022 2021 2020 2019 2018 2017 Other

All Journal Article Presentation Other

[Journal Article] Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy2022
- Author(s)
  Sano Masataka、Maejima Yasuhiro、Nakagama Shun、Shiheido-Watanabe Yuka、Tamura Natsuko、Hirao Kenzo、Isobe Mitsuaki、Sasano Tetsuo
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 10 Pages: 876147-876147
- DOI
  10.3389/fcell.2022.876147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08399, KAKENHI-PROJECT-19K18985
[Journal Article] Plasma apolipopotein C-2 elevation is associated with Takayasu arteritis2021
- Author(s)
  Tamura N, Maejima Y, Shiheido-Watanabe Y, Nakagama S, Isobe M, Sasano T
- Journal Title
  
  Sci Rep
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18985
[Journal Article] Effect of Periodontal Disease on Long-Term Outcomes After Percutaneous Coronary Intervention for De Novo Coronary Lesions in Non-Smokers.2021
- Author(s)
  Fukushima T, Yonetsu T, Aoyama N, Tashiro A, Niida T, Shiheido-Watanabe Y, Maejima Y, Isobe M, Iwata T, Sasano T.
- Journal Title
  
  Circ J.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18985
[Journal Article] Rivaroxaban, a Direct Oral Factor Xa Inhibitor, Attenuates Atherosclerosis by Alleviating Factor Xa-PAR2-Mediated Autophagy Suppression.2021
- Author(s)
  Ito Y, Maejima Y, Nakagama S, Shiheido-Watanabe Y, Tamura N, Sasano T.
- Journal Title
  
  JACC Basic Transl Sci.
  
  Volume: 6 Issue: 12 Pages: 964-980
- DOI
  10.1016/j.jacbts.2021.09.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08399, KAKENHI-PROJECT-19K18985
[Journal Article] Linagliptin, A Xanthine-Based Dipeptidyl Peptidase-4 Inhibitor, Ameliorates Experimental Autoimmune Myocarditis2021
- Author(s)
  Shiheido-Watanabe Y, Maejima Y, Kasama T, Tamura N, Nakagama S, Ito Y, Hirao K, Isobe M, Sasano T
- Journal Title
  
  JACC Basic Transl Sci
  
  Volume: 6 Pages: 527-542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18985
[Journal Article] Periodontal condition in Japanese coronary heart disease patients - A comparison between coronary and non-coronary heart diseases.2019
- Author(s)
  Aoyama Norio, Kobayashi Naho, Hanatani Tomoya, Ashigaki Norihiko, Yoshida Asuka, Shiheido Yuka, Sato Hiroki, Takamura Chisato, Yoshikawa Shunji, Matsuo Katsuhiko, Izumi Yuichi, Isobe Mitsuaki.
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 54 Pages: 259-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K17347
[Journal Article] Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis2018
- Author(s)
  Tamura Natsuko、Maejima Yasuhiro、Matsumura Takayoshi、Vega Rick B.、Amiya Eisuke、Ito Yusuke、Shiheido-Watanabe Yuka、Ashikaga Takashi、Komuro Issei、Kelly Daniel P.、Hirao Kenzo、Isobe Mitsuaki
- Journal Title
  
  Circulation: Genomic and Precision Medicine
  
  Volume: 11 Issue: 10
- DOI
  10.1161/circgen.118.002296
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09570, KAKENHI-PROJECT-18K15841, KAKENHI-PROJECT-17K17347
[Journal Article] Increased Oral Porphyromonas gingivalis Prevalence in Cardiovascular Patients with Uncontrolled Diabetes Mellitus.2018
- Author(s)
  Aoyama Norio, Suzuki Jun-ichi, Kobayashi Naho, Hanatani Tomoya, Ashigaki Norihiko, Yoshida Asuka, Shiheido Yuka, Sato Hiroki, Izumi Yuichi, Isobe Mitsuaki.
- Journal Title
  
  International Heart Journal
  
  Volume: 59
- NAID
  130007428176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K17347
[Journal Article] Synergistic effects of HMG-CoA reductase inhibitor and angiotensin II receptor blocker on load-induced heart failure2018
- Author(s)
  Ito Yusuke、Maejima Yasuhiro、Tamura Natsuko、Shiheido-Watanabe Yuka、Konishi Masanori、Ashikaga Takashi、Hirao Kenzo、Isobe Mitsuaki
- Journal Title
  
  FEBS Open Bio
  
  Volume: 8 Issue: 5 Pages: 799-816
- DOI
  10.1002/2211-5463.12416
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17347, KAKENHI-PROJECT-17K09570
[Journal Article] Japanese Cardiovascular Disease Patients with Diabetes Mellitus Suffer Increased Tooth Loss in Comparison to Those without Diabetes Mellitus -A Cross-sectional Study2018
- Author(s)
  Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 6 Pages: 777-782
- DOI
  10.2169/internalmedicine.9578-17
- NAID
  130006507416
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17347, KAKENHI-PROJECT-16H05824, KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-18K08097
[Journal Article] Associations among tooth loss, systemic inflammation and antibody titers to periodontal pathogens in Japanese patients with cardiovascular disease2017
- Author(s)
  Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Minabe Masato、 Izumi Yuichi、Isobe Mitsuaki
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 53 Issue: 1 Pages: 117-122
- DOI
  10.1111/jre.12494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K17347, KAKENHI-PROJECT-16H05824
[Journal Article] <i>Porphyromonas Gingivalis</i> Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice2017
- Author(s)
  Rungtiwa Srisuwantha、 Yuka Shiheido、 Norio Aoyama、 Hiroki Sato、 Keitetsu Kure、 Narongsak Laosrisin、 Yuichi Izumi、 Jun-ichi Suzuki
- Journal Title
  
  Int. Heart J.
  
  Volume: 58 Issue: 5 Pages: 762-768
- DOI
  10.1536/ihj.16-500
- NAID
  130006179119
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17347
[Journal Article] Japanese workers with long leisure time have deteriorated periodontal condition: A cross-sectional study2017
- Author(s)
  Aoyama Norio、Suzuki Jun-ichi、Sato Hiroki、Yoshida Asuka、Shiheido Yuka、Izumi Yuichi
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 59 Issue: 2 Pages: 104-107
- DOI
  10.1016/j.job.2017.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K17347
[Journal Article] Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia2017
- Author(s)
  Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
- Journal Title
  
  BMC Cardiovascular Disorders
  
  Volume: 17 Issue: 1 Pages: 267-267
- DOI
  10.1186/s12872-017-0703-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17347, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-16H05824
[Journal Article] Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation2017
- Author(s)
  Aoyama N, Suzuki JI, Kobayashi N, Hanatani T, Ashigaki N, Yoshida A, Shiheido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M
- Journal Title
  
  Heart Vessels
  
  Volume: 32 Issue: 11 Pages: 1314-1319
- DOI
  10.1007/s00380-017-1003-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K17347, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-16H05824
[Presentation] SNARE Proteins are Critical Factors for Periodontal Pathogens-mediated Aggravation of Myocardial Infarction2022
- Author(s)
  Yuka Shiheido-Watanabe, Yasuhiro Maejima, Natsuko Tamura, Shun Nakagama, Tetsuro Sasano.
- Organizer
  第86回　日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18985
[Presentation] 歯周病原細菌感染がオートファジー制御異常を介して心筋梗塞マウスモデルに与える影響とその分子機序の解明2022
- Author(s)
  渡辺（始平堂）由佳、前嶋康浩、中釜瞬、田村夏子、范沁涛、笹野哲郎.
- Organizer
  第10回 Heart Science Club
- Data Source
  KAKENHI-PROJECT-19K18985
[Presentation] Association of Periodontitis with Clinical Outcomes after Catheter Ablation for Paroxysmal Atrial Fibrillation2022
- Author(s)
  Akira Tashiro, Taishi Yonetsu, Norio Aoyama, Yuka Shiheido-Watanabe, Takayuki Niida, Mitsuaki Isobe, Takanori Iwata, Tetsuo Sasano.
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18985
[Presentation] SNARE Proteins are Critical Factors for Periodontal Pathogen-mediated Aggravation of Myocardial Infarction2022
- Author(s)
  Yuka Shiheido-Watanabe, Yasuhiro Maejima, Natsuko Tamura, Shun Nakagama, Tetsuo Sasano
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18985
[Presentation] 歯周病菌の感染が心筋梗塞マウスモデルの病態に及ぼす影響とその分子機序の解明2021
- Author(s)
  渡辺（始平堂）由佳、前嶋康浩、田村夏子、中釜瞬、米津太志、笹野哲郎
- Organizer
  第262回日本循環器学会関東甲信越地方会
- Data Source
  KAKENHI-PROJECT-19K18985
[Presentation] Invasion of a periodontal pathogen, Porphyromonas gingivalis, in myocardium causes dysregulation of autophagic machinery through abrogating function of VAMP82020
- Author(s)
  Yuka Shiheido-Watanabe, Yasuhiro Maejima, Natsuko Tamura, Shun Nakagama, Tetsuo Sasano
- Organizer
  第84回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18985
[Presentation] Porphyromonas gingivalis , a periodontal pathogen, dysregulates autophagy by abrogating autophagosomelysosome fusion in cardiomyocytes2019
- Author(s)
  Yuka Shiheido-Watanabe, Yasuhiro Maejima, Natsuko Tamura, Shun Nakagama, Tetsuo Sasano
- Organizer
  第3回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-19K18985
[Presentation] Apolipoprotein A-1 is a Candidate of Novel Biomarkers of Takayasu Arteritis.2019
- Author(s)
  田村夏子、前嶋康浩、始平堂由佳、伊藤祐輔、平尾見三、磯部光章
- Organizer
  第83回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17347
[Presentation] Critical role for dipeptidyl peptidase-4 activity in the pathogenesis of experimental autoimmune myocarditis.2018
- Author(s)
  Yasuhiro Maejima, Yuka Shiheido-Watanabe, Natsuko Tamura, Yusuke Ito, Kenzo Hirao, Mitsuaki Isobe.
- Organizer
  Heart Failure Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17347
[Presentation] SGLT2 inhibitor directly protects oxidative stress-mediated cardiomyocyte injury by suppressing mitochondrial damage-mediated apoptosis.2018
- Author(s)
  Yasuhiro Maejima, Shun Nakagama, Yuka Shiheido-Watanabe, Yusuke Ito, Natsuko Tamura, Kenzo Hirao, Mitsuaki Isobe.
- Organizer
  第22回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17347
[]
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1. 前嶋康浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 磯部光章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 熊谷英敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 池田祐一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shiheido Yuka 始平堂 由佳

Research Projects

Research Products

Co-Researchers

Effect of periodontal infection on cardiac hypertrophy through dysregulation of autophagy and its mechanism.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the influence of periodontal pathogen infection on the association between diabetic myocardial disease and selective autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasma apolipopotein C-2 elevation is associated with Takayasu arteritis2021

Author(s)

Journal Title

Data Source

[Journal Article] Effect of Periodontal Disease on Long-Term Outcomes After Percutaneous Coronary Intervention for De Novo Coronary Lesions in Non-Smokers.2021

Author(s)

Journal Title

Data Source

[Journal Article] Rivaroxaban, a Direct Oral Factor Xa Inhibitor, Attenuates Atherosclerosis by Alleviating Factor Xa-PAR2-Mediated Autophagy Suppression.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Linagliptin, A Xanthine-Based Dipeptidyl Peptidase-4 Inhibitor, Ameliorates Experimental Autoimmune Myocarditis2021

Author(s)

Journal Title

Data Source

[Journal Article] Periodontal condition in Japanese coronary heart disease patients - A comparison between coronary and non-coronary heart diseases.2019

Author(s)

Journal Title

Data Source

[Journal Article] Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased Oral Porphyromonas gingivalis Prevalence in Cardiovascular Patients with Uncontrolled Diabetes Mellitus.2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Synergistic effects of HMG-CoA reductase inhibitor and angiotensin II receptor blocker on load-induced heart failure2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Japanese Cardiovascular Disease Patients with Diabetes Mellitus Suffer Increased Tooth Loss in Comparison to Those without Diabetes Mellitus -A Cross-sectional Study2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Associations among tooth loss, systemic inflammation and antibody titers to periodontal pathogens in Japanese patients with cardiovascular disease2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <i>Porphyromonas Gingivalis</i> Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Japanese workers with long leisure time have deteriorated periodontal condition: A cross-sectional study2017

Author(s)

Shiheido Yuka 始平堂由佳