HARA HIRONORI 原弘典

… Alternative Names

原弘典ハラヒロノリ

HARA Hironori 原弘典

Less

Researcher Number	60792439
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 病院診療医(出向)
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京大学, 医学部附属病院, 病院診療医(出向) 2018: 東京大学, 医学部附属病院, 助教 2017: 東京大学, 医学部附属病院, 特任臨床医
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine
Keywords	Principal Investigator 虚血性心疾患 / 個別化医療 / YAP / Hippo経路 / 心筋再生

虚血性心疾患予後改善のための個別化治療選択モデルの構築Principal Investigator
- Principal Investigator
  
  原弘典
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Drug discovery targeting Hippo-YAP pathway for heart regenerationPrincipal Investigator
- Principal Investigator
  
  HARA Hironori
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo

All 2023 2022 2019 2018 2017 Other

All Journal Article Presentation Other

[Journal Article] Impact of repeat revascularization within 5 years on 10-year mortality after percutaneous or surgical revascularization2023
- Author(s)
  Wang Rutao、Lunardi Mattia、Hara Hironori、Gao Chao、Ono Masafumi、Davierwala Piroze M.、Holmes David R.、Mohr Friedrich W.、Curzen Nick、Burzotta Francesco、van Geuns Robert-Jan、Kappetein Arie Pieter、Head Stuart J.、Thuijs Daniel J. F. M.、Tao Ling、Garg Scot、Onuma Yoshinobu、Wijns William、Serruys Patrick W.
- Journal Title
  
  Clinical Research in Cardiology
  
  Volume: 112 Issue: 9 Pages: 1302-1311
- DOI
  10.1007/s00392-023-02211-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16066
[Journal Article] PGC-1α-mediated angiogenesis prevents pulmonary hypertension in mice2023
- Author(s)
  Fujiwara T, Takeda N, Hara H, Ishii S, Numata G, Tokiwa H, Katoh M, Maemura S, Suzuki T, Takiguchi H, Yanase T, Kubota Y, Nomura S, Hatano M, Ueda K, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Nishimura S, Komuro I.
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 17 Pages: 162632-162632
- DOI
  10.1172/jci.insight.162632
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16064, KAKENHI-PROJECT-22K16066, KAKENHI-PROJECT-22K08276, KAKENHI-PROJECT-23K07473, KAKENHI-PROJECT-21K08023, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-21H02908, KAKENHI-PROJECT-23K27352
[Journal Article] Impact of residual angina on long-term clinical outcomes after percutaneous coronary intervention or coronary artery bypass graft for complex coronary artery disease2022
- Author(s)
  Ono Masafumi、Serruys Patrick W、Kawashima Hideyuki、Lunardi Mattia、Wang Rutao、Hara Hironori、Gao Chao、Garg Scot、O'Leary Neil、Wykrzykowska Joanna J、Piek Jan J、Holmes David R、Onuma Yoshinobu、et al
- Journal Title
  
  European Heart Journal - Quality of Care and Clinical Outcomes
  
  Volume: － Issue: 5 Pages: 490-501
- DOI
  10.1093/ehjqcco/qcac052
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16066
[Journal Article] Mortality after multivessel revascularisation involving the proximal left anterior descending artery2022
- Author(s)
  Ono Masafumi、Hara Hironori、Gao Chao、Kawashima Hideyuki、Wang Rutao、O’Leary Neil、Wykrzykowska Joanna J、Piek Jan J、Mack Michael J、Holmes David、Morice Marie-Claude、Head Stuart、Kappetein Arie Pieter、Noack Thilo、Davierwala Piroze M、Mohr Friedrich W、Garg Scot、Onuma Yoshinobu、Serruys Patrick W
- Journal Title
  
  Heart
  
  Volume: 108 Issue: 22 Pages: 1784-1791
- DOI
  10.1136/heartjnl-2022-320934
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16066
[Journal Article] Ticagrelor monotherapy versus aspirin monotherapy at 12 months after percutaneous coronary intervention: a landmark analysis of the GLOBAL LEADERS trial2022
- Author(s)
  Ono Masafumi、Hara Hironori、Kawashima Hideyuki、Gao Chao、Wang Rutao、Wykrzykowska Joanna J.、Piek Jan J.、Garg Scot、Hamm Christian、Steg Philippe Gabriel、Valgimigli Marco、Windecker Stephan、Vranckx Pascal、Onuma Yoshinobu、Serruys Patrick Serruys
- Journal Title
  
  EuroIntervention
  
  Volume: 18 Issue: 5 Pages: e377-e388
- DOI
  10.4244/eij-d-21-00870
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16066
[Journal Article] Impact of proton pump inhibitors on efficacy of antiplatelet strategies with ticagrelor or aspirin after percutaneous coronary intervention: Insights from the GLOBAL LEADERS trial2022
- Author(s)
  Ono Masafumi、Onuma Yoshinobu、Kawashima Hideyuki、Hara Hironori、Gao Chao、Wang Rutao、O'Leary Neil、Benit Edouard、Janssens Luc、Ferrario Maurizio、Dominici Marcello、Huber Kurt、Garg Scot、Wykrzykowska Joanna J.、Piek Jan J.、Hamm Christian、Windecker Stephan、et al
- Journal Title
  
  Catheterization and Cardiovascular Interventions
  
  Volume: 100 Issue: 1 Pages: 72-82
- DOI
  10.1002/ccd.30217
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16066
[Journal Article] Diagnostic concordance and discordance between angiography-based quantitative flow ratio and fractional flow reserve derived from computed tomography in complex coronary artery disease2022
- Author(s)
  Kawashima Hideyuki、Kogame Norihiro、Ono Masafumi、Hara Hironori、Takahashi Kuniaki、Reiber Johan H.C.、Thomsen Brian、de Winter Robbert J.、Tanaka Kaoru、La Meir Mark、de Mey Johan、Schneider Ulrich、Doenst Torsten、et al
- Journal Title
  
  Journal of Cardiovascular Computed Tomography
  
  Volume: 16 Issue: 4 Pages: 336-342
- DOI
  10.1016/j.jcct.2022.02.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16066
[Journal Article] Effect of Patient-Reported Preprocedural Physical and Mental Health on 10-Year Mortality After Percutaneous or Surgical Coronary Revascularization2022
- Author(s)
  Ono Masafumi、Serruys Patrick W.、Garg Scot、Kawashima Hideyuki、Gao Chao、Hara Hironori、Lunardi Mattia、Wang Rutao、O’Leary Neil、Wykrzykowska Joanna J.、Piek Jan J.、Mack Michael J.、Holmes David R.、Morice Marie-Claude、Kappetein Arie Pieter、Thuijs Daniel J.F.M.、et al
- Journal Title
  
  Circulation
  
  Volume: 146 Issue: 17 Pages: 1268-1280
- DOI
  10.1161/circulationaha.121.057021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16066
[Journal Article] Sirolimus-eluting stents with ultrathin struts versus everolimus-eluting stents for patients undergoing percutaneous coronary intervention: final three-year results of the TALENT trial2022
- Author(s)
  de Winter Robbert de Winter、Zaman Azfar、Hara Hironori、Gao Chao、Ono Masafumi、Garg Scot、Smits Pieter Smits、Tonino Pim Tonino、Hofma Sjoerd Hofma、Moreno Raul、Choudhury Anirban、Petrov Ivo、Cequier Angel、Colombo Antonio、Kaul Upendra、Onuma Yoshinobu、Serruys Patrick Serruys
- Journal Title
  
  EuroIntervention
  
  Volume: 18 Issue: 6 Pages: 492-502
- DOI
  10.4244/eij-d-21-00766
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16066
[Journal Article] Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes2019
- Author(s)
  Ito Masamichi、Hara Hironori、Takeda Norifumi、Naito Atsuhiko T.、Nomura Seitaro、Kondo Masaki、Hata Yutaka、Uchiyama Masanobu、Morita Hiroyuki、Komuro Issei
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 128 Pages: 90-95
- DOI
  10.1016/j.yjmcc.2019.01.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15987, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-19H03414, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-17H06173
[Journal Article] Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury2018
- Author(s)
  Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I.
- Journal Title
  
  JACC: Basic to Translational Science
  
  Volume: 3 Issue: 5 Pages: 639-653
- DOI
  10.1016/j.jacbts.2018.07.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-18K06571, KAKENHI-PUBLICLY-18H05105, KAKENHI-PROJECT-17J05193, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K15987, KAKENHI-PROJECT-19K07948, KAKENHI-PROJECT-18K08097
[Journal Article] Pathophysiology and therapeutic potential of cardiac fibrosis2017
- Author(s)
  Hara Hironori、Takeda Norifumi、Komuro Issei
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 37 Issue: 1 Pages: 13-13
- DOI
  10.1186/s41232-017-0046-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15987, KAKENHI-PROJECT-15K09132
[Presentation] Discovery of a small molecule to increase cardiomyocytes and protect the heart after ischemic injury.2018
- Author(s)
  Hara H, Takeda N, Saito T, Fujiwara T, Maemura S, Hata Y, Uchiyama M, Komuro I
- Organizer
  第1回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-17K15987
[Presentation] Discovery of a small molecule to increase cardiomyocytes and protect the heart after ischemic injury.2018
- Author(s)
  Hara H, Takeda N, Saito T, Fujiwara T, Maemura S, Hata Y, Uchiyama M, Komuro I
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15987
[Presentation] Discovery of a small molecule to increase cardiomyocytes and protect the heart after ischemic injury.2017
- Author(s)
  Hara H, Takeda N, Saito T, Fujiwara T, Maemura S, Hata Y, Uchiyama M, Komuro I
- Organizer
  American Heart Association 2017 Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15987
[Presentation] 心筋細胞増殖作用と心筋障害への保護作用を併せ持つ新薬創出の試み2017
- Author(s)
  原弘典、武田憲文、斉藤竜男、藤原隆行、前村園子、畑裕、内山真伸、小室一成
- Organizer
  第21回日本心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15987
[Presentation] Hippo 経路を標的として心筋細胞増殖と心筋再生を増幅する薬剤の開発2017
- Author(s)
  原弘典、武田憲文、斉藤竜男、畑裕、内山真伸、小室一成
- Organizer
  第54回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15987
[Presentation] Hippo経路を標的として心筋細胞増殖・再生を促進する薬剤の開発2017
- Author(s)
  原弘典、武田憲文、斉藤竜男、藤原隆行、前村園子、畑裕、内山真伸、小室一成
- Organizer
  Molecular Cardiovascular Metabolic Conference 2017
- Data Source
  KAKENHI-PROJECT-17K15987
[]
[]

1. Takeda Norifumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 熊谷英敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 東口治弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 池田祐一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 常盤洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARA HIRONORI 原 弘典

原 弘典 ハラ ヒロノリ

HARA Hironori 原 弘典

Research Projects

Research Products

Co-Researchers

虚血性心疾患予後改善のための個別化治療選択モデルの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery targeting Hippo-YAP pathway for heart regenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Impact of repeat revascularization within 5 years on 10-year mortality after percutaneous or surgical revascularization2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PGC-1α-mediated angiogenesis prevents pulmonary hypertension in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of residual angina on long-term clinical outcomes after percutaneous coronary intervention or coronary artery bypass graft for complex coronary artery disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mortality after multivessel revascularisation involving the proximal left anterior descending artery2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ticagrelor monotherapy versus aspirin monotherapy at 12 months after percutaneous coronary intervention: a landmark analysis of the GLOBAL LEADERS trial2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of proton pump inhibitors on efficacy of antiplatelet strategies with ticagrelor or aspirin after percutaneous coronary intervention: Insights from the GLOBAL LEADERS trial2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diagnostic concordance and discordance between angiography-based quantitative flow ratio and fractional flow reserve derived from computed tomography in complex coronary artery disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of Patient-Reported Preprocedural Physical and Mental Health on 10-Year Mortality After Percutaneous or Surgical Coronary Revascularization2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sirolimus-eluting stents with ultrathin struts versus everolimus-eluting stents for patients undergoing percutaneous coronary intervention: final three-year results of the TALENT trial2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathophysiology and therapeutic potential of cardiac fibrosis2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Discovery of a small molecule to increase cardiomyocytes and protect the heart after ischemic injury.2018

Author(s)

HARA HIRONORI 原弘典

原弘典ハラヒロノリ

HARA Hironori 原弘典