mukae kuousuke 迎恭輔

… Alternative Names

Kyosuke Mukae 迎恭輔

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Researcher Number	60793974
Other IDs	https://orcid.org/0000-0001-6411-2990
Affiliation (Current)	2025: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 臨床腫瘍研究所, 専門研究員
Affiliation (based on the past Project Information) *help	2025: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 臨床腫瘍研究所, 主任 2022 – 2023: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 臨床腫瘍研究所, 主任 2021: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 臨床腫瘍研究所, 研究員 2019 – 2020: 埼玉県立がんセンター(臨床腫瘍研究所), 臨床腫瘍研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 90130:Medical systems-related / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator iPS細胞 / 神経芽腫 / 神経堤細胞 / NCC / 体幹部 / MYCN / 癌化 / APB / ALT / ATRX / iPS … More Except Principal Investigator … More 核酸 / 抽出精製 / 装置開発 / 自動化 / DNA / RNA / iPS / 神経芽腫 / iPS細胞 / 分子標的 / 細胞分化 / 発がん Less

ATRX/TP53変異 iPS細胞モデルを用いたALT経路誘導発がんの新規メカニズム解明Principal Investigator
- Principal Investigator
  
  迎恭輔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Research Institute for Clinical Oncology Saitama Cancer Center
微量検体の高効率RNA・DNA抽出及び解析前処理システム化に関する研究
- Principal Investigator
  
  武居修
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Research Institute for Clinical Oncology Saitama Cancer Center
iPS細胞から誘導された神経芽腫発がんモデルを用いた悪性腫瘍の治療開発Principal Investigator
- Principal Investigator
  
  迎恭輔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Research Institute for Clinical Oncology Saitama Cancer Center
Discover for the second-hit gene regions using comprehensive gene destruction in neuroblastoma carcinogenesis
- Principal Investigator
  
  Takenobu Hisanori
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Research Institute for Clinical Oncology Saitama Cancer Center
Development of a treatment for ALT-positive refractory tumors using iPS cells model of neuroblastoma tumorigenesisPrincipal Investigator
- Principal Investigator
  
  Kyosuke Mukae
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Research Institute for Clinical Oncology Saitama Cancer Center

All 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Autophagy accelerates cell death after desiccation and hydration stress in Physcomitrium2023
- Author(s)
  Mukae Kyosuke、Sakil Md. Arif、Kotake Toshihisa、Inoue-Aono Yuko、Moriyasu Yuji
- Journal Title
  
  Environmental and Experimental Botany
  
  Volume: 213 Pages: 105412-105412
- DOI
  10.1016/j.envexpbot.2023.105412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15517
[Journal Article] Development of RNA/DNA automated extraction and purification device for infectious disease diagnosis2023
- Author(s)
  Mukae Kyosuke、Takei Osamu、Imai Fumi、Kamijo Takehiko
- Journal Title
  
  Practical Laboratory Medicine
  
  Volume: 37 Pages: e00335-e00335
- DOI
  10.1016/j.plabm.2023.e00335
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15517, KAKENHI-PROJECT-22K12880, KAKENHI-PROJECT-19H03625
[Journal Article] Development of an osteosarcoma model with <i>MYCN</i> amplification and <i>TP53</i> mutation in hiPS cell‐derived neural crest cells2023
- Author(s)
  Mukae Kyosuke、Takenobu Hisanori、Endo Yuki、Haruta Masayuki、Shi Tianyuan、Satoh Shunpei、Ohira Miki、Funato Michinori、Toguchida Junya、Osafune Kenji、Nakahata Tatsutoshi、Kanda Hiroaki、Kamijo Takehiko
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 5 Pages: 1898-1911
- DOI
  10.1111/cas.15730
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15517, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-23K07239, KAKENHI-PROJECT-19H03625
[Journal Article] ATM depletion induces proteasomal degradation of FANCD2 and sensitizes neuroblastoma cells to PARP inhibitors2023
- Author(s)
  Parvin Sultana、Akter Jesmin、Takenobu Hisanori、Katai Yutaka、Satoh Shunpei、Okada Ryu、Haruta Masayuki、Mukae Kyosuke、Wada Tomoko、Ohira Miki、Ando Kiyohiro、Kamijo Takehiko
- Journal Title
  
  BMC Cancer
  
  Volume: 23 Issue: 1 Pages: 1-13
- DOI
  10.1186/s12885-023-10772-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15517, KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-23K07239, KAKENHI-PROJECT-20K07579, KAKENHI-PROJECT-19H03625
[Journal Article] Polycomb group protein BMI1 protects neuroblastoma cells against DNA damage-induced apoptotic cell death2023
- Author(s)
  Akita Nobuhiro、Okada Ryu、Mukae Kyosuke、Sugino Ryuichi P.、Takenobu Hisanori、Chikaraishi Koji、Ochiai Hidemasa、Yamaguchi Yohko、Ohira Miki、Koseki Haruhiko、Kamijo Takehiko
- Journal Title
  
  Experimental Cell Research
  
  Volume: 422 Issue: 1 Pages: 113412-113412
- DOI
  10.1016/j.yexcr.2022.113412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-22K15517, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-19H03625
[Journal Article] Amino acids supplied through the autophagic/endocytic pathway promote starch synthesis in Physcomitrella protonemal cells2022
- Author(s)
  Md. Arif Sakil, Kyosuke Mukae, Ryo Funada, Toshihisa Kotake, Shigeaki Ueno, Most Mohoshena Aktar, Md. Shyduzzaman Roni, Yuko Inoue-Aono, Yuji Moriyasu
- Journal Title
  
  Plants
  
  Volume: 11 Issue: 16 Pages: 2157-2157
- DOI
  10.3390/plants11162157
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K02089, KAKENHI-PROJECT-22K15517, KAKENHI-PROJECT-21K06243
[Journal Article] Hydrogen Peroxide Mediates Premature Senescence Caused by Darkness and Inorganic Nitrogen Starvation in Physcomitrium patens2022
- Author(s)
  Roni Md. Shyduzzaman、Sakil Md. Arif、Aktar Most Mohoshena、Takatsuka Chihiro、Mukae Kyosuke、Inoue-Aono Yuko、Moriyasu Yuji
- Journal Title
  
  Plants
  
  Volume: 11 Issue: 17 Pages: 2280-2280
- DOI
  10.3390/plants11172280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15517, KAKENHI-PROJECT-21K06243
[Journal Article] Polycomb EZH1 regulates cell cycle/5‐fluorouracil sensitivity of neuroblastoma cells in concert with MYCN2022
- Author(s)
  Shinno Yoshitaka、Takenobu Hisanori、Sugino Ryuichi P.、Endo Yuki、Okada Ryu、Haruta Masayuki、Satoh Shunpei、Mukae Kyosuke、Shaliman Dilibaerguli、Wada Tomoko、Akter Jesmin、Ando Kiyohiro、Nakazawa Atsuko、Yoshida Hideo、Ohira Miki、Hishiki Tomoro、Kamijo Takehiko
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 12 Pages: 4193-4206
- DOI
  10.1111/cas.15555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-22K15517, KAKENHI-PROJECT-20K08174, KAKENHI-PROJECT-19H03625
[Journal Article] Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma2021
- Author(s)
  Akter Jesmin、Katai Yutaka、Sultana Parvin、Takenobu Hisanori、Haruta Masayuki、Sugino Ryuichi P.、Mukae Kyosuke、Satoh Shunpei、Wada Tomoko、Ohira Miki、Ando Kiyohiro、Kamijo Takehiko
- Journal Title
  
  Oncogenesis
  
  Volume: 10 Issue: 11 Pages: 1256-1256
- DOI
  10.1038/s41389-021-00363-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15256, KAKENHI-PROJECT-19K16759, KAKENHI-PROJECT-20K07579, KAKENHI-PROJECT-20K08174, KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-19H03625
[Patent] 核酸抽出方法、及び核酸抽出装置2021
- Inventor(s)
  武居　修、上條　岳彦、迎　恭輔
- Industrial Property Rights Holder
  武居　修、上條　岳彦、迎　恭輔
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-047528
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K16759
[Presentation] Analysis of gene expression regulation by methylation in differentiation into cranial and trunk NCCs derived from hiPSC2023
- Author(s)
  Kyosuke Mukae, Ritsuko Onuki, Satoshi Yamashita, Naoko Hattori, Miki Ohira, Masayuki Haruta, Shunpei Satoh, Hisanori Takenobu, Kiyohiro Ando, Toshikazu Ushijima, Kenji Osafune, Tatsutoshi Nakahata, Takehiko Kamijo
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15517
[Presentation] 感染症診断に用いる検体RNA/DNA抽出,精製,PCR前処理装置の開発と評価2023
- Author(s)
  武居修、迎恭輔、明貝路子、福田俊、鈴木みずほ、上條岳彦
- Organizer
  日本分子生物学会2023年会
- Data Source
  KAKENHI-PROJECT-22K12880
[Presentation] PRC2阻害とエピジェネティック阻害剤を組み合わせた神経芽腫の効果的な治療法の開発2022
- Author(s)
  竹信尚典、遠藤悠紀、ディルバーサルマン、秦佳孝、大平美紀、杉野隆一、岡田龍、春田雅之、佐藤俊平、迎恭輔、ジェスミンアクター、和田朋子、中澤温子、上條岳彦
- Organizer
  第81回日本癌学会
- Data Source
  KAKENHI-PROJECT-20K08174
[Presentation] CDX1は遺伝子発現制御を介して神経芽腫細胞における幹細胞性および増殖の制御をする2022
- Author(s)
  竹信尚典、杉野隆一、大平美紀、春田雅之、佐藤俊平、迎恭輔、和田朋子、岡田龍、ディルバーサルマン、上條岳彦
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K08174
[Presentation] Soft agar-based transformation generates a high-grade chondroblastic osteosarcoma model from hiPSC-derived NCCs2022
- Author(s)
  迎　恭輔、竹信尚典、神田浩明、大平美紀、遠藤悠紀、春田雅之、石天源、佐藤　俊平、戸口田　淳也、長船　健二、中畑　龍俊、上條岳彦
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15517
[Presentation] Development of a chondroblastic osteosarcoma model from iPSCbased neural crest cells2021
- Author(s)
  Kyosuke Mukae, Hisanori Takenobu, Hiroaki Kanda, Miki Ohira, Yuki Endo, Masayuki Haruta, Ryuichi Sugino, Shunpei Satoh, Junya Toguchida, Kenji Osafune, Tatsutoshi Nakahata, Takehiko Kamijo
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16759
[Presentation] パイオニア転写因子CDX1は神経芽腫細胞における発生関連遺伝子の発現を制御する2021
- Author(s)
  竹信尚典、杉野隆一、大平美紀、春田雅之、迎恭輔、和田朋子、力石浩志、遠藤悠紀、秋田直洋、岡田龍、ディルバーサルマン、上條岳彦
- Organizer
  第80回日本がん学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08174
[Presentation] 神経芽腫における分化関連遺伝子のエピジェネティックな発現抑制メカニズムの解明2021
- Author(s)
  Hisanori Takenobu, Zhenghao Li, Ryuichi P. Sugino, Kyosuke Mukae, Miki Ohira, Masayuki Haruta, Yuki Endo, Ryu Okada, Dilibaerguli Shaliman, Sultana Parvin, Takehiko Kamijo
- Organizer
  第14回日本エピジェネティック研究会年会
- Data Source
  KAKENHI-PROJECT-20K08174
[Presentation] Tumor sphere specific gene CDX1 binds to OCT4 and MAX promoters to regulates stemness2020
- Author(s)
  Hisanori Takenobu, Miki Ohira, Ryuichi Sugino, Dilibaerguli Shaliman, Koji Chikaraishi, Ryu Okada, Kyosuke Mukae, Tomoko Wada, Yuki Endo, Nobuhiro Akita, Masayuki Haruta, Takehiko Kamijo
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08174
[Presentation] iPS細胞由来神経堤細胞からの人工的発がんモデル開発2020
- Author(s)
  Kyosuke Mukae, Hisanori Takenobu, Hiroaki Kanda, Miki Ohira, Yuki Endo, Masayuki Haruta, Junya Toguchida, Kenji Osafune, Tatsutoshi Nakahata, Takehiko Kamijo
- Organizer
  第62回日本小児血液・癌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08174
[Presentation] Development of artificial tumorigenesis model from iPSC-based neural crest cells2020
- Author(s)
  迎　恭輔、竹信尚典、神田浩明、大平美紀、遠藤悠紀、春田雅之、戸口田　淳也、長船　健二、中畑　龍俊、上條岳彦
- Organizer
  第62回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16759
[Presentation] Development of neuroblastoma model from iPSC-based neural crest cells2019
- Author(s)
  迎恭輔、竹信尚典、杉野隆一、大平美紀、佐藤俊平、遠藤悠紀、岡田龍、春田雅之、戸口田淳也、長船健二、中畑龍俊、上條岳彦
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16759

1. Takenobu Hisanori (60392247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 武居修 (00500480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 上野茂昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 市川美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. AKTER JESMIN

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

mukae kuousuke 迎 恭輔

Kyosuke Mukae 迎 恭輔

Research Projects

Research Products

Co-Researchers

ATRX/TP53変異 iPS細胞モデルを用いたALT経路誘導発がんの新規メカニズム解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

微量検体の高効率RNA・DNA抽出及び解析前処理システム化に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

iPS細胞から誘導された神経芽腫発がんモデルを用いた悪性腫瘍の治療開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discover for the second-hit gene regions using comprehensive gene destruction in neuroblastoma carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a treatment for ALT-positive refractory tumors using iPS cells model of neuroblastoma tumorigenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Autophagy accelerates cell death after desiccation and hydration stress in Physcomitrium2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of RNA/DNA automated extraction and purification device for infectious disease diagnosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of an osteosarcoma model with <i>MYCN</i> amplification and <i>TP53</i> mutation in hiPS cell‐derived neural crest cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ATM depletion induces proteasomal degradation of FANCD2 and sensitizes neuroblastoma cells to PARP inhibitors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polycomb group protein BMI1 protects neuroblastoma cells against DNA damage-induced apoptotic cell death2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Amino acids supplied through the autophagic/endocytic pathway promote starch synthesis in Physcomitrella protonemal cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydrogen Peroxide Mediates Premature Senescence Caused by Darkness and Inorganic Nitrogen Starvation in Physcomitrium patens2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polycomb EZH1 regulates cell cycle/5‐fluorouracil sensitivity of neuroblastoma cells in concert with MYCN2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma2021

Author(s)

Journal Title

DOI

Data Source

mukae kuousuke 迎恭輔

Kyosuke Mukae 迎恭輔