Kamata Ryo 鎌田諒

Researcher Number	60801420
Other IDs	https://orcid.org/0000-0001-6970-9657
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員 2021 – 2023: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員 2021: 慶應義塾大学, 政策・メディア研究科(藤沢), 研究員 2020: 自治医科大学, 医学部, 客員研究員 2017 – 2019: 自治医科大学, 医学部, ポスト・ドクター
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 43010:Molecular biology-related / Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 動物 / 蛋白質 / ユビキチン / 免疫学 / 循環器 / キネシン / 自然免疫応答 / 染色体分配制御 / 染色体不安定性 / cGAS-STING経路 … More / CENP-E / Compartmentalization / RAC / IMPDH / migration / leading edge / GTP / 代謝 / 細胞遊走 / プロテアソーム / NLRP3 / 炎症 / ARIH2 / インフラマソーム / 循環器・高血圧 … More Except Principal Investigator ボトルネック効果 / 一細胞解析・空間解析 / fitness cost / CINパラドクス / 染色体不安定性（CIN） / ユビキチン / インフラマソーム / 炎症 / タンパク質分解 / タンパク質修飾 / 心血管病 / サイトカイン / 炎症反応 Less

Study on the Elucidation of the Cancer Chromosomal Instability (CIN) Paradox and the Development of Novel Therapeutic Strategies Targeting CIN Vulnerabilities
- Principal Investigator
  
  大橋紹宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
CTNNB1/PIK3CA二重変異を有する子宮体がんに対するb-catenin阻害剤の検討
- Principal Investigator
  
  山盛智子 (森田智子)
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  National Cancer Center Japan
Mechanism of Chromosomal Instability-mediated Induction of Innate Immune Responses by CENP-E InhibitorsPrincipal Investigator
- Principal Investigator
  
  鎌田諒
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Novel Regulation of Cell Migration by the GTP Metabolic Compartment of the Leading EdgePrincipal Investigator
- Principal Investigator
  
  Kamata Ryo
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  National Cancer Center Japan
Elucidation of the mechanism of NLRP3 inflammasome regulation by ARIH2Principal Investigator
- Principal Investigator
  
  Kamata Ryo
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
Role of ARIH2 in the inflammasome-related cardiovascular disease
- Principal Investigator
  
  Takahashi Masafumi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
Elucidation of NLRP3 inflammasome regulation mechanism by E3 ubiquitin ligasePrincipal Investigator
- Principal Investigator
  
  Kamata Ryo
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Jichi Medical University

All 2024 2023 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Abstract 411: PI3K-AKT-mTOR signaling pathways play important roles in chromosomal instability-induced innate immune response in cancer cells2024
- Author(s)
  Kamata Ryo、Saito Hitoshi、Hakozaki Yumi、Kashima Yukie、Yamamoto Gaku、Morita Tomoko Yamamori、Lu Pinyi、Ohashi Akihiro
- Journal Title
  
  Cancer Research
  
  Volume: 84 Issue: 6_Supplement Pages: 411-411
- DOI
  10.1158/1538-7445.am2024-411
- Data Source
  KAKENHI-PROJECT-23K06708
[Journal Article] Abstract 4945: Computational modeling-based discovery of novel anticancer drug candidates targeting centromere-associated protein E2024
- Author(s)
  Lu Pinyi、Kamata Ryo、Weil Michael R.、Ohashi Naomi、Ohashi Akihiro、Stahlberg Eric A.
- Journal Title
  
  Cancer Research
  
  Volume: 84 Issue: 6_Supplement Pages: 4945-4945
- DOI
  10.1158/1538-7445.am2024-4945
- Data Source
  KAKENHI-PROJECT-23K06708
[Journal Article] Abstract 1938: WEE1 inhibition prevents and overcomes resistance to KRAS inhibitors in lung cancer by enhancing MCL1-mediated apoptosis2024
- Author(s)
  Yamamoto Gaku、Tanaka Kosuke、Kamata Ryo、Nakao Takehiro、Mori Shunta、Liu Jie、Kobayashi Susumu S.、Ohashi Akihiro
- Journal Title
  
  Cancer Research
  
  Volume: 84 Issue: 6_Supplement Pages: 1938-1938
- DOI
  10.1158/1538-7445.am2024-1938
- Data Source
  KAKENHI-PROJECT-23K06708
[Journal Article] Abstract 301: CENP-E inhibitors activate cGAS-STING pathway by inducing chromosome misalignment and micronucleation after mitotic slippage2023
- Author(s)
  Kamata Ryo、Saito Hitoshi、Hakozaki Yumi、Kashima Yukie、Morita Tomoko Yamamori、Lu Pinyi、Ohashi Akihiro
- Journal Title
  
  Cancer Research
  
  Volume: 83 Issue: 7_Supplement Pages: 301-301
- DOI
  10.1158/1538-7445.am2023-301
- Data Source
  KAKENHI-PROJECT-23K06708
[Journal Article] Abstract 5739: Targeting WEE1 to improve the therapy of KRAS G12C mutant non-small cell lung cancer2023
- Author(s)
  Yamamoto Gaku、Tanaka Kosuke、Kamata Ryo、Mori Shunta、Liu Jie、Yamauchi Toyohiro、Sakae Yuta、Ohashi Akihiro、Kobayashi Susumu S.
- Journal Title
  
  Cancer Research
  
  Volume: 83 Issue: 7_Supplement Pages: 5739-5739
- DOI
  10.1158/1538-7445.am2023-5739
- Data Source
  KAKENHI-PROJECT-23K06708
[Journal Article] SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides2021
- Author(s)
  Ikeda Yoshiki、Hirayama Akiyoshi、Kofuji Satoshi、Hirota Yoshihisa、Kamata Ryo、Osaka Natsuki、Fujii Yuki、Sasaki Mika、Ikeda Satsuki、Smith Eric P、Bachoo Robert、Soga Tomoyoshi、Sasaki Atsuo T
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 170 Issue: 6 Pages: 699-711
- DOI
  10.1093/jb/mvab077
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165, KAKENHI-PROJECT-21K11709, KAKENHI-PROJECT-21K15019, KAKENHI-PROJECT-18KK0455
[Journal Article] Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification2021
- Author(s)
  Osaka Natsuki、Hirota Yoshihisa、Ito Doshun、Ikeda Yoshiki、Kamata Ryo、Fujii Yuki、Chirasani Venkat R.、Campbell Sharon L.、Takeuchi Koh、Senda Toshiya、Sasaki Atsuo T.
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 8 Pages: 1-12
- DOI
  10.3389/fmolb.2021.707439
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165, KAKENHI-PROJECT-21K15019
[Journal Article] Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease.2020
- Author(s)
  4)Anzai F, Watanabe S, Kimura H, Kamata R, Karasawa T, Komada T, Nakamura J, Nagi-Miura N, Ohno N, Takeishi Y, Takahashi M
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 138 Pages: 185-196
- DOI
  10.1016/j.yjmcc.2019.11.158
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-19K08523, KAKENHI-PROJECT-19K21319, KAKENHI-PROJECT-19K08916
[Journal Article] Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages.2020
- Author(s)
  1)Watanabe S, Usui-Kawanishi F, Karasawa, Kimura H, Kamata R, Inoue, Mise N, Kasahara T, Takahashi M
- Journal Title
  
  J Cell Physiol
  
  Volume: - Issue: 10 Pages: 7554-7566
- DOI
  10.1002/jcp.29659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-16K09521, KAKENHI-PROJECT-19K21319, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-19K06358, KAKENHI-PROJECT-20K07365, KAKENHI-PROJECT-20K17290
[Journal Article] NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury2020
- Author(s)
  Ito Homare、Kimura Hiroaki、Karasawa Tadayoshi、Hisata Shu、Sadatomo Ai、Inoue Yoshiyuki、Yamada Naoya、Aizawa Emi、Hishida Erika、Kamata Ryo、Komada Takanori、Watanabe Sachiko、Kasahara Tadashi、Suzuki Takuji、Horie Hisanaga、Kitayama Joji、Sata Naohiro、Yamaji-Kegan Kazuyo、Takahashi Masafumi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 205 Issue: 5 Pages: 1393-1405
- DOI
  10.4049/jimmunol.2000217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-19K08630, KAKENHI-PROJECT-20K07365, KAKENHI-PROJECT-20K17290, KAKENHI-PROJECT-20K17629, KAKENHI-PROJECT-17K09889
[Journal Article] ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome2020
- Author(s)
  Watanabe Sachiko、Usui-Kawanishi Fumitake、Komada Takanori、Karasawa Tadayoshi、Kamata Ryo、Yamada Naoya、Kimura Hiroaki、Dezaki Katsuya、Ohmori Tsukasa、Takahashi Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 531 Issue: 2 Pages: 125-132
- DOI
  10.1016/j.bbrc.2020.07.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-19K06358, KAKENHI-PROJECT-20K07365, KAKENHI-PROJECT-20K17290, KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08370
[Journal Article] GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition2020
- Author(s)
  Aizawa Emi、Karasawa Tadayoshi、Watanabe Sachiko、Komada Takanori、Kimura Hiroaki、Kamata Ryo、Ito Homare、Hishida Erika、Yamada Naoya、Kasahara Tadashi、Mori Yoshiyuki、Takahashi Masafumi
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 5 Pages: 101070-101070
- DOI
  10.1016/j.isci.2020.101070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21319, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-20K17290
[Journal Article] GSDME-dependentincomplete pyroptosis permits selective IL-1α release under caspase-1 inhibition2020
- Author(s)
  Aizawa E, Karasawa T, Watanabe S, Komada T, Kimura H, Kamata R, ItoH, Hishida E, Yamada N, Kasahara T, Mori Y, Takahashi M
- Journal Title
  
  iScience
  
  Volume: －
- Data Source
  KAKENHI-PROJECT-18K08112
[Journal Article] Glucose regulates hypoxia-induced NLRP3inflammasome activation in macrophages2020
- Author(s)
  Watanabe S, Usui-Kawanishi F, Karasawa T, Kimura H, Kamata R, InoueY, Mise N, Kasahara T, Takahashi M
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: －
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08112
[Journal Article] Role of NLRP3 Inflammasome in Atherosclerosis and Aortic Aneurysm2019
- Author(s)
  Kamata Ryo、Takahashi Masafumi
- Journal Title
  
  The Journal of Japanese College of Angiology
  
  Volume: 59 Issue: 10 Pages: 83-87
- DOI
  10.7133/jca.19-00022
- NAID
  130007726288
- ISSN
  0387-1126, 1880-8840
- Year and Date
  2019-10-10
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17536
[Journal Article] Crucial role of NLRP3 inflammasome in the development of peritoneal dialysis-related peritoneal fibrosis.2019
- Author(s)
  6)Hishida E, Ito H, Komada T, Karasawa T, Kimura H, Watanabe S, Kamata R, Aizawa E, Kasahara T, Morishita Y, AkimotoT, Nagata D, Takahashi M
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 10363-10363
- DOI
  10.1038/s41598-019-46504-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-18K15900, KAKENHI-PROJECT-18K16329, KAKENHI-PROJECT-19K21319
[Journal Article] Inflammasome-independent and atypical processing of IL-1β contributes to acid aspiration-induced acute lung injury.2019
- Author(s)
  5)Mizushina Y, Karasawa T, Aizawa K, Kimura H, Watanabe S, Kamata R, Komada T, Mato N, Kasahara T, Koyama S, Bando M, Hagiwara K, Takahashi M
- Journal Title
  
  J Immunol
  
  Volume: 203 Issue: 1 Pages: 236-246
- DOI
  10.4049/jimmunol.1900168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-18K15900, KAKENHI-PROJECT-19K21319
[Journal Article] Role of TLR5 in inflammation and tissue damage after intestinal ischemia-reperfusion injury.2019
- Author(s)
  7)Ito H, Sadatomo A, Inoue Y, Yamada N, Aizawa E, Hishida E, Kamata R, Karasawa T, Kimura H, Watanabe S, Komada T, Horie H, Kitagawa J, Sata N, Takahashi M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 519 Issue: 1 Pages: 15-22
- DOI
  10.1016/j.bbrc.2019.08.083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-18K15900, KAKENHI-PROJECT-18K16329, KAKENHI-PROJECT-19K21319
[Journal Article] Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.2018
- Author(s)
  Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, Ohno N, Kasahara T, Minota S, Takahashi M.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 7601-7601
- DOI
  10.1038/s41598-018-25856-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485
[Journal Article] Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights2018
- Author(s)
  Karasawa Tadayoshi、Kawashima Akira、Usui-Kawanishi Fumitake、Watanabe Sachiko、Kimura Hiroaki、Kamata Ryo、Shirasuna Koumei、Koyama Yutaro、Sato-Tomita Ayana、Matsuzaka Takashi、Tomoda Hiroshi、Park Sam-Yong、Shibayama Naoya、Shimano Hitoshi、Kasahara Tadashi、Takahashi Masafumi
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 38 Issue: 4 Pages: 744-756
- DOI
  10.1161/atvbaha.117.310581
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09521, KAKENHI-PROJECT-17K09889, KAKENHI-PUBLICLY-16H01395, KAKENHI-ORGANIZER-26105001, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-15K09146, KAKENHI-PROJECT-16K19544, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K19724, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-16K09808, KAKENHI-INTERNATIONAL-15K21719
[Patent] METHODS AND MOLECULAR PROBES FOR SUPER-RESOLUTION IMAGING AND QUANTIFICATION OF GUANINE NUCLEOTIDE TRIPHOSPHATE2021
- Inventor(s)
  Ryo Kamata
- Industrial Property Rights Holder
  Ryo Kamata
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K15019
[Presentation] CENP-E 阻害剤は染色体の不均等分配を誘導し小核形成と免疫応答を惹起する2023
- Author(s)
  鎌田　諒
- Organizer
  第31回日本医学会総会 -6NCリトリート 6NCが拓く新たなサイエンスの地平-
- Data Source
  KAKENHI-PROJECT-23K06708
[Presentation] CENP-E阻害剤は染色体不均等分配を惹起し小核形成とcGAS-STING経路を活性化する2023
- Author(s)
  鎌田　諒
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06708
[Presentation] CENP-E阻害剤は染色体の不均等分配を誘導し小核形成と免疫応答を惹起する2023
- Author(s)
  鎌田　諒
- Organizer
  第27回日本がん分子標的治療学会学術集会 (佐賀県)
- Data Source
  KAKENHI-PROJECT-23K06708
[Presentation] CENP-E阻害剤は染色体不安定性を誘導し自然免疫応答を惹起する2023
- Author(s)
  鎌田　諒
- Organizer
  第９回がんと代謝研究会in松山
- Data Source
  KAKENHI-PROJECT-23K06708
[Presentation] GTPエネルギー代謝のメカニカル制御が駆動するストレス-レジリエンスな細胞遊走2021
- Author(s)
  鎌田　諒
- Organizer
  日本分子生物学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15019
[Presentation] 脂肪細胞分化におけるLMP7の役割．2018
- Author(s)
  木村博昭、唐澤直義、渡邊幸子、鎌田諒、駒田敬則、笠原忠、高橋将文．
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-18K08112
[Presentation] 腸管虚血再灌流障害におけるNLRP3インフラマソームの役割の解明．2018
- Author(s)
  伊藤誉、佐田友藍、井上賢之、鎌田諒、渡邊幸子、唐澤直義、木村博昭、佐田尚宏、高橋将文．
- Organizer
  第39回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-18K08112
[Presentation] 低酸素刺激によるNLRP3インフラマソーム活性化機構の解明2018
- Author(s)
  渡邊幸子、河西文武、木村博昭、唐澤直義、鎌田諒、高橋将文．
- Organizer
  第39回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-18K08112
[Presentation] E3ユビキチンリガーゼARIH2によるNLRP3インフラマソーム制御機構の解明2018
- Author(s)
  鎌田　諒
- Organizer
  第59回日本脈管学会
- Data Source
  KAKENHI-PROJECT-17H07055

1. 仲尾岳大 (20817358)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. Takahashi Masafumi (40296108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
3. 木村博昭 (70593622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
4. 唐澤直義 (60631893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 渡邊幸子 (80770619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
6. 大橋紹宏 (80835249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中井一貴 (21003063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山下大生 (40970835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 波江野洋 (70706754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 鹿島幸恵 (80831883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山盛智子 (10767750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 向原徹 (80435718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. USUI Fumitake

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 佐々木敦朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 駒田敬則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kamata Ryo 鎌田 諒

Research Projects

Research Products

Co-Researchers

Study on the Elucidation of the Cancer Chromosomal Instability (CIN) Paradox and the Development of Novel Therapeutic Strategies Targeting CIN Vulnerabilities

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CTNNB1/PIK3CA二重変異を有する子宮体がんに対するb-catenin阻害剤の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of Chromosomal Instability-mediated Induction of Innate Immune Responses by CENP-E InhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel Regulation of Cell Migration by the GTP Metabolic Compartment of the Leading EdgePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of NLRP3 inflammasome regulation by ARIH2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of ARIH2 in the inflammasome-related cardiovascular disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of NLRP3 inflammasome regulation mechanism by E3 ubiquitin ligasePrincipal Investigator

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[Journal Article] Abstract 411: PI3K-AKT-mTOR signaling pathways play important roles in chromosomal instability-induced innate immune response in cancer cells2024

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[Journal Article] Abstract 4945: Computational modeling-based discovery of novel anticancer drug candidates targeting centromere-associated protein E2024

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[Journal Article] Abstract 1938: WEE1 inhibition prevents and overcomes resistance to KRAS inhibitors in lung cancer by enhancing MCL1-mediated apoptosis2024

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[Journal Article] Abstract 301: CENP-E inhibitors activate cGAS-STING pathway by inducing chromosome misalignment and micronucleation after mitotic slippage2023

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[Journal Article] Abstract 5739: Targeting WEE1 to improve the therapy of KRAS G12C mutant non-small cell lung cancer2023

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[Journal Article] SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides2021

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[Journal Article] Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification2021

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Kamata Ryo 鎌田諒