Kamata Ryo 鎌田諒

Researcher Number	60801420
Other IDs	https://orcid.org/0000-0001-6970-9657
Affiliation (Current)	2024: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員 2021: 慶應義塾大学, 政策・メディア研究科(藤沢), 研究員 2020: 自治医科大学, 医学部, 客員研究員 2017 – 2019: 自治医科大学, 医学部, ポスト・ドクター
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 43010:Molecular biology-related / Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 動物 / 蛋白質 / ユビキチン / 免疫学 / 循環器 / CENP-E / キネシン / 自然免疫応答 / 染色体分配制御 / 染色体不安定性 … More / Compartmentalization / RAC / IMPDH / migration / leading edge / GTP / 代謝 / 細胞遊走 / プロテアソーム / NLRP3 / 炎症 / ARIH2 / インフラマソーム / 循環器・高血圧 … More Except Principal Investigator ユビキチン / インフラマソーム / 炎症 / タンパク質分解 / タンパク質修飾 / 心血管病 / サイトカイン / 炎症反応 Less

Mechanism of Chromosomal Instability-mediated Induction of Innate Immune Responses by CENP-E InhibitorsPrincipal Investigator
- Principal Investigator
  
  鎌田諒
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Novel Regulation of Cell Migration by the GTP Metabolic Compartment of the Leading EdgePrincipal Investigator
- Principal Investigator
  
  Kamata Ryo
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  National Cancer Center Japan
Elucidation of the mechanism of NLRP3 inflammasome regulation by ARIH2Principal Investigator
- Principal Investigator
  
  Kamata Ryo
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
Role of ARIH2 in the inflammasome-related cardiovascular disease
- Principal Investigator
  
  Takahashi Masafumi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
Elucidation of NLRP3 inflammasome regulation mechanism by E3 ubiquitin ligasePrincipal Investigator
- Principal Investigator
  
  Kamata Ryo
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Jichi Medical University

All 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides2021
- Author(s)
  Ikeda Yoshiki、Hirayama Akiyoshi、Kofuji Satoshi、Hirota Yoshihisa、Kamata Ryo、Osaka Natsuki、Fujii Yuki、Sasaki Mika、Ikeda Satsuki、Smith Eric P、Bachoo Robert、Soga Tomoyoshi、Sasaki Atsuo T
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 170 Issue: 6 Pages: 699-711
- DOI
  10.1093/jb/mvab077
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165, KAKENHI-PROJECT-21K11709, KAKENHI-PROJECT-21K15019, KAKENHI-PROJECT-18KK0455
[Journal Article] Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification2021
- Author(s)
  Osaka Natsuki、Hirota Yoshihisa、Ito Doshun、Ikeda Yoshiki、Kamata Ryo、Fujii Yuki、Chirasani Venkat R.、Campbell Sharon L.、Takeuchi Koh、Senda Toshiya、Sasaki Atsuo T.
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 8 Pages: 1-12
- DOI
  10.3389/fmolb.2021.707439
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165, KAKENHI-PROJECT-21K15019
[Journal Article] Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease.2020
- Author(s)
  4)Anzai F, Watanabe S, Kimura H, Kamata R, Karasawa T, Komada T, Nakamura J, Nagi-Miura N, Ohno N, Takeishi Y, Takahashi M
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 138 Pages: 185-196
- DOI
  10.1016/j.yjmcc.2019.11.158
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-19K08523, KAKENHI-PROJECT-19K21319, KAKENHI-PROJECT-19K08916
[Journal Article] Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages.2020
- Author(s)
  1)Watanabe S, Usui-Kawanishi F, Karasawa, Kimura H, Kamata R, Inoue, Mise N, Kasahara T, Takahashi M
- Journal Title
  
  J Cell Physiol
  
  Volume: - Issue: 10 Pages: 7554-7566
- DOI
  10.1002/jcp.29659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-16K09521, KAKENHI-PROJECT-19K21319, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-19K06358, KAKENHI-PROJECT-20K07365, KAKENHI-PROJECT-20K17290
[Journal Article] NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury2020
- Author(s)
  Ito Homare、Kimura Hiroaki、Karasawa Tadayoshi、Hisata Shu、Sadatomo Ai、Inoue Yoshiyuki、Yamada Naoya、Aizawa Emi、Hishida Erika、Kamata Ryo、Komada Takanori、Watanabe Sachiko、Kasahara Tadashi、Suzuki Takuji、Horie Hisanaga、Kitayama Joji、Sata Naohiro、Yamaji-Kegan Kazuyo、Takahashi Masafumi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 205 Issue: 5 Pages: 1393-1405
- DOI
  10.4049/jimmunol.2000217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-19K08630, KAKENHI-PROJECT-20K07365, KAKENHI-PROJECT-20K17290, KAKENHI-PROJECT-20K17629, KAKENHI-PROJECT-17K09889
[Journal Article] ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome2020
- Author(s)
  Watanabe Sachiko、Usui-Kawanishi Fumitake、Komada Takanori、Karasawa Tadayoshi、Kamata Ryo、Yamada Naoya、Kimura Hiroaki、Dezaki Katsuya、Ohmori Tsukasa、Takahashi Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 531 Issue: 2 Pages: 125-132
- DOI
  10.1016/j.bbrc.2020.07.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-18K08524, KAKENHI-PROJECT-19K06358, KAKENHI-PROJECT-20K07365, KAKENHI-PROJECT-20K17290, KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08370
[Journal Article] GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition2020
- Author(s)
  Aizawa Emi、Karasawa Tadayoshi、Watanabe Sachiko、Komada Takanori、Kimura Hiroaki、Kamata Ryo、Ito Homare、Hishida Erika、Yamada Naoya、Kasahara Tadashi、Mori Yoshiyuki、Takahashi Masafumi
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 5 Pages: 101070-101070
- DOI
  10.1016/j.isci.2020.101070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21319, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-20K17290
[Journal Article] GSDME-dependentincomplete pyroptosis permits selective IL-1α release under caspase-1 inhibition2020
- Author(s)
  Aizawa E, Karasawa T, Watanabe S, Komada T, Kimura H, Kamata R, ItoH, Hishida E, Yamada N, Kasahara T, Mori Y, Takahashi M
- Journal Title
  
  iScience
  
  Volume: －
- Data Source
  KAKENHI-PROJECT-18K08112
[Journal Article] Glucose regulates hypoxia-induced NLRP3inflammasome activation in macrophages2020
- Author(s)
  Watanabe S, Usui-Kawanishi F, Karasawa T, Kimura H, Kamata R, InoueY, Mise N, Kasahara T, Takahashi M
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: －
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08112
[Journal Article] Role of NLRP3 Inflammasome in Atherosclerosis and Aortic Aneurysm2019
- Author(s)
  Kamata Ryo、Takahashi Masafumi
- Journal Title
  
  The Journal of Japanese College of Angiology
  
  Volume: 59 Issue: 10 Pages: 83-87
- DOI
  10.7133/jca.19-00022
- NAID
  130007726288
- ISSN
  0387-1126, 1880-8840
- Year and Date
  2019-10-10
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17536
[Journal Article] Crucial role of NLRP3 inflammasome in the development of peritoneal dialysis-related peritoneal fibrosis.2019
- Author(s)
  6)Hishida E, Ito H, Komada T, Karasawa T, Kimura H, Watanabe S, Kamata R, Aizawa E, Kasahara T, Morishita Y, AkimotoT, Nagata D, Takahashi M
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 10363-10363
- DOI
  10.1038/s41598-019-46504-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-18K15900, KAKENHI-PROJECT-18K16329, KAKENHI-PROJECT-19K21319
[Journal Article] Inflammasome-independent and atypical processing of IL-1β contributes to acid aspiration-induced acute lung injury.2019
- Author(s)
  5)Mizushina Y, Karasawa T, Aizawa K, Kimura H, Watanabe S, Kamata R, Komada T, Mato N, Kasahara T, Koyama S, Bando M, Hagiwara K, Takahashi M
- Journal Title
  
  J Immunol
  
  Volume: 203 Issue: 1 Pages: 236-246
- DOI
  10.4049/jimmunol.1900168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-18K15900, KAKENHI-PROJECT-19K21319
[Journal Article] Role of TLR5 in inflammation and tissue damage after intestinal ischemia-reperfusion injury.2019
- Author(s)
  7)Ito H, Sadatomo A, Inoue Y, Yamada N, Aizawa E, Hishida E, Kamata R, Karasawa T, Kimura H, Watanabe S, Komada T, Horie H, Kitagawa J, Sata N, Takahashi M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 519 Issue: 1 Pages: 15-22
- DOI
  10.1016/j.bbrc.2019.08.083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485, KAKENHI-PROJECT-18K15900, KAKENHI-PROJECT-18K16329, KAKENHI-PROJECT-19K21319
[Journal Article] Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.2018
- Author(s)
  Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, Ohno N, Kasahara T, Minota S, Takahashi M.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 7601-7601
- DOI
  10.1038/s41598-018-25856-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09889, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K08485
[Journal Article] Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights2018
- Author(s)
  Karasawa Tadayoshi、Kawashima Akira、Usui-Kawanishi Fumitake、Watanabe Sachiko、Kimura Hiroaki、Kamata Ryo、Shirasuna Koumei、Koyama Yutaro、Sato-Tomita Ayana、Matsuzaka Takashi、Tomoda Hiroshi、Park Sam-Yong、Shibayama Naoya、Shimano Hitoshi、Kasahara Tadashi、Takahashi Masafumi
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 38 Issue: 4 Pages: 744-756
- DOI
  10.1161/atvbaha.117.310581
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09521, KAKENHI-PROJECT-17K09889, KAKENHI-PUBLICLY-16H01395, KAKENHI-ORGANIZER-26105001, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-26253009, KAKENHI-PROJECT-15K09146, KAKENHI-PROJECT-16K19544, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-18K19724, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-16K09808, KAKENHI-INTERNATIONAL-15K21719
[Patent] METHODS AND MOLECULAR PROBES FOR SUPER-RESOLUTION IMAGING AND QUANTIFICATION OF GUANINE NUCLEOTIDE TRIPHOSPHATE2021
- Inventor(s)
  Ryo Kamata
- Industrial Property Rights Holder
  Ryo Kamata
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K15019
[Presentation] GTPエネルギー代謝のメカニカル制御が駆動するストレス-レジリエンスな細胞遊走2021
- Author(s)
  鎌田　諒
- Organizer
  日本分子生物学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15019
[Presentation] 脂肪細胞分化におけるLMP7の役割．2018
- Author(s)
  木村博昭、唐澤直義、渡邊幸子、鎌田諒、駒田敬則、笠原忠、高橋将文．
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-18K08112
[Presentation] 腸管虚血再灌流障害におけるNLRP3インフラマソームの役割の解明．2018
- Author(s)
  伊藤誉、佐田友藍、井上賢之、鎌田諒、渡邊幸子、唐澤直義、木村博昭、佐田尚宏、高橋将文．
- Organizer
  第39回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-18K08112
[Presentation] 低酸素刺激によるNLRP3インフラマソーム活性化機構の解明2018
- Author(s)
  渡邊幸子、河西文武、木村博昭、唐澤直義、鎌田諒、高橋将文．
- Organizer
  第39回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-18K08112
[Presentation] E3ユビキチンリガーゼARIH2によるNLRP3インフラマソーム制御機構の解明2018
- Author(s)
  鎌田　諒
- Organizer
  第59回日本脈管学会
- Data Source
  KAKENHI-PROJECT-17H07055

1. Takahashi Masafumi (40296108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
2. 木村博昭 (70593622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
3. 唐澤直義 (60631893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. 渡邊幸子 (80770619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
5. 仲尾岳大 (20817358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. USUI Fumitake

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 佐々木敦朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 駒田敬則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kamata Ryo 鎌田 諒

Research Projects

Research Products

Co-Researchers

Mechanism of Chromosomal Instability-mediated Induction of Innate Immune Responses by CENP-E InhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel Regulation of Cell Migration by the GTP Metabolic Compartment of the Leading EdgePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of NLRP3 inflammasome regulation by ARIH2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of ARIH2 in the inflammasome-related cardiovascular disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of NLRP3 inflammasome regulation mechanism by E3 ubiquitin ligasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GSDME-dependentincomplete pyroptosis permits selective IL-1α release under caspase-1 inhibition2020

Author(s)

Journal Title

Data Source

[Journal Article] Glucose regulates hypoxia-induced NLRP3inflammasome activation in macrophages2020

Author(s)

Journal Title

Data Source

[Journal Article] Role of NLRP3 Inflammasome in Atherosclerosis and Aortic Aneurysm2019

Author(s)

Journal Title

Kamata Ryo 鎌田諒