Kuniishi Hiroshi 國石洋

Researcher Number	60805034
Other IDs
Affiliation (Current)	2025: 福井大学, 子どものこころの発達研究センター, 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 福井大学, 子どものこころの発達研究センター, 助教 2023: 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, 特別研究員 2021: 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, 特別研究員 2019 – 2020: 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, リサーチフェロー 2018: 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related Except Principal Investigator Basic Section 52030:Psychiatry-related / Basic Section 10040:Experimental psychology-related
Keywords	Principal Investigator 幼少期ストレス / 光遺伝学 / 扁桃体 / 眼窩前頭皮質 / ニューロモジュレーション / 発達変化 / 社会隔離 / AMPA受容体 / シナプス / ストレス … More Except Principal Investigator … More 精神疾患 / インターロイキン-6 / ノルアドレナリン / ランダム化比較試験 / taVNS / ニューロモデュレーション / 迷走神経 / 心拍変動 / 脳画像解析 / 経皮的耳介迷走神経刺激 / 自律神経 / 5－アミノレブリン酸 / MRS / ５－アミノレブリン酸 / 脳 / 酸化ストレス / グルタチオン / 自閉スペクトラム症 / 動物モデル / ラット / ヒストンアセチル化 / GABA / ヒストン修飾 / グルタミン酸脱炭酸酵素 / ヒストン脱アセチル化酵素 / エピジェネティクス / 統合失調症 Less

耳介迷走神経刺激のASDモデルマウスに対する有効性とその脳内メカニズムの検討Principal Investigator
- Principal Investigator
  
  國石洋
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  University of Fukui
Glutathione system in the brain of children with autism spectrum disorder
- Principal Investigator
  
  松崎秀夫
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  University of Fukui
The mechanism of action of transcutaneous vagus nerve stimulation to treat psychiatric disorders.
- Principal Investigator
  
  山田光彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tokyo Kasei Gakuin University
幼少期ストレスモデルマウスに対する前頭葉ニューロモジュレーションの改善効果検討Principal Investigator
- Principal Investigator
  
  國石洋
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  University of Fukui
The involvement of abnormal histone modification in schizophrenia-related behaviors in rodent models
- Principal Investigator
  
  Furuie Hiroki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 10040:Experimental psychology-related
- Research Institution
  National Center of Neurology and Psychiatry
Stress-induced effects on the development of orbitofrontal-amygdala circuit.Principal Investigator
- Principal Investigator
  
  Kuniishi Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Center of Neurology and Psychiatry

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] 日本神経化学会奨励賞受賞者研究紹介「思春期の社会経験依存的な眼窩前頭皮質-扁桃体回路のシナプス機能の変化」2023
- Author(s)
  國石　洋
- Journal Title
  
  神経化学
  
  Volume: 62(2) Pages: 1-4
- Data Source
  KAKENHI-PROJECT-22K15759
[Journal Article] Subregion-dependent synaptic changes in the orbitofrontal-amygdala pathways by adolescent social isolation in mice2023
- Author(s)
  國石洋, 山田光彦
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 158 Issue: 1 Pages: 47-50
- DOI
  10.1254/fpj.22108
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22K15759, KAKENHI-PROJECT-21J01636, KAKENHI-PROJECT-23K27536
[Journal Article] Effects of riluzole on psychiatric disorders with anxiety or fear as primary symptoms: A systematic review.2023
- Author(s)
  Yoshitaka Kawashima, Misa Yamada, Hiroki Furuie, Hiroshi Kuniishi, Kie Akagi, Tomoko Kawashima, Takamasa Noda, Mitsuhiko Yamada
- Journal Title
  
  Neuropsychopharmacology reports
  
  Volume: 43 Issue: 3 Pages: 320-327
- DOI
  10.1002/npr2.12364
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07630, KAKENHI-PROJECT-21K03136, KAKENHI-PROJECT-23K27527
[Journal Article] Adolescent social isolation induces distinct changes in the medial and lateral OFC-BLA synapse and social and emotional alterations in adult mice2022
- Author(s)
  Kuniishi Hiroshi, Nakatake Yuko, Sekiguchi Masayuki, Yamada Mitsuhiko
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: 47 Issue: 9 Pages: 1597-1607
- DOI
  10.1038/s41386-022-01358-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15759, KAKENHI-PROJECT-21J01636
[Journal Article] The contribution of orbitofrontal cortex to stress-related psychiatric disorders: stress induced synaptic change in the orbitofrontal-basolateral amygdala pathway2021
- Author(s)
  Kuniishi Hiroshi、Sekiguchi Masayuki、Yamada Mitsuhiko
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 156 Issue: 2 Pages: 62-65
- DOI
  10.1254/fpj.20085
- NAID
  130007993081
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K15533
[Journal Article] Early life stress from allergic dermatitis causes depressive-like behaviors in adolescent male mice through neuroinflammatory priming2020
- Author(s)
  Okito Hashimoto, Hiroshi Kuniishi, Yuko Nakatake, Mitsuhiko Yamada, Keiji Wada, Masayuki Sekiguchi
- Journal Title
  
  Brain, Behavior, and Immunity
  
  Volume: 90 Pages: 319-331
- DOI
  10.1016/j.bbi.2020.09.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17349, KAKENHI-PROJECT-18K15533
[Journal Article] Stress induces insertion of calcium-permeable AMPA receptors in the OFC-BLA synapse and modulates emotional behaviours in mice2020
- Author(s)
  Kuniishi Hiroshi、Yamada Daisuke、Wada Keiji、Yamada Mitsuhiko、Sekiguchi Masayuki
- Journal Title
  
  Translational Psychiatry
  
  Volume: 10 Issue: 1
- DOI
  10.1038/s41398-020-0837-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] 思春期社会隔離マウスの社会性と内側眼窩前頭葉-扁桃体シナプス異常に対する再社会化飼育の改善効果の臨界期2023
- Author(s)
  國石洋、山田光彦、松﨑秀夫
- Organizer
  第 66 回⽇本神経化学会⼤会
- Data Source
  KAKENHI-PROJECT-22K15759
[Presentation] 耳介迷走神経活性化による社会行動の調節2023
- Author(s)
  國石　洋
- Organizer
  第2回日本神経化学会若手KYOUEN
- Invited
- Data Source
  KAKENHI-PROJECT-22K15759
[Presentation] マウスにおける耳介迷走神経刺激による社会性の調整作用2023
- Author(s)
  國石洋、謝敏カク、松﨑秀夫
- Organizer
  第50回日本脳科学会
- Data Source
  KAKENHI-PROJECT-22K15759
[Presentation] Adolescent social isolation induces pathway-selective functional changes in the medial and lateral orbitofrontal-amygdala circuits.2023
- Author(s)
  Hiroshi Kuniishi
- Organizer
  17th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Young Investigator Colloquium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15759
[Presentation] 思春期社会隔離マウスの社会性異常に対する耳介迷走神経刺激の効果2023
- Author(s)
  國石洋、松﨑秀夫
- Organizer
  第45回日本生物学的精神医学会年会
- Data Source
  KAKENHI-PROJECT-22K15759
[Presentation] マウス耳介迷走神経刺激による文脈的恐怖消去学習の促進作用2023
- Author(s)
  國石洋、竹内絵理、山田光彦、松﨑秀夫
- Organizer
  第46回日本神経科学大会, シンポジウム「神経ネットワークによる臓器連関システムが担う生体の恒常性維持機構とその破綻」
- Invited
- Data Source
  KAKENHI-PROJECT-22K15759
[Presentation] 離乳後の社会経験剥奪によるマウス眼窩前頭皮質-扁桃体回路の機能的変化2022
- Author(s)
  國石洋
- Organizer
  第14回自閉症学研究会,
- Data Source
  KAKENHI-PROJECT-22K15759
[Presentation] 思春期の社会経験剥奪による内側・外側眼窩前頭皮質-扁桃体投射における経路選択的なシナプス機能の変化と社会性・情動行動の制御2022
- Author(s)
  國石洋, 山田光彦, 松﨑秀夫
- Organizer
  第128回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-22K15759
[Presentation] mpact of adolescent social experience on the orbitofrontal-amygdala synaptic function and, social and emotional behaviors in mice.2022
- Author(s)
  Hirosihi Kuniishi, Mitsuhiko Yamada
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K15759
[Presentation] 発達期マウスにおける社会隔離飼育は内側・外側OFC-BLA経路のシナプス伝達に異なる影響を与える2021
- Author(s)
  國石洋、関口正幸、山田光彦
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] 不安を主症状とする精神疾患に対するRiluzoleの効果：システマティックレビューによる検討.2021
- Author(s)
  山田光彦, 川島義高, 山田美佐, 古家宏樹, 國石洋, 立花良之, 野田隆政
- Organizer
  第42回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] Adolescent social isolation disrupts synaptic transmission in medial orbitofrontal cortex-basolateral amygdala pathway and social behavior in mice2020
- Author(s)
  國石洋、中武優子、山田光彦,関口正幸
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] ストレスによる眼窩面前頭前野-扁桃体回路の可塑的変化：光遺伝学を利用した検討2020
- Author(s)
  國石洋、関口正幸、山田光彦
- Organizer
  第93回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] 発達期のマウスにおける隔離飼育ストレスは内側眼窩前頭皮質-扁桃体シナプス伝達と社会行動の異常を引き起こす2020
- Author(s)
  國石洋, 中武優子, 和田圭司, 山田光彦
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] Stress alters postsynaptic properties in the OFC-BLA pathway and modulates emotional behaviors in mice2020
- Author(s)
  Hiroshi Kuniishi, Daisuke Yamada, Keiji Wada, Mitsuhiko Yamada, Masayuki Sekiguchi
- Organizer
  FENS Forum 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] マウスにおける発達期社会的隔離飼育は社会性と扁桃体基底外側核シナプス機能の異常をもたらす2020
- Author(s)
  國石洋、中武優子、関口正幸、山田光彦
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] Stress induced postsynaptic plasticity in the orbitofrontal-amygdala pathway in mice2019
- Author(s)
  Hiroshi Kuniishi, Daisuke Yamada, Keiji Wada, Mitsuhiko Yamada, Masayuki Sekiguchi
- Organizer
  6th Congress of AsCNP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] ストレスによるマウス眼窩前頭皮質―扁桃体シナプス伝達変化とストレス関連行動への寄与2019
- Author(s)
  國石　洋、山田　大輔、和田　圭司、山田　光彦、関口　正幸
- Organizer
  NEURO2019
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] 異なる２つの前頭前皮質‐扁桃体経路におけるストレス応答性のシナプス伝達変化2019
- Author(s)
  國石洋、山田光彦、関口正幸
- Organizer
  令和元年度生理学研究所研究会「情動の生起と変容の多面的理解に向けて」
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] 眼窩前頭皮質-扁桃体回路におけるストレス応答性のシナプス伝達変化2019
- Author(s)
  國石洋、関口正幸、山田光彦
- Organizer
  医療心理懇話会第4回集会
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] ストレスはマウスの眼窩前頭皮質-扁桃体および前部帯状回-扁桃体経路のシナプス伝達に異なる影響を与える2018
- Author(s)
  國石洋、山田大輔、和田圭司、山田光彦、関口正幸
- Organizer
  第28回臨床精神神経薬理学会・第48回神経精神薬理学会合同年回
- Data Source
  KAKENHI-PROJECT-18K15533
[Presentation] 光遺伝学的手法による眼窩前頭皮質-扁桃体シナプス伝達の単離とストレスが与える影響の検討2018
- Author(s)
  國石洋、山田大輔、和田圭司、山田光彦、関口正幸
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K15533

1. 山田光彦 (60240040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. Furuie Hiroki (90639105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 三輪秀樹 (80468488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 松崎秀夫 (00334970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 謝敏カク (40444210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 関口敦 (50547289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMADA Misa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 橋本興人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuniishi Hiroshi 國石 洋

Research Projects

Research Products

Co-Researchers

耳介迷走神経刺激のASDモデルマウスに対する有効性とその脳内メカニズムの検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Glutathione system in the brain of children with autism spectrum disorder

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of action of transcutaneous vagus nerve stimulation to treat psychiatric disorders.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

幼少期ストレスモデルマウスに対する前頭葉ニューロモジュレーションの改善効果検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The involvement of abnormal histone modification in schizophrenia-related behaviors in rodent models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Stress-induced effects on the development of orbitofrontal-amygdala circuit.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] 日本神経化学会奨励賞受賞者研究紹介「思春期の社会経験依存的な眼窩前頭皮質-扁桃体回路のシナプス機能の変化」2023

Author(s)

Journal Title

Data Source

[Journal Article] Subregion-dependent synaptic changes in the orbitofrontal-amygdala pathways by adolescent social isolation in mice2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Effects of riluzole on psychiatric disorders with anxiety or fear as primary symptoms: A systematic review.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adolescent social isolation induces distinct changes in the medial and lateral OFC-BLA synapse and social and emotional alterations in adult mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The contribution of orbitofrontal cortex to stress-related psychiatric disorders: stress induced synaptic change in the orbitofrontal-basolateral amygdala pathway2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Early life stress from allergic dermatitis causes depressive-like behaviors in adolescent male mice through neuroinflammatory priming2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stress induces insertion of calcium-permeable AMPA receptors in the OFC-BLA synapse and modulates emotional behaviours in mice2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 思春期社会隔離マウスの社会性と内側眼窩前頭葉-扁桃体シナプス異常に対する再社会化飼育の改善効果の臨界期2023

Kuniishi Hiroshi 國石洋