Kobayashi Ryu 小林竜

Researcher Number	60805612
Affiliation (Current)	2025: 横浜市立大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2020 – 2021: 横浜市立大学, 医学研究科, 客員研究員 2020: 横浜市立大学, 医学部, 客員研究員 2017 – 2019: 横浜市立大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Endocrinology Except Principal Investigator Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 慢性腎臓病 / レニン-アンジオテンシン系 / 高血圧 / 尿細管 / レニン・アンジオテンシン系 / レニンアンジオテンシン系 Except Principal Investigator 新規治療 / 腎性老化 / 高血圧 / 治療標的 … More / 病態解明 / 腎臓病・高血圧 / 受容体 / 情報伝達系 Less

AT1 receptor binding protein activation strategy in the treatment of hypertension and related organ injuryPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Ryu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yokohama City University
Therapeutic Strategy against Renal Aging via Novel Dual Actions of Receptor-binding Molecule
- Principal Investigator
  
  TAMURA Kouichi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Yokohama City University
Angiotensin II type 1 receptor binding molecule as a therapeutic target for hypertensionPrincipal Investigator
- Principal Investigator
  
  Kobayashi Ryu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Endocrinology
- Research Institution
  Yokohama City University

All 2022 2021 2019 2018 2017

All Journal Article Presentation

[Journal Article] Comparison of effects of SGLT-2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in type 2 diabetes mellitus patients with/without albuminuria: A systematic review and network meta-analysis2022
- Author(s)
  Kawai Yuki、Uneda Kazushi、Yamada Takayuki、Kinguchi Sho、Kobayashi Kazuo、Azushima Kengo、Kanaoka Tomohiko、Toya Yoshiyuki、Wakui Hiromichi、Tamura Kouichi
- Journal Title
  
  Diabetes Research and Clinical Practice
  
  Volume: 183 Pages: 109146-109146
- DOI
  10.1016/j.diabres.2021.109146
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08730, KAKENHI-PROJECT-19K17575, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-20K07786, KAKENHI-PROJECT-20K21606
[Journal Article] LPIN1 is a new target gene for essential hypertension2022
- Author(s)
  Fujiwara Akira、Ozawa Moe、Sumida Koichiro、Hirawa Nobuhito、Yatsu Keisuke、Ichihara Nao、Haze Tatsuya、Komiya Shiro、Ohki Yuki、Kobayashi Yusuke、Wakui Hiromichi、Tamura Kouichi
- Journal Title
  
  Journal of Hypertension
  
  Volume: 40(3) Issue: 3 Pages: 536-543
- DOI
  10.1097/hjh.0000000000003046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08586, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-20K07786, KAKENHI-PROJECT-20K21606, KAKENHI-PROJECT-19K08709
[Journal Article] Influence of stress induced by the first announced state of emergency due to coronavirus disease 2019 on outpatient blood pressure management in Japan.2022
- Author(s)
  Kobayashi K, Chin K, Umezawa S, Ito S, Yamamoto H, Nakano S, Takada N, Hatori N, Tamura K.
- Journal Title
  
  Hypertens Res.
  
  Volume: 45 Issue: 4 Pages: 675-685
- DOI
  10.1038/s41440-021-00832-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-20K21606
[Journal Article] Association of the ratio of visceral-to-subcutaneous fat volume with renal function among patients with primary aldosteronism.2021
- Author(s)
  Haze T, Hatakeyama M, Komiya S, Kawano R, Ohki Y, Suzuki S, Kobayashi Y, Fujiwara A, Saka S, Tamura K, Hirawa N.
- Journal Title
  
  Hypertens Res.
  
  Volume: 44 Issue: 10 Pages: 1341-1351
- DOI
  10.1038/s41440-021-00719-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-20K21606
[Journal Article] Sex Difference in the Association Between Subtype Distribution and Age at Diagnosis in Patients with Primary Aldosteronism.2019
- Author(s)
  Akasaka H, Yamamoto K, Rakugi H, Nagasawa M, Nakamaru R, Ichijo T, Takeda Y, Kurihara I, Katabami T, Tsuiki M, Wada N, Ogawa Y, Kawashima J, Sone M, Kamemura K, Yoshimoto T, Matsuda Y, Fujita M, Kobayashi H, Watanabe M, Tamura K, et al.
- Journal Title
  
  Hypertension.
  
  Volume: 74 Issue: 2 Pages: 368-374
- DOI
  10.1161/hypertensionaha.119.13006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02735
[Journal Article] Lateralizing Asymmetry of Adrenal Imaging and Adrenal Vein Sampling in Patients With Primary Aldosteronism.2019
- Author(s)
  Wada N, Shibayama Y, Yoneda T, Katabami T, Kurihara I, Tsuiki M, Ichijo T, Ogawa Y, Kawashima J, Sone M, Yoshimoto T, Matsuda Y, Fujita M, Kobayashi H, Tamura K, Kamemura K, Otsuki M, Okamura S, Naruse M; JPAS/JRAS Study Group.
- Journal Title
  
  J Endocr Soc.
  
  Volume: 3 Issue: 7 Pages: 1393-1402
- DOI
  10.1210/js.2019-00131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02735
[Journal Article] Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice2019
- Author(s)
  Azushima Kengo、Uneda Kazushi、Wakui Hiromichi、Ohki Kohji、Haruhara Kotaro、Kobayashi Ryu、Haku Sona、Kinguchi Sho、Yamaji Takahiro、Minegishi Shintaro、Ishigami Tomoaki、Yamashita Akio、Tamura Kouichi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 6201-6201
- DOI
  10.1038/s41598-019-42657-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-17H06993, KAKENHI-PROJECT-17K19665, KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-19K17575, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-19K21318
[Journal Article] Improved home BP profile with dapagliflozin is associated with amelioration of albuminuria in Japanese patients with diabetic nephropathy: the Yokohama add-on inhibitory efficacy of dapagliflozin on albuminuria in Japanese patients with type 2 diabetes study (Y-AIDA study).2019
- Author(s)
  Kinguchi S, Wakui H, Ito Y, Kondo Y, Azushima K, Osada U, Yamakawa T, Iwamoto T, Yutoh J, Misumi T, Aoki K, Yasuda G, Yoshii T, Yamada T, Ono S, Shibasaki-Kurita T, Hosokawa S, Orime K, Hanaoka M, Sasaki H, Inazumi K, Yamada T, Kobayashi R, Ohki K, Haruhara K, Kobayashi Y, Yamanaka T, Terauchi Y, Tamura K.
- Journal Title
  
  Cardiovasc Diabetol.
  
  Volume: 18 Issue: 1 Pages: 110-110
- DOI
  10.1186/s12933-019-0912-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-19K21318
[Journal Article] Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line2019
- Author(s)
  Yamaji T, Yamashita A, Wakui H, Azushima K, Uneda K, Fujikawa Y, Haku S, Kobayashi R, Ohki K, Haruhara K, Kinguchi S, Ishii T, Yamada T, Urate S, Suzuki T, Abe E, Tanaka S, Kamimura D, Ishigami T, Toya Y, Takahashi H, Tamura K.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 16550-16550
- DOI
  10.1038/s41598-019-52566-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-19K17575, KAKENHI-PROJECT-19K18010, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-19K21318
[Journal Article] Effects of ATRAP in Renal Proximal Tubules on Angiotensin‐Dependent Hypertension2019
- Author(s)
  Kinguchi Sho、Wakui Hiromichi、Azushima Kengo、Haruhara Kotaro、Koguchi Tomoyuki、Ohki Kohji、Uneda Kazushi、Matsuda Miyuki、Haku Sona、Yamaji Takahiro、Yamada Takayuki、Kobayashi Ryu、Minegishi Shintaro、Ishigami Tomoaki、Yamashita Akio、Fujikawa Tetsuya、Tamura Kouichi
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 8 Issue: 8
- DOI
  10.1161/jaha.119.012395
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-17H06993, KAKENHI-PROJECT-17K19665, KAKENHI-PROJECT-17K16091, KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-19K17575, KAKENHI-PROJECT-19K18010, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-19K21318
[Journal Article] Early Enhanced Leucine-Rich α-2-Glycoprotein-1 Expression in Glomerular Endothelial Cells of Type 2 Diabetic Nephropathy Model Mice2018
- Author(s)
  haku Sona、Wakui Hiromichi、Azushima Kengo、Haruhara Kotaro、Kinguchi Sho、Ohki Kohji、Uneda Kazushi、Kobayashi Ryu、Matsuda Miyuki、Yamaji Takahiro、Yamada Takayuki、Minegishi Shintaro、Ishigami Tomoaki、Yamashita Akio、Ohashi Kenichi、Tamura Kouichi
- Journal Title
  
  BioMed Research International
  
  Volume: 2018 Pages: 1-9
- DOI
  10.1155/2018/2817045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09313, KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-17K19665, KAKENHI-PROJECT-17K09730
[Journal Article] Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile2018
- Author(s)
  Haruhara Kotaro、Wakui Hiromichi、Azushima Kengo、Kurotaki Daisuke、Kawase Wataru、Uneda Kazushi、Haku Sona、Kobayashi Ryu、Ohki Kohji、Kinguchi Sho、Ohsawa Masato、Minegishi Shintaro、Ishigami Tomoaki、Matsuda Miyuki、Yamashita Akio、Nakajima Hideaki、Tamura Tomohiko、Tsuboi Nobuo、Yokoo Takashi、Tamura Kouichi
- Journal Title
  
  Atherosclerosis
  
  Volume: 269 Pages: 236-244
- DOI
  10.1016/j.atherosclerosis.2018.01.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19665, KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-15H04331, KAKENHI-PROJECT-17H06993, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-16K09647, KAKENHI-PROJECT-17K09730
[Journal Article] Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue2018
- Author(s)
  Ohki Kohji、Wakui Hiromichi、Kishio Nozomu、Azushima Kengo、Uneda Kazushi、Haku Sona、Kobayashi Ryu、Haruhara Kotaro、Kinguchi Sho、Yamaji Takahiro、Yamada Takayuki、Minegishi Shintaro、Ishigami Tomoaki、Toya Yoshiyuki、Yamashita Akio、Imajo Kento、Nakajima Atsushi、Kato Ikuma、Ohashi Kenichi、Tamura Kouichi
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2846-2846
- DOI
  10.1038/s41598-018-21270-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19665, KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-15H04331, KAKENHI-PROJECT-17H06993, KAKENHI-PROJECT-16K19558, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-18H02735, KAKENHI-PROJECT-19K21318
[Journal Article] Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II-infused mice2017
- Author(s)
  Wakui Hiromichi、Sumida Koichiro、Fujita Megumi、Ohtomo Yuta、Ohsawa Masato、Kobayashi Ryu、Uneda Kazushi、Azushima Kengo、Haruhara Kotaro、Yatsu Keisuke、Hirawa Nobuhito、Minegishi Shintaro、Ishigami Tomoaki、Umemura Satoshi、Tamura Kouichi
- Journal Title
  
  Physiological Reports
  
  Volume: 5 Issue: 11 Pages: e13316-e13316
- DOI
  10.14814/phy2.13316
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09647, KAKENHI-PROJECT-16K09648, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-17H06993, KAKENHI-PROJECT-15K09293
[Journal Article] Angiotensin II Type 1 Receptor‐Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin2017
- Author(s)
  Uneda Kazushi、Wakui Hiromichi、Maeda Akinobu、Azushima Kengo、Kobayashi Ryu、Haku Sona、Ohki Kohji、Haruhara Kotaro、Kinguchi Sho、Matsuda Miyuki、Ohsawa Masato、Minegishi Shintaro、Ishigami Tomoaki、Toya Yoshiyuki、Atobe Yoshitoshi、Yamashita Akio、Umemura Satoshi、Tamura Kouichi
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 6 Issue: 8
- DOI
  10.1161/jaha.117.006120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09647, KAKENHI-PROJECT-17K09313, KAKENHI-PROJECT-17K19665, KAKENHI-PUBLICLY-17H05671, KAKENHI-PROJECT-15H04331, KAKENHI-PROJECT-17H06993, KAKENHI-PROJECT-15K09293
[Presentation] An emerging role of angiotensin receptor binding protein ATRAP as a possible novel player in pathophysiology of visceral obesity and metabolic disorders.2018
- Author(s)
  ouichi Tamura, Kohji Ohki, Kengo Azushima, Kazushi Uneda, Ryu Kobayashi, Sho Kinguchi, Kotaro Haruhara, Takahiro Yamaji, Takayuki Yamada, Hiromichi Wakui.
- Organizer
  Symposium 73, WCP2018 Kyoto: New perspectives on the function and pharmacology of the renin-angiotensin system. The 18th World Congress of Basic and Clinical Pharmacology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02735
[Presentation] Novel Receptor Binding Protein ATRAP in the Regulation of Renal Sodium Reabsorption and Blood Pressure Response.2018
- Author(s)
  Kouichi Tamura, Ryu Kobayashi, Kengo Azushima, Kazushi Uneda, Sona Haku, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Masato Ohsawa, Shin-ichiro Masuda, Miyuki Matsuda, Akio Yamashita, Hiromichi Wakui.
- Organizer
  Technical Session 1A: Salt and Cardiovascular Health. World Salt Symposium 2018: Salt of the Earth
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02735
[Presentation] Proximal tubule Angiotensin II Type 1 Receptor-associated Protein Regulates Kidney Aging and Lifespan through Sirtuin1-mediated Pathway.2018
- Author(s)
  17.Takahiro Yamaji, Kazushi Uneda, Shingo Urate, Takayuki Yamada, Sho Kinguchi, Sona Haku, Kotaro Haruhara, Kohji Ohki, Ryu Kobayashi, Kengo Azushima, Hiromichi Wakui, Yoshiyuki Toya, Akio Yamashita, Kouichi Tamura.
- Organizer
  The 51th Annual Meeting & Scientific Exposition of American Society of Nephrology (ASN Kidney Week 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02735
[Presentation] An angiotensin II type 1 receptor binding molecule has a critical role in hypertension in CKD model2017
- Author(s)
  Ryu Kobayashi
- Organizer
  Premium Hypertension Conference
- Data Source
  KAKENHI-PROJECT-17H06993
[Presentation] 慢性腎臓病における高血圧の進展に腎ATRAP発現の低下が深く関わる2017
- Author(s)
  小林　竜
- Organizer
  第３９回　腎臓セミナー・Nexus Japan
- Data Source
  KAKENHI-PROJECT-17H06993

1. TAMURA Kouichi (40285143)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. 涌井広道 (10587330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. 山下暁朗 (20405020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. 畝田一司 (90780370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. KANAOKA Tomohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 平和伸仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 藤原亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 大澤正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 戸谷義幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Ryu 小林 竜

Research Projects

Research Products

Co-Researchers

AT1 receptor binding protein activation strategy in the treatment of hypertension and related organ injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic Strategy against Renal Aging via Novel Dual Actions of Receptor-binding Molecule

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Angiotensin II type 1 receptor binding molecule as a therapeutic target for hypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Comparison of effects of SGLT-2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in type 2 diabetes mellitus patients with/without albuminuria: A systematic review and network meta-analysis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LPIN1 is a new target gene for essential hypertension2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Influence of stress induced by the first announced state of emergency due to coronavirus disease 2019 on outpatient blood pressure management in Japan.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of the ratio of visceral-to-subcutaneous fat volume with renal function among patients with primary aldosteronism.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sex Difference in the Association Between Subtype Distribution and Age at Diagnosis in Patients with Primary Aldosteronism.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lateralizing Asymmetry of Adrenal Imaging and Adrenal Vein Sampling in Patients With Primary Aldosteronism.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Improved home BP profile with dapagliflozin is associated with amelioration of albuminuria in Japanese patients with diabetic nephropathy: the Yokohama add-on inhibitory efficacy of dapagliflozin on albuminuria in Japanese patients with type 2 diabetes study (Y-AIDA study).2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of ATRAP in Renal Proximal Tubules on Angiotensin‐Dependent Hypertension2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Early Enhanced Leucine-Rich α-2-Glycoprotein-1 Expression in Glomerular Endothelial Cells of Type 2 Diabetic Nephropathy Model Mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile2018

Author(s)

Journal Title

Kobayashi Ryu 小林竜