Shimomura Osamu 下村治

… Alternative Names

Osamu Shimomura 下村治

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Researcher Number	60808070
Other IDs
Affiliation (Current)	2025: 筑波大学, 医学医療系, 講師
Affiliation (based on the past Project Information) *help	2017 – 2024: 筑波大学, 医学医療系, 講師
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 90120:Biomaterials-related / Medium-sized Section 50:Oncology and related fields / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator 糖鎖 / レクチン / 膵癌 / 膵臓がん / 糖タンパク / 早期診断 / Liquid biopsy / 循環腫瘍細胞 / 肝胆膵外科 / 膵癌マーカー … More / 神経叢浸潤 / 分子標的治療 / 新規膵癌治療 / 膵癌治療 / 光感受性レクチン融合薬 / 光免疫療法 / 早期診断法 / ELISA / 膵臓癌 … More Except Principal Investigator レクチン / 糖鎖 / 標的治療 / 膵癌 / 膵がん / 糖鎖ーレクチン / 近赤外線 / 光免疫 / IR700 / 光免疫治療 / 細胞特異的デリバリー / 核酸 / １細胞解析 / 膵がん幹細胞 / １細胞 / シングルセル / 糖鎖マーカー / シングルセルグライコミクス / 膵液瘻 / 閉鎖陰圧療法 / 膵液瘻予防 / リキッドバイオプシー / 胃癌 / 胃癌ゲノム型 / レクチン薬物複合体 / rBC2 / バイオマーカー / ゲノム / 薬物治療 / シアリル化糖鎖 / rBC2LCN / スキルス胃癌 / rBC2LC-N / がん標的治療 / 薬剤融合タンパク / がん特異的糖鎖 / 癌標的治療 / 緑膿菌外毒素(PE38) / 糖鎖標的治療 Less

レクチンによる細胞特異的核酸デリバリー技術の開発
- Principal Investigator
  
  佐野将之
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
血中循環腫瘍細胞をレクチンで捕獲する新規回収法と診断技術の開発Principal Investigator
- Principal Investigator
  
  下村治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  University of Tsukuba
膵液瘻予防を目的とした閉鎖陰圧療法の開発
- Principal Investigator
  
  久倉勝治
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  University of Tsukuba
Discovery of glycan markers of pancreatic cancer stem cells by single-cell glycomics
- Principal Investigator
  
  Tateno Hiroaki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Novel Cancer Therapy by Combination of Glycan-Lectin Reaction and Photoimmunotherapy
- Principal Investigator
  
  小田竜也
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  University of Tsukuba
Glycan expression profile of schirrhous gastric cancer
- Principal Investigator
  
  Akashi Yoshimasa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  University of Tsukuba
A novel UV-controlled cancer therapy using lectin-doxorubicin prodrug conjugate targeting pancreatic cancer glycansPrincipal Investigator
- Principal Investigator
  
  Shimomura Osamu
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  University of Tsukuba
Novel cancer therapy strategies, targeting cancer cell surface glycans using lectins (=glycan binding protein) as drug carriers.
- Principal Investigator
  
  ODA Tatsuya
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  University of Tsukuba
The detection of early stage pancreatic cancer with sandwich ELISA using tumor specific lectinsPrincipal Investigator
- Principal Investigator
  
  Osamu Shimomura
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  University of Tsukuba
Sandwich ELISA assay using antibody and lectin for early detection of pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  下村治
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Digestive surgery
- Research Institution
  University of Tsukuba

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: <scp><sup>18</sup>F</scp>‐labeled <scp>rBC2LCN</scp> lectin2023
- Author(s)
  Kuroda Yukihito、Oda Tatsuya、Shimomura Osamu、Louphrasitthiphol Pakavarin、Mathis Bryan J.、Tateno Hiroaki、Hatano Kentaro
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 8 Pages: 3364-3373
- DOI
  10.1111/cas.15846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20467, KAKENHI-PROJECT-23K24172
[Journal Article] rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma2023
- Author(s)
  Mawaribuchi Shuuji、Shimomura Osamu、Oda Tatsuya、Hiemori Keiko、Shimizu Kayoko、Yamase Kenya、Date Mutsuhiro、Tateno Hiroaki
- Journal Title
  
  Glycobiology
  
  Volume: cwad009 Issue: 4 Pages: 342-352
- DOI
  10.1093/glycob/cwad009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06454, KAKENHI-PROJECT-20K20467, KAKENHI-PROJECT-23K24172
[Journal Article] Lectin‐based phototherapy targeting cell surface glycans for pancreatic cancer2023
- Author(s)
  Kuroda Yukihito、Oda Tatsuya、Shimomura Osamu、Hashimoto Shinji、Akashi Yoshimasa、Miyazaki Yoshihiro、Furuya Kinji、Furuta Tomoaki、Nakahashi Hiromitsu、Louphrasitthiphol Pakavarin、Mathis Bryan J、Nakajima Takahito、Tateno Hiroaki
- Journal Title
  
  International Journal of Cancer
  
  Volume: 152 Issue: 7 Pages: 1425-1437
- DOI
  10.1002/ijc.34362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20467, KAKENHI-PROJECT-23K24172
[Journal Article] Total Superior Mesenteric Artery Nerve Plexus Preservation During Pancreaticoduodenectomy for Pancreatic Cancer2023
- Author(s)
  Miyazaki Yoshihiro、Oda Tatsuya、Shimomura Osamu、Hashimoto Shinji、Doi Manami、Takahashi Kazuhiro、Owada Yohei、Furuya Kinji、Ogawa Koichi、Ohara Yusuke、Akashi Yoshimasa、Enomoto Tsuyoshi
- Journal Title
  
  World Journal of Surgery
  
  Volume: 47 Issue: 11 Pages: 2816-2824
- DOI
  10.1007/s00268-023-07111-4
- Data Source
  KAKENHI-PROJECT-22K08888
[Journal Article] Usefulness of Human Jejunal Spheroid Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans2022
- Author(s)
  Michiba Kazuyoshi、Maeda Kazuya、Shimomura Osamu、Miyazaki Yoshihiro、Hashimoto Shinji、Oda Tatsuya、Kusuhara Hiroyuki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 50 Issue: 3 Pages: 204-213
- DOI
  10.1124/dmd.121.000796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03401, KAKENHI-PROJECT-20H03402, KAKENHI-PROJECT-20K20467, KAKENHI-PROJECT-23K24172
[Journal Article] Glycan expression profile of signet ring cell gastric cancer cells and potential applicability of rBC2LCN-targeted lectin drug conjugate therapy2022
- Author(s)
  Yang Yu、Akashi Yoshimasa、Shimomura Osamu、Tateno Hiroaki、Saito Sayoko、Hiemori Keiko、Miyazaki Yoshihiro、Furuta Tomoaki、Kitaguchi Daichi、Kuroda Yukihito、Pakavarin Louphrasitthiphol、Oda Tatsuya
- Journal Title
  
  Gastric Cancer
  
  Volume: 25 Issue: 5 Pages: 896-905
- DOI
  10.1007/s10120-022-01312-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20467, KAKENHI-PROJECT-20K09097, KAKENHI-PROJECT-23K24172
[Journal Article] Lectin drug conjugate therapy for colorectal cancer2020
- Author(s)
  Kitaguchi Daichi、Oda Tatsuya、Enomoto Tsuyoshi、Ohara Yusuke、Owada Yohei、Akashi Yoshimasa、Furuta Tomoaki、Yu Yang、Kimura Sota、Kuroda Yukihito、Kurimori Ko、Miyazaki Yoshihiro、Furuya Kinji、Shimomura Osamu、Tateno Hiroaki
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 12 Pages: 4548-4557
- DOI
  10.1111/cas.14687
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09097, KAKENHI-PROJECT-20K16404, KAKENHI-PROJECT-18K16340, KAKENHI-PROJECT-19K18078
[Journal Article] Retrocolic Gastrojejunostomy After Pancreaticoduodenectomy: A Satisfactory Delayed Gastric-Emptying Rate.2019
- Author(s)
  Miyazaki Y1, Oda T, Shimomura O, Enomoto T, Akashi Y, Hisakura K, Ohara Y, Kimura S, Hashimoto S, Ohkohchi N.
- Journal Title
  
  Pancreas.
  
  Volume: 48 Issue: 4 Pages: 579-584
- DOI
  10.1097/mpa.0000000000001295
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04057, KAKENHI-PROJECT-20K20467
[Journal Article] Indocyanine green fluorescence-navigated laparoscopic metastasectomy for peritoneal metastasis of hepatocellular carcinoma: a case report.2018
- Author(s)
  Miyazaki Y1, Kurata M2, Oshiro Y1, Shimomura O1, Takahashi K1, Oda T1, Ohkohchi N1.
- Journal Title
  
  Surg Case Rep.
  
  Volume: 4 Issue: 1 Pages: 130-133
- DOI
  10.1186/s40792-018-0537-x
- NAID
  120007128329
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04057
[Journal Article] Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.2018
- Author(s)
  Ohara Y, Oda T, Enomoto T, Hisakura K, Akashi Y, Ogawa K, Owada Y, Domoto Y, Miyazaki Y, Shimomura O, Kurata M, Ohkohchi N.
- Journal Title
  
  World J Surg Oncol
  
  Volume: 16 Issue: 1 Pages: 1457-8
- DOI
  10.1186/s12957-018-1457-8
- NAID
  120007133820
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16340, KAKENHI-PROJECT-18H04057
[Patent] ＢＣ２ＬＣＮを用いたサンドイッチアッセイによるがんの検査方法2019
- Inventor(s)
  舘野浩章、小田竜也、下村治
- Industrial Property Rights Holder
  舘野浩章、小田竜也、下村治
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-187197
- Filing Date
  2019
- Acquisition Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-18K16298
[Presentation] Near-infrared photoimmunotherapy for pancreatic cancer: Targeting cell surface glycans using lectin-photoabsorber conjugate (LPC)2022
- Author(s)
  Yukihito Kuroda, Osamu Shimomura, Hiromitsu Nakahashi, Tomoaki Furuta, Yoshihiro Miyazaki, Takahito Nakajima, Hiroaki Tateno, Tatsuya Oda
- Organizer
  AACR　American Association for Cancer Research Annual meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17638
[Presentation] Glycan expression profile of signet gastric cancer and potential applicability of lectin drug conjugate2022
- Author(s)
  Yoshimsa Akashi, Yu Yang, Osamu Shimomura, Yoshihiro Miyazaki, Tatsuya Oda, et al.
- Organizer
  第94回日本胃癌学会
- Data Source
  KAKENHI-PROJECT-20K09097
[Presentation] 膵癌のGlycobiology研究の最前線2022
- Author(s)
  下村　治
- Organizer
  日本外科学会
- Data Source
  KAKENHI-PROJECT-20K17638
[Presentation] Glycan expression profile of signet ring cell gastric cancer2022
- Author(s)
  明石義正, Yang Yu, 下村治, 小川光一, 榎本剛史, 大原佑介, 大和田洋平, 宮崎貴寛, 橋本真治, 高橋一広, 土井愛美, 古屋欽司, 馬上頌子, 小田竜也
- Organizer
  第94回　日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-20K09097
[Presentation] A novel UV-controlled cancer therapy using lectin-doxorubicin prodrug conjugate targetingpancreatic cancer glycans2021
- Author(s)
  Yukihito Kuroda, Osamu Shimomura, Fumi Minoshima, Hiroaki Tateno, Tatsuya Oda
- Organizer
  日本癌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17638
[Presentation] 研究学園都市で行う膵癌研究～外科医の基礎研究継承、現状と課題について2021
- Author(s)
  下村　治
- Organizer
  日本外科学会
- Data Source
  KAKENHI-PROJECT-18K16298
[Presentation] Brand-new biomarker for early pancreatic cancer; the rBC2LCN lectin; Glycoprotein X sandwich assay surpass CA19-9 detection value.2021
- Author(s)
  Osamu Shimomura
- Organizer
  日本肝胆膵外科学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16298
[Presentation] 研究学園都市で行う膵癌研究～外科医の基礎研究継承，現状と課題について2021
- Author(s)
  下村　治
- Organizer
  日本外科学会
- Data Source
  KAKENHI-PROJECT-20K17638
[Presentation] Development of a novel drug delivery system using lectin-drug conjugate as a promising next generation cancer therapy2021
- Author(s)
  Osamu Shimomura
- Organizer
  日本生化学学会
- Data Source
  KAKENHI-PROJECT-20K17638
[Presentation] Development of diagnostic systems of pancreatic ductal adenocarcinoma targeting serum glycoproteins using rBC2LCN lectin2020
- Author(s)
  Osamu Shimomura
- Organizer
  American Association for Cancer Research, annual meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16298
[Presentation] A novel UV-controlled cancer therapy using lectin-doxorubicin prodrug conjugate targetingpancreatic cancer glycans2020
- Author(s)
  Yukihito Kuroda, Osamu Shimomura, Fumi Minoshima, Hiroaki Tateno, Tatsuya Oda
- Organizer
  The 79th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-20K17638
[Presentation] 結合タンパク「レクチン」を用いた新規膵癌標的治療法の開発2018
- Author(s)
  下村治; 小田竜也; 舘野浩章; 木村聡大; 宮崎貴寛; 小澤佑輔、大河内信弘、
- Organizer
  第49回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-18H04057
[Presentation] レクチン薬剤複合体を用いた膵癌細胞表面糖鎖をターゲットにした新規癌治療【Molecular Cancer Therapeutics】2018
- Author(s)
  下村治; 小田竜也; 舘野浩章; 小澤佑介; 木村聡大; 坂下信悟、野口雅之、大河内信弘
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18H04057

1. ODA Tatsuya (20282353)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
2. Tateno Hiroaki (30450670)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. Akashi Yoshimasa (50709722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 久倉勝治 (60550168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 橋本真治 (60624666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 宮崎貴寛 (90909433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 佐野将之 (80415687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 寺村裕治 (10365421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 松阪諭 (00372665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 楠原洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 前田和哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 籏野健太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 回渕修治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 森健作

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimomura Osamu 下村 治

Osamu Shimomura 下村 治

Research Projects

Research Products

Co-Researchers

レクチンによる細胞特異的核酸デリバリー技術の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血中循環腫瘍細胞をレクチンで捕獲する新規回収法と診断技術の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵液瘻予防を目的とした閉鎖陰圧療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of glycan markers of pancreatic cancer stem cells by single-cell glycomics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel Cancer Therapy by Combination of Glycan-Lectin Reaction and Photoimmunotherapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Glycan expression profile of schirrhous gastric cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel UV-controlled cancer therapy using lectin-doxorubicin prodrug conjugate targeting pancreatic cancer glycansPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel cancer therapy strategies, targeting cancer cell surface glycans using lectins (=glycan binding protein) as drug carriers.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The detection of early stage pancreatic cancer with sandwich ELISA using tumor specific lectinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Sandwich ELISA assay using antibody and lectin for early detection of pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: <scp><sup>18</sup>F</scp>‐labeled <scp>rBC2LCN</scp> lectin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lectin‐based phototherapy targeting cell surface glycans for pancreatic cancer2023

Author(s)

Journal Title

DOI

Data Source

Shimomura Osamu 下村治

Osamu Shimomura 下村治

[Patent] ＢＣ２ＬＣＮを用いたサンドイッチアッセイによるがんの検査方法2019

[Presentation] 研究学園都市で行う膵癌研究～外科医の基礎研究継承、現状と課題について2021