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Okubo Naoki  大久保 直輝

ORCIDConnect your ORCID iD *help
Researcher Number 60816578
Other IDs
Affiliation (Current) 2025: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Affiliation (based on the past Project Information) *help 2018 – 2025: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Basic Section 56020:Orthopedics-related
Except Principal Investigator
Basic Section 59010:Rehabilitation science-related / Basic Section 56020:Orthopedics-related
Keywords
Principal Investigator
体内時計 / 概日リズム / 変形性関節症 / サルコペニア / 温熱刺激 / 温熱療法 / 関節軟骨 / Cry / 時計遺伝子
Except Principal Investigator
サルコペニア … More / 関節リウマチ / 運動耐容能 / 嫌気性代謝閾値 / 軽度高気圧高酸素 / FOXO / B-SES / 血液検査 / 無自覚のロコモティブシンドローム / 転倒 / 下肢筋力 / 下肢機能 / 地域高齢者 / サルコペニアインデックス / ロコモ / 地域住民健診 / ロコモティブシンドローム / 概日リズム / 器官培養 / 変形性関節症 / 時計遺伝子 / 体内時計 / 関節炎 Less
  • Research Projects

    (7 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (10 People)
  •  Elucidation of the Mechanism of Sarcopenia Induced by Circadian Rhythm Disruption and Investigation of the Preventive Effects of ExercisePrincipal Investigator

    • Principal Investigator
      大久保 直輝
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Development of Innovative Sarcopenia Treatment through EMS and FOXO Expression Inhibition

    • Principal Investigator
      遠山 将吾
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Development of a new rehabilitation environment for the frail elderly - mild hyperbaric hyperoxia -

    • Principal Investigator
      森原 徹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  construction of prediction system for early locomotive syndrome by blood test aiming to extend healthy life expectancy

    • Principal Investigator
      後藤 毅
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  the study of cartilage metabolism controlled by hyperthermia focusing on the circadian clockPrincipal Investigator

    • Principal Investigator
      大久保 直輝
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  comprehensive study for circadian clock and arthritis

    • Principal Investigator
      Fujiwara Hiroyoshi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Patophysiology of osteoarthritisPrincipal Investigator

    • Principal Investigator
      Okubo Naoki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Kyoto Prefectural University of Medicine

All 2024 2023 2022 2020 2019

All Journal Article Presentation

  • [Journal Article] Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis2020

    • Author(s)
      Bekki H.、Duffy T.、Okubo N.、Olmer M.、Alvarez-Garcia O.、Lamia K.、Kay S.、Lotz M.
    • Journal Title

      Osteoarthritis and Cartilage

      Volume: 28 Issue: 7 Pages: 966-976

    • DOI

      10.1016/j.joca.2020.04.004

    • Data Source
      KAKENHI-PROJECT-18K09040, KAKENHI-PROJECT-18K16629
  • [Journal Article] REV-ERBα and REV-ERBβ function as key factors regulating Mammalian Circadian Output2019

    • Author(s)
      Ikeda Ryosuke、Tsuchiya Yoshiki、Koike Nobuya、Umemura Yasuhiro、Inokawa Hitoshi、Ono Ryutaro、Inoue Maho、Sasawaki Yuh、Grieten Tess、Okubo Naoki、Ikoma Kazuya、Fujiwara Hiroyoshi、Kubo Toshikazu、Yagita Kazuhiro
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 10171-10171

    • DOI

      10.1038/s41598-019-46656-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06338, KAKENHI-PROJECT-18K09040, KAKENHI-PROJECT-19K06679, KAKENHI-PROJECT-19K22516, KAKENHI-PROJECT-18K16629, KAKENHI-PROJECT-18H02600
  • [Presentation] マウス大腿骨器官培養における軟骨体内時計と温熱刺激2024

    • Author(s)
      瀬谷 崇, 大久保直輝,高橋謙治
    • Organizer
      第50回日本生体電気・物理刺激研究会
    • Data Source
      KAKENHI-PROJECT-21K16661
  • [Presentation] マウス大腿骨器官培養を用いた温熱刺激に伴う体内時計の変化2023

    • Author(s)
      瀬谷 崇,大久保直輝,小池宜也,土谷佳樹,梅村康浩,八木田和弘,高橋謙治
    • Organizer
      第38回日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-21K16661
  • [Presentation] Sarcopenia index is a true surrogate marker for the diagnosis of sarcopenia in community-dwelling older adults2022

    • Author(s)
      Kazufumi Hisamoto, Naoki Okubo, Tsuyoshi Goto, Shuji Nakagawa, Yuji Arai, Kenji Takahashi
    • Organizer
      The 8th ASIAN CONFERENCE for FRAILTY AND SARCOPENIA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09406
  • [Presentation] Suppression of circadian clock protein cryptochrome2 promotes osteoarthritis2019

    • Author(s)
      H Bekki, T Duffy, N Okubo, M Olmer, O Alvarez-Garcia, K Lamia, S Kay, M.K. Lotz
    • Organizer
      Osteoarthritis research society international 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16629
  • [Presentation] 変形性関節症におけるCRY2の発現低下2019

    • Author(s)
      大久保直輝、戸次 大史、Martin Lotz
    • Organizer
      第26回日本時間生物学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K16629
  • 1.  Fujiwara Hiroyoshi (90381962)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  小田 良 (80516469)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  後藤 毅 (10627011)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  遠山 将吾 (00388183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  新井 祐志 (50347449)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  森原 徹 (90336735)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  福岡 義之 (20265028)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  小池 宣也 (00399685)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  八木田 和弘 (90324920)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  土谷 佳樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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