Shimi Takeshi 志見剛

Researcher Number	60817568
Other IDs	https://orcid.org/0000-0002-9864-1820
Affiliation (Current)	2025: 金沢大学, ナノ生命科学研究所, 特任准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 金沢大学, ナノ生命科学研究所, 特任准教授 2023: 東京工業大学, 科学技術創成研究院, 研究員 2018 – 2022: 東京工業大学, 科学技術創成研究院, 特任准教授
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Basic Section 32010:Fundamental physical chemistry-related
Keywords	Principal Investigator ラミン / 核ラミナ / cGAS / BAF / ヌクレオポリン / 核膜孔複合体 / 核膜孔 / ヘテロクロマチン / 細胞シート / 超解像度顕微鏡 … More / クライオ電子顕微鏡トモグラフィー / ラミノパチー / Laminopathies / Nucleoporin / Nuclear pore complex / lamin / Lamina … More Except Principal Investigator クロマチン / ラミンA / ラミナ / １分子分光 / １分子 / 分子間相互作用 / １分子観察 / ナノレベルイメージング / 細胞核 / クライオ蛍光顕微鏡 / 蛍光顕微鏡 / 1分子イメージング / RNAP2 / 核膜孔 / 蛍光 / ラミン / 化学 / 物理化学 / 顕微鏡 / 細胞 Less

Elucidation of molecular mechanisms for the relationship of mutual dependence between the nuclear lamina and heterochromatinPrincipal Investigator
- Principal Investigator
  
  志見剛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kanazawa University
細胞核形成における分子機構についての研究
- Principal Investigator
  
  藤芳暁
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 32010:Fundamental physical chemistry-related
- Research Institution
  Institute of Science Tokyo
Elucidation of molecular mechanisms for reassembling the nuclear lamina and NPCsPrincipal Investigator
- Principal Investigator
  
  Takeshi Shimi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tokyo Institute of Technology
細胞シート工学を用いたラミノパチー疾患モデル構築と核ラミナ修復機構の解明Principal Investigator
- Principal Investigator
  
  志見剛
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Kanazawa University
  Tokyo Institute of Technology
Structural study of the association between the nuclear lamina and nuclear pore complexesPrincipal Investigator
- Principal Investigator
  
  Shimi Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tokyo Institute of Technology

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome2023
- Author(s)
  Kono Yohei、Pack Chan-Gi、Ichikawa Takehiko、Komatsubara Arata、Adam Stephen A.、Miyazawa Keisuke、Rolas Loic、Nourshargh Sussan、Medalia Ohad、Goldman Robert D.、Fukuma Takeshi、Kimura Hiroshi、Shimi Takeshi
- Journal Title
  
  bioRxiv
  
  Volume: N/A
- DOI
  10.1101/2023.09.02.555826
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0158, KAKENHI-PROJECT-21H04764
[Journal Article] Superfluid helium nanoscope insert with millimeter working range2022
- Author(s)
  Kamiya Naoki、Kuramoto Kazuki、Takishima Kento、Yumoto Tatsuya、Oda Haruka、Shimi Takeshi、Kimura Hiroshi、Matsushita Michio、Fujiyoshi Satoru
- Journal Title
  
  Review of Scientific Instruments
  
  Volume: 93 Issue: 10 Pages: 103703-103703
- DOI
  10.1063/5.0107395
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H05534, KAKENHI-PLANNED-18H05527, KAKENHI-PUBLICLY-21H00246, KAKENHI-PROJECT-23K21093
[Journal Article] Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins2021
- Author(s)
  Mark Kittisopikul, Takeshi Shimi, Meltem Tatli, Joseph Riley Tran, Yixian Zheng, Ohad Medalia, Khuloud Jaqaman, Stephen A. Adam, and Robert D. Goldman
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 220 Issue: 4
- DOI
  10.1083/jcb.202007082
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06617, KAKENHI-PROJECT-20KK0158
[Journal Article] Adaptive-Resolution Multi-Orientation Analysis of Complex Filamentous Network Images2020
- Author(s)
  Mark Kittisopikul, Amir Vahabikashi, Takeshi Shimi, Robert D. Goldman, Khuloud Jaqaman
- Journal Title
  
  Bioinformatics
  
  Volume: 36 Issue: 20 Pages: 5093-5103
- DOI
  10.1093/bioinformatics/btaa627
- Data Source
  KAKENHI-PROJECT-19K21178
[Journal Article] Nuclear Lamins A/C and B1 Provide a Structural Framework That Organizes and Anchors Nuclear Pore Complexes2020
- Author(s)
  Kittisopikul Mark、Shimi Takeshi、Tatli Meltem、Tran Joseph R.、Zheng Yixian、Medalia Ohad、Jaqaman Khuloud、Adam Stephen A.、Goldman Robert D.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.04.03.022798
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21178
[Journal Article] A mosaic of old and young nucleoporins2019
- Author(s)
  Shimi Takeshi、Kimura Hiroshi
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 218 Issue: 2 Pages: 385-386
- DOI
  10.1083/jcb.201811170
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05527, KAKENHI-PROJECT-17H01417, KAKENHI-PROJECT-19K21178
[Journal Article] Adaptive-Resolution Multi-Orientation Analysis of Complex Filamentous Network Images2019
- Author(s)
  Kittisopikul Mark、Vahabikashi Amir、Shimi Takeshi、Goldman Robert D.、Jaqaman Khuloud
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/757005
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21178
[Presentation] 核膜修復におけるA型ラミンのテール領域に関する網羅的解析2023
- Author(s)
  河野洋平、白燦基、市川壮彦、福間剛士、木村宏、志見剛
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20KK0158
[Presentation] Fluorescence labeling techniqe for cryogenic single molecule nanoscopy2023
- Author(s)
  藏本和輝, 武藤慶, 宮崎龍也, 山口潤一郎, 松下道雄, 志見剛, 木村宏, 藤芳暁
- Organizer
  分子生物学会
- Data Source
  KAKENHI-PROJECT-23K21093
[Presentation] Defective repair of nuclear envelope ruptures in laminopathies2023
- Author(s)
  志見剛、河野洋平、Stephen A. Adam、Yixian Zheng、Ohad Medalia、Robert D. Goldman、木村宏
- Organizer
  日本生理学会第100回記念大会　シンポジウム：核膜研究の最前線
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0158
[Presentation] Defective repair of nuclear envelope ruptures in laminopathies2023
- Author(s)
  志見剛、河野洋平、Stephen A. Adam、Yixian Zheng、Ohad Medalia、Robert D. Goldman、木村宏
- Organizer
  日本生理学会第100回記念大会　シンポジウム：核膜研究の最前線
- Invited
- Data Source
  KAKENHI-PROJECT-20K06617
[Presentation] ハッチンソン・ギルフォード・プロジェリア症候群において核ラミナの修復が遅延する分子メカニズムの解明2023
- Author(s)
  河野洋平、白燦基、市川壮彦、福間剛士、木村宏、志見剛
- Organizer
  第41回染色体ワークショッフ・第22回核タイナミクス研究会
- Data Source
  KAKENHI-PROJECT-20KK0158
[Presentation] The differential dynamics of nuclear lamin A and C in repair of nuclear envelope ruptures2022
- Author(s)
  志見剛、河野洋平、Stephen A. Adam、Yixian Zheng、Ohad Medalia、Robert D. Goldman、木村宏
- Organizer
  第95回日本生化学会大会　シンポジウム：プレイオトロピックな核膜の生物学
- Invited
- Data Source
  KAKENHI-PROJECT-20K06617
[Presentation] 細胞内の１分子を三次元でナノレベル分解能で観察できるクライオ三次元ナノスコピーの開発2022
- Author(s)
  成瀬寛太, 松田剛, 溝内雄太, 志見剛, 木村宏, 中田栄司, 森井孝, 松下道雄, 藤芳暁
- Organizer
  日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21093
[Presentation] 生体試料の3次元イメージングのための可変浸レンズを用いた光シート蛍光顕微鏡の開発2022
- Author(s)
  湯本達也, 志見剛, 木村宏, 松下道雄, 藤芳暁
- Organizer
  分子生物学会
- Data Source
  KAKENHI-PROJECT-23K21093
[Presentation] 細胞内１分子ナノスコピーのための近赤外蛍光標識技術の開発2022
- Author(s)
  藏本和輝, 武藤慶, 宮崎龍也, 山口潤一郎, 成瀬寛太, 神谷直輝，荒巻秀和, 松下道雄, 小田春佳, 志見剛, 木村宏, 藤芳暁
- Organizer
  日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-23K21093
[Presentation] The differential dynamics of nuclear lamin A and C in repair of nuclear envelope ruptures2022
- Author(s)
  志見剛、河野洋平、Stephen A. Adam、Yixian Zheng、Ohad Medalia、Robert D. Goldman、木村宏
- Organizer
  第95回日本生化学会大会　シンポジウム：プレイオトロピックな核膜の生物学
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0158
[Presentation] A型ラミンが損傷した核ラミナを修復する分子メカニズム2021
- Author(s)
  志見剛, 河野洋平, Pack CG, Adam SA, Zheng Y, Medalia O, Goldman RD, 木村宏
- Organizer
  第73回日本細胞生物学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06617
[Presentation] A型ラミンが損傷した核ラミナを修復する分子メカニズム2021
- Author(s)
  志見剛, 河野洋平, Pack CG, Adam SA, Zheng Y, Medalia O, Goldman RD, 木村宏
- Organizer
  第73回日本細胞生物学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0158
[Presentation] 近赤外蛍光プローブを利用した三次元ナノスコピー2021
- Author(s)
  成瀬寛太, 武藤慶, 宮崎龍也, 山口潤一郎, 松田剛, 溝内雄太, 志見剛, 木村宏, 松下道雄, 藤芳暁
- Organizer
  日本物理学会2021年秋季大会
- Data Source
  KAKENHI-PROJECT-23K21093
[Presentation] Laminopathy-associated defects in repairing the nuclear lamina after nuclear rupture2020
- Author(s)
  Takeshi Shimi, Yohei Kono, Chan-Gi Pack, Stephen A. Adam, Yixian Zheng, Robert D. Goldman, Hiroshi Kimura
- Organizer
  第43回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K06617
[Presentation] The C-terminal tail region of A-type lamins is invloved in recovering from nuclear rupture2020
- Author(s)
  Yohei Kono, Chan-Gi Pack, Stephen A. Adam, Yixian Zheng, Robert D. Goldman, Hiroshi Kimura, Takeshi Shimi
- Organizer
  第43回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20KK0158
[Presentation] Laminopathy-associated defects in repairing the nuclear lamina after nuclear rupture2020
- Author(s)
  Takeshi Shimi, Yohei Kono, Chan-Gi Pack, Stephen A. Adam, Yixian Zheng, Robert D. Goldman, Hiroshi Kimura
- Organizer
  第43回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20KK0158
[Presentation] Elys anchors the Nuclear Pore Complex to Nuclear Lamins2019
- Author(s)
  M. Kittisopikul, T. Shimi, M. Tatli, S.A. Adam, Y. Zheng, O. Medalia, K. Jaqaman, R.D. Goldman
- Organizer
  ASCB/EMBO 2019 Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21178
[Presentation] クライオ電子顕微鏡トモグラフィーと超解像度顕微鏡による核ラミンー核膜孔間の相互作用の解明2019
- Author(s)
  Takeshi Shimi, Mark Kittisopikul, Stephen A. Adam, Yixian Zheng, Khuloud Jaqaman, Robert D. Goldman
- Organizer
  第42回分子生物学会・年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K21178
[Presentation] 核ラミナによる核膜孔複合体の分布を制御する分子機構2018
- Author(s)
  Takeshi Shimi, Mark Kittisopikul, Stephen A. Adam, Yixian Zheng, Khuloud Jaqaman, Robert D. Goldman
- Organizer
  第36回染色体ワークショップ・第17回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19K21178
[Presentation] Nuclear lamins provide a structural framework that anchors nuclear pore complexes2018
- Author(s)
  Mark Kittisopikul, Takeshi Shimi, Stephen A Adam, Yixian Zheng, Khuloud Jaqaman, Robert D Goldman
- Organizer
  Cold Spring Harbor Laboratory for the Nuclear Organization & Function meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21178

1. 河野洋平 (20831697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 宮澤佳甫 (40845525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 木村宏 (30241392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. 藤芳暁 (70371705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 工藤史貴 (00361783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Shimi Takeshi 志見 剛

Research Projects

Research Products

Co-Researchers

Elucidation of molecular mechanisms for the relationship of mutual dependence between the nuclear lamina and heterochromatinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞核形成における分子機構についての研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanisms for reassembling the nuclear lamina and NPCsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞シート工学を用いたラミノパチー疾患モデル構築と核ラミナ修復機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural study of the association between the nuclear lamina and nuclear pore complexesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Superfluid helium nanoscope insert with millimeter working range2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adaptive-Resolution Multi-Orientation Analysis of Complex Filamentous Network Images2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nuclear Lamins A/C and B1 Provide a Structural Framework That Organizes and Anchors Nuclear Pore Complexes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A mosaic of old and young nucleoporins2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adaptive-Resolution Multi-Orientation Analysis of Complex Filamentous Network Images2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 核膜修復におけるA型ラミンのテール領域に関する網羅的解析2023

Author(s)

Organizer

Data Source

[Presentation] Fluorescence labeling techniqe for cryogenic single molecule nanoscopy2023

Author(s)

Organizer

Data Source

[Presentation] Defective repair of nuclear envelope ruptures in laminopathies2023

Author(s)

Organizer

Shimi Takeshi 志見剛