Harada Kazuki 原田一貴

Researcher Number	60830734
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立環境研究所, 環境リスク・健康領域, 研究員 2025: 東京大学, 大学院総合文化研究科, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 東京大学, 大学院総合文化研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 48020:Physiology-related / 0802:Biomedical structure and function and related fields Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 48:Biomedical structure and function and related fields
Keywords	Principal Investigator アルギニンバソプレシン / Kmt2c遺伝子 / メタボローム / 脳腸相関 / エピジェネティクス / 自閉スペクトラム症 / 糖代謝 / バソプレシン / インクレチン / グルカゴン様ペプチド-1 … More / 社会行動 / てんかん / バソプレシン受容体 / 蛍光タンパク質センサー / 蛍光タンパク質 / 超小型内視顕微鏡 / 生体イメージング … More Except Principal Investigator 腸内細菌 / 消化管ホルモン / フォトトロピン / ホルモン分泌 / キナーゼ / イメージング Less

腸内細菌代謝物による認知的柔軟性制御における消化管ホルモンを介した分子機構の解析
- Principal Investigator
  
  坪井貴司
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Tokyo
ホルモン分泌における環状ヌクレオチドシグナリングを照らすキナーゼ光スイッチ開発
- Principal Investigator
  
  坪井貴司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  The University of Tokyo
Metabolic and digestive symptoms of autism spectrum disorder-related gene Kmt2c mutant micePrincipal Investigator
- Principal Investigator
  
  原田一貴
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Analysis on the mechanism of glucose metabolism by interaction beteween vasopressin and glucagon-like peptide-1Principal Investigator
- Principal Investigator
  
  Harada Kazuki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  The University of Tokyo
Regulation of incretin secretion by microbiota metabolites
- Principal Investigator
  
  TSUBOI Takashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Tokyo
Elucidation of mechanisms of neuronal disorders in vasopressin receptor-deficient mice by using microendoscopyPrincipal Investigator
- Principal Investigator
  
  Harada Kazuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0802:Biomedical structure and function and related fields
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] F‐actin determines the time‐dependent shift in docking dynamics of glucagon‐like peptide‐1 granules upon stimulation of secretion2023
- Author(s)
  Harada Kazuki、Takashima Maoko、Kitaguchi Tetsuya、Tsuboi Takashi
- Journal Title
  
  FEBS Letters
  
  Volume: 597 Issue: 5 Pages: 657-671
- DOI
  10.1002/1873-3468.14580
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04121
[Journal Article] Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells2022
- Author(s)
  Osuga Yuri、Harada Kazuki、Tsuboi Takashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 588 Pages: 118-124
- DOI
  10.1016/j.bbrc.2021.12.043
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04765, KAKENHI-PUBLICLY-20H04836, KAKENHI-PROJECT-20H00575, KAKENHI-PROJECT-20H04121
[Journal Article] Development of red genetically encoded biosensor for visualization of intracellular glucose dynamics2022
- Author(s)
  Mita Marie、Sugawara Izumi、Harada Kazuki、Ito Motoki、Takizawa Mai、Ishida Kentaro、Ueda Hiroshi、Kitaguchi Tetsuya、Tsuboi Takashi
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 29 Issue: 1 Pages: 98-108.e4
- DOI
  10.1016/j.chembiol.2021.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23820, KAKENHI-PUBLICLY-20H04765, KAKENHI-PUBLICLY-20H04836, KAKENHI-PROJECT-18H03851, KAKENHI-PROJECT-20H00575, KAKENHI-PROJECT-20J14411, KAKENHI-PROJECT-20H04121
[Journal Article] Development of a red fluorescent protein-based cGMP indicator applicable for live-cell imaging2022
- Author(s)
  Takizawa Mai、Osuga Yuri、Ishida Rika、Mita Marie、Harada Kazuki、Ueda Hiroshi、Kitaguchi Tetsuya、Tsuboi Takashi
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 833-833
- DOI
  10.1038/s42003-022-03790-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20659, KAKENHI-PROJECT-20H04121
[Journal Article] Green fluorescent protein-based lactate and pyruvate indicators suitable for biochemical assays and live cell imaging.2020
- Author(s)
  Harada K*, Chihara T*, Hayasaka Y*, Mita M, Takizawa M, Ishida K, Arai M, Tsuno S, Matsumoto M, Ishihara T, Ueda H, Kitaguchi T, Tsuboi T. *Equal contribution
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-020-76440-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23820, KAKENHI-PUBLICLY-20H04765, KAKENHI-PUBLICLY-20H04836, KAKENHI-PROJECT-18H03851, KAKENHI-PROJECT-20H04121, KAKENHI-PROJECT-20J14411, KAKENHI-PROJECT-17K08529, KAKENHI-PROJECT-19H03326, KAKENHI-PROJECT-17H06113
[Presentation] Regulation of glucose metabolism is mediated by arginine vasopressin and glucagon-like peptide-1 in mice2022
- Author(s)
  Kazuki Harada, Takashi Tsuboi
- Organizer
  第21回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K16118
[Presentation] .L-フェニルアラニンによるグルカゴン様ペプチド-1分泌調節機構2021
- Author(s)
  大須賀佑里, 原田一貴, 坪井貴司
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20H04121

1. TSUBOI Takashi (80415231)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 北口哲也 (60432374)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 末次憲之 (60514156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 三田真理恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Harada Kazuki 原田 一貴

Research Projects

Research Products

Co-Researchers

腸内細菌代謝物による認知的柔軟性制御における消化管ホルモンを介した分子機構の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ホルモン分泌における環状ヌクレオチドシグナリングを照らすキナーゼ光スイッチ開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metabolic and digestive symptoms of autism spectrum disorder-related gene Kmt2c mutant micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis on the mechanism of glucose metabolism by interaction beteween vasopressin and glucagon-like peptide-1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of incretin secretion by microbiota metabolites

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanisms of neuronal disorders in vasopressin receptor-deficient mice by using microendoscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] F‐actin determines the time‐dependent shift in docking dynamics of glucagon‐like peptide‐1 granules upon stimulation of secretion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of red genetically encoded biosensor for visualization of intracellular glucose dynamics2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a red fluorescent protein-based cGMP indicator applicable for live-cell imaging2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Green fluorescent protein-based lactate and pyruvate indicators suitable for biochemical assays and live cell imaging.2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Regulation of glucose metabolism is mediated by arginine vasopressin and glucagon-like peptide-1 in mice2022

Author(s)

Organizer

Data Source

[Presentation] .L-フェニルアラニンによるグルカゴン様ペプチド-1分泌調節機構2021

Author(s)

Organizer

Data Source

Harada Kazuki 原田一貴