UCHIHARA Tomoyuki 内原智幸

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Uchihara Tomoyuki 内原智幸

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Researcher Number	60835172
Other IDs
Affiliation (Current)	2025: 公益財団法人がん研究会, がん研究所発がん研究部, 客員研究員
Affiliation (based on the past Project Information) *help	2023: 公益財団法人がん研究会, がん研究所発がん研究部, 客員研究員 2021 – 2022: 熊本大学, 大学院生命科学研究部(医), 特定研究員 2020: 熊本大学, 病院, 非常勤診療医師 2019: 熊本大学, 病院, 診療助手
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 50010:Tumor biology-related Except Principal Investigator Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator CAFs / 胃がん / 腫瘍微小環境 / オープンクロマチン領域 / 単一核マルチオーム解析 / シングルセル解析 / エピゲノム / CTCs / ストローマ / cCAFs … More / CTCクラスター / CTC / 血行性転移 / 抗血小板療法 / CTC クラスター / cCAF / 抗癌剤抵抗性 / 癌関連線維芽細胞 / 腫瘍間質 (ストローマ) / 抗ガン剤抵抗性 / 細胞外小胞 / 胃癌 … More Except Principal Investigator 空間的遺伝子発現解析 / ストローマ / 多様性 / CAFs / 間質 / 胃がん / シングルセル解析 Less

単一核マルチオーム解析を用いた胃がん間質不均一性の解明Principal Investigator
- Principal Investigator
  
  内原智幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Japanese Foundation for Cancer Research
To elucidate of new mechanism of hematogenous metastasis by stromal cells in gastric cancerPrincipal Investigator
- Principal Investigator
  
  Uchihara Tomoyuki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kumamoto University
Elucidation of diversity and therapeutic target in scirrhous gastric cancer stroma
- Principal Investigator
  
  ISHIMOTO Takatsugu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kumamoto University
To identify molecular mechanism of anticancer drug resistance through tumor stroma of gastric cancerPrincipal Investigator
- Principal Investigator
  
  Uchihara Tomoyuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment2024
- Author(s)
  Yonemura A、Semba T、Zhang J、Fan Y、Yasuda-Yoshihara N、Wang H、Uchihara T、Yasuda T、Nishimura A、Fu L、Hu X、Wei F、Kitamura F、Akiyama T、Yamashita K、Eto K、Iwagami S、Iwatsuki M、Miyamoto Y、Matsusaki K、Yamasaki J、Nagano O、Saya H、Song S、Tan P、Baba H、Ajani Jaffer A.、Ishimoto T
- Journal Title
  
  Cell Reports
  
  Volume: 43 Issue: 1 Pages: 113613-113613
- DOI
  10.1016/j.celrep.2023.113613
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-23K08113, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23H00410, KAKENHI-PROJECT-23K27689
[Journal Article] RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination2024
- Author(s)
  Zhang Jun、Fu Lingfeng、Wang Huaitao、Yonemura Atsuko、Semba Takashi、Yasuda-Yoshihara Noriko、Nishimura Akiho、Tajiri Takuya、Tong Yilin、Yasuda Tadahito、Uchihara Tomoyuki、Yamazaki Masaya、Okamoto Yuya、Yamasaki Juntaro、Nagano Osamu、Baba Hideo、Ishimoto Takatsugu
- Journal Title
  
  Cancer Letters
  
  Volume: 591 Pages: 216901-216901
- DOI
  10.1016/j.canlet.2024.216901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27689
[Journal Article] A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts2023
- Author(s)
  Wei F , Uchihara T , Yonemura A , Yasuda-Yoshihara N , Yasuda T , Semba T , Fukuda M , Akiyama T , Kitamura F , Kariya R , Yamasaki J , Aihara K , Yamashita K , Nagano O , Okada S , Baba H , Ishimoto T
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 10 Pages: 2604-2615
- DOI
  10.1111/febs.16712
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20K08961, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-23K06745, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
[Journal Article] Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion2023
- Author(s)
  Hu X、Yasuda T、Yasuda-Yosihara N、Yonemura A、Umemoto T、Nakachi Y、Yamashita K、Semba T、Arima K、Uchihara T、Nishimura A、Bu L、Fu Li、Wei F、Zhang J、Tong Y、Wang H、Iwamoto K、Fukuda T、Nakagawa H、Taniguchi K、Miyamoto Y、Baba H、Ishimoto T
- Journal Title
  
  JHEP Reports
  
  Volume: 5 Issue: 12 Pages: 100892-100892
- DOI
  10.1016/j.jhepr.2023.100892
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21K08686, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-20H03758, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K27463, KAKENHI-PROJECT-23K27669
[Journal Article] IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment2023
- Author(s)
  Zhang Jun、Fu Lingfeng、Yasuda-Yoshihara Noriko、Yonemura Atsuko、Wei Feng、Bu Luke、Hu Xichen、Akiyama Takahiko、Kitamura Fumimasa、Yasuda Tadahito、Semba Takashi、Uchihara Tomoyuki、Itoyama Rumi、Yamashita Kohei、Eto Kojiro、Iwagami Shiro、Yashiro Masakazu、Komohara Yoshihiro、Baba Hideo、Ishimoto Takatsugu
- Journal Title
  
  Gastric Cancer
  
  Volume: 26 Issue: 2 Pages: 187-202
- DOI
  10.1007/s10120-022-01352-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
[Journal Article] Tumor microenvironmental 15‐PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer2022
- Author(s)
  Bu L, Yonemura A, Yasuda-Yoshihara N, Uchihara T, Ismagulov G, Takasugi S, Yasuda T, Okamoto Y, Kitamura F, Akiyama T, Arima K, Itoyama R, Zhang J, Fu L, Hu X, Wei, F, Arima Y, Moroishi T, Nishiyama K, Sheng G, Mukunoki T, Otani J, Baba H, Ishimoto T
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 10 Pages: 3579-3592
- DOI
  10.1111/cas.15495
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-21H02490, KAKENHI-PROJECT-20K09038, KAKENHI-PROJECT-21K19535
[Journal Article] Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.2022
- Author(s)
  T. Akiyama, T. Yasuda, T. Uchihara, N. Yasuda-Yoshihara, BJY. Tan, A. Yonemura, T. Semba, J. Yamasaki, Y. Komohara, K. Ohnishi, F. Wei, L. Fu, J. Zhang, F. Kitamura, K. Yamashita, K. Eto, S. Iwagami, H. Tsukamoto, T. Umemoto, M. Masuda, O. Nagano, Y. Satou, H. Saya, P. Tan, H. Baba, T. Ishimoto
- Journal Title
  
  Cancer Res.
  
  Volume: 83 Issue: 5 Pages: 753-770
- DOI
  10.1158/0008-5472.can-22-1890
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07370, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
[Journal Article] Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer2021
- Author(s)
  Itoyama R, Yasuda-Yoshihara N, Kitamura F, Yasuda T, Bu L, Yonemura A, Uchihara T, Arima K, Hu X, Jun Z, Okamoto Y, Akiyama T, Yamashita K, Nakao Y, Yusa T, Kitano Y, Higashi T, Miyata T, Imai K, Hayashi H, Yamashita Y, Mikawa T, Kondoh H, Baba H, Ishimoto T
- Journal Title
  
  Cancer Letters
  
  Volume: 523 Pages: 29-42
- DOI
  10.1016/j.canlet.2021.09.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07887, KAKENHI-PROJECT-20K16418, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-20K09038, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-21K16384, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-20K20658
[Journal Article] Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination2021
- Author(s)
  Yasuda T, Koiwa M, Yonemura A, Miyake K, Kariya R, Kubota S, Yokomizo-Nakano T, Yasuda-Yoshihara N, Uchihara T, Itoyama R, Bu L, Fu L, Arima K, Izumi D, Iwagami S, Eto K, Iwatsuki M, Baba Y, Yoshida N, Ohguchi H, Okada S, Matsusaki K, Sashida G, Takahashi A, Tan P, Baba H, Ishimoto T.
- Journal Title
  
  Cell Reports
  
  Volume: 34 Issue: 8 Pages: 108779-108779
- DOI
  10.1016/j.celrep.2021.108779
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08543, KAKENHI-PROJECT-19K16749, KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-20K08985, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-21K16384, KAKENHI-PROJECT-21KK0153
[Journal Article] Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance2020
- Author(s)
  Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani Jaffer A, Tan Patrick, Baba H, Ishimoto T
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 16 Pages: 3222-3235
- DOI
  10.1158/0008-5472.can-19-3803
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09177, KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-20K08985, KAKENHI-PROJECT-18H02694, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-18K08543, KAKENHI-PROJECT-19K16720, KAKENHI-PROJECT-19K16749, KAKENHI-PROJECT-18H02883
[Presentation] Annexin A6 in Extracellular Vesicles from Cancer-associated Fibroblasts Induces Drug Resistance2021
- Author(s)
  内原　智幸
- Organizer
  第80回日本癌学会学術総会、ポスター
- Data Source
  KAKENHI-PROJECT-21K16384
[Presentation] Cancer associated fibroblasts由来細胞外小胞による胃がん薬剤治療抵抗性メカニズムの解明2020
- Author(s)
  内原　智幸、石本　崇胤、馬場　秀夫
- Organizer
  第31回日本消化器癌発生学会総会　研究奨励賞受賞講演
- Data Source
  KAKENHI-PROJECT-19K16720
[Presentation] 胃癌Cancer associated fibroblasts由来細胞外小胞中のAnnexin A6 はIntegrin/FAK-YAPシグナルを介した抗がん剤抵抗性を促進する2020
- Author(s)
  内原　智幸, 石本　崇胤, 江藤　弘二郎, 長井　洋平, 岩槻　政晃, 岩上　志朗, 馬場　祥史, 吉田　直矢, 馬場　秀夫
- Organizer
  第53回制癌剤適応研究会シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16720
[Presentation] 胃癌Cancer associated fibroblasts由来細胞外小胞中のAnnexin A6 はIntegrin/FAK-YAPシグナルを介した抗がん剤抵抗性を促進する2020
- Author(s)
  内原　智幸、石本　崇胤、江藤　弘二郎、長井　洋平、岩槻　政晃、岩上　志朗、馬場　祥史、吉田　直矢、馬場　秀夫
- Organizer
  第53回制癌剤適応研究会
- Data Source
  KAKENHI-PROJECT-19K16720

1. ISHIMOTO Takatsugu (00594889)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 安田忠仁 (00867947)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 林洋光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 山崎淳太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 千場隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 大西紘二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 三河拓己

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 有馬浩太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 泉大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 三宅慧輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

UCHIHARA Tomoyuki 内原 智幸

Uchihara Tomoyuki 内原 智幸

Research Projects

Research Products

Co-Researchers

単一核マルチオーム解析を用いた胃がん間質不均一性の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

To elucidate of new mechanism of hematogenous metastasis by stromal cells in gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of diversity and therapeutic target in scirrhous gastric cancer stroma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

To identify molecular mechanism of anticancer drug resistance through tumor stroma of gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor microenvironmental 15‐PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Annexin A6 in Extracellular Vesicles from Cancer-associated Fibroblasts Induces Drug Resistance2021

UCHIHARA Tomoyuki 内原智幸

Uchihara Tomoyuki 内原智幸