Takeuchi Chihiro 竹内千尋

Researcher Number	60836055
Other IDs	https://orcid.org/0000-0002-2746-9189
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, 外来研究員 2025: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2023: 東京大学, 医学部附属病院, 助教 2022: 星薬科大学, 薬学部, 特任助教 2021: 国立研究開発法人国立がん研究センター, 研究所, 特任研究員 2019 – 2020: 東京大学, 医学部附属病院, 届出研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 幹細胞 / クロマチンアクセシビリティ / エピゲノム不安定性 / DNAメチル化 / 胃癌 / 分化異常 / シングルセル / エピゲノム / オルガノイド / 活性窒素 … More / エンハンサーリプログラミング / シングルセル解析 / 慢性炎症 / 腸上皮化生 / 内科 / 発現・制御 / 癌 / microarray / 遺伝子発現解析 / 十二指腸腫瘍 / APC mutation / Wnt/βcatenin pathway / 非乳頭部十二指腸上皮性腫瘍 / 網羅的遺伝子発現解析 / miRNA Less

Research Projects
(3 results)
Research Products
(13 results)

胃の分化状態に基づくエピゲノム異常感受性の違いとそのメカニズムの解明Principal Investigator
- Principal Investigator
  
  竹内千尋
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Induction of epigenomic instability in chronic gastrointestinal inflammation and its significance in metaplasiaPrincipal Investigator
- Principal Investigator
  
  Takeuchi Chiihro
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hoshi University
  National Cancer Center Japan
Identification of miRNAs involved in the premalignant lesions in gastrointestinal tract and their malignant transformationPrincipal Investigator
- Principal Investigator
  
  Takeuchi Chihiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Precancerous nature of intestinal metaplasia with increased chance of conversion and accelerated DNA methylation2023
- Author(s)
  Takeuchi Chihiro、Yamashita Satoshi、Liu Yu-Yu、Takeshima Hideyuki、Sasaki Akiko、Fukuda Masahide、Hashimoto Taiki、Naka Tomoaki、Ishizu Kenichi、Sekine Shigeki、Yoshikawa Takaki、Hamada Akinobu、Yamamichi Nobutake、Fujishiro Mitsuhiro、Ushijima Toshikazu
- Journal Title
  
  Gut
  
  Volume: 73 Issue: 2 Pages: 255-267
- DOI
  10.1136/gutjnl-2023-329492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07425
[Journal Article] Marked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation2023
- Author(s)
  Takeuchi Chihiro、Sato Junichi、Yamamichi Nobutake、Kageyama-Yahara Natsuko、Sasaki Akiko、Akahane Takemi、Aoki Rika、Nakajima Shigemi、Ito Masayoshi、Yamamichi Mitsue、Niimi Keiko、et al.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 59 Issue: 2 Pages: 95-108
- DOI
  10.1007/s00535-023-02055-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08073, KAKENHI-PROJECT-23K07425, KAKENHI-PROJECT-21K09862, KAKENHI-PROJECT-21H03178, KAKENHI-PROJECT-23K27688
[Journal Article] The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa2023
- Author(s)
  Irie Takahiro、Yamada Harumi、Takeuchi Chihiro、Liu Yu-Yu、Charvat Hadrien、Shimazu Taichi、Ando Takayuki、Maekita Takao、Abe Seiichiro、Takamaru Hiroyuki、Kodama Masaaki、Murakami Kazunari、Sugimoto Kiichi、Sakamoto Kazuhiro、Ushijima Toshikazu
- Journal Title
  
  Gastric Cancer
  
  Volume: 26 Issue: 5 Pages: 667-676
- DOI
  10.1007/s10120-023-01399-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07425
[Journal Article] Mouse methylation profiles for leukocyte cell types, and estimation of leukocyte fractions in inflamed gastrointestinal DNA samples2023
- Author(s)
  Nishiyama Kazuhiro、Nishinakamura Hitomi、Takeshima Hideyuki、Yuyu Liu、Takeuchi Chihiro、Hattori Naoko、Takeda Haruna、Yamashita Satoshi、Wakabayashi Mika、Sato Kotomi、Obama Kazutaka、Ushijima Toshikazu
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 10 Pages: 0290034-0290034
- DOI
  10.1371/journal.pone.0290034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07425
[Presentation] Precancerous nature of intestinal metaplasia with accelerated DNA methylation along with altered epigenomic landscape2023
- Author(s)
  Chihiro Takeuchi, Satoshi Yamashita, Yu-Yu Liu, Hideyuki Takeshima, Toshikazu Ushijima
- Organizer
  AACR Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07425
[Presentation] 腸上皮化生の前癌性: エピジェネティックなフットプリントと不安定性2023
- Author(s)
  竹内千尋、山下聡、リュウユユ、竹島秀幸、牛島俊和
- Organizer
  第34回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-23K07425
[Presentation] DNAメチル化の加速とエピゲノム景観の変化を伴う腸上皮化生の前癌性2023
- Author(s)
  竹内千尋、山下聡、リュウユユ、竹島秀幸、牛島俊和
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K07425
[Presentation] DNAメチル化の加速とエピゲノム景観の変化を伴う腸上皮化生の前癌性2023
- Author(s)
  竹内千尋、山下聡、リュウユユ、竹島秀幸、牛島俊和
- Organizer
  第16回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-23K07425
[Presentation] Precancerous nature of intestinal metaplasia with accelerated DNA methylation along with altered epigenomic landscape2022
- Author(s)
  Chihiro Takeuchi
- Organizer
  第33回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-21K15941
[Presentation] Precancerous nature of intestinal metaplasia with accelerated DNA methylation and enhancer reprogramming2022
- Author(s)
  Chihiro Takeuchi
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-21K15941
[Presentation] Precancerous nature of intestinal metaplasia with accelerated driver gene methylation2022
- Author(s)
  Chihiro Takeuchi
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15941
[Presentation] Precancerous nature of intestinal metaplasia with increased NOS2 expression and accelerated DNA methylation induction2021
- Author(s)
  Chihiro Takeuchi
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15941
[Presentation] 内視鏡生検検体から基礎研究への展開：遺伝子発現解析とエピゲノム解析2020
- Author(s)
  竹内千尋
- Organizer
  第20回新都心内視鏡病態機能研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K17483

Takeuchi Chihiro 竹内 千尋

Research Projects

Research Products

胃の分化状態に基づくエピゲノム異常感受性の違いとそのメカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Induction of epigenomic instability in chronic gastrointestinal inflammation and its significance in metaplasiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of miRNAs involved in the premalignant lesions in gastrointestinal tract and their malignant transformationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Precancerous nature of intestinal metaplasia with increased chance of conversion and accelerated DNA methylation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Marked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mouse methylation profiles for leukocyte cell types, and estimation of leukocyte fractions in inflamed gastrointestinal DNA samples2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] Precancerous nature of intestinal metaplasia with accelerated DNA methylation along with altered epigenomic landscape2023

Author(s)

Organizer

Data Source

[Presentation] 腸上皮化生の前癌性: エピジェネティックなフットプリントと不安定性2023

Author(s)

Organizer

Data Source

[Presentation] DNAメチル化の加速とエピゲノム景観の変化を伴う腸上皮化生の前癌性2023

Author(s)

Organizer

Data Source

[Presentation] DNAメチル化の加速とエピゲノム景観の変化を伴う腸上皮化生の前癌性2023

Author(s)

Organizer

Data Source

[Presentation] Precancerous nature of intestinal metaplasia with accelerated DNA methylation along with altered epigenomic landscape2022

Author(s)

Organizer

Data Source

[Presentation] Precancerous nature of intestinal metaplasia with accelerated DNA methylation and enhancer reprogramming2022

Author(s)

Organizer

Data Source

[Presentation] Precancerous nature of intestinal metaplasia with accelerated driver gene methylation2022

Author(s)

Organizer

Data Source

[Presentation] Precancerous nature of intestinal metaplasia with increased NOS2 expression and accelerated DNA methylation induction2021

Author(s)

Organizer

Data Source

[Presentation] 内視鏡生検検体から基礎研究への展開： 遺伝子発現解析とエピゲノム解析2020

Author(s)

Organizer

Data Source

Takeuchi Chihiro 竹内千尋

[Presentation] 内視鏡生検検体から基礎研究への展開：遺伝子発現解析とエピゲノム解析2020