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Osada Naoki  長田 直希

ORCIDConnect your ORCID iD *help
Researcher Number 60840858
Affiliation (Current) 2025: 自治医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2019 – 2024: 自治医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related / 0901:Oncology and related fields
Except Principal Investigator
Basic Section 54010:Hematology and medical oncology-related
Keywords
Principal Investigator
転写制御 / 多発性骨髄腫 / Ikaros / エピジェネティクス / Ikaros複合体 / 免疫調節薬 / RNA結合タンパク / 抗がん剤耐性 / Long non-coding RNA / ChIp-Atlas … More / 免疫調節薬耐性 / ChIPシークエンス / IKZF1複合体 / ChIP-Seq / AP-1ファミリー / Lenalidomide耐性 / ChIP-Atlas / 薬剤耐性 … More
Except Principal Investigator
ゲノム解析 / 転写制御 / 多発性骨髄腫 Less
  • Research Projects

    (4 results)
  • Research Products

    (6 results)
  • Co-Researchers

    (2 People)
  •  多発性骨髄腫の予後悪化に働く long non-cording RNA(lncRNA)の探索と機能解明Principal Investigator

    • Principal Investigator
      長田 直希
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Jichi Medical University
  •  t(11;14)陽性骨髄腫におけるCyclin D1の転写活性化作用の解明と新規治療への応用

    • Principal Investigator
      古川 雄祐
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Teikyo University of Science & Technology
  •  Exploration of IKZF transcription factor complexes that induce immunomodulatory drugs (IMiDs) resistance.Principal Investigator

    • Principal Investigator
      Osada Naoki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Jichi Medical University
  •  Functional analyses of the Ikaros complex in multiple myeloma to identify novel therapeutic targets.Principal Investigator

    • Principal Investigator
      Osada Naoki
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0901:Oncology and related fields
    • Research Institution
      Jichi Medical University

All 2023 2022

All Journal Article Presentation

  • [Journal Article] c‐FOS is an integral component of the IKZF1 transactivator complex and mediates lenalidomide resistance in multiple myeloma2023

    • Author(s)
      Osada Naoki、Kikuchi Jiro、Iha Hidekatsu、Yasui Hiroshi、Ikeda Sho、Takahashi Naoto、Furukawa Yusuke
    • Journal Title

      Clinical and Translational Medicine

      Volume: 13 Issue: 8

    • DOI

      10.1002/ctm2.1364

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08401
  • [Presentation] c-FOS転写因子はIKZF1標的遺伝子の転写活性化を介して免疫調節薬耐性を誘導する2023

    • Author(s)
      長田直希、菊池次郎、松岡紗恵、安井寛、池田翔、高橋直人、仲宗根秀樹、古川雄祐
    • Organizer
      第48回骨髄腫学会
    • Data Source
      KAKENHI-PROJECT-21K08401
  • [Presentation] c-FOS転写因子はIKZF1標的遺伝子の転写活性化を介して免疫調節薬耐性を誘導する2023

    • Author(s)
      長田直希、菊池次郎、松岡紗恵、安井寛、池田翔、高橋直人、仲宗根秀樹、古川雄祐
    • Organizer
      第85回日本血液学会
    • Data Source
      KAKENHI-PROJECT-21K08401
  • [Presentation] c-FOS転写因子はIKZF1標的遺伝子の転写活性化を介して免疫調節薬耐性を誘導する2023

    • Author(s)
      長田直希、菊池次郎、松岡紗恵、安井寛、池田翔、高橋直人、仲宗根秀樹、古川雄祐
    • Organizer
      第82回癌学会
    • Data Source
      KAKENHI-PROJECT-21K08401
  • [Presentation] c-FOS転写因子はIKZF1標的遺伝子の転写活性化を介して免疫調節薬耐性を誘導する2022

    • Author(s)
      長田直希、菊池次郎、安井寛、池田翔、高橋直人、古川雄祐
    • Organizer
      第84回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08401
  • [Presentation] c-FOS mediates IMiDs resistance by acting as a co-activator of IKZF1-target genes in multiple myeloma.2022

    • Author(s)
      長田直希、菊池次郎、安井寛、古川雄祐
    • Organizer
      第47回日本骨髄腫学会
    • Data Source
      KAKENHI-PROJECT-21K08401
  • 1.  古川 雄祐 (00199431)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  菊池 次郎 (60371035)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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