Ohashi Ayaka 大橋彩香

Researcher Number	60844371
Other IDs
Affiliation (Current)	2025: 聖マリアンナ医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 聖マリアンナ医科大学, 医学部, 助教 2020 – 2021: 聖マリアンナ医科大学, 医学研究科, 特任助教 2019: 聖マリアンナ医科大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / 0901:Oncology and related fields
Keywords	Principal Investigator サイトカイン / CAEBV / 慢性活動性Epstein-Barrウイルス病 / 血管内皮細胞 / 慢性活動性EBウイルス感染症 / Flt3 / Flt3-L / バイオマーカー / RNase / RNA … More / 液性因子 / 血液凝固 / 血管障害 / 慢性活動性EBウイルス病 / 凝固 / IL-1β / 血管病変 / RNase inhibitor / RNase 1 / 傍腫瘍細胞 / マイクロRNA / RNase1 / miR-BARTs / エクソソーム Less

慢性活動性Epstein-Barrウイルス病新規治療標的分子の同定と治療薬開発Principal Investigator
- Principal Investigator
  
  大橋彩香
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  St. Marianna University School of Medicine
Elucidation of angiopathy mechanism and development of therapeutic methods in chronic active Epstein-Barr virus diseasePrincipal Investigator
- Principal Investigator
  
  Ohashi Ayaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  St. Marianna University School of Medicine
Analysis of Epstein-Barr virus derived RNA in CAEBV: involvement in onset and potential therapeutic targetsPrincipal Investigator
- Principal Investigator
  
  Ohashi Ayaka
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  St. Marianna University School of Medicine

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book Patent

[Book] 日本臨牀増刊「新リンパ腫学」2023
- Author(s)
  大橋彩香、上村悠、新井文子
- Total Pages
  5
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-20K16410
[Journal Article] Streptococcal infection and autoimmune diseases2024
- Author(s)
  Ohashi Ayaka、Murayama Masanori A.、Miyabe Yoshishige、Yudoh Kazuo、Miyabe Chie
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 15 Pages: 1361123-1361123
- DOI
  10.3389/fimmu.2024.1361123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14632, KAKENHI-PROJECT-21K06955, KAKENHI-PROJECT-23K07883
[Journal Article] Clinical significance of anti-Epstein-Barr virus antibodies in systemic chronic active Epstein-Barr virus disease2024
- Author(s)
  Nishio Miwako、Saito Minori、Yoshimori Mayumi、Kumaki Yuki、Ohashi Ayaka、Susaki Eri、Yonese Ichiro、Sawada Megumi、Arai Ayako
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 14 Pages: 1320292-1320292
- DOI
  10.3389/fmicb.2023.1320292
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14632, KAKENHI-PROJECT-23K07854
[Journal Article] Aortitis after administration of pegfilgrastim to a healthy donor for peripheral blood stem cell collection2023
- Author(s)
  Uemura Yu、Oshima Kumi、Fuseya Aika、Hosokai Akane、Ohashi Ayaka、Kanno Masatoshi、Arai Ayako
- Journal Title
  
  International Journal of Hematology
  
  Volume: 118 Issue: 6 Pages: 772-775
- DOI
  10.1007/s12185-023-03649-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14632
[Journal Article] Simvastatin Induces Anti-Tumor Effects on Systemic CAEBV <i>In Vitro</i> and <i>In Vivo</i>2022
- Author(s)
  Oshima Kumi、Yoshimori Mayumi、Ohashi Ayaka、Nishio Miwako、Shimizu Norio、Arai Ayako
- Journal Title
  
  Journal of St. Marianna University
  
  Volume: 13 Issue: 2 Pages: 59-68
- DOI
  10.17264/stmarieng.13.59
- ISSN
  2185-1336, 2189-0277
- URL
  https://marianna-u.repo.nii.ac.jp/records/2000164
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16410
[Journal Article] The Plasma Level of Interleukin-1β Can Be a Biomarker of Angiopathy in Systemic Chronic Active Epstein?Barr Virus Infection2022
- Author(s)
  Ohashi Ayaka、Uemura Yu、Yoshimori Mayumi、Wada Naomi、Imadome Ken-Ichi、Yudo Kazuo、Koyama Takatoshi、Shimizu Norio、Nishio Miwako、Arai Ayako
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 13 Pages: 874998-874998
- DOI
  10.3389/fmicb.2022.874998
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ1211, KAKENHI-PROJECT-20K16261, KAKENHI-PROJECT-20K16410
[Journal Article] Plasma interferon-γ concentration: a potential biomarker of disease activity of systemic chronic active Epstein-Barr virus infection2022
- Author(s)
  UemuraY, Ohashi A, Yoshimori M, Nishio M, Hirakawa T, Shimizu N, Wada N, Imadome K, Arai A.
- Journal Title
  
  Frontiers in Virology
  
  Volume: 2 Pages: 999929-999929
- DOI
  10.3389/fviro.2022.999929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16254, KAKENHI-PROJECT-22KJ1211, KAKENHI-PROJECT-20K16261, KAKENHI-PROJECT-20K16410
[Journal Article] Interferon-γ Produced by EBV-Positive Neoplastic NK-Cells Induces Differentiation into Macrophages and Procoagulant Activity of Monocytes, Which Leads to HLH2021
- Author(s)
  Yoshimori Mayumi、Nishio Miwako、Ohashi Ayaka、Tateishi Megumi、Mimura Ayaka、Wada Naomi、Saito Minori、Shimizu Norio、Imadome Ken-Ichi、Arai Ayako
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 20 Pages: 5097-5097
- DOI
  10.3390/cancers13205097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08720, KAKENHI-PROJECT-20K16261, KAKENHI-PROJECT-20K16410
[Journal Article] Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection2021
- Author(s)
  Yoshimori Mayumi、Shibayama Haruna、Imadome Ken-Ichi、Kawano Fuyuko、Ohashi Ayaka、Nishio Miwako、Shimizu Norio、Kurata Morito、Fujiwara Shigeyoshi、Arai Ayako
- Journal Title
  
  Blood Advances
  
  Volume: 5 Issue: 7 Pages: 1805-1815
- DOI
  10.1182/bloodadvances.2020002417
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16410, KAKENHI-PROJECT-19K23907, KAKENHI-PROJECT-20K08720
[Patent] 慢性活動性Epstein-Barrウイルス感染症(CAEBV)の検出方法2022
- Inventor(s)
  新井文子、今留謙一、大橋彩香、上村悠
- Industrial Property Rights Holder
  新井文子、今留謙一、大橋彩香、上村悠
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-048139
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] 慢性活動性EBウイルス病に対するアレムツズマブの有効性の検証2023
- Author(s)
  大島久美 , 佐野文明 , 大橋彩香 , 宮部斉重 , 伏屋愛加 , 鈴木黎 , 上村悠 , 辻村浩司 , 清水則夫 , 今留謙一 , 新井文子
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14632
[Presentation] CAEBVのEBV感染細胞由来細胞外小胞は単球のマクロファージへの分化を誘導しHLHの原因となる2023
- Author(s)
  洲﨑瑛莉 , 吉森真由美 , 齊藤美緑 , 福田笑夏 , 大橋彩香 , 西尾美和子 , 新井文子
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14632
[Presentation] EBウイルス陽性T/NK腫瘍細胞由来細胞外小胞の単球に対する役割2023
- Author(s)
  洲崎瑛梨, 吉森真由美, 齊藤美緑, 福田笑夏, 大橋彩香, 西尾美和子, 新井文子
- Organizer
  第36回ヘルペスウイルス研究会
- Data Source
  KAKENHI-PROJECT-23K14632
[Presentation] HLA半合致末梢血幹細胞移植を行った慢性活動性EBウイルス感染症2022
- Author(s)
  平川経晃、齊木祐輔、内田晶子、上村悠、大橋彩香、吉森真由美、小島尚美、清水則夫、今留謙一、新井文子
- Organizer
  日本造血・免疫細胞療法学会総会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] EBV陽性T,NK細胞腫瘍、慢性活動性EBV感染症に対するBCL2阻害剤の効果2022
- Author(s)
  Ayaka Ohashi, Morito Kurata, Ayako Arai
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] Will BCL2 be a Potent Therapeutic Target for Systemic Chronic Active Epstein-Barr Virus Disease?2022
- Author(s)
  Ayaka Ohashi, Mayumi Yoshimori, Miwako Nishio, Kaoru Koike, Norio Shimizu, Kazuo Yudo, Morito Kurata, Ayako Arai
- Organizer
  12th AACR-JCA Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] Expression profile of EBV-derived micro-RNA in systemic chronic active EBV disease2022
- Author(s)
  Mayumi Yoshimori, Ayaka Ohashi, Kotaro Yoshioka, Takanori Yokota, Norio Shimizu, Miwako Nishio, Ayako Arai
- Organizer
  64th ASH Annual Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] BCL2及びBCL-xL阻害剤は慢性活動性EBV感染症の腫瘍・炎症の両側面に有効である2022
- Author(s)
  Ayaka Ohashi, Yusuke Saiki, Ken Shimizu, Marie Obuchi, Norio Shimizu, Kazuo Yudo, Morito Kurata, Mayumi Yoshimori, Miwako Nishio, Ayako Arai
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] HLA半合致同種造血幹細胞移植症後のHuman herpesvirus 7型脳症2022
- Author(s)
  上村悠、神野正敏、大橋彩香、今留謙一、大島久美、小島尚美、清水則夫、新井文子
- Organizer
  第35回ヘルペスウイルス研究会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] HLHに伴う高サイトカイン血症に対するPEとCHDFの効果2021
- Author(s)
  Uchida A, Uemura Y，Hirakawa T, Ohashi A，Yoshimori M，Kojima S， Sakurada T，Arai A
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] 慢性活動性EBV感染症患者血漿中のIL-1βは血管病変のバイオマーカーとなり得る2021
- Author(s)
  Ayaka Ohashi, Yu Uemura, Mayumi Yoshimori, Naomi Wada, Ken-Ichi Imadome, Kazuo Yudo, Miwako Nishio, and Ayako Arai
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] 全身性慢性活動性EBウイルス感染症患者の血漿中INF-γ濃度の意義2021
- Author(s)
  Yu Uemura, Mayumi Yoshimori, Ayaka Ohashi, Tsuneaki Hirakawa, Naomi Wada, Ken-Ichi Imadome, Ayako Arai
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] The Plasma Level of IL-1β As a Biomarker of Angiopathy in Systemic Chronic Active EBV Infection2021
- Author(s)
  Ayaka Ohashi, Yu Uemura, Mayumi Yoshimori, Naomi Wada, Ken-Ichi Imadome, Kazuo Yudo, Takatoshi Koyama, Miwako Nishio, Ayako Arai
- Organizer
  63rd ASH Annual meeting and exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] Plasma level of IL-1β in Chronic Active EBV Infection can be a biomarker of angiopathy2021
- Author(s)
  Ayaka Ohashi, Yu Uemura, Mayumi Yoshimori, Naomi Wada, Ken-Ichi Imadome, Kazuo Yudo, Miwako Nishio, and Ayako Arai
- Organizer
  19th International Symposium on Epstein-Barr Virus and associated diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] What plasma level of Interferon-γ indicates in systemic chronic active Epstein-Barr virus infection2021
- Author(s)
  Yu Uemura, Mayumi Yoshimori, Ayaka Ohashi, Tsuneaki Hirakawa, Naomi Wada, Ken-Ichi Imadome, Ayako Arai
- Organizer
  19th International Symposium on Epstein-Barr Virus and associated diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] What plasma level of interferon-γ indicates in systemic chronic active Epstein-Barr virus infection2021
- Author(s)
  Yu Uemura, Mayumi Yoshimori, Ayaka Ohashi, Tsuneaki Hirakawa, Naomi Wada, Ken-Ichi Imadome, Ayako Arai
- Organizer
  63rd ASH Annual meeting and exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] 慢性活動性EBウイルス感染症患者血漿中のIL-1βは血管病変のバイオマーカーとなり得る2021
- Author(s)
  大橋彩香、上村悠、吉森真由美、和田尚美、今留謙一、遊道和雄、小山高敏、西尾美和子、新井文子
- Organizer
  第34回ヘルペスウイルス研究会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] EBV-Positive Neoplastic NK-Cells Induce Macrophage Differentiation from monocytes, Leading to HLH2020
- Author(s)
  Mayumi Yoshimori, Megumi Tateishi, Ayaka Ohashi, Shixing Wu, Ken-Ichi Imadome, Norio Shimizu, Miwako Nishio, Ayako Arai
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] EBV-Positive Neoplastic NK-Cells Induce Macrophage Differentiation from monocytes, Leading to HLH2020
- Author(s)
  Mayumi Yoshimori, Megumi Tateishi, Ayaka Ohashi, Shixing Wu, Ken-Ichi Imadome, Norio Shimizu, Miwako Nishio, Ayako Arai
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23907
[Presentation] The Elucidation of Targets of EBV-Derived Micro-RNA in Chronic Active EBV Infection2020
- Author(s)
  Wu Shixing, Mayumi Yoshimori, Megumi Tateishi, Ayaka Ohashi, Shimizu Norio, Miwako Nishi, Ayako Arai
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23907
[Presentation] Products of EBV-Positive Neoplastic NK-Cells Induce Differentiation into Macrophages and Procoagulant Activity of Monocytes, which Leads to HLH2020
- Author(s)
  Mayumi Yoshimori, Megumi Tateishi, Ayaka Ohashi, Shixing Wu, Ken-Ichi Imadome, Norio Shimizu, Miwako Nishio, Ayako Arai
- Organizer
  25th Congress of European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23907
[Presentation] Products of EBV-Positive Neoplastic NK-Cells Induce Differentiation into Macrophages and Procoagulant Activity of Monocytes, which Leads to HLH2020
- Author(s)
  Mayumi Yoshimori, Megumi Tateishi, Ayaka Ohashi, Shixing Wu, Ken-Ichi Imadome, Norio Shimizu, Miwako Nishio, Ayako Arai
- Organizer
  25th Congress of European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] The Cytokines of EBV+Neoplastic NK-Cells Enhance the Procoagulant Activity of Monocytes Causing DIC2020
- Author(s)
  Megumi Tateishi, Mayumi Yoshimori, Ayaka Ohashi, Shixing Wu, Norio Shimizu, Miwako Nishio, Ayako Arai
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] The Elucidation of Targets of EBV-Derived Micro-RNA in Chronic Active EBV Infection2020
- Author(s)
  Wu Shixing, Mayumi Yoshimori, Megumi Tateishi, Ayaka Ohashi, Shimizu Norio, Miwako Nishio, Ayako Arai
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16410
[Presentation] The Cytokines of EBV+Neoplastic NK-Cells Enhance the Procoagulant Activity of Monocytes Causing DIC2020
- Author(s)
  Megumi Tateishi, Mayumi Yoshimori, Ayaka Ohashi, Shixing Wu, Norio Shimizu, Miwako Nishio, Ayako Arai
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23907
[Presentation] The expression and the secretion of ribonuclease inhibitors by tumor and vascular endothelial cells2019
- Author(s)
  大橋彩香
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23907

1. 吉森真由美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 新井文子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 上村悠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohashi Ayaka 大橋 彩香

Research Projects

Research Products

Co-Researchers

慢性活動性Epstein-Barrウイルス病新規治療標的分子の同定と治療薬開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of angiopathy mechanism and development of therapeutic methods in chronic active Epstein-Barr virus diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Epstein-Barr virus derived RNA in CAEBV: involvement in onset and potential therapeutic targetsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 日本臨牀増刊「新リンパ腫学」2023

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Streptococcal infection and autoimmune diseases2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of anti-Epstein-Barr virus antibodies in systemic chronic active Epstein-Barr virus disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aortitis after administration of pegfilgrastim to a healthy donor for peripheral blood stem cell collection2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simvastatin Induces Anti-Tumor Effects on Systemic CAEBV <i>In Vitro</i> and <i>In Vivo</i>2022

Author(s)

Journal Title

DOI

ISSN

URL

Language

Data Source

[Journal Article] The Plasma Level of Interleukin-1β Can Be a Biomarker of Angiopathy in Systemic Chronic Active Epstein?Barr Virus Infection2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasma interferon-γ concentration: a potential biomarker of disease activity of systemic chronic active Epstein-Barr virus infection2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interferon-γ Produced by EBV-Positive Neoplastic NK-Cells Induces Differentiation into Macrophages and Procoagulant Activity of Monocytes, Which Leads to HLH2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection2021

Author(s)

Journal Title

DOI

Data Source

[Patent] 慢性活動性Epstein-Barrウイルス感染症(CAEBV)の検出方法2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 慢性活動性EBウイルス病に対するアレムツズマブ の有効性の検証2023

Author(s)

Organizer

Ohashi Ayaka 大橋彩香

[Presentation] 慢性活動性EBウイルス病に対するアレムツズマブの有効性の検証2023