EGUCHI Takahiro 江口貴大

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Eguchi Takahiro 江口貴大

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Researcher Number	60845056
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 研究所ジェロサイエンス研究センター, 研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立長寿医療研究センター, 研究所ジェロサイエンス研究センター, 研究員 2023: 国立研究開発法人国立長寿医療研究センター, 研究所ジェロサイエンス研究センター, 研究員 2020 – 2022: 東京大学, 医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Medium-sized Section 48:Biomedical structure and function and related fields
Keywords	Principal Investigator 筋萎縮 / 骨格筋 / サルコペニア / p25 / Cabp7 / 神経筋接合部 / 筋肥大・萎縮シグナル / CaMKII / 筋肥大 Except Principal Investigator 神経筋シナプス形成シグナル … More / 神経筋疾患 / 神経科学 / シグナル伝達 / 神経筋シナプス Less

NMJ維持制御メカニズムの理解に基づく筋病態の治療技術基盤の開発Principal Investigator
- Principal Investigator
  
  江口貴大
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  National Center for Geriatrics and Gerontology
骨格筋量制御に向けた筋萎縮シグナルの解明Principal Investigator
- Principal Investigator
  
  江口貴大
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  National Center for Geriatrics and Gerontology
A study of molecular mechanisms regulating skeletal muscle mass and strengthPrincipal Investigator
- Principal Investigator
  
  Eguchi Takahiro
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  The University of Tokyo
Signaling in NMJ formation and therapeutic intervention against neuromuscular disorders
- Principal Investigator
  
  Yamanashi Yuji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice2024
- Author(s)
  Eguchi Takahiro、Tezuka Tohru、Watanabe Yuji、Inoue-Yamauchi Akane、Sagara Hiroshi、Ozawa Manabu、Yamanashi Yuji
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 2 Pages: 108997-108997
- DOI
  10.1016/j.isci.2024.108997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14459, KAKENHI-PROJECT-20H03162, KAKENHI-PROJECT-23K27084
[Journal Article] Peroxisome proliferator-activated receptor γ coactivator 1α regulates downstream of tyrosine kinase-7 (Dok-7) expression important for neuromuscular junction formation2024
- Author(s)
  Sugimoto Takumi、Sakamaki Chihiro、Kimura Tokushi、Eguchi Takahiro、Miura Shinji、Kamei Yasutomi
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 1780-1780
- DOI
  10.1038/s41598-024-52198-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18436, KAKENHI-PROJECT-23K14459, KAKENHI-PROJECT-23K24796
[Journal Article] Adeno-associated virus-mediated expression of an inactive CaMKIIβ mutant enhances muscle mass and strength in mice2022
- Author(s)
  Eguchi Takahiro、Yamanashi Yuji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 589 Pages: 192-196
- DOI
  10.1016/j.bbrc.2021.12.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00496, KAKENHI-PROJECT-21K15369
[Journal Article] 特集新組織学シリーズⅡ:骨格筋-今後の研究の発展に向けて Ⅱ.骨格筋組織を支える細胞の役割･応答神経筋接合部(NMJ)の形成･維持メカニズム-NMJを標的とした治療技術の開発を目指して2021
- Author(s)
  江口貴大、山梨裕司
- Journal Title
  
  生体の科学
  
  Volume: 72 Issue: 6 Pages: 527-531
- DOI
  10.11477/mf.2425201435
- ISSN
  0370-9531, 1883-5503
- Year and Date
  2021-12-15
- Data Source
  KAKENHI-PROJECT-20H00496
[Journal Article] DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice2020
- Author(s)
  Ueta R, Sugita S, Minegishi Y, Shimotoyodome A, Ota N, Ogiso N, Eguchi T, Yamanashi Y
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 8 Pages: 101385-101385
- DOI
  10.1016/j.isci.2020.101385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01532, KAKENHI-PROJECT-20H00496, KAKENHI-PROJECT-18K06127
[Presentation] 肝臓-骨格筋連関に着目したサルコペニア発症メカニズムの解明2024
- Author(s)
  江口貴大、伊藤尚基
- Organizer
  第８回若手による骨格筋細胞研究会
- Data Source
  KAKENHI-PROJECT-23K14459
[Presentation] 神経筋接合部（NMJ）の維持機構とNMJ標的治療技術の開発2023
- Author(s)
  江口貴大
- Organizer
  第31回日本運動生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K14459
[Presentation] CDK5活性化因子p35を起点とした神経筋シナプス形成・維持制御メカニズムの解析2022
- Author(s)
  江口貴大、依田実朗、山梨裕司
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15369
[Presentation] CDK5活性化因子p35を起点とした神経筋シナプス形成・維持制御メカニズムの解析2022
- Author(s)
  江口貴大、依田実朗、山梨裕司
- Organizer
  第８回日本筋学会学術集会（ポスター発表）
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] A study of therapeutic interventions aimed at enhancing neuromuscular junction innervation and skeletal muscle mass2021
- Author(s)
  江口貴大、范文蘭、山梨裕司
- Organizer
  The 16th International Symposium of the Institute Network for Biomedical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] A study of therapeutic interventions aimed at enhancing neuromuscular junction innervation and skeletal muscle mass2021
- Author(s)
  江口貴大、范文蘭、山梨裕司
- Organizer
  The 16th International Symposium of the Institute Network for Biomedical Sciences
- Data Source
  KAKENHI-PROJECT-21K15369
[Presentation] 骨格筋における変異型CaMKIIβの強制発現は筋肥大を誘導する2021
- Author(s)
  江口貴大、范文蘭、山梨裕司
- Organizer
  第7回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] 骨格筋における変異型CaMKIIβの強制発現は筋肥大を誘導する2021
- Author(s)
  江口貴大、范文蘭、山梨裕司
- Organizer
  第７回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15369
[Presentation] 神経筋接合部（NMJ）の形成増強治療は老齢マウスにおけるNMJの神経結合を増強し、運動機能と筋力を強化する2020
- Author(s)
  江口貴大、杉田聡、峯岸慶彦、下豊留玲、太田宣康、小木曽昇、植田亮、山梨裕司
- Organizer
  第6回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] DOK7発現ベクターの投与は老齢マウスのNMJにおける神経結合を増強し、運動機能と筋力を強化する2020
- Author(s)
  江口貴大、杉田聡、峯岸慶彦、下豊留玲、太田宣康、小木曽昇、植田亮、山梨裕司
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H00496

1. Yamanashi Yuji (40202387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 荒川正行 (90398868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 植田亮 (10445025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 亀井康富

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

EGUCHI Takahiro 江口 貴大

Eguchi Takahiro 江口 貴大

Research Projects

Research Products

Co-Researchers

NMJ維持制御メカニズムの理解に基づく筋病態の治療技術基盤の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

骨格筋量制御に向けた筋萎縮シグナルの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study of molecular mechanisms regulating skeletal muscle mass and strengthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Signaling in NMJ formation and therapeutic intervention against neuromuscular disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peroxisome proliferator-activated receptor γ coactivator 1α regulates downstream of tyrosine kinase-7 (Dok-7) expression important for neuromuscular junction formation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adeno-associated virus-mediated expression of an inactive CaMKIIβ mutant enhances muscle mass and strength in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 特集 新組織学シリーズⅡ:骨格筋-今後の研究の発展に向けて Ⅱ.骨格筋組織を支える細胞の役割･応答 神経筋接合部(NMJ)の形成･維持メカニズム-NMJを標的とした治療技術の開発を目指して2021

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 肝臓-骨格筋連関に着目したサルコペニア発症メカニズムの解明2024

Author(s)

Organizer

Data Source

[Presentation] 神経筋接合部（NMJ）の維持機構とNMJ標的治療技術の開発2023

Author(s)

Organizer

Data Source

[Presentation] CDK5活性化因子p35を起点とした神経筋シナプス形成・維持制御メカニズムの解析2022

Author(s)

Organizer

Data Source

[Presentation] CDK5活性化因子p35を起点とした神経筋シナプス形成・維持制御メカニズムの解析2022

Author(s)

Organizer

Data Source

[Presentation] A study of therapeutic interventions aimed at enhancing neuromuscular junction innervation and skeletal muscle mass2021

Author(s)

Organizer

Data Source

[Presentation] A study of therapeutic interventions aimed at enhancing neuromuscular junction innervation and skeletal muscle mass2021

Author(s)

Organizer

Data Source

EGUCHI Takahiro 江口貴大

Eguchi Takahiro 江口貴大

[Journal Article] 特集新組織学シリーズⅡ:骨格筋-今後の研究の発展に向けて Ⅱ.骨格筋組織を支える細胞の役割･応答神経筋接合部(NMJ)の形成･維持メカニズム-NMJを標的とした治療技術の開発を目指して2021