Habara Makoto 羽原誠

Researcher Number	60846525
Other IDs
Affiliation (Current)	2025: 山口大学, 共同獣医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 山口大学, 共同獣医学部, 助教 2022 – 2023: 山口大学, 共同獣医学部, 助教 2020 – 2021: 山口大学, 共同獣医学部, 助教(特命)
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator ER陽性乳がん / 乳がん / FKBP51 / FKBP52 / FKBP / ER / エストロゲン受容体 / プロリン異性化酵素 / 受容体 / 生命科学データベース … More / 肺がん / NanoBiT / ユビキチンリガーゼ / 核内受容体 / PPIase / 乳癌 / ER陽性乳癌 Less

Research Projects
(3 results)
Research Products
(16 results)

生命科学データベースから見出した新規がん予後不良因子の機能解析と治療への適用Principal Investigator
- Principal Investigator
  
  羽原誠
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Yamaguchi University
ER陽性乳癌における予後不良因子FKBP52の治療標的としての可能性Principal Investigator
- Principal Investigator
  
  羽原誠
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Yamaguchi University
Role of proline isomerase in ER-positive breast cancer and its potential as a therapeutic targetPrincipal Investigator
- Principal Investigator
  
  Habara Makoto
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Yamaguchi University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] FOXO1 promotes cancer cell growth through MDM2-mediated p53 degradation2024
- Author(s)
  Tomiyasu Haruki、Habara Makoto、Hanaki Shunsuke、Sato Yuki、Miki Yosei、Shimada Midori
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 4 Pages: 107209-107209
- DOI
  10.1016/j.jbc.2024.107209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15542
[Journal Article] Decoding estrogen receptor regulation to develop novel therapies for ER-positive breast cancer2023
- Author(s)
  羽原誠、島田緑
- Journal Title
  
  生化学
  
  Volume: 95 Issue: 4 Pages: 546-550
- DOI
  10.14952/SEIKAGAKU.2023.950546
- ISSN
  0037-1017
- Year and Date
  2023-08-25
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-22K15542
[Journal Article] Dephosphorylation of NFAT by Calcineurin inhibits Skp2-mediated degradation2023
- Author(s)
  Hanaki Shunsuke、Habara Makoto、Sato Yuki、Tomiyasu Haruki、Miki Yosei、Shibutani Shusaku、Shimada Midori
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 175 Issue: 3 Pages: 235-244
- DOI
  10.1093/jb/mvad103
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15542, KAKENHI-PROJECT-22KJ2348, KAKENHI-PROJECT-21H02403
[Journal Article] Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc2023
- Author(s)
  Masaki Takahiro、Habara Makoto、Hanaki Shunsuke、Sato Yuki、Tomiyasu Haruki、Miki Yosei、Shimada Midori
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 13116-13116
- DOI
  10.1038/s41598-023-40412-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15542, KAKENHI-PROJECT-22KJ2348
[Journal Article] Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability2023
- Author(s)
  Masaki Takahiro、Habara Makoto、Shibutani Shusaku、Hanaki Shunsuke、Sato Yuki、Tomiyasu Haruki、Shimada Midori
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 641 Pages: 84-92
- DOI
  10.1016/j.bbrc.2022.12.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15542, KAKENHI-PROJECT-21H02403, KAKENHI-PROJECT-22KJ2348, KAKENHI-PROJECT-20K21503
[Journal Article] Estrogen receptor α revised: Expression, structure, function, and stability2022
- Author(s)
  Habara Makoto、Shimada Midori
- Journal Title
  
  BioEssays
  
  Volume: 44 Issue: 12 Pages: 2200148-2200148
- DOI
  10.1002/bies.202200148
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15542, KAKENHI-PROJECT-21H02403, KAKENHI-PROJECT-20K21503
[Journal Article] FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer2022
- Author(s)
  Habara Makoto、Sato Yuki、Goshima Takahiro、Sakurai Masashi、Imai Hiroyuki、Shimizu Hideyuki、Katayama Yuta、Hanaki Shunsuke、Masaki Takahiro、Morimoto Masahiro、Nishikawa Sayaka、Toyama Tatsuya、Shimada Midori
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 15
- DOI
  10.1073/pnas.2110256119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16333, KAKENHI-PROJECT-21H02403, KAKENHI-PROJECT-20K21503, KAKENHI-PROJECT-22KJ2348
[Journal Article] FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells2021
- Author(s)
  Maeda Keisuke、Habara Makoto、Kawaguchi Mitsuyasu、Matsumoto Hiroaki、Hanaki Shunsuke、Masaki Takahiro、Sato Yuki、Matsuyama Hideyasu、Kunieda Kazuki、Nakagawa Hidehiko、Shimada Midori
- Journal Title
  
  Molecular Oncology
  
  Volume: 16 Issue: 4 Pages: 940-956
- DOI
  10.1002/1878-0261.13030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16333, KAKENHI-PUBLICLY-21H00290, KAKENHI-PROJECT-21H02403, KAKENHI-PROJECT-20K21503
[Journal Article] PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage2021
- Author(s)
  Hanaki Shunsuke、Habara Makoto、Masaki Takahiro、Maeda Keisuke、Sato Yuki、Nakanishi Makoto、Shimada Midori
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 7 Pages: 2739-2752
- DOI
  10.1111/cas.14924
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16333, KAKENHI-PROJECT-21H02403, KAKENHI-PROJECT-20K21503
[Journal Article] Calcineurin regulates the stability and activity of estrogen receptor α2021
- Author(s)
  Masaki Takahiro、Habara Makoto、Sato Yuki、Goshima Takahiro、Maeda Keisuke、Hanaki Shunsuke、Shimada Midori
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 44
- DOI
  10.1073/pnas.2114258118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16333, KAKENHI-PROJECT-21H02403, KAKENHI-PROJECT-20K21503
[Journal Article] UV‐induced activation of ATR is mediated by UHRF22021
- Author(s)
  Hanaki Shunsuke、Habara Makoto、Shimada Midori
- Journal Title
  
  Genes to Cells
  
  Volume: 26 Issue: 6 Pages: 447-454
- DOI
  10.1111/gtc.12851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16333, KAKENHI-PROJECT-20K21503
[Presentation] BRCA1はがん細胞においてc-Mycを安定化させ、細胞増殖を促進する2023
- Author(s)
  羽原誠、花木駿介、佐藤悠紀、富安遥己、三木陽清、太田智彦、島田緑
- Organizer
  第46回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15542
[Presentation] プロリン異性化酵素FKBP52とFKBP51は乳がん細胞においてエストロゲン受容体αの安定性を制御する2022
- Author(s)
  羽原誠, 佐藤悠紀, 正木貴大, 花木駿介, 富安遥己, 島田緑
- Organizer
  第45回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15542
[Presentation] プロリン異性化酵素FKBPによるエストロゲン受容体αを介した乳がん増殖制御2022
- Author(s)
  羽原誠, 佐藤悠紀, 正木貴大, 花木駿介, 富安遥己, 島田緑
- Organizer
  2022年度若手支援技術講習会
- Data Source
  KAKENHI-PROJECT-22K15542
[Presentation] カルシニューリンはエストロゲン受容体αの安定性および活性を制御する2021
- Author(s)
  羽原誠、正木貴大、佐藤悠紀、前田啓介、花木駿介、島田緑
- Organizer
  第10回日本プロテインホスファターゼ研究会学術集会
- Data Source
  KAKENHI-PROJECT-20K16333
[Presentation] 乳がんの予後不良因子サイクリンD1の発現調節機構の解明2020
- Author(s)
  羽原　誠、五島　隆宏、正木貴大、前田　啓介、花木　駿介、佐藤　悠紀、加藤　洋一、島田　緑
- Organizer
  第163回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16333

Habara Makoto 羽原 誠

Research Projects

Research Products

生命科学データベースから見出した新規がん予後不良因子の機能解析と治療への適用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ER陽性乳癌における予後不良因子FKBP52の治療標的としての可能性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of proline isomerase in ER-positive breast cancer and its potential as a therapeutic targetPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] FOXO1 promotes cancer cell growth through MDM2-mediated p53 degradation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decoding estrogen receptor regulation to develop novel therapies for ER-positive breast cancer2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Dephosphorylation of NFAT by Calcineurin inhibits Skp2-mediated degradation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Estrogen receptor α revised: Expression, structure, function, and stability2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calcineurin regulates the stability and activity of estrogen receptor α2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] UV‐induced activation of ATR is mediated by UHRF22021

Author(s)

Journal Title

DOI

Data Source

[Presentation] BRCA1はがん細胞においてc-Mycを安定化させ、細胞増殖を促進する2023

Habara Makoto 羽原誠