ZHANG ZHIKUAN 張志寛

Researcher Number	60866937
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator クライオ電子顕微鏡 / クライオ電顕 / インフラマソーム / 免疫受容体 / 構造生物学 / COVID19 / ウイルス粒子形成 / M protein / 粒子形成 / Membrane protein … More / SARS-CoV-2 / ベータコロナウイルス / NOD-like receptor / NLR / NOD2 / 自然免疫 / 炎症性腸疾患 Less

NLRP1インフラマソームの活性化と抑制機構の解明Principal Investigator
- Principal Investigator
  
  張志寛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
Structural study of beta-coronavirus particle formation mechanismPrincipal Investigator
- Principal Investigator
  
  ZHANG ZHIKUAN
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
Structural analysis of NOD2, a protein involved in inflammatory bowel disease pathogenesisPrincipal Investigator
- Principal Investigator
  
  ZHANG ZHIKUAN
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Structural basis of hepatitis B virus receptor binding2024
- Author(s)
  Asami Jinta、Park Jae-Hyun、Nomura Yayoi、Kobayashi Chisa、Mifune Junki、Ishimoto Naito、Uemura Tomoko、Liu Kehong、Sato Yumi、Zhang Zhikuan、Muramatsu Masamichi、Wakita Takaji、Drew David、Iwata So、Shimizu Toshiyuki、Watashi Koichi、Park Sam-Yong、Nomura Norimichi、Ohto Umeharu
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 31 Issue: 3 Pages: 447-454
- DOI
  10.1038/s41594-023-01191-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19447, KAKENHI-PROJECT-23K18211, KAKENHI-PROJECT-23K18239, KAKENHI-PROJECT-22K15046, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-23K24142, KAKENHI-PROJECT-23K27415
[Journal Article] Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome2023
- Author(s)
  Zhang Zhikuan、Shibata Takuma、Fujimura Akiko、Kitaura Jiro、Miyake Kensuke、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature
  
  Volume: 622 Issue: 7981 Pages: 188-194
- DOI
  10.1038/s41586-023-06532-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18211, KAKENHI-PROJECT-22K19424, KAKENHI-PROJECT-22K15046, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-23K27637
[Journal Article] A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus2023
- Author(s)
  Ishizaka Sally T.、Hawkins Lynn、Chen Qian、Tago Fumitoshi、Yagi Takuya、Sakaniwa Kentaro、Zhang Zhikuan、Shimizu Toshiyuki、Shirato Manabu
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 957 Pages: 175962-175962
- DOI
  10.1016/j.ejphar.2023.175962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15046, KAKENHI-PROJECT-23H00366
[Journal Article] Structure of SARS-CoV-2 membrane protein essential for virus assembly2022
- Author(s)
  Zhang Zhikuan、Nomura Norimichi、Muramoto Yukiko、Ekimoto Toru、Uemura Tomoko、Liu Kehong、Yui Moeko、Kono Nozomu、Aoki Junken、Ikeguchi Mitsunori、Noda Takeshi、Iwata So、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 4399-4399
- DOI
  10.1038/s41467-022-32019-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07086, KAKENHI-PROJECT-21K19327, KAKENHI-PROJECT-22K15046, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21K19207, KAKENHI-PLANNED-18H05426, KAKENHI-PUBLICLY-21H00228, KAKENHI-PROJECT-23K23820, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-20H03380
[Journal Article] Propofol directly binds to and inhibits <scp>TLR7</scp>2022
- Author(s)
  Koutsogiannaki Sophia、Bu Weiming、Maisat Wiriya、Manzor Mariel、Zhang Zhikuan、Ohto Umeharu、Eckenhoff Roderic G.、Yuki Koichi
- Journal Title
  
  The FASEB Journal
  
  Volume: 36 Issue: 8
- DOI
  10.1096/fj.202200312r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15046, KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820
[Journal Article] Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation2022
- Author(s)
  Ohto Umeharu、Kamitsukasa Yukie、Ishida Hanako、Zhang Zhikuan、Murakami Karin、Hirama Chie、Maekawa Sakiko、Shimizu Toshiyuki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 11
- DOI
  10.1073/pnas.2121353119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-21K19207
[Journal Article] Structure of the?bile acid transporter?and HBV receptor NTCP2022
- Author(s)
  Asami Jinta、Kimura Kanako Terakado、Fujita-Fujiharu Yoko、Ishida Hanako、Zhang Zhikuan、Nomura Yayoi、Liu Kehong、Uemura Tomoko、Sato Yumi、Ono Masatsugu、Yamamoto Masaki、Noda Takeshi、Shigematsu Hideki、Drew David、Iwata So、Shimizu Toshiyuki、Nomura Norimichi、Ohto Umeharu
- Journal Title
  
  Nature
  
  Volume: 606 Issue: 7916 Pages: 1021-1026
- DOI
  10.1038/s41586-022-04845-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15046, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21J12207, KAKENHI-PROJECT-22J14378, KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820, KAKENHI-PLANNED-19H05777
[Journal Article] Cryo-EM structures of Toll-like receptors in complex with UNC93B12021
- Author(s)
  Ishida Hanako、Asami Jinta、Zhang Zhikuan、Nishizawa Tomohiro、Shigematsu Hideki、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 28 Issue: 2 Pages: 173-180
- DOI
  10.1038/s41594-020-00542-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PROJECT-20K16274, KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-18K06172, KAKENHI-PROJECT-19H00976
[Journal Article] Improving particle quality in cryo-EM analysis using a PEGylation method2021
- Author(s)
  Zhang Zhikuan、Shigematsu Hideki、Shimizu Toshiyuki、Ohto Umeharu
- Journal Title
  
  Structure
  
  Volume: 29 Issue: 10 Pages: 1192-1199.e4
- DOI
  10.1016/j.str.2021.05.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-21K19328
[Journal Article] Structural Basis for the Inhibition Mechanism of TLR72021
- Author(s)
  ZHANG Zhikuan
- Journal Title
  
  Nihon Kessho Gakkaishi
  
  Volume: 63 Issue: 3 Pages: 181-182
- DOI
  10.5940/jcrsj.63.181
- NAID
  130008083573
- ISSN
  0369-4585, 1884-5576
- Year and Date
  2021-08-31
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15730
[Journal Article] Structural analysis reveals TLR7 dynamics underlying antagonism2020
- Author(s)
  Tojo Shingo、Zhang Zhikuan、Matsui Hiroyuki、Tahara Masahiro、Ikeguchi Mitsunori、Kochi Mami、Kamada Mami、Shigematsu Hideki、Tsutsumi Akihisa、Adachi Naruhiko、Shibata Takuma、Yamamoto Masaki、Kikkawa Masahide、Senda Toshiya、Isobe Yoshiaki、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41467-020-19025-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-19H03197, KAKENHI-PROJECT-18K06172, KAKENHI-PROJECT-19H03451
[Presentation] Structural analysis of SARS-CoV-2 membrane protein2023
- Author(s)
  Zhikuan Zhang, Umeharu Ohto, Toshiyuki Shimizu
- Organizer
  26th Congress and General Assembly of the International Union of Crystallography (IUCr 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15046

1. OHTO Umeharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 村本裕紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 村松正道

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ZHANG ZHIKUAN 張 志寛

Research Projects

Research Products

Co-Researchers

NLRP1インフラマソームの活性化と抑制機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural study of beta-coronavirus particle formation mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural analysis of NOD2, a protein involved in inflammatory bowel disease pathogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Structural basis of hepatitis B virus receptor binding2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of SARS-CoV-2 membrane protein essential for virus assembly2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Propofol directly binds to and inhibits <scp>TLR7</scp>2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the?bile acid transporter?and HBV receptor NTCP2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cryo-EM structures of Toll-like receptors in complex with UNC93B12021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Improving particle quality in cryo-EM analysis using a PEGylation method2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural Basis for the Inhibition Mechanism of TLR72021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Structural analysis reveals TLR7 dynamics underlying antagonism2020

Author(s)

Journal Title

DOI

ZHANG ZHIKUAN 張志寛