Mitsuzawa Shio 光澤志緒

Researcher Number	60869618
Other IDs
Affiliation (Current)	2025: 東北大学, 大学病院, 医員 2025: 東北大学, 医学系研究科, 大学院非常勤講師
Affiliation (based on the past Project Information) *help	2024: 東北大学, 大学病院, 医員 2023: 東北大学, 医学系研究科, 医員 2020 – 2022: 東北大学, 医学系研究科, 大学院非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator 人工多能性幹細胞（iPS細胞） / 運動ニューロン選択的変性 / TDP-43 / TARDBP / 筋萎縮性側索硬化症 / 軸索 / 運動ニューロン / 人工多能性幹細胞 / TAR-DNA binding protein / 運動ニューロン脆弱性 / PHOX2B / iPS細胞

軸索に着目した筋萎縮性側索硬化症の運動ニューロン変性に抵抗する分子機構の解明Principal Investigator
- Principal Investigator
  
  光澤志緒
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tohoku University
Axonal RNA study based on Dying back hypothesis for novel factors involved in motor neuron selective degeneration of Amyotrophic Lateral Sclerosis.Principal Investigator
- Principal Investigator
  
  Mitsuzawa Shio
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tohoku University

All 2023 2021 2020

All Journal Article Presentation

[Journal Article] Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations2021
- Author(s)
  Mitsuzawa S, Suzuki N, Akiyama T, Ishikawa M, Sone T, Kawada J, Funayama R, Shirota M, Mitsuhashi H, Morimoto S, Ikeda K, Shijo T, Ohno A, Nakamura N, Ono H, Ono R, Osana S, Nakagawa T, Nishiyama A, Izumi R, Kaneda S, Ikeuchi Y, Nakayama K, Fujii T, Warita H, Okano H, Aoki M.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 16 Issue: 6 Pages: 1527-1541
- DOI
  10.1016/j.stemcr.2021.04.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07837, KAKENHI-PROJECT-20K05288, KAKENHI-PROJECT-20K12157, KAKENHI-PROJECT-21K07411, KAKENHI-PROJECT-20K16593, KAKENHI-PROJECT-20K19478, KAKENHI-PROJECT-20K07897
[Presentation] TARDBP変異 iPS細胞を用いた軸索に焦点をあてた筋萎縮性側索硬化症の運動ニューロン脆弱性の病態研究2023
- Author(s)
  光澤志緒、鈴木直輝、割田仁、岡野　栄之、青木正志
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16593
[Presentation] iPS細胞由来運動ニューロン軸索を用いた筋萎縮性側索硬化症の病態研究2023
- Author(s)
  光澤志緒、鈴木直輝、青木正志
- Organizer
  第128回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-20K16593
[Presentation] Axonal growth impairment in motor neurons with TARDBP mutations were mediated by PHOX2B downregulation2021
- Author(s)
  Shio Mitsuzawa, Suzuki, Akiyama, Ishikawa, Sone, Kawada, Funayama, Shirota, Mitsuhashi, Morimoto, Ikeda, Shijo, Ohno, Nakamura, H. Ono, R. Ono, Osana, Nakagawa, Nishiyama, Izumi, Kaneda, Ikeuchi, Nakayama, Fujii, Kato, Warita, Okano, Aoki.
- Organizer
  32th international symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16593
[Presentation] Axonal growth impairment in iPS-derived motor neurons with TARDBP mutations.2021
- Author(s)
  Shio Mitsuzawa, Suzuki, Akiyama, Ishikawa, Sone, Kawada, Funayama, Mitsuhashi, Nishiyama, Ikeda, Shijo, Nakamura, H. Ono, R. Ono, Izumi, Ohno, Nakagawa, Nakayama, Warita, Okano, Aok.
- Organizer
  62st Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-20K16593
[Presentation] REDUCED PHOX2B STABILITY CAUSES AXONAL GROWTH IMPAIRMENT IN MOTOR NEURONS WITH ALS-LINKED TARDBP MUTATIONS2021
- Author(s)
  Shio Mitsuzawa, Suzuki, Akiyama, Ishikawa, Sone, Kawada, Funayama, Mitsuhashi, Morimoto, Ikeda, Shijo, Ohno, Nakamura, H. Ono, R. Ono, Nishiyama, Izumi, Kaneda, Ikeuchi, Nakayama, Fujii, Warita, Okano, Aoki.
- Organizer
  ISSCR Tokyo 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16593
[Presentation] Reduced PHOX2B stability causes axonal growth impairment in motor　neurons with TARDBP mutations2021
- Author(s)
  Shio Mitsuzawa, Naoki Suzuki, Tetsuya Akiyama, Mitsuru Ishikawa, Takefumi Sone, Jiro Kawada, Hiroaki Mitsuhashi, Satoru Morimoto, Kensuke Ikeda, Tomomi Shijo, Akiyuki Ohno, Naoko Nakamura, Hiroya Ono, Risako Ono, Ayumi Nishiyama, Rumiko Izumi, Masaaki Kato, Hitoshi Warita, Hideyuki Okano, Masashi Aoki
- Organizer
  PACTALS 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16593
[Presentation] Axonal pathology in amyotrophic lateral sclerosis with TARDBP mutations.2020
- Author(s)
  Shio Mitsuzawa, Naoki Suzuki, Tetsuya Akiyama, Mitsuru Ishikawa, Takefumi Sone, Jiro Kawada, Ryo Funayama, Hiroaki Mitsuhashi, Ayumi Nishiyama, Kensuke Ikeda, Tomomi Shijo, Naoko Nakamura, Hiroya Ono, Risako Ono, Rumiko Izumi, Tadashi Nakagawa, Keiko Nakayama, Hitoshi Warita, Hideyuki Okano, and Masashi Aoki
- Organizer
  第61回日本神経学会学術大会（61st Annual Meeting of the Japanese Society of Neurology）
- Data Source
  KAKENHI-PROJECT-20K16593

1. 中川直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mitsuzawa Shio 光澤 志緒

Research Projects

Research Products

Co-Researchers

軸索に着目した筋萎縮性側索硬化症の運動ニューロン変性に抵抗する分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Axonal RNA study based on Dying back hypothesis for novel factors involved in motor neuron selective degeneration of Amyotrophic Lateral Sclerosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] TARDBP変異 iPS細胞を用いた軸索に焦点をあてた筋萎縮性側索硬化症の運動ニューロン脆弱性の病態研究2023

Author(s)

Organizer

Data Source

[Presentation] iPS細胞由来運動ニューロン軸索を用いた筋萎縮性側索硬化症の病態研究2023

Author(s)

Organizer

Data Source

[Presentation] Axonal growth impairment in motor neurons with TARDBP mutations were mediated by PHOX2B downregulation2021

Author(s)

Organizer

Data Source

[Presentation] Axonal growth impairment in iPS-derived motor neurons with TARDBP mutations.2021

Author(s)

Organizer

Data Source

[Presentation] REDUCED PHOX2B STABILITY CAUSES AXONAL GROWTH IMPAIRMENT IN MOTOR NEURONS WITH ALS-LINKED TARDBP MUTATIONS2021

Author(s)

Organizer

Data Source

[Presentation] Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations2021

Author(s)

Organizer

Data Source

[Presentation] Axonal pathology in amyotrophic lateral sclerosis with TARDBP mutations.2020

Author(s)

Organizer

Data Source

Mitsuzawa Shio 光澤志緒

[Presentation] Reduced PHOX2B stability causes axonal growth impairment in motor　neurons with TARDBP mutations2021