MUKAI TAKEO 向井丈雄

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Mukai Takeo 向井丈雄

向井丈雄ムカイタケオ

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Researcher Number	60871324
Other IDs	https://orcid.org/0000-0001-6648-1271
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2025: 東京大学, 医学部附属病院, 助教 2020 – 2023: 東京大学, 医学部附属病院, 助教 2018: 東京大学, 医科学研究所, 特別研究員(PD) 2017: 東京大学, 大学院医学系研究科, 特別研究員(DC2)
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 90110:Biomedical engineering-related / Embryonic/Neonatal medicine / Basic Section 51030:Pathophysiologic neuroscience-related / 0902:General internal medicine and related fields Except Principal Investigator Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 臍帯 / 間葉系細胞 / ミクログリア / 臍帯由来間葉系細胞 / ニューロン / ＲｈｏＧＴＰａｓｅ / 貪食能 / ミトコンドリア / アクチンダイナミクス / 新生児脳障害 … More / 再生医療 / 神経栄養因子 / 脳性麻痺 / 新生児低酸素性虚血性脳症 / 共培養 / 神経保護効果 … More Except Principal Investigator 抗炎症 / 再生医療 / 臍帯 / 放射線性臓器障害 / 間葉系細胞 / 高次脳機能 / 低体温療法 / 長期予後 / 発達 / 低酸素性虚血性脳症 / フォローアップ / 発達遅滞 / 自閉スペクトラム症 / 脳性麻痺 / 新生児低酸素性虚血性脳症 Less

臍帯オミックス解析による在胎発育パターン解明と発達予測メチル化マーカーの探索Principal Investigator
- Principal Investigator
  
  向井丈雄
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  The University of Tokyo
Research and development of treatment for radiation-induced organ injuries using umbilical cord-derived mesenchymal stromal cells
- Principal Investigator
  
  長村登紀子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  The University of Tokyo
臍帯由来細胞の神経保護効果におけるcell-to-cell contactの必要性の検討Principal Investigator
- Principal Investigator
  
  向井丈雄
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  The University of Tokyo
A large prospective registry study to explore new indications for therapeutic hypothermia for neonatal encephalopathy
- Principal Investigator
  
  竹内章人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  独立行政法人国立病院機構岡山医療センター(臨床研究部)
Migration of umbilical cord-derived cells to injured neurons and microglia in 3D co-culturePrincipal Investigator
- Principal Investigator
  
  Mukai Takeo
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokyo
Elucidation of mitochondrial regulation and actin dynamics of umbilical cord-derived mesenchymal cells on microgliaPrincipal Investigator
- Principal Investigator
  
  Mukai Takeo
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  The University of Tokyo
新生児脳神経障害における臍帯由来間葉系細胞の機能解析と新規治療への応用Principal Investigator
- Principal Investigator
  
  向井丈雄
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Superior migration ability of umbilical cord-derived mesenchymal stromal cells (MSCs) toward activated lymphocytes in comparison with those of bone marrow and adipose-derived MSCs2024
- Author(s)
  Hori Akiko、Takahashi Atsuko、Miharu Yuta、Yamaguchi Satoru、Sugita Masatoshi、Mukai Takeo、Nagamura Fumitaka、Nagamura-Inoue Tokiko
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 12 Pages: 1329218-1329218
- DOI
  10.3389/fcell.2024.1329218
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K17432, KAKENHI-PROJECT-23K17188, KAKENHI-PROJECT-21K10298
[Journal Article] Predictive value of the Thompson score for short-term adverse outcomes in neonatal encephalopathy2023
- Author(s)
  Aoki H, Shibasaki J, Tsuda K, Yamamoto K, Takeuchi A, Sugiyama Y, Isayama T, Mukai T, Ioroi T, Yutaka N, Takahashi A, Tokuhisa T, Nabetani M, Iwata O; Baby Cooling Registry of Japan Collaboration Team.
- Journal Title
  
  Pediatr Res .
  
  Volume: 93(4) Issue: 4 Pages: 1057-1063
- DOI
  10.1038/s41390-022-02212-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08247, KAKENHI-PROJECT-22K07906
[Journal Article] Prolonged requirements for mechanical ventilation and tube feeding support predicted 18-month outcomes for neonatal encephalopathy2023
- Author(s)
  Tsuda K, Shibasaki J, Takeuchi A, Mukai T, Sugiyama Y, Isayama T, Ioroi T, Takahashi A, Yutaka N, Iwata O; Baby Cooling Registry of Japan.
- Journal Title
  
  Acta Paediatr .
  
  Volume: 112(4) Issue: 4 Pages: 734-741
- DOI
  10.1111/apa.16687
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08247, KAKENHI-PROJECT-22K07906
[Journal Article] Cell Therapies for Autism Spectrum Disorder Based on New Pathophysiology: A Review2023
- Author(s)
  Makoto Nabetani , Takeo Mukai , Akihiko Taguchi
- Journal Title
  
  Cell transplantation
  
  Volume: 32 Pages: 96368972311632-96368972311632
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15618
[Journal Article] Umbilical cord-derived mesenchymal stromal cell therapy to prevent the development of neurodevelopmental disorders related to low birth weight2023
- Author(s)
  Tsuji Masahiro、Mukai Takeo、Sato Yoshiaki、Azuma Yasue、Yamamoto Saki、Cayetanot Florence、Bodineau Laurence、Onoda Atsuto、Nagamura-Inoue Tokiko、Coq Jacques-Olivier
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 3841-3857
- DOI
  10.1038/s41598-023-30817-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K10212, KAKENHI-PROJECT-21KK0176, KAKENHI-PROJECT-19K17324, KAKENHI-PROJECT-21K15618, KAKENHI-PROJECT-23K18403, KAKENHI-PROJECT-21K07794, KAKENHI-PROJECT-23K24593
[Journal Article] Cite Share Three-year outcome following neonatal encephalopathy in a high-survival cohort.2022
- Author(s)
  Tsuda K, Shibasaki J, Isayama T, Takeuchi A, Mukai T, Sugiyama Y, Ioroi T, Takahashi A, Yutaka N, Iwata S, Nabetani M, Iwata O.
- Journal Title
  
  Sci Rep.
  
  Volume: 13;12(1) Issue: 1 Pages: 7945-7945
- DOI
  10.1038/s41598-022-12091-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08247, KAKENHI-PROJECT-22K07906
[Journal Article] Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuries2022
- Author(s)
  Takeo Mukai, Kenshi Sei, Tokiko Nagamura-Inoue
- Journal Title
  
  Journal of integrative neuroscienc
  
  Volume: 21 Issue: 2 Pages: 44-44
- DOI
  10.31083/j.jin2102044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15618
[Journal Article] Treatment of Extremely Preterm Infants With Birthweight Below 300 g: Case Series2021
- Author(s)
  Yoshihiko Shitara, Satsuki Kakiuchi, Takeo Mukai, Kohei Kashima, Motohiro Kato, Naoto Takahashi
- Journal Title
  
  Frontiers in Pediatrics
  
  Volume: 9 Pages: 758683-758683
- DOI
  10.3389/fped.2021.758683
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16916, KAKENHI-PROJECT-21K15618
[Journal Article] Umbilical cord-derived mesenchymal stromal cells immunomodulate and restore actin dynamics and phagocytosis of LPS-activated microglia via PI3K/Akt/Rho GTPase pathway.2021
- Author(s)
  Takeo Mukai, Elena Di Martino, Shunichiro Tsuji, Klas Blomgren, Tokiko Nagamura-Inoue, Ulrika Aden
- Journal Title
  
  Cell death discovery
  
  Volume: 7 Issue: 1 Pages: 46-46
- DOI
  10.1038/s41420-021-00436-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22892
[Journal Article] Mesenchymal Stromal Cells Perspective: New Potential Therapeutic for the Treatment of Neurological Diseases2021
- Author(s)
  Takeo Mukai, Kenshi Sei, Tokiko Nagamura-Inoue
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 8 Pages: 1159-1159
- DOI
  10.3390/pharmaceutics13081159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22892, KAKENHI-PROJECT-21K15618
[Journal Article] The Immunomodulatory Effect of Triptolide on Mesenchymal Stromal Cells2021
- Author(s)
  Haiping He Atsuko Takahashi Takeo Mukai Akiko Hori Miwako Narita Arinobu Tojo Tonghua Yang Tokiko Nagamura-Inoue
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 12-12
- DOI
  10.3389/fimmu.2021.686356
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22892, KAKENHI-PROJECT-21K15618
[Journal Article] Preventing Brain Damage from Hypoxic Ischemic Encephalopathy in Neonates: Update on Mesenchymal Stromal Cells and Umbilical Cord Blood Cells2021
- Author(s)
  Makoto Nabetani , Takeo Mukai, Haruo Shintaku
- Journal Title
  
  American Journal of Perinatology
  
  Volume: 5 Issue: 16 Pages: 5-5
- DOI
  10.1055/s-0041-1726451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22892, KAKENHI-PROJECT-21K15618
[Journal Article] Body Temperature, Heart Rate, and Short-Term Outcome of Cooled Infants2019
- Author(s)
  Tsuda Kennosuke、Iwata Sachiko、Mukai Takeo、Shibasaki Jun、Takeuchi Akihito、Ioroi Tomoaki、Sano Hiroyuki、Yutaka Nanae、Takahashi Akihito、Takenouchi Toshiki、Osaga Satoshi、Tokuhisa Takuya、Takashima Sachio、Sobajima Hisanori、Tamura Masanori、Hosono Shigeharu、Nabetani Makoto、Iwata Osuke
- Journal Title
  
  Therapeutic Hypothermia and Temperature Management
  
  Volume: 9 Issue: 1 Pages: 76-85
- DOI
  10.1089/ther.2018.0019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09005, KAKENHI-PROJECT-18K07795, KAKENHI-PROJECT-18K15722, KAKENHI-PROJECT-17J02535, KAKENHI-PROJECT-15K09733
[Journal Article] Dose-Dependent Effect of Intravenous Administration of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Neonatal Stroke Mice2018
- Author(s)
  Tanaka E, Ogawa Y, Mukai T, Sato Y, Hamazaki T, Nagamura-Inoue T, Harada-Shiba M, Shintaku H, Tsuji M.
- Journal Title
  
  Frontiers in neurology
  
  Volume: 9 Pages: 133-133
- DOI
  10.3389/fneur.2018.00133
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J02535
[Journal Article] Mesenchymal stromal cells as a potential therapeutic for neurological disorders.2018
- Author(s)
  Mukai T, Tojo A1, Nagamura-Inoue T
- Journal Title
  
  Regenerative Therapy
  
  Volume: 9 Pages: 32-37
- DOI
  10.1016/j.reth.2018.08.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J02535
[Journal Article] Umbilical Cord-Derived Mesenchymal Stromal Cells Contribute to Neuroprotection in Neonatal Cortical Neurons Damaged by Oxygen-Glucose Deprivation2018
- Author(s)
  Mukai Takeo、Tojo Arinobu、Nagamura-Inoue Tokiko
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 9 Pages: 466-466
- DOI
  10.3389/fneur.2018.00466
- NAID
  40021867531
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J02535
[Journal Article] Intravenous injection of umbilical cord-derived mesenchymal stromal cells attenuates reactive gliosis and hypomyelination in a neonatal intraventricular hemorrhage model2017
- Author(s)
  Mukai T, Mori Y, Shimazu T, Takahashi A, Tsunoda H, Yamaguchi S, Kiryu S, Tojo A, Nagamura-Inoue T.
- Journal Title
  
  Neuroscience
  
  Volume: 355 Pages: 175-187
- DOI
  10.1016/j.neuroscience.2017.05.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J02535
[Patent] 急性脳症治療剤及び急性脳症の治療方法2023
- Inventor(s)
  1.長村登紀子、成健史、向井丈雄
- Industrial Property Rights Holder
  1.長村登紀子、成健史、向井丈雄
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-192078
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K17432
[Presentation] 新生児領域における幹細胞の臨床応用とその可能性新生児脳障害に対する臍帯由来間葉系細胞の治療応用2022
- Author(s)
  向井丈雄
- Organizer
  第58回日本周産期・新生児医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15618
[Presentation] 臍帯由来間葉系細胞が活性化型ミクログリアに及ぼす特性変化についての検討2021
- Author(s)
  向井丈雄
- Organizer
  第20回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20K22892
[Presentation] Cell Therapy for Neonatal brain injury2019
- Author(s)
  Takeo Mukai, Ulrika Aden
- Organizer
  Karolinska Institute- JAPAN Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J02535
[Presentation] 臍帯由来間葉系細胞由来BDNF・HGFは神経修復を促進する2018
- Author(s)
  向井丈雄
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-17J02535
[Presentation] EXPERIENCE OF NATIONWIDE ONLINE CASE REGISTRY OF THERAPEUTIC HYPOTHERMIA FOR NEWBORNS WITH HYPOXIC-ISCHEMIC-ENCEPHALOPATHY FROM THE FIRST 3 YEARS IN JAPAN2018
- Author(s)
  2.T. Mukai, M. Nabetani, K. Tsuda, H. Sano, N. Yutaka, T. Ioroi, A. Takahashi, A. Takeuchi, J. Shibasaki, S. Hosono, T. Tokuhisa, T. Takenouchi, H. Sobajima, M. Tamura, O. Iwata.
- Organizer
  The 7th Congress of the European Academy of Paediatric Societies (Paris)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J02535
[Presentation] Japanese approach to extremely preterm infants and perspective of regenerative therapy2018
- Author(s)
  Takeo Mukai, Ulrika Aden
- Organizer
  Karolinska Institute Neonatal Seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J02535
[Presentation] 新生児脳神経系障害における臍帯由来間葉系細胞の機能解析と新規治療への応用2017
- Author(s)
  向井丈雄
- Organizer
  第120回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-17J02535
[Presentation] Neurotropism and Neuroprotective effect in umbilical cord-Mesenchymal Stromal Cells2017
- Author(s)
  Takeo Mukai
- Organizer
  ISCT, London
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J02535

1. 竹内章人 (40731386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 津田兼之介 (20727507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岩田欧介 (30465710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 柴崎淳 (30540471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 小林徹 (50431713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 諫山哲哉 (80818146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 長村登紀子 (70240736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鹿嶋晃平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 井上登紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

MUKAI TAKEO 向井 丈雄

Mukai Takeo 向井 丈雄

向井 丈雄 ムカイ タケオ

Research Projects

Research Products

Co-Researchers

臍帯オミックス解析による在胎発育パターン解明と発達予測メチル化マーカーの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research and development of treatment for radiation-induced organ injuries using umbilical cord-derived mesenchymal stromal cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

臍帯由来細胞の神経保護効果におけるcell-to-cell contactの必要性の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A large prospective registry study to explore new indications for therapeutic hypothermia for neonatal encephalopathy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Migration of umbilical cord-derived cells to injured neurons and microglia in 3D co-culturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mitochondrial regulation and actin dynamics of umbilical cord-derived mesenchymal cells on microgliaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新生児脳神経障害における臍帯由来間葉系細胞の機能解析と新規治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Superior migration ability of umbilical cord-derived mesenchymal stromal cells (MSCs) toward activated lymphocytes in comparison with those of bone marrow and adipose-derived MSCs2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predictive value of the Thompson score for short-term adverse outcomes in neonatal encephalopathy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prolonged requirements for mechanical ventilation and tube feeding support predicted 18-month outcomes for neonatal encephalopathy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell Therapies for Autism Spectrum Disorder Based on New Pathophysiology: A Review2023

Author(s)

Journal Title

Data Source

[Journal Article] Umbilical cord-derived mesenchymal stromal cell therapy to prevent the development of neurodevelopmental disorders related to low birth weight2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cite Share Three-year outcome following neonatal encephalopathy in a high-survival cohort.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mesenchymal stromal cells: cell-based therapies for traumatic central nervous system injuries2022

Author(s)

Journal Title

MUKAI TAKEO 向井丈雄

Mukai Takeo 向井丈雄

向井丈雄ムカイタケオ

[Presentation] 新生児領域における幹細胞の臨床応用とその可能性新生児脳障害に対する臍帯由来間葉系細胞の治療応用2022