CHOU KYOUGI 張羽協義

… Alternative Names

ZHANG XIEYI 張協義

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Researcher Number	60878510
Other IDs
Affiliation (Current)	2025: 金沢大学, 医学系, 助教
Affiliation (based on the past Project Information) *help	2025: 金沢大学, 医学系, 助教 2023: 東京理科大学, 研究推進機構総合研究院, プロジェクト研究員 2023: 東京理科大学, 研究推進機構総合研究院, 研究員 2020 – 2022: 高崎健康福祉大学, 薬学部, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 58040:Forensics medicine-related
Keywords	Principal Investigator P-糖タンパク質 / 転写調節因子 / 足場タンパク / 薬物排出系トランスポーター / 上皮間葉転換 / 法医解剖 / 薬物排出実験 / 血液脳関門 / 一塩基多型 / 足場タンパク質 … More / 多剤耐性 / 間葉上皮転換 / HCC827肺がん細胞 / 肺がん / がん転移 / SNAIファミリー … More Except Principal Investigator 抗がん薬 / 濾胞性リンパ腫 / がん薬物耐性 / P-糖タンパク質 / 脆弱性 / バイオマーカー / 脳動脈瘤 / 脳脊髄液 / 膜タンパク質複合体 / 膜裏打ちタンパク / 転移能 / 薬物耐性 / CD44 / 膜局在 / 排出系トランスポーター Less

難治性リンパ腫における膜タンパク複合体形成の同定とその阻害の有用性評価
- Principal Investigator
  
  矢野健太郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Yokohama College of Pharmacy
Analysis of progression of cerebral aneurysm and fragility of intracranial tissue accessing biomarker
- Principal Investigator
  
  塚正彦
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Kanazawa University
Elucidation of single nucleotide polymorphisms in P-glycoprotein and their differences in substrate specificityPrincipal Investigator
- Principal Investigator
  
  張羽協義
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
膜タンパクの局在制御に基づくがん悪性化克服法の研究
- Principal Investigator
  
  矢野健太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Yokohama College of Pharmacy
肺がん転移時の間葉上皮転換過程における薬剤耐性の変動とそのメカニズムの解明Principal Investigator
- Principal Investigator
  
  張協義
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Science
  Takasaki University of Health and Welfare
Mechanism of multidrug resistance acquisition by transcriptional regulators involved in lung cancer metastasisPrincipal Investigator
- Principal Investigator
  
  ZHANG XIEYI
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Takasaki University of Health and Welfare

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Mechanism of Induction of P-gp Activity During MET Induced by DEX in Lung Cancer Cell Line2024
- Author(s)
  Liu Wangyang、Zhang Xieyi、Sunakawa Hiroki、Perera Liyanage Manosika Buddhini、Martha Larasati、Mizoi Kenta、Ogihara Takuo
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: in press Issue: 6 Pages: 1674-1681
- DOI
  10.1016/j.xphs.2024.02.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15345
[Journal Article] Clinical Analysis and <i>in Vitro</i> Correlation of BCRP-Mediated Drug–Drug Interaction in the Gastrointestinal Tract2024
- Author(s)
  Perera Liyanage Manosika Buddhini、Okazaki Kenzo、Woo Yunje、Takahashi Saori、Zhang Xieyi、Mizoi Kenta、Takahashi Toshinari、Ogihara Takuo
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 4 Pages: 750-757
- DOI
  10.1248/bpb.b23-00786
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-04-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15345
[Journal Article] Transporter and metabolic enzyme-mediated intra-enteric circulation of SN-38, an active metabolite of irinotecan: A new concept2023
- Author(s)
  Martha Larasati、Nakata Akane、Furuya Shinnosuke、Liu Wangyang、Zhang Xieyi、Mizoi Kenta、Ogihara Takuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 665 Pages: 19-25
- DOI
  10.1016/j.bbrc.2023.04.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15345
[Journal Article] A lightweight 0.25 mm lead equivalence protective apron for shielding radiological technologists from radiation exposure during single-photon emission computed tomography in nuclear medicine2022
- Author(s)
  Takao Kanzaki, Tetsuya Higuchi, Xieyi Zhang, Yasuyuki Takahashi, Makoto Sakai, Yoshito Tsushima
- Journal Title
  
  Radioprotection
  
  Volume: － Issue: 2 Pages: 143-148
- DOI
  10.1051/radiopro/2022006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22717
[Journal Article] Imaging modalities for monitoring acute therapeutic effects after near-infrared photoimmunotherapy in vivo2022
- Author(s)
  Xieyi Zhang, Takahito Nakajima, Kenta Mizoi, Yoshito Tsushima, Takuo Ogihara
- Journal Title
  
  Journal of Biophotonics
  
  Volume: 15 Issue: 1
- DOI
  10.1002/jbio.202100266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07626, KAKENHI-PROJECT-20K22717
[Journal Article] P-Glycoprotein?Mediated Pharmacokinetic Interactions Increase Pimozide hERG Channel Inhibition2022
- Author(s)
  Morishita Hiroki、Perera Liyanage Manosika Buddhini、Zhang Xieyi、Mizoi Kenta、Ito Masa-aki、Yano Kentaro、Ogihara Takuo
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 111 Issue: 12 Pages: 3411-3416
- DOI
  10.1016/j.xphs.2022.09.025
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06782, KAKENHI-PROJECT-20K16010, KAKENHI-PROJECT-21K20729
[Journal Article] Effect of metformin on <sup>18</sup>F-fluorodeoxyglucose uptake and positron emission tomographic imaging2021
- Author(s)
  Xieyi Zhang, Takuo Ogihara, Min Zhu, Dolgormaa Gantumur, Yang Li, Kenta Mizoi, Hiroki Kamioka, Yoshito Tsushima
- Journal Title
  
  The British Journal of Radiology
  
  Volume: 95 Issue: 1130 Pages: 20200810-20200810
- DOI
  10.1259/bjr.20200810
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22717
[Journal Article] Correlations of mRNA Levels among Efflux Transporters, Transcriptional Regulators, and Scaffold Proteins in Non-Small-Cell Lung Cancer2021
- Author(s)
  Xieyi Zhang, Wangyang Liu, Kazue Edaki, Yuta Nakazawa, Hiroki Kamioka, Atsushi Fujita, Ryoichi Onozato, Misa Iijima, Shigeru Tsuchida, Takahiro Arai, Yukiyoshi Fujita, Kenta Mizoi, Takuo Ogihara
- Journal Title
  
  Canadian Journal of Infectious Diseases and Medical Microbiology
  
  Volume: － Pages: 4005327-4005327
- DOI
  10.1155/2021/4005327
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22717
[Presentation] HCC827肺がん細胞の転移におけるP-糖タンパク質および足場タンパク質の変動2023
- Author(s)
  劉汪洋、上岡宏規、伴野拓巳、張協義、リヤナゲペレーラマノシカブッディニ、荻原琢男
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-22K15345
[Presentation] P-糖タンパク質を介した血液脳関門における薬物-内因性基質相互作用の評価2023
- Author(s)
  砂川大樹、髙橋玲子、張協義、塚正彦、古宮淳一、崔吉道、溝井健太、荻原琢男
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15345
[Presentation] The expression of scaffold proteins and efflux transporters in HCC827 lung cancer cells after EMT/MET inducement2023
- Author(s)
  Wangyang Liu, Liyanage Manosika Buddhini Perera, Larasati Martha, Xieyi Zhang, Takuo Ogihara
- Organizer
  日本薬物動態学会第38回年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15345
[Presentation] 消化管におけるBCRPを介した薬物相互作用の臨床解析とin vitro相関の検討2023
- Author(s)
  劉汪洋、岡﨑賢三、髙橋紗織、張協義、溝井健太、荻原琢男
- Organizer
  第17回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-22K15345
[Presentation] EMT/METを誘導したHCC827肺がん細胞におけるP-糖タンパク質の活性変動2022
- Author(s)
  劉汪洋、上岡宏規、伴野拓巳、中澤佑太、張協義、リヤナゲペレーラマノシカブッディニ、溝井健太、荻原琢男
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15345
[Presentation] A lightweight 0.25 mm lead equivalence protective apron for shielding radiological technologists from radiation exposure during single-photon emission computed tomography (SPECT)2021
- Author(s)
  Takao Kanzaki, Tetsuya Higuchi, Xieyi Zhang, Yasuyuki Takahashi, Makoto Sakai, Hirotaka Shimada, Takayuki Suto, Yoshito Tsushima
- Organizer
  Progress in Radiology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22717
[Presentation] The role of scaffold proteins in regulating P-gp expression during epithelial-mesenchymal transition in lung cancer2021
- Author(s)
  Xieyi Zhang, Hiroki Kamioka, Yuta Nakazawa, Kazue Edaki, Kenta Mizoi, Takuo Ogihara
- Organizer
  日本薬物動態学会第36回年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22717
[Presentation] The effect of P-gp mediated pharmacokinetic interactions on pimozide hERG channel inhibition2021
- Author(s)
  Hiroki Morishita, Keisuke Takahashi, Misaki Ishii, Masaaki Ito, Xieyi Zhang, Kenta Mizoi, Kentaro Yano, Takuo Ogihara
- Organizer
  日本薬物動態学会第36回年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22717
[Presentation] Effect of pimozide accumulation by P-glycoprotein (P-gp) inhibition on hERG channel on cardiomyocytes2021
- Author(s)
  Keisuke Takahashi, Misaki Ishii, Hiroki Morishita, Masa-aki Ito, Xieyi Zhang, Hiroki Kamioka, Kenta Mizoi, Kentaro Yano, Takuo Ogihara
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K22717
[Presentation] The role of transcriptional factors and scaffold proteins in mediating MRP2 expression in lung cancer cells2021
- Author(s)
  Yuta Nakazawa, Xieyi Zhang, Kazue Edaki, Kenta Mizoi, Takuo Ogihara
- Organizer
  日本薬物動態学会第36回年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22717
[Presentation] CYP3A4阻害薬の薬物相互作用マトリックス表の作成と副作用発現リスクの解析2021
- Author(s)
  Furuya Shinnosuke, Xieyi Zhang, kenta Mizoi, Takuo Ogihara
- Organizer
  第4回群馬県薬学大会
- Data Source
  KAKENHI-PROJECT-20K22717
[Presentation] Physiological roles of ERM proteins in supporting membrane expression of efflux transporters2020
- Author(s)
  Xieyi Zhang, Kenta Mizo, Hiroki Kamioka, Kentaro Yano, Takuo Ogihara
- Organizer
  第5回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-20K22717

1. 矢野健太郎 (40644290)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 岩瀬由未子 (00521882)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 桑原隆 (90786576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 塚正彦 (00272956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 中島崇仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

CHOU KYOUGI 張羽 協義

ZHANG XIEYI 張 協義

Research Projects

Research Products

Co-Researchers

難治性リンパ腫における膜タンパク複合体形成の同定とその阻害の有用性評価

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of progression of cerebral aneurysm and fragility of intracranial tissue accessing biomarker

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of single nucleotide polymorphisms in P-glycoprotein and their differences in substrate specificityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膜タンパクの局在制御に基づくがん悪性化克服法の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肺がん転移時の間葉上皮転換過程における薬剤耐性の変動とそのメカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of multidrug resistance acquisition by transcriptional regulators involved in lung cancer metastasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mechanism of Induction of P-gp Activity During MET Induced by DEX in Lung Cancer Cell Line2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Analysis and <i>in Vitro</i> Correlation of BCRP-Mediated Drug–Drug Interaction in the Gastrointestinal Tract2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Transporter and metabolic enzyme-mediated intra-enteric circulation of SN-38, an active metabolite of irinotecan: A new concept2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A lightweight 0.25 mm lead equivalence protective apron for shielding radiological technologists from radiation exposure during single-photon emission computed tomography in nuclear medicine2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Imaging modalities for monitoring acute therapeutic effects after near-infrared photoimmunotherapy in vivo2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] P-Glycoprotein?Mediated Pharmacokinetic Interactions Increase Pimozide hERG Channel Inhibition2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of metformin on <sup>18</sup>F-fluorodeoxyglucose uptake and positron emission tomographic imaging2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correlations of mRNA Levels among Efflux Transporters, Transcriptional Regulators, and Scaffold Proteins in Non-Small-Cell Lung Cancer2021

CHOU KYOUGI 張羽協義

ZHANG XIEYI 張協義