Nakashima Yu 中嶋優

Researcher Number	60902038
Affiliation (Current)	2025: 富山大学, 学術研究部薬学・和漢系, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 富山大学, 学術研究部薬学・和漢系, 助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related Except Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator 2OG依存性酸化酵素 / 漢方 / 阻害剤 / 生薬 / AspH Except Principal Investigator 酵素機能改変 / 生合成 / アルカロイド

FIHを標的とした代謝異常関連脂肪肝MAFLDの治療に有効なシード化合物の探索Principal Investigator
- Principal Investigator
  
  中嶋優
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Toyama
Searching for effective anti-cancer seed compounds for refractory cancers targeting AspHPrincipal Investigator
- Principal Investigator
  
  Nakashima Yu
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Toyama
AchE阻害活性アルカロイドの骨格生合成酵素の機能解析と改変
- Principal Investigator
  
  森田洋行
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Toyama

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Phenolic Derivatives with Anti‐Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam2023
- Author(s)
  Do Kiep Minh、Nakashima Yu、Kodama Takeshi、Lee Yuan‐E、Nguyen Hien Minh、Ikumi Naotaka、Morita Hiroyuki
- Journal Title
  
  Chemistry & Biodiversity
  
  Volume: 20 Issue: 12 Pages: 202301482-202301482
- DOI
  10.1002/cbdv.202301482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06179, KAKENHI-PROJECT-23K24040
[Journal Article] Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes2023
- Author(s)
  Hoang Nhat Nam、Kodama Takeshi、Nakashima Yu、Do Kiep Minh、Hnin Saw Yu Yu、Lee Yuan-E、Prema、Ikumi Naotaka、Morita Hiroyuki
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 77 Issue: 4 Pages: 891-897
- DOI
  10.1007/s11418-023-01731-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06179, KAKENHI-PROJECT-23K24040
[Journal Article] Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism2023
- Author(s)
  Nakashima Yu、Kawakami Atsushi、Ogasawara Yasushi、Maeki Masatoshi、Tokeshi Manabu、Dairi Tohru、Morita Hiroyuki
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 4752-4752
- DOI
  10.1038/s41467-023-40232-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05130, KAKENHI-PROJECT-22H04976, KAKENHI-PROJECT-23K24040
[Journal Article] Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase2022
- Author(s)
  Hamdy Sherif Ahmed、Kodama Takeshi、Nakashima Yu、Han Xiaojie、Matsui Takashi、Morita Hiroyuki
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 76 Issue: 4 Pages: 873-879
- DOI
  10.1007/s11418-022-01635-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06036, KAKENHI-PROJECT-23K24040
[Journal Article] Catalytic potential of a fungal indole prenyltransferase toward b-carbolines, harmine and harman, and their prenylation effect on antibacterial activities2022
- Author(s)
  SA. Hamdy、T. Kodama、 Y. Nakashima、 X. Han、H. Morita
- Journal Title
  
  J Biosci Bioeng
  
  Volume: 134 Issue: 4 Pages: 311-317
- DOI
  10.1016/j.jbiosc.2022.07.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] The structural-guided studies for Amaryllidaceae O-methyltransferases2024
- Author(s)
  Hnin SYY, Nakashima Y, Kodama T, Morita H.
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Catalytic potential of O-methyltransferase in the biosynthesis of Amaryllidaceae alkaloids with different substrates2023
- Author(s)
  Saw Yu Yu Hnin, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] X線結晶構造解析に基づくラッソペプチドエピメリ化酵素MslHの酵素反応機構の解明2023
- Author(s)
  中嶋優，川上篤士，小笠原泰志，大利徹，森田洋行
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] ラッソペプチドのエピメリ化を担うMslHの結晶構造解析2023
- Author(s)
  中嶋優，川上篤士，小笠原泰志，大利徹，森田洋行
- Organizer
  酵素工学研究会第90回講演会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] ラッソペプチド生合成を担うエピメリ化酵素MslH のX 線結晶構造解析(第2)．2023
- Author(s)
  中嶋優，川上篤士，小笠原泰志，大利徹，森田洋行
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Structural-based engineering of Amaryllidaceae-O-methyltransferases (2nd)．2023
- Author(s)
  Hnin SYY, Nakashima Y, Kodama T, Morita H．
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] X-ray crystallographic analysis of lasso peptide epimerase; MslH2023
- Author(s)
  Yu Nakashima, Atsushi Kawakami, Yasushi Ogasawara, Tohru Dairi, Hiroyuki Morita
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Crystal structure analysis of norbelladine 4-O-methyltransferase from Lycoris longituba2023
- Author(s)
  Saw Yu Yu Hnin, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Dual engineering of olivetolic acid cyclase and tetraketide synthase to generate longer alkyl-chain olivetolic acid analogs2023
- Author(s)
  Yuan-E Lee, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood2023
- Author(s)
  Hiroyuki Morita, Xiao-Hui Wang, Bo-Wen Gao, Yu Nakashima, Ikuro Abe, Peng-Fei Tu, She-Po Shi
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] 新規ペプチドエピメラーゼMslHの反応機構解析2022
- Author(s)
  川上篤士，中嶋優，森田洋行，小笠原泰志，大利徹
- Organizer
  第36回日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Structural-based engineering of norbelladine-O-methyltransferase2022
- Author(s)
  Saw Yu Yu Hnin, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
- Organizer
  日本生薬学会第 68 回年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Dual engineering of olivetolic acid cyclase and tetraketide synthase to generate longer alkyl-chain olivetolic acid analogs2022
- Author(s)
  Yuan-E Lee, Yu Nakashima, Takeshi Kodama, Xinrui Chen, Hiroyuki Morita
- Organizer
  Active Enzyme Molecule 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] ラッソペプチド生合成を担うエピメリ化酵素MslHのX線結晶構造解析2022
- Author(s)
  中嶋優，川上篤士，小笠原泰志，大利徹，森田洋行
- Organizer
  日本生薬学会第 68 回年会
- Data Source
  KAKENHI-PROJECT-23K24040

1. 森田洋行 (20416663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
2. 児玉猛 (40710207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. 松井崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 小笠原泰志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakashima Yu 中嶋 優

Research Projects

Research Products

Co-Researchers

FIHを標的とした代謝異常関連脂肪肝MAFLDの治療に有効なシード化合物の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Searching for effective anti-cancer seed compounds for refractory cancers targeting AspHPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

AchE阻害活性アルカロイドの骨格生合成酵素の機能解析と改変

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Phenolic Derivatives with Anti‐Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Catalytic potential of a fungal indole prenyltransferase toward b-carbolines, harmine and harman, and their prenylation effect on antibacterial activities2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] The structural-guided studies for Amaryllidaceae O-methyltransferases2024

Author(s)

Organizer

Data Source

[Presentation] Catalytic potential of O-methyltransferase in the biosynthesis of Amaryllidaceae alkaloids with different substrates2023

Author(s)

Organizer

Data Source

[Presentation] X線結晶構造解析に基づくラッソペプチドエピメリ化酵素MslHの酵素反応機構の解明2023

Author(s)

Organizer

Data Source

[Presentation] ラッソペプチドのエピメリ化を担うMslHの結晶構造解析2023

Author(s)

Organizer

Data Source

[Presentation] ラッソペプチド生合成を担うエピメリ化酵素MslH のX 線結晶構造解析(第2)．2023

Author(s)

Organizer

Data Source

[Presentation] Structural-based engineering of Amaryllidaceae-O-methyltransferases (2nd)．2023

Author(s)

Organizer

Data Source

[Presentation] X-ray crystallographic analysis of lasso peptide epimerase; MslH2023

Author(s)

Organizer

Data Source

[Presentation] Crystal structure analysis of norbelladine 4-O-methyltransferase from Lycoris longituba2023

Author(s)

Organizer

Data Source

[Presentation] Dual engineering of olivetolic acid cyclase and tetraketide synthase to generate longer alkyl-chain olivetolic acid analogs2023

Nakashima Yu 中嶋優