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Nakashima Yu  中嶋 優

ORCIDConnect your ORCID iD *help
Researcher Number 60902038
Affiliation (Current) 2025: 富山大学, 学術研究部薬学・和漢系, 助教
Affiliation (based on the past Project Information) *help 2022 – 2024: 富山大学, 学術研究部薬学・和漢系, 助教
Review Section/Research Field
Principal Investigator
Basic Section 47050:Environmental and natural pharmaceutical resources-related
Except Principal Investigator
Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords
Principal Investigator
2OG依存性酸化酵素 / 漢方 / 阻害剤 / 生薬 / AspH
Except Principal Investigator
酵素機能改変 / 生合成 / アルカロイド
  • Research Projects

    (3 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (4 People)
  •  FIHを標的とした代謝異常関連脂肪肝MAFLDの治療に有効なシード化合物の探索Principal Investigator

    • Principal Investigator
      中嶋 優
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      University of Toyama
  •  Searching for effective anti-cancer seed compounds for refractory cancers targeting AspHPrincipal Investigator

    • Principal Investigator
      Nakashima Yu
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      University of Toyama
  •  AchE阻害活性アルカロイドの骨格生合成酵素の機能解析と改変

    • Principal Investigator
      森田 洋行
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      University of Toyama

All 2024 2023 2022

All Journal Article Presentation

  • [Journal Article] Phenolic Derivatives with Anti‐Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam2023

    • Author(s)
      Do Kiep Minh、Nakashima Yu、Kodama Takeshi、Lee Yuan‐E、Nguyen Hien Minh、Ikumi Naotaka、Morita Hiroyuki
    • Journal Title

      Chemistry & Biodiversity

      Volume: 20 Issue: 12 Pages: 202301482-202301482

    • DOI

      10.1002/cbdv.202301482

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K06179, KAKENHI-PROJECT-23K24040
  • [Journal Article] Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes2023

    • Author(s)
      Hoang Nhat Nam、Kodama Takeshi、Nakashima Yu、Do Kiep Minh、Hnin Saw Yu Yu、Lee Yuan-E、Prema、Ikumi Naotaka、Morita Hiroyuki
    • Journal Title

      Journal of Natural Medicines

      Volume: 77 Issue: 4 Pages: 891-897

    • DOI

      10.1007/s11418-023-01731-9

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K06179, KAKENHI-PROJECT-23K24040
  • [Journal Article] Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism2023

    • Author(s)
      Nakashima Yu、Kawakami Atsushi、Ogasawara Yasushi、Maeki Masatoshi、Tokeshi Manabu、Dairi Tohru、Morita Hiroyuki
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 4752-4752

    • DOI

      10.1038/s41467-023-40232-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22H05130, KAKENHI-PROJECT-22H04976, KAKENHI-PROJECT-23K24040
  • [Journal Article] Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase2022

    • Author(s)
      Hamdy Sherif Ahmed、Kodama Takeshi、Nakashima Yu、Han Xiaojie、Matsui Takashi、Morita Hiroyuki
    • Journal Title

      Journal of Natural Medicines

      Volume: 76 Issue: 4 Pages: 873-879

    • DOI

      10.1007/s11418-022-01635-0

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06036, KAKENHI-PROJECT-23K24040
  • [Journal Article] Catalytic potential of a fungal indole prenyltransferase toward b-carbolines, harmine and harman, and their prenylation effect on antibacterial activities2022

    • Author(s)
      SA. Hamdy、T. Kodama、 Y. Nakashima、 X. Han、H. Morita
    • Journal Title

      J Biosci Bioeng

      Volume: 134 Issue: 4 Pages: 311-317

    • DOI

      10.1016/j.jbiosc.2022.07.004

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] The structural-guided studies for Amaryllidaceae O-methyltransferases2024

    • Author(s)
      Hnin SYY, Nakashima Y, Kodama T, Morita H.
    • Organizer
      日本農芸化学会2024年度大会
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] Catalytic potential of O-methyltransferase in the biosynthesis of Amaryllidaceae alkaloids with different substrates2023

    • Author(s)
      Saw Yu Yu Hnin, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] X線結晶構造解析に基づくラッソペプチドエピメリ化酵素MslHの酵素反応機構の解明2023

    • Author(s)
      中嶋 優,川上 篤士,小笠原 泰志,大利 徹,森田 洋行
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] ラッソペプチドのエピメリ化を担うMslHの結晶構造解析2023

    • Author(s)
      中嶋優,川上篤士,小笠原泰志,大利徹,森田洋行
    • Organizer
      酵素工学研究会第90回講演会
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] ラッソペプチド生合成を担うエピメリ化酵素MslH のX 線結晶構造解析(第2).2023

    • Author(s)
      中嶋優,川上篤士,小笠原泰志,大利徹,森田洋行
    • Organizer
      日本生薬学会第69回年会
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] Structural-based engineering of Amaryllidaceae-O-methyltransferases (2nd).2023

    • Author(s)
      Hnin SYY, Nakashima Y, Kodama T, Morita H.
    • Organizer
      日本生薬学会第69回年会
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] X-ray crystallographic analysis of lasso peptide epimerase; MslH2023

    • Author(s)
      Yu Nakashima, Atsushi Kawakami, Yasushi Ogasawara, Tohru Dairi, Hiroyuki Morita
    • Organizer
      4th International Conference on Natural Product Discovery and Development in the Genomic Era
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] Crystal structure analysis of norbelladine 4-O-methyltransferase from Lycoris longituba2023

    • Author(s)
      Saw Yu Yu Hnin, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
    • Organizer
      4th International Conference on Natural Product Discovery and Development in the Genomic Era
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] Dual engineering of olivetolic acid cyclase and tetraketide synthase to generate longer alkyl-chain olivetolic acid analogs2023

    • Author(s)
      Yuan-E Lee, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
    • Organizer
      4th International Conference on Natural Product Discovery and Development in the Genomic Era
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood2023

    • Author(s)
      Hiroyuki Morita, Xiao-Hui Wang, Bo-Wen Gao, Yu Nakashima, Ikuro Abe, Peng-Fei Tu, She-Po Shi
    • Organizer
      4th International Conference on Natural Product Discovery and Development in the Genomic Era
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] 新規ペプチドエピメラーゼMslHの反応機構解析2022

    • Author(s)
      川上篤士,中嶋優,森田洋行,小笠原泰志,大利徹
    • Organizer
      第36回日本放線菌学会大会
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] Structural-based engineering of norbelladine-O-methyltransferase2022

    • Author(s)
      Saw Yu Yu Hnin, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
    • Organizer
      日本生薬学会第 68 回年会
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] Dual engineering of olivetolic acid cyclase and tetraketide synthase to generate longer alkyl-chain olivetolic acid analogs2022

    • Author(s)
      Yuan-E Lee, Yu Nakashima, Takeshi Kodama, Xinrui Chen, Hiroyuki Morita
    • Organizer
      Active Enzyme Molecule 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24040
  • [Presentation] ラッソペプチド生合成を担うエピメリ化酵素MslHのX線結晶構造解析2022

    • Author(s)
      中嶋優,川上篤士,小笠原泰志,大利徹,森田洋行
    • Organizer
      日本生薬学会第 68 回年会
    • Data Source
      KAKENHI-PROJECT-23K24040
  • 1.  森田 洋行 (20416663)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 15 results
  • 2.  児玉 猛 (40710207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 3.  松井 崇
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  小笠原 泰志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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