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TAKAHASHI Kenji
高橋 健治
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Alternative Names
高橋 建治 タカハシ ケンジ
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Researcher Number
70011533
Other IDs
External Links
Affiliation (based on the past Project Information)
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1995 – 2001: Tokyo University of Pharmacy and Life Science, School of Life Science, Professor, 生命科学部, 教授
1994: 東京大学, 大学院理学系研究科, 教授
1993 – 1994: 東京大学, 大学院・理学系研究科, 教授
1990 – 1993: 東京大学, 理学部, 教授
1990: 東京大学, 理学部・生物化学科, 教授
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1990: Univ. Tokyo, Dept. SCience, Prof., 理学部・生物雑学科, 教授
1986 – 1988: University of Tokyo, Faculty of Science, 理学部, 教授
1986: 東大, 理学部, 教授
1985: 東京大学, 理, 教授
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Review Section/Research Field
Principal Investigator
Structural biochemistry
/
物質生物化学
/
Cell biology
/
広領域
Except Principal Investigator
物質生物化学
/
Pathological medical chemistry
/
Biological pharmacy
/
動物形態・分類学
/
Biophysics
/
医薬分子機能学
/
代謝生物化学
Keywords
Principal Investigator
プロテアーゼ / アスパラギン酸プロテアーゼ / 大腸菌 / X線結晶構造解析 / 基質特異性 / cDNA / NMR / 遺伝子 / ペプシノーゲン / ATP依存性プロテアーゼ
…
More
/ 超遠心分析 / 部位特異的変異 / 環境汚染物質 / CAAXモチーフ特異的プロテアーゼ / カテプシンE / 自己触媒的活性化 / Proctase A / Cathepsin E / site-directed mutagenesis / α-キモトリプシン / エンテロペプチダーゼ / ヘプシン / トリプシン / プロガストリン分解プロテアーゼ / Brugia malayi / システインプロテアーゼ / カテプシンD / フィラリア / 金属プロテアーゼ / Aspartic protease / ペプシン / Pepsinogen / Gene / ATP依存プロテアーゼ / ATPアーゼ / Lonプロテアーゼ / プロテアーゼLa / 多量体構造 / 電子顕微鏡観察 / 光散乱 / グルタチオンS-転移酵素 / ハロゲン化炭化水素代謝酵素 / 構造・機能相関 / キメラ酵素 / 触媒残基 / ハロゲン化炭化水素 / 脱ハロゲン化 / グルタチオンS-トランスフェラーゼ / 蛋白工学 / 活性部位残基 / 細胞内プロテオリシス / 可視化解析 / 二重蛍光基質 / FRET / 海馬スライス培養 / カスパーゼ1 / 細胞死 / グルタミン酸刺激 / 蛍光基質 / アクリロダン標識基質 / 細胞内注入 / コラゲナーゼ / カスパーゼ / 二重蛍光標識基質 / 細胞内プロテアーゼ / FRET(蛍光共鳴エネルギー転移) / 神経活性ペプチド / 神経ペプチド / カルシウム依存プロテアーゼ / 細胞骨格結合プロテアーゼ / 脊髄プロテアーゼ / カルボキシルプロテア-ゼ / 酸性プロテア-ゼ / プロクタ-ゼA / コピアプロテア-ゼ / 粘菌酸性プロテア-ゼ / プロテア-ゼ前駆体 / 水溶性カルボジイミド / X線結晶解析 / トランスポゾンプロテア-ゼ / 粘菌プロテア-ゼ / ペプシノ-ゲン / Carboxyl protease / Acid protease / Copia protease / Physarum acid protease / Protease precursor / Autocatalytic activation / プロクターゼA / プロクターゼB / カルボキシルプロテアーゼ / 部位特異的変異導入法 / 活性中心アスパラギン酸残基 / カルボキシル プロテアーゼ / 活性中心カルボキシル基 / 前駆体活性化 / 部位指定突然異導入法 / 部位指定突然変異導入法 / Proctase B / carboxyl proteinase / autocatalytic activation / active site asparticacid residue / X-ray crystallography / ペプチドライブラリー / 樹脂固定化ペプチド / 系統的特異性検索法 / エンドペプチダーゼ / サブサイト特異性 / 化学合成 / Peptide libraty / Resin-bound peptide / substrate specificity / Systematic specificity analysis / Protease / Endopeptidase / Chymotrypsin / Subsite specificity / 胃・腸管系プロテアーゼ / VIP分解エンドペプチダーゼ / 胃トリプシン / α_2マクログラブリン / α_2マクログロブリン / プロリルエンドペプチダーゼ / αキモトリプシン / β-アミロイドペプチド / 細胞内トリプシン / プロセシング / 蛋白分解 / gastrointestinal proteinase / VIP-degrading endopeptidase / gastric trypsin / enteropeptidase / hepsin / pepsinogen / _2-macroglobulin / trypsin / フィラリア・プロテアーゼ / cDNAライブラリー / システイン・プロテアーゼ / クローニング / 塩基配列決定 / ヒト・フィラリア / ウシ・フィラリア / フィラリアプロテアーゼ / カテプシンロ / ガストリックシン / カテプシンS / 塩基配列解析 / PCR / Filarial proteinase / cDNA Library / Aspartic proteinase / Cryteine proteinase / Cloning / Base sequence analysis / Human filaria / Bovine filaria / 脳・腸管系プロテアーゼ / コロプシン / 膜結合プロテアーゼ / カテプシンE遺伝子 / 膜結合性プロテアーゼ / セリンプロテアーゼ / CAAX-モチーフ特異的プロテアーゼ / Brain-gut proteinase / Progastrin-cleaving proteinase / CAAX-motif-specific proteinase / Hepsin / Colopsin / Membrane-bound proteinase / Proteinase / マレー系状虫 / 脱ユビチキン化プロテアーゼ / cDNAクローニング / 異宿主発現 / マレー糸状虫 / 組織内分布 / 抗体染色 / 線虫 / filaria / cysteine protease / metalloprotease / deubiquitinating enzyme / cDNA cloning / heterologous expression / 一次構造 / 活性化機構 / 転写制御因子 / DNAメチル化 / 塩基配列 / 活性化 / メチル化 / Rhizopusペプシン / Slowーmoving protease / プレペプシノーゲン / エクソン / イントロン / プロガストリックシン / シグナルペプチド / Primary structure / Activation mechanism / Site-directed mutagenesis / DNA methylation / モノクローナル抗体 / ELISA法 / ラジオイムノアッセイ / 胃潰瘍 / 胃癌 / 酵素免疫測定法 / ELISA / Slow-movingプロテアーゼ(SMP) / Pepsin / Monoclenal antibody / Enzyme-linked immunosotbent assay (ELISA) / Radioimmunoassay / Gastric ulcer
…
More
Except Principal Investigator
NMR / グルタチオントランスフェラーゼ / グルタチオン / 触媒機構 / プロテアーゼ / 核磁気共鳴法 / 加水分解酵素 / プロテア-ゼ / 基質特異性 / チオレドキシン / Caenorhabditis elegans / Brugia malayi / RNAi / カルパイン / カテプシン / ミオシン / アクトミオシン / ATPase / 反応中間体 / サブフラグメント1 / 活性部位の共通性と独自性 / 機能発現機構 / アクロモバクタープロテアーゼI / リボヌクレアーゼ / ホスホリパーゼA_2 / 非ペプシン型プロテアーゼ / 立体構造の相同性 / 蛋白工学 / タンパク質立体構造 / X線結晶解析 / 部位特異的変異 / 薬物代謝酵素 / 静電ポテンシャル / 分子動力学 / システイン / チオール / 発現系 / 変異原性試験 / RNA合成 / タンパク質合成 / 細胞内プロセシング / リボソームRNA / キャッピング / シグナルペプチド / スプライシング / ウイロイドRNA / プロテアーゼによる情報発現 / 筋組織特異的94Kカルパイン / スロンボモジュリンの発現調節 / 血球内凝固因子 / 脳梗塞巣活性化カルパイン / アミロイドジェニックプロテアーゼ / カテプシンの細胞内選別輸送 / カテプシンの抗原提示への関与 / 筋組織特異的94Kカルバイン / カテプシン-インバリアント鎖による抗原提示の調節 / 筋組織特異的カルパイン / プロガストリンの活性化 / 心筋梗塞巣活性化カルパイン / カテプシンBの抗原阻囎への関与 / トランスゴルジ膜結合性プロセシングプロテアーゼ / プロテア-ゼによる情報発現 / プレプロタキキニン遺伝子発現調節因子 / カルパインの活性化 / カルパインペプチドの白血球遊走活性 / T細胞エイズレセプタ- / 26Sプロテアソ-ム / ニュ-カッスル病ウイルス / Limited proteolysis / 94K calpain / Thrombomodulin / Hematocyte coagulation factor / Calpain activation due to inafarotion / Amyloidogenic protease / Intracellular protease transport / Antigen presentation / 哺乳類卵巣 / 成熟卵胞 / Mammalian Ovary / Maturation of Follicle / Proteinase / 酸性プロテアーゼ / 非ペプシン型 / 核磁気共鳴 / X線結晶構造解析 / 3次元構造解析 / 構造解析 / クロコウジカビ / 非ペプシン型酸性プロテアーゼ / 3次元構造 / Acid proteinase / Non-pepsin-type / Nuclear magnetic resonance / x-ray crystallography / Three-dimensional structural analysis / Structural analysis / フィラリア / 線虫 / ポストゲノム / 寄生虫 / 阻害剤 / cDNA / アスパラギン酸プロテアーゼ / システインプロテアーゼ / 金属プロテアーゼ / filaria / nematode / protease / post genome / parasite / プロテオリシス / プレプロエンザイムの活性化 / シグナルペプチダーゼ / プロティナーゼインヒビター / キニノーゲン / プロティナーゼの活性制御 / Proteolysis / Proteinase inhibitor / Kininogen / Calpain / Calpastatin / Cathepsin / Signal peptidase / プロテアソ-ム / 遺伝子発現 / アテプシン / 病態 / プロテアーゼインヒビター / カルシウムプロテアーゼ / ATPプロテアーゼ / プロセシング / Protease / calpain / cathepsin / proteasome / gene expression
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Research Projects
(
30
results)
Co-Researchers
(
42
People)
Project Start Year (Newest)
Project Start Year (Oldest)
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化
Principal Investigator
井上 英史
Project Period (FY)
1999
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Tokyo University of Pharmacy and Life Science
Post-genome study on filarial proteases for development of inhibitors.
Principal Investigator
HIDESHI Inoue
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
医薬分子機能学
Research Institution
Tokyo University of Pharmacy and Life Science
Molecular Biological Studies on the Proteases and .Their Inhibifors of Filarial Parasites
Principal Investigator
Principal Investigator
TAKAHASHI Kenji
Project Period (FY)
1999 – 2001
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Structural biochemistry
Research Institution
Tokyo University of Pharmacy and Life Science
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化
Principal Investigator
井上 英史
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Tokyo University of Pharmacy and Life Science
生細胞における蛋白質分解過程の可視化解析
Principal Investigator
Principal Investigator
高橋 健治
Project Period (FY)
1998 – 2000
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Cell biology
Research Institution
Tokyo University of Pharmacy and Life Science
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化
Principal Investigator
井上 英史
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Tokyo University of Pharmacy and Life Science
Structural, Functional and Physiological Characterization of Novel Brain-Gut Proteinases
Principal Investigator
Principal Investigator
TAKAHASHI Kenji
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Structural biochemistry
Research Institution
Tokyo University of Pharmacy and Life Science
環境汚染物質の除去を目的としたハロゲン化炭素水素代謝酵素の蛋白工学的研究
Principal Investigator
Principal Investigator
高橋 健治
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Tokyo University of Pharmacy and Life Science
立体構造と蛋白工学的解析に基づくグルタチオン・トランスフェラーゼの機能発現機構
Principal Investigator
井上 英史
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Biological pharmacy
Research Institution
Tokyo University of Pharmacy and Life Science
Studies on Filarial Proteinases and Their Inhibitors for Development of Filarial Drugs
Principal Investigator
Principal Investigator
TAKAHASHI Kenji
Project Period (FY)
1996 – 1998
Research Category
Grant-in-Aid for international Scientific Research
Research Field
Structural biochemistry
Research Institution
Tokyo University of Pharmacy and Life Science
大腸菌ATP依存性プロテアーゼLonの構造と機能
Principal Investigator
Principal Investigator
高橋 健治
Project Period (FY)
1995
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Tokyo University of Pharmacy and Life Science
環境汚染物質の除去を目的としたハロゲン化炭化水素代謝酵素の蛋白工学的研究
Principal Investigator
Principal Investigator
高橋 健治
Project Period (FY)
1995
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Tokyo University of Pharmacy and Life Science
Systematic search for novel proteinases in gastrointestinal tract and studies on their physiological roles and structure/function
Principal Investigator
Principal Investigator
TAKAHASHI Kenji
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Structural biochemistry
Research Institution
Tokyo University of Pharmacy and Life Science
大腸菌ATP依存性プロテアーゼLonの構造と機能
Principal Investigator
Principal Investigator
高橋 健治
Project Period (FY)
1994
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
Development of a systematic method for analyzing the specificity of proteases and its application
Principal Investigator
Principal Investigator
TAKAHASHI Kenji
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for Developmental Scientific Research (B)
Research Field
Structural biochemistry
Research Institution
Tokyo University of Pharmacy and Life Science
The University of Tokyo
大腸菌ATP依存性プロテアーゼLonの構造と機能
Principal Investigator
Principal Investigator
高橋 健治
Project Period (FY)
1993
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
Studies on Carboxyl Proteinases : Comparative Analysis of Functional Structures and Catalytic Mechanisms of Proctases A and B
Principal Investigator
Principal Investigator
TAKAHASHI Kenji
Project Period (FY)
1993 – 1994
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Structural biochemistry
Research Institution
The University of Tokyo
Three-dimensional structural analysis of non-pepsin-type acid proteinase using NMR and x-ray crystaliography
Principal Investigator
TANOKURA Masaru
Project Period (FY)
1993 – 1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Biophysics
Research Institution
The University of Tokyo
加水分解酵素の機能発現機構
Principal Investigator
崎山 文夫
Project Period (FY)
1992
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
物質生物化学
Research Institution
Osaka University
BIOCHEMICAL AND INNUNOHISTOCHEMICAL STUDIES OF A NOVEL PROTEINASE PRESENT IN THE FOLLICULAR FLUID OF MAMMALIAN OVARY
Principal Investigator
TAKAHASHI Takayuki
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
動物形態・分類学
Research Institution
HOKKAIDO UNIVERSITY
The University of Tokyo
りん核磁気共鳴法によるアクトミオシン反応中間体の立体構造の研究
Principal Investigator
TANOKURA Masaru
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
加水分解酵素の機能発現機構
Principal Investigator
崎山 文夫
Project Period (FY)
1991
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
物質生物化学
Research Institution
Osaka University
Roles of proteases in signal transduction and their disorders
Principal Investigator
SASAKI Makoto
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Pathological medical chemistry
Research Institution
Nagoys City Unversity Medcal School
Studies on the molecular properties and the structure-function relationships of carboxyl proteases of novel type
Principal Investigator
Principal Investigator
TAKAHASHI Kenji
Project Period (FY)
1990 – 1991
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
物質生物化学
Research Institution
The University of Tokyo
Regulation and Pathology of Gene Expression of Intracellular Proteases Science, Dept. Mol. Biol., Director
Principal Investigator
SUZUKI Koichi
Project Period (FY)
1988 – 1990
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Pathological medical chemistry
Research Institution
Tokyo Metropolitan Institute of Medical Science
RNAおよびタンパク質生合成におけるプロセシング
Principal Investigator
水島 昭二
Project Period (FY)
1986
Research Category
Grant-in-Aid for Special Project Research
Research Institution
Nagoya University
Development of an immunochemical method for determination of human kepsinogen isozynogens and its clinical application
Principal Investigator
Principal Investigator
TAKAHASHI Kenji
Project Period (FY)
1986 – 1987
Research Category
Grant-in-Aid for Developmental Scientific Research
Research Field
広領域
Research Institution
The University of Tokyo
神経活性ペプチドの生成,分解に関与するプロテアーゼ系の解析
Principal Investigator
Principal Investigator
高橋 健治
Project Period (FY)
1985
Research Category
Grant-in-Aid for Special Project Research
Research Institution
The University of Tokyo
Biological significance of proteolysis and its regulation
Principal Investigator
SASAKI Makoto
Project Period (FY)
1985 – 1986
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
代謝生物化学
Research Institution
Nagoya City University Medical School
Studies on the structure and function of aspartic proteases and their genes
Principal Investigator
Principal Investigator
TAKAHASHI Kenji
Project Period (FY)
1985 – 1988
Research Category
Grant-in-Aid for General Scientific Research (A)
Research Field
物質生物化学
Research Institution
The University of Tokyo
# of Projects (Dsc)
# of Projects (Asc)
1.
INOUE Hideshi
(20184765)
# of Collaborated Projects:
13 results
# of Collaborated Products:
0 results
2.
KOJIMA Masaki
(90277252)
# of Collaborated Projects:
9 results
# of Collaborated Products:
0 results
3.
SUZUKI Koichi
(80011948)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
4.
MURAMATSU Tomonari
(70212256)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
5.
TANOKURA Masaru
(60136786)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
6.
IWANAGA Sadaaki
(90029942)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
7.
SASAKI Makoto
(10080003)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
8.
NISHII Wataru
(30287461)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
TAKAHASHI Takayuki
(80197152)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
KATUNUMA Nobuhiko
(50035375)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
ICHIHARA Akira
(20035405)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
MURACHI Takashi
(10089104)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
崎山 文夫
(40029947)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
勝部 幸輝
(20032013)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
15.
OHKUBO Iwao
(80152073)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
YAMAGATA Hideo
(20023468)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
MIKI Kazumasa
(70107639)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
SUGITA Hideo
(80009951)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
KATO Keitaro
(70037571)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
三井 幸雄
(40012637)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
井本 泰治
(90038282)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
工藤 佳久
(20080179)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
中村 健
(50227906)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
水島 昭二
(50013313)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
石浜 明
(80019869)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
緒方 規矩雄
(00018285)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
上代 淑人
(90012690)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
丹治 雅夫
(50212048)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
木南 英紀
(10035496)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
市原 明
(40035374)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
SENARCTH Dis
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
R.WEERAPPULI ウィーラプリ アール
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
ATHAUDA Sena
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
ATHOUDA Senarath B.P.
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
WINALASIRI Weerappuli R.
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
DISSONAYAKE Senarath
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
37.
SENARATH Dis
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
38.
WEELAPPULI R
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
39.
SENARATH B.P
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
40.
DISSANAYAKE セナラッツ
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
41.
WIMALASIRI W
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
42.
DISSANAYAKE セナラッツ.
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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