SAWAI Hiroaki 澤井宏明

… Alternative Names

沢井宏明サワイヒロアキ

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Researcher Number	70012648
Other IDs
External Links
Affiliation (based on the past Project Information) *help	1995 – 2004: 群馬大学, 工学部, 教授 1988 – 1993: 群馬大学, 工学部, 教授 1986: 東大, 薬学部, 助手
Review Section/Research Field	Principal Investigator Synthetic chemistry / Bioorganic chemistry / Science and Engineering / Synthetic chemistry
Keywords	Principal Investigator DNA / 核酸 / PCR / 標識化 / オリゴヌクレオチド / Nucleic Acid / 機能性DNA / 生体機能利用 / DNAポリメラーゼ / 5-Substituted 2'-Deoxyuridines … More / Modified Nucleic Acids / 修飾核酸 / 核酸結合形成 / 触媒 / 希土類錯体 / 生理活性物質 / Metal Ion Catalyst / Selective Synthesis / Pyrophosphate Bond / 2'-5' Internucleotide Bond / Oligonucleotide / Uranyl Complex / Biologically Active Compounds / 2´- 5´結合 / 核酸-金属錯体 / 核酸関連生理活性物質 / 金属イオン触媒 / 選択合成 / ピロリン酸結合 / 2'-5'結合 / ウラニル錯体 / 5-Substituted 2'-Deoxycytidines / Enzymatic reaction / DNA Catalyst / DNA Polymerase / 5位置換チミヂン / 化学合成 / 5位置換チミジン / 生体機能 / 酵素合成 / Aptamer / Molecular Recognition / Enzymatic Reaction / Modified Substrate / DNA polymerase / Modified DNA / 試験管内選択 / DNA触媒 / DNAアプタマー / 糖鎖 / アプタマー / 分子認識 / 酵素反応 / 修飾基質 / 修飾DNA / Labeled DNA / Tris-Amine / RNA Cleaving Activity / 2-Substituted Deoxyuanosine Derivatives / 2'-Modiifed Nucleosides / アンチセンス核酸 / α-ヌクレオシド / 2'デオキシウリジン誘導体 / 2重鎖形成能 / 2'-位置換スクレオシド / トリスアシン / 標識化DNA / トリスアミン / RNA分解活性 / 2位置換グアノシン誘導体 / 2'-位置換ヌクレオシド / 2'-デオキシウリジン誘導体 / たんぱく合成阻害 / 細胞増殖阻害 / インターフェロン / 2′-5′オリゴヌクレオチド / 蛍光 / 修触核酸 / ユーロピウム / アクチニド系金属イオン / 補酵素類 / 合成 / ピロりん酸結合 / Cd^<2+>ー錯体 / Mn^<2+>ー錯体 / 二価金属イオン触媒 … More Except Principal Investigator キャップ構造 / 2-5A / アンチセンス核酸 / オリゴチオアデニル酸 / ヌクレオチドリンポルフィリン誘導体 / オリゴヌクレオチド / リン酸トリエステル修飾DNA / 人工制限酵素 / 5'-ポリリン酸ヌクレオチド / 人工光制限酵素 / オリゴヌクレオチドP(V)ポリフィリン誘導体 / 2'-O-D-リボフラノシルアデノシン / CMP-シアル酸 / ピロリン酸結合 / 修飾塩基 / アセチルセルロ-ス担体 / オリゴヌクレオチドりんポルフィリン誘導体 / グアノシンのメチル化 / 2ー5A / 水酸基活性化法 Less

Enzymatic Synthesis of Modified DNAs by PCR, and Their ApplicationPrincipal Investigator
- Principal Investigator
  
  SAWAI Hiroaki
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Gunma University
Preparation of Novel Modified Oligonucleotides by Chemic-Enzymatic Method and Their Application for the production of New DNA CatalystPrincipal Investigator
- Principal Investigator
  
  SAWAI Hiroaki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Gunma University
Preparation of Novel Modified Oligonucleotides and Their Application to Man-made Enzymes with Sequence-Specific RNA-Cleaving ActivityPrincipal Investigator
- Principal Investigator
  
  SAWAI Hiroaki
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Synthetic chemistry
- Research Institution
  Gunma University
希土類錯体を触媒に用いた水溶液中での核酸結合形成反応Principal Investigator
- Principal Investigator
  
  沢井宏明
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gunma University
希土類錯体を触媒に用いた水溶液中での核酸結合形成反応Principal Investigator
- Principal Investigator
  
  沢井宏明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gunma University
特異な構造をもつRNAの化学合成と反応
- Principal Investigator
  
  早川芳宏
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
特異な構造をもつRNAの化学合成と反応
- Principal Investigator
  
  早川芳宏
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
Mn^<2+>ーおよびCd^<2+>ー錯体を用いた核酸系生理活性物質の簡便で効率的な合成Principal Investigator
- Principal Investigator
  
  沢井宏明
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Gunma University
Efficient and Selective Synthesis of Biologically Active Compounds Related to Nucleic Acid by Uranyl Complex CatalystPrincipal Investigator
- Principal Investigator
  
  SAWAI Hiroaki
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Gunma University
細胞増殖阻害活性を有するオリゴヌクレオチド類の合成とその抗腫瘍作用Principal Investigator
- Principal Investigator
  
  沢井宏明
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo

All 2004 2003

All Journal Article Book

[Book] 人工修飾核酸を用いた試験管内選択法(セレックス法)の拡張「ゲノムケミストリー」2003
- Author(s)
  澤井宏明他
- Total Pages
  17
- Publisher
  講談社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] Selective Binding and Cleavage of DNA by Stereoisomers of N,N'-Bis(phenanthrolin-2-yl)-1,2-cycolhexanediamine Conjugate, and their Copper Complexes2004
- Author(s)
  K.Hyashi, R.Nakjima, I.Kiyosawa, H.Ozaki, H.Sawai
- Journal Title
  
  Chem.Lett. 33
  
  Pages: 684-685
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] Bis(phenanthroline)-ethylenediamine conjugate displays excimer fluorescence upon binding with DNA2004
- Author(s)
  K.Hatashi, H.Akutsu, H.Ozaki, H.Sawai
- Journal Title
  
  Chem.Comm.
  
  Pages: 1386-1387
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] Screening of modified DNA aptamers that recognize DNA secondary structure2004
- Author(s)
  M.Kuwahara, T.Kasamatsu, M.Hasgawa, A.Shoji, H.Ozaki, H.Sawai
- Journal Title
  
  Nucleic Acids Symp.Ser. 48
  
  Pages: 265-266
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] Detection of biomolecule by aotamer beacon2004
- Author(s)
  A.Nishihira, H.Ozaki, M.Wakabayashiu, M.Kuwahara, H.Sawai
- Journal Title
  
  Nucleic Acids Symp.Ser. 48
  
  Pages: 135-136
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] 5位置換ピリミヂンヌクレオシドを含むオリゴヌクレオチドの合成とその性質2004
- Author(s)
  尾崎宏明, 桑原正靖, 澤井宏明
- Journal Title
  
  有機合成化学協会誌 62
  
  Pages: 1238-1248
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] Sialllyllactose-binding modified DNa aptamer bearing additional functionality by SELEX2004
- Author(s)
  M.M.Masud, M, M.Kuwahara, H.Ozaki, H.Sawai
- Journal Title
  
  Bioorg.Med.Chem. 12
  
  Pages: 1111-1120
- Data Source
  KAKENHI-PROJECT-13132202

1. OZAKI Hiroaki (90211820)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. 早川芳宏 (50022702)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 石戸良治 (60016037)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 清水剛夫 (10025893)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 畑辻明 (00016049)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KUWAHARA Masayasu (40334130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 篠塚和夫 (20206105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAWAI Hiroaki 澤井 宏明

沢井 宏明 サワイ ヒロアキ

Research Projects

Research Products

Co-Researchers

Enzymatic Synthesis of Modified DNAs by PCR, and Their ApplicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Preparation of Novel Modified Oligonucleotides by Chemic-Enzymatic Method and Their Application for the production of New DNA CatalystPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Preparation of Novel Modified Oligonucleotides and Their Application to Man-made Enzymes with Sequence-Specific RNA-Cleaving ActivityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

希土類錯体を触媒に用いた水溶液中での核酸結合形成反応Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

希土類錯体を触媒に用いた水溶液中での核酸結合形成反応Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

特異な構造をもつRNAの化学合成と反応

Principal Investigator

Project Period (FY)

Research Category

Research Institution

特異な構造をもつRNAの化学合成と反応

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Mn^<2+>ーおよびCd^<2+>ー錯体を用いた核酸系生理活性物質の簡便で効率的な合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Efficient and Selective Synthesis of Biologically Active Compounds Related to Nucleic Acid by Uranyl Complex CatalystPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞増殖阻害活性を有するオリゴヌクレオチド類の合成とその抗腫瘍作用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] 人工修飾核酸を用いた試験管内選択法(セレックス法)の拡張「ゲノムケミストリー」2003

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Selective Binding and Cleavage of DNA by Stereoisomers of N,N'-Bis(phenanthrolin-2-yl)-1,2-cycolhexanediamine Conjugate, and their Copper Complexes2004

Author(s)

Journal Title

Data Source

[Journal Article] Bis(phenanthroline)-ethylenediamine conjugate displays excimer fluorescence upon binding with DNA2004

Author(s)

Journal Title

Data Source

[Journal Article] Screening of modified DNA aptamers that recognize DNA secondary structure2004

Author(s)

Journal Title

Data Source

[Journal Article] Detection of biomolecule by aotamer beacon2004

Author(s)

SAWAI Hiroaki 澤井宏明

沢井宏明サワイヒロアキ