Osaki Tokio 尾崎登喜雄

… Alternative Names

OSAKI Tokio 尾崎登喜雄

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Researcher Number	70031995
External Links
Affiliation (Current)	2025: 高知大学, その他部局等(名誉教授), 名誉教授
Affiliation (based on the past Project Information) *help	2012: 高知大学, その他部局等, 名誉教授 2007 – 2011: Kochi University, 名誉教授 2003: Kochi Medical School, Department of Oral Surgery, Professor, 医学部, 教授 1995 – 2002: 高知医科大学, 医学部, 教授
Review Section/Research Field	Principal Investigator 病態科学系歯学(含放射線系歯学) / Surgical dentistry / Surgical dentistry Except Principal Investigator 病態科学系歯学(含放射線系歯学)
Keywords	Principal Investigator p21 / p53 / Mn-SOD / 活性酸素 / CdK / 5-FU / 唾液 / アポトーシス / 放射線 / β-catenin … More / claudin / occludin / tight junction / reactive oxygen species / invasion / oral cancer / 活性酵素 / β-カテニン / クラウジン / オクルジン / タイトジャンクション / 浸潤 / 口腔癌 / reactive oxygen intermediates / macrophage / neutrophil / saliva / lactoferrin peptide / lactoferrin / candidiasis / ディフェンシン / NADPH / マクロファージ / 好中球 / ラクトフェリンペプタイド / ラクトフェリン / カンジダ症 / bcl-2 family / differentiation induction / apoptosis induction / cdk / bcl-2ファミリー / 分化誘導 / アポトーシス誘導 / cyclin-dependent kinase / gamma-rays / TGF-beta / apoptosis / squamous cell carcinoma cells / 扁平上皮癌 / サイクリン依存キナーゼ / TGF-β / 扁平上皮癌細胞 / MIC / Genotype / Phenotype / 抗真菌剤 / 口腔カンジダ菌 / 病原性 / カンジダ / 抗菌ペプチド / 病原因子 / 口腔カンジダ症 / Tfam / POLG / OGG1 / DNA損傷修復 / 相同組み換え / 17-AAG / Rad51 / DNA損傷 / 口腔扁平上皮癌 … More Except Principal Investigator Mn-SOD / Peptide 2 / 活性酸素 / cytokine / CD59 / サイトカイン / neutrophils / aspergillosis / candidiasis / cytochrome P450 / β-defensin / α-defensin / antimicrobial peptide / カンジタ症 / チトクロームp450 / Peptide2 / 好中球 / アスペルギルス症 / カンジダ症 / チトクロームP450 / β-ディフェンシン / α-ディフェンシン / 抗菌ペプタイド / cytotoxic activity / lymphocyte subpopulation / reactive oxygen species / surface antigens / intranodal injection / peplomycin / ミトコンドリア / AIF / チトクロームC / Fas L / Fas / FGF-2 / IFN-γ / IL-2 / T細胞 / 細胞傷害能 / リンパ球亜集団 / 細胞傷害活性 / リンパ球亜群 / 表面抗原 / リンパ節内注入 / ペプロマイシン / LAK cells / HィイD22ィエD2OィイD22ィエD2 / reactive oxygen intermediates / apoptosis / squamous cell carcinoma cells / LAK細胞 / H_2O_2 / アポトーシス / 扁平上皮癌細胞 / lipopolysaccharide (LPS) / nuclear factor (NF)-_KB / mononulcear leukocytes / beta_1 and beta_2 integrins / keratinocytes / oral lichen planus / 細胞内シグナル伝達 / チロシンリン酸化 / 接着因子 / migration / LPS / NF-KB / 単核球 / β_1およびβ_2インテグリン / ケラチノサイト / 口腔扁平苔癬 Less

Investigation of factors involved in the acquisition of pathogenicity of oral Candida species and their control by anti-microbial peptidesPrincipal Investigator
- Principal Investigator
  
  OSAKI Tokio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kochi University
Development of novel treatment for oral cancer due to analysis of DNA repair systemPrincipal Investigator
- Principal Investigator
  
  OSAKI Tokio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kochi University
Biological investigation of antimicrobial peptides for the regulation of fungal infections
- Principal Investigator
  
  UETA Eisaku
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Kochi Medical School
Basic investigation on moledules which regulate the sensitivity of oral squamous cell carcinoma (cells) to chemo-radio-immunotherapyPrincipal Investigator
- Principal Investigator
  
  OSAKI Tokio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kochi Medical School
BIOFILM OF ORAL CANDIDA AND BIOLOGICAL INVESTIGATION ON CANDIDA-REGULATING FACTORS IN SALIVAPrincipal Investigator
- Principal Investigator
  
  OSAKI Tokio
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Kochi Medical school
GROWTH OF METASTATIC CACNER CELLS IN THE LYMPH NODES AND ITS REGULATION BY LYMPHOCYTES
- Principal Investigator
  
  YAMAMOTO Tetsuya
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  高知医科大学
CLINICAL AND BASIC INVESTIGATION ON APOPTOSIS OF HEAD AND NECK CARCINOMAS BY MULTIDISCIPLINARY TREATMENTSPrincipal Investigator
- Principal Investigator
  
  OSAKI Tokio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Kochi Medical School
THE ROLE OF REACTIVE OXYGEN INTERMEDIATES AND THEIR SCAVENGERS ON APOPTOSIS INDUCTION OF SQUAMOUS CELL CARClNOMA CELLS
- Principal Investigator
  
  YONEDA Kazunori
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Kochi Medical School
Intracellular Signal Transduction in Oral Keratinocytes and Infiltrated Lymphocytes Obtained from Patients with Oral Lichen Planus-Biochemical Analysis of the Mechanism of Enhanced Cytokine Generation from Keratinocytes and Infiltration of Lymphocytes
- Principal Investigator
  
  YAMAMOTO Tetsuya
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Kochi Medical School
THE MECHANISM OF DIFFERENTIATION IN SQUAMOUS CELL CARCINOMA CELLS AND INDUCTION OF APOPTOSIS IN HEAD AND NECK CARCINOMASPrincipal Investigator
- Principal Investigator
  
  OSAKI Tokio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kochi Medical School

All 2011 2008 2007

All Journal Article Presentation Book

[Book] 口腔内科学2008
- Author(s)
  尾崎登喜雄
- Total Pages
  462
- Publisher
  株式会社飛鳥出版室
- Data Source
  KAKENHI-PROJECT-19592300
[Journal Article] Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system2008
- Author(s)
  Eisaku Ueta, Eri Sasabe, Zhu Yang, Tokio Osaki, Tetsuya Yamamoto
- Journal Title
  
  Cancer Science 99
  
  Pages: 2230-2237
- NAID
  10024013145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592300
[Journal Article] Enhancement of apoptotic damage of squamous cell carcinoma. cells by inhibition of the mitochondria] DNA repairinlg system.2008
- Author(s)
  Ueta E, Sasabe F, Yang Z, Osaki T, Yamamoto T
- Journal Title
  
  Cancer Sci 99
  
  Pages: 2230-2237
- Data Source
  KAKENHI-PROJECT-19592300
[Journal Article] The endogenous reactive oxygen species promote NF-KB activation by targeting on activation of NF-kB-inducing kinase in oral squamous carcinoma cell2007
- Author(s)
  Wang Y, Huang X, Cang H, Gao F, Ymamoto T, Osaki T, Yi J
- Journal Title
  
  Free Radic Res 41(9)
  
  Pages: 963-971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592300
[Journal Article] The involvement of hypoxia-inducible factor-1αin the susceptibility toγ-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells.2007
- Author(s)
  Sasabe E, Zhou X, Li D, Oku N, Yamamoto T, Osaki T
- Journal Title
  
  Int J Cancer 120(2)
  
  Pages: 268-77
- Data Source
  KAKENHI-PROJECT-19592300
[Journal Article] EGCG-targeted p57/KTP2 reduces tumorigenicity of oral carcinoma. cells: Role of c-Jun N-terminal kinase.2007
- Author(s)
  Yamamoto T, Digumarthi H, Aranbayeva. Z, Wataha J, Lewis j, Messer R, Qin H, Dickinson D, Osaki T, Schuster GS, Hsu S
- Journal Title
  
  Toxicol Appl Pharmacol 224(3)
  
  Pages: 318-325
- Data Source
  KAKENHI-PROJECT-19592300
[Journal Article] The endogenous reactive oxygen species promote NF-KB activation by targeting on activation of NF-KB-inducing kinase in oral squamous carcinoma cells.2007
- Author(s)
  Yumei Wang, Xinzhi Huang, Hui Cang, Fei Gao, Tetsuya Yamamoto, Tokio Osaki, jing Yi
- Journal Title
  
  Free Radical Research 41(9)
  
  Pages: 963-971
- Data Source
  KAKENHI-PROJECT-19592300
[Presentation] Repetitive-sequence-based PCR法を用いた口腔カンジダ菌のGenotypingに関する検討2011
- Author(s)
  森下慶子、成川玄、尾崎登喜雄、山本哲也
- Organizer
  第3回高知口腔科学研究会
- Place of Presentation
  高知医療センター・黒潮ホール、高知市
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22592217

1. YAMAMOTO Tetsuya (00200824)

# of Collaborated Projects: 10 results

# of Collaborated Products: 6 results
2. UETA Eisaku (10203431)

# of Collaborated Projects: 9 results

# of Collaborated Products: 2 results
3. KIMURA Tsuyoshi (10294836)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. YONEDA Kazunori (90182849)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. KAMATANI Takaaki (00315003)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SASABE Eri (40363288)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
7. SATAKE Hidetaka (10304685)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OKU Naohisa (20363286)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TATEISHI Yoshihisa (20372732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SUGIHARA Kazumasa (00117516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAMIKAWA Yoshiaki (30332901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MORISHITA Keiko (10527584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. KITAMURA Naoya (70351921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OHNO Seiji (40624995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Osaki Tokio 尾崎 登喜雄

OSAKI Tokio 尾崎 登喜雄

Research Projects

Research Products

Co-Researchers

Investigation of factors involved in the acquisition of pathogenicity of oral Candida species and their control by anti-microbial peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel treatment for oral cancer due to analysis of DNA repair systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biological investigation of antimicrobial peptides for the regulation of fungal infections

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic investigation on moledules which regulate the sensitivity of oral squamous cell carcinoma (cells) to chemo-radio-immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

BIOFILM OF ORAL CANDIDA AND BIOLOGICAL INVESTIGATION ON CANDIDA-REGULATING FACTORS IN SALIVAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

GROWTH OF METASTATIC CACNER CELLS IN THE LYMPH NODES AND ITS REGULATION BY LYMPHOCYTES

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CLINICAL AND BASIC INVESTIGATION ON APOPTOSIS OF HEAD AND NECK CARCINOMAS BY MULTIDISCIPLINARY TREATMENTSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE ROLE OF REACTIVE OXYGEN INTERMEDIATES AND THEIR SCAVENGERS ON APOPTOSIS INDUCTION OF SQUAMOUS CELL CARClNOMA CELLS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Intracellular Signal Transduction in Oral Keratinocytes and Infiltrated Lymphocytes Obtained from Patients with Oral Lichen Planus-Biochemical Analysis of the Mechanism of Enhanced Cytokine Generation from Keratinocytes and Infiltration of Lymphocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE MECHANISM OF DIFFERENTIATION IN SQUAMOUS CELL CARCINOMA CELLS AND INDUCTION OF APOPTOSIS IN HEAD AND NECK CARCINOMASPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 口腔内科学2008

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Enhancement of apoptotic damage of squamous cell carcinoma. cells by inhibition of the mitochondria] DNA repairinlg system.2008

Author(s)

Journal Title

Data Source

[Journal Article] The endogenous reactive oxygen species promote NF-KB activation by targeting on activation of NF-kB-inducing kinase in oral squamous carcinoma cell2007

Osaki Tokio 尾崎登喜雄

OSAKI Tokio 尾崎登喜雄