YASUYUKI Igarashi 五十嵐靖之

… Alternative Names

Researcher Number	70091965
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007: Hokkaido University, Faculty of Advanced Life Science, Professor 2006: 北海道大学, 大学院先端生命科学研究院, 教授 1999 – 2004: 北海道大学, 大学院・薬学研究科, 教授 2003: 北海道大学, 薬学研究科, 教授
Review Section/Research Field	Principal Investigator Biological Sciences / Functional biochemistry / Functional biochemistry Except Principal Investigator Urology / Biological Sciences / Biological pharmacy / 応用薬理学・医療系薬学 / Biological pharmacy
Keywords	Principal Investigator スフィンゴシン1-リン酸 / スフィンゴ脂質 / 糖脂質 / スフィンゴシンキナーゼ / セラミド / 細胞膜ミクロドメイン / シグナル伝達 / G蛋白質 / Edg受容体 / 生理活性脂質 … More Except Principal Investigator ガングリオシド / GALA / 2型糖尿病 / スフィンゴ糖脂質 / 阻害剤 / 促進剤 / 記憶 / シナプス / 神経機能 / トランスフェリン / アポトーシス / 生活習慣病 / インスリン抵抗性 / マイクロドメイン / 癌 / 抗ガン剤抵抗性 / VDAC / TNFα / ターゲティング / L-PDMP / ミトコンドリア / チトクロームC / GD3 / Transitionall cell carcinoma / Cyclooxygenase / Lipoxygenase / 5-LOX / Seminal vesicle / ガンクリオシド / インシュリン抵抗性 / スルファチド / ラミニン / フィブロネクチン / インテグリン / 造腫瘍能 / 細胞接着 / Gangliosides / Inhibitor / Stimulator / Neuronal Function / Apoptosis / type 2 Diabetes / Insulin Resistance / 細胞内動態制御 / トランスフェリン修飾リポソーム / エンドサイトーシス / リサイクル / リポソーム / 耐性 / intracellular trafficking / transferrin liposomes / endocytosis / recycling / 脂肪細胞 / lifestyle-related disease / type 2 diabetes / ganalioside / Insulin resistance / microdomain / adioocyte Less

Biological functions of Sphingolipids and their relevance to pathological phenomenaPrincipal Investigator
- Principal Investigator
  
  YASUYUKI Igarashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
癌および2型糖尿病の病態とスフィンゴ糖脂質マイクロドメイン
- Principal Investigator
  
  井ノ口仁一
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Involvement of ganglioside in lifestyle-related disease and cancer, and the development of new diagnostic method and therapeutic strategy
- Principal Investigator
  
  INOKUCHI Jun-ichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Molecular Mechanism of production and secretion of platelet-derived bioactive lysolipidsPrincipal Investigator
- Principal Investigator
  
  IGARASHI Yasuyuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築
- Principal Investigator
  
  HIDEYOSHI Harashima
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
ガングリオシド発現調節による大脳皮質シナプス機能および神経分化に関する研究
- Principal Investigator
  
  井口仁一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
スフィンゴ脂質による生体膜ドメイン形成と多機能シグナリングPrincipal Investigator
- Principal Investigator
  
  五十嵐靖之
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
スフィンゴシン1-リン酸とその受容体の情報伝達機構と生理機能の解析Principal Investigator
- Principal Investigator
  
  五十嵐靖之
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
新規転移関連遺伝子及びアラキドン酸代謝酵素と発癌・浸潤・転移の解析
- Principal Investigator
  
  白浜勉
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kagoshima University
Intracellular control of transferrin-modified liposomes with Cholesteryl GALA for optimum drug delivery system
- Principal Investigator
  
  HIDEYOSHI Harashima
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HOKKAIDO UNIVERSITY
ガングリオシド発現調節による大脳皮質のシナプス機能および神経分化に関する研究
- Principal Investigator
  
  INOKUCHI Jin-ichi
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
Biological functions of a lipid mediator, sphingosine 1-phosphatePrincipal Investigator
- Principal Investigator
  
  IGARASHI Yasuyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
Studies on neuronal functions by modulators of glycosphingolipid synthesis
- Principal Investigator
  
  INOKUCHI Jin-ichi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY

All 2008 2007 2006

All Journal Article Presentation Book

[Book] Cell Growth Arrest by Sialic Acid Clusters in Ganglioside GM3 Mimetic Polymers.2007
- Author(s)
  Uemura S, Feng F, Kume M, Yamada K, Kabayama K, Nishimura SI, Igarashi Y, Inokuchi JI.
- Publisher
  Glycobiology
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry2008
- Author(s)
  Ikeda M, Kihara A, Denpoh A, Igarashi Y.
- Journal Title
  
  Mol. Biol. Cell (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The Rim101 pathway is involved in Rsbl expression induced by altered lipid asymmetry2008
- Author(s)
  Ikeda M, Kihara A, DenpohA, Igarashi Y.
- Journal Title
  
  Mol. Biol. Cell 19(5)
  
  Pages: 1922-1931
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The attenuation of cell motility observed with high doses of Sphingosine 1 phosphate or phosphorylated FTY720 involves RGS2 through its intarartions with the receptor S1P1.2008
- Author(s)
  Kohno T, Igarashi Y.
- Journal Title
  
  Gene Cell (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Membrane topology and essential amino acid residues of PHS1, a 3-hydoroxyacyl-CoA Dehydratase involved in very long-chain fatty acid elongation2008
- Author(s)
  Kihara A, Sakuraba H, Ikeda M, Denpoh A, Igarashi Y.
- Journal Title
  
  J. Biol. Chem (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Sphingosine 1-phosphate Inhibits Nitric Oxide Production induced by Interleukin-1 in Rat Vascular Smooth Muscle Cells.2008
- Author(s)
  Machida T, Hamaya Y, Izumi S, Hamaya Y, Iizuka K, Igarashi Y, Minami M, Levi R, Hirafuji M
- Journal Title
  
  Journal of Pharmacology And Experimental Therapeutics. in press
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Membrane topology and essential amino acid residues of PHS1, a 3-hydoroxyacyl-CoA Dehydratase involved in very long-chain fatty acid elongation.2008
- Author(s)
  Kihara A, Sakuraba H, Ikeda M, Denpoh A, Igarashi Y.
- Journal Title
  
  J. Biol. Chem. (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P1.2008
- Author(s)
  Kohno T, Igarashi Y.
- Journal Title
  
  Gene Cell. (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry2008
- Author(s)
  Ikeda M, Kihara A, Denpoh A, Igarashi Y.
- Journal Title
  
  Mol. Biol. Cell 19(5)
  
  Pages: 1922-1931
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Sphingosine 1-phosphate Inhibits Nitric Oxide Production induced by Interleukin-1 in Rat Vascular Smooth Muscle Cells.2008
- Author(s)
  Machida T, Hamaya Y, Izumi S, Hamaya Y, Iizuka K, Igarashi Y, Minami M, Levi R, Hirafuji M
- Journal Title
  
  Journal of Pharmacology And Experimental Therapeutics. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/Iysosomes.2007
- Author(s)
  Kasahara K, Nakayama Y, Kihara A, Matsuda D, Ikeda K, Kuga T, Fukumoto Y, Igarashi Y, Yamaguchi N.
- Journal Title
  
  Exp. Cell Res. Jul 15;313(12)
  
  Pages: 2651-2666
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] スフィンゴ脂質の生理活性と代謝調節2007
- Author(s)
  五十嵐靖之、木原章雄
- Journal Title
  
  バイオとナノの融合II 新生命科学の応用北海道大学COE研究成果編集委員会編
  
  Pages: 117-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells.2007
- Author(s)
  Nodai A, Machida T, Izumi S, Hamaya Y, Kohno T, Igarashi Y, Iizuka K, Minami M, Hirafuji M.
- Journal Title
  
  Life Sci. 17;80(19)
  
  Pages: 1768-1776
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The immunomodulator FTY720 is phosphorylated and released from platelets.2007
- Author(s)
  Anada Y, Igarashi Y, Kihara A.
- Journal Title
  
  Eur J Pharm. 30;568(1-3)
  
  Pages: 106-111
- NAID
  120000970269
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer.2007
- Author(s)
  Noguchi M, Suzuki T, Kabayama K, Takahashi H, Chiba H, Shiratori M, Abe S, Watanabe A, Satoh M, Hasegawa T, Tagami S, Ishii A, Saito M, Kaneko M, Iseki K, Igarashi Y, Inokuchi J.
- Journal Title
  
  Cancer Science. Oct;98(10)
  
  Pages: 1625-32
- NAID
  10019997729
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its sythesis to its degradation.2007
- Author(s)
  Iwaki S, Sano T, Takagi T, Osumi M, Kihara A, and Igarashi Y.
- Journal Title
  
  J. Biol. Chem 282(39)
  
  Pages: 28485-28492
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomesllysosomes.2007
- Author(s)
  Kasahara K, Nakayama Y, Kihara A, Matsuda D, Ikeda K, Kuga T, Fukumoto Y, Igarashi Y, Yamaguchi N.
- Journal Title
  
  Exp. Cell Res 313(12)
  
  Pages: 2651-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells.2007
- Author(s)
  Mitsutake S, Yokose U, Kato M, Matsuoka I, Yoo LM, Kim TJ, Yoo HS, Fujimoto K, Ando Y, Sugiura M, Kohama T, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun. Nov23;363(3)
  
  Pages: 519-524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-602007
- Author(s)
  Date T, Mitsutake S, Igarashi Y
- Journal Title
  
  In Vitro Cellular & Developmental Biology-Animal Nov-Dec; 43(10)
  
  Pages: 321-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The immunomodulator FTY720 is phosphorylated and released from platelets.2007
- Author(s)
  Anada Y, Igarashi Y, KiharaA.
- Journal Title
  
  Eur J Pharm 568(1-3)
  
  Pages: 106-11
- NAID
  120000970269
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.2007
- Author(s)
  Kihara A, Mitsutake S, Mizutani Y, Igarashi Y.
- Journal Title
  
  Prog. Lipid Res. Mar; 46(2)
  
  Pages: 126-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Transbilayer movement of ceramide in the plasma membrane of live cells.2007
- Author(s)
  Mitsutake M, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun 359(3)
  
  Pages: 622-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its sythesis to its degradation.2007
- Author(s)
  Iwaki S, Sano T, Takagi T, Osumi M, Kihara A, and Igarashi Y
- Journal Title
  
  J. Biol. Chem. vol.282 no.39
  
  Pages: 28485-28492
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Transbilayer movement of ceramide in the plasma membrane of live cells.2007
- Author(s)
  Mitsutake M, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun. Aug 3;359(3)
  
  Pages: 622-627
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance.2007
- Author(s)
  Kabayama K, Sato T, Saito K, Loberto N, Prinetti A, Sonnino S, Kinjo M, Igarashi Y, Inokuchi JI.
- Journal Title
  
  Proc Natl Acad Sci USA. vol.104 no.34
  
  Pages: 13678-13683
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.2007
- Author(s)
  Kihara A, Mitsutake S, Mizutani Y, Igarashi Y.
- Journal Title
  
  Prog. Lipid Res. Mar;46(2)
  
  Pages: 126-44
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes.2007
- Author(s)
  Kasahara K, Nakayama Y, Kihara A, Matsuda D, Ikeda K, Kuga T, Fukumoto Y, Igarashi Y, Yamaguchi N.
- Journal Title
  
  Exp. Cell Res. 0715;313(12)
  
  Pages: 2651-2666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Lack of sphingosine 1-phosphate (S1P)-degrading enzymes in erythrocytes, a potential major source of plasma SIP in addition to platelets.2007
- Author(s)
  Ito K, Anada Y, Tani M, Ikeda M, Sano T, Kihara A, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun 357(1)
  
  Pages: 212-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells.2007
- Author(s)
  Nodai A, Machida T, Izumi S, Hamaya Y, Kohno T, Igarashi Y, Iizuka K, Minami M, Hirafuji M.
- Journal Title
  
  Life Sci 80(19)
  
  Pages: 1768-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Regulation of the transport and protein levels of the inositol phosphoryl ceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg22007
- Author(s)
  Uemura S, Kihara A, Iwaki S, Inokuchi JI, Igarashi Y.
- Journal Title
  
  J Biol Chem. 23;282(12)
  
  Pages: 8613-8621
- NAID
  120000969952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space.2007
- Author(s)
  Tani M, Ito M, Igarashi Y.
- Journal Title
  
  Cell Signal Feb; 19(2)
  
  Pages: 229-237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Ceramide kinase expression is altered during macrophage like cell differentiation of the leukemia cell line HL-602007
- Author(s)
  Date T, Mitsutake S, Igarashi Y.
- Journal Title
  
  In Vitro Cellular & Developmental Biology-Animal 43(10)
  
  Pages: 321-3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Lack of sphingosine 1-phosphate (S1P)-degrading enzymes in erythrocytes, a potential major source of plasma S1P in addition to platelets.2007
- Author(s)
  Ito K, Anada Y, Tani M, Ikeda M, Sano T, Kihara A, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun. May25;357(1)
  
  Pages: 212-217
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells.2007
- Author(s)
  Mitsutake S, Yokose U, Kato M, Matsuoka I, Yoo LM, Kim TJ, Yoo HS, Fujimoto K, Ando Y, Sugiura M, Kohama T, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun. Nov 23;363(3)
  
  Pages: 519-524
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer.2007
- Author(s)
  Noguchi M, Suzuki T, Kabayama K, Takahashi H, Chiba H, Shiratori M, Abe S, Watanabe A, Satoh M, Hasegawa T, Tagami S, Ishii A, Saito M, Kaneko M, Iseki K, Igarashi Y, Inokuchi J.
- Journal Title
  
  Cancer Science 98(10)
  
  Pages: 1625-32
- NAID
  10019997729
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Transbilayer movement of ceramide in the plasma membrane of live cells.2007
- Author(s)
  Mitsutake M, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun. 0803;359(3)
  
  Pages: 622-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance.2007
- Author(s)
  Kabayama K, Sato T, Saito K, Loberto N, Prinetti A, Sonnino S, Kinjo M, Igarashi Y, Inokuchi JI.
- Journal Title
  
  Proc Natl Acad Sci U S A. vol.104 no.34
  
  Pages: 13678-13683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.2007
- Author(s)
  Kihara A, Mitsutake S, Mizutani Y, Igarashi Y.
- Journal Title
  
  Prog. Lipid Res 46(2)
  
  Pages: 126-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Cell Growth Arrest by Sialic Acid Clusters in Ganglioside GM3 Mimetic Polymers.2007
- Author(s)
  Uemura S, Feng F, Kume M, Yamada K, Kabayama K, Nishimura SI, Igarashi Y, Inokuchi JI.
- Journal Title
  
  Glycobiology 17
  
  Pages: 568-577
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast cell activation2007
- Author(s)
  Kumada H, Mitsutake M, Igarashi Y.
- Journal Title
  
  Biosci. Biotech. Biochem. Vol.71 No.10
  
  Pages: 2581-2584
- NAID
  10027520327
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance.2007
- Author(s)
  Kabayama K, Sato T, Saito K, Loberto N, Prinetti A, Sonnsno S, Kinjo M, Igarashi Y, Inokuchi JI.
- Journal Title
  
  Proc Natl Acad Sci U S A 1047(34)
  
  Pages: 13678-13683
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Lack of sphingosine 1-phosphate (S1P)-degrading enzymes in erythrocytes, a potential major source of plasma S1P in addition to platelets.2007
- Author(s)
  Ito K, Anada Y, Tani M, Ikeda M, Sano T, Kihara A, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun. May 25;357(1)
  
  Pages: 212-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Regulation of the transport and protein levels of the inositol phosphoryl ceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.2007
- Author(s)
  Uemura S, Kihara A, Iwaki S, Inokuchi JI, Igarashi Y.
- Journal Title
  
  J Biol Chem. 23;282(12)
  
  Pages: 8613-8621
- NAID
  120000969952
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Ceramide/sphingosinelsphingosine 1-phosphate metabolism on the cell surface and in the extracellular space.2007
- Author(s)
  Tani M, Ito M, Igarashi Y.
- Journal Title
  
  Cell Signal 19(2)
  
  Pages: 229-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Ceramide/ sphingosine/ sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space.2007
- Author(s)
  Tani M, Ito M, Igarashi Y.
- Journal Title
  
  Cell Signal Feb;19(2)
  
  Pages: 229-237
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast cell activation.2007
- Author(s)
  Kumada H, Mitsutake M, Igarashi Y.
- Journal Title
  
  Biosci. Biotech. Biochem 71(10)
  
  Pages: 2581-2584
- NAID
  10027520327
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells.2007
- Author(s)
  Mitsutake S, Yokose U, Kato M, Matsuoka I, Yoo LM, Kim TJ, Yoo ITS, Fujimoto K, Ando Y, Sugiura M, Kohama T, Igarashi Y
- Journal Title
  
  Biochem Biophys Res Commun 363(3)
  
  Pages: 519-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] スフィンゴ脂質の生理活性と代謝調節2007
- Author(s)
  五十嵐靖之、木原章雄
- Journal Title
  
  バイオとナノの融合II新生命科学の応用北海道大学COE研究成果編集委員会編
  
  Pages: 117-131
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csgl and Cshl by the Ca2+-binding protein Csg2.2007
- Author(s)
  Uemura S, Kihara A, Iwaki S, Inokuchi JI, Igarashi Y.
- Journal Title
  
  J Biol Chem 282(12)
  
  Pages: 8613-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-602007
- Author(s)
  Date T, Mitsutake S, Igarashi Y
- Journal Title
  
  In Vitro Cellular & Developmental Biology-Animal Nov-Dec;43(10)
  
  Pages: 321-323
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] LASS3 is a testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity.2006
- Author(s)
  Mizutani Y, KiharaA, Igarashi Y.
- Journal Title
  
  Biochem. J 398(3)
  
  Pages: 531-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner.2006
- Author(s)
  Kobayashi N, Nishi T, Hirata T, Kihara A, Sano T, Igarashi Y, Yamaguchi A.
- Journal Title
  
  J Lipid Res 47(3)
  
  Pages: 614-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.2006
- Author(s)
  Ohno Y, Kihara A, Sano T, Igarashi Y.
- Journal Title
  
  Biochim Biophys Acta 1761(4)
  
  Pages: 474-83
- NAID
  120000959467
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein.2006
- Author(s)
  Inagaki Y, Mitsutake S, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun 343(3)
  
  Pages: 982-987
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Changes in SIP1 and S1P2 expression during embryonal development and primitive endoderm differentiation of F9 cells.2006
- Author(s)
  HiragaY, KiharaA, Sano T, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun 344(3)
  
  Pages: 852-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The interaction between the pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate regulates the plasma membrane targeting and ceramide 1-phosphate levels.2006
- Author(s)
  Kim TJ, Mitsutake S, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun 342(2)
  
  Pages: 611-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Mouse sphingosine kinase isoforms SPHK1a and SPHKIb differ in enzymatic traits including stability, localization, modification, and oligomerization.2006
- Author(s)
  Kihara A, Anada Y, Igarashi Y.
- Journal Title
  
  J Biol Chem 281(7)
  
  Pages: 4532-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] 免疫抑制剤FTY720の代謝と血小板からの放出2007
- Author(s)
  山中雅夫、穴田佳大、木原章雄、五十嵐靖之
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  北海道大学(札幌)JCBL49:228-231
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] トポロジーに着目したスフィンゴミエリン代謝マシーナリー、Machinery of sphimgpmyelin metabolism.2007
- Author(s)
  谷元洋, Yusuff Hannun, 五十嵐靖之, 伊藤信
- Organizer
  第80回日本生化学会大会・第30回日本分子生物学会年会合同大会
- Place of Presentation
  パシフィコ横浜(横浜)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] Phs1ファミリーによるスフィンゴ脂質輸送・代謝調節2007
- Author(s)
  木原章雄、五十嵐靖之
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  日本科学未来館(東京)JCBL48:20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] インスリン抵抗状態においてガングリオシドGM3はインスリン受容体とカベオリンの複合体形成を解離する、Dissociation of the insulin receptor and Caveolin-1 complex by ganglioside GM3 in the state of insulin resistance.2007
- Author(s)
  樺山一哉、佐藤貴重, 斉藤久美子、ロベルト・ニコレッタ、プリネッティ・アレサンドソニーノ・サンドロ, 金城政孝、五十嵐靖之、井ノ口仁一
- Organizer
  第80回日本生化学会大会・第30回日本分子生物学会年会合同大会
- Place of Presentation
  パシフィコ横浜(横浜)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] スフィンゴシンキナーゼ2によるB細胞のFas依存性細胞死の抑制,Involvement of sphingosine kinase 2 in Fas-mediated cell death in B cells.2007
- Author(s)
  横山三紀、田島俊孝, 五十嵐靖之、柳下正樹
- Organizer
  第80回日本生化学会大会・第30回日本分子生物学会年会合同大会
- Place of Presentation
  パシフィコ横浜(横浜)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] マウス表皮細胞株における核内受容体PPARbによるセラミドキナーゼ(CERK)遺伝子発現の調節機構2007
- Author(s)
  辻潔美、光武進、五十嵐靖之
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  北海道大学(札幌)、JCBL49:58-61
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] 出芽酵母におけるスフィンゴ糖脂質合成の調節機構2007
- Author(s)
  上村聡志, 木原章雄, 岩城壮一郎、井ノ口仁一、五十嵐靖之
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  北海道大学(札幌)、JCBL49:103-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] Phs1ファミリーによるホスファチジルイノシトール輸送とスフィンゴ脂質代謝に及ぼす影響、Traffikingof PI and effects on sphingolipid metabolism by Psh1 family.2007
- Author(s)
  木原章雄、五十嵐靖之
- Organizer
  第80回日本生化学会大会・第30回日本分子生物学会年会合同大会
- Place of Presentation
  パシフィコ横浜(横浜)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] スフィンゴシン1-リン酸受容体S1P1のパルミトイル化およびパルミトイルトランスフェラーゼDHHCファミリーの解析2007
- Author(s)
  大野祐介, 伊藤彩子、木原章雄、五十嵐靖之
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  北海道大学(札幌)、JCBL49:30-33
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] ヒトパルミトイルトランスフェラーゼDHHCファミリーの細胞内局在と組織分布2006
- Author(s)
  大野祐介, 木原章雄、佐野孝光, 五十嵐靖之
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  日本科学未来館(東京)、JCBL48:215-218
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] 赤血球/血小板におけるスフィンゴシン1-リン酸およびFTY720Pの生成放出機構2006
- Author(s)
  穴田佳大, 伊藤清春、谷元洋、池田未佳、佐野孝光、木原章雄、五十嵐靖之
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  日本科学未来館(東京),JCBL48:219-222
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] セラミド1-リン酸賛成径路の解明2006
- Author(s)
  光武進, 花田賢太郎、五十嵐靖之
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  日本科学未来館(東京)、JCBL48:230-231
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] 酵母スフィンゴイド塩基キナーゼLcb4pにおいて見られる細胞膜-ER間新規輸送機構2006
- Author(s)
  岩城壮一郎、佐野孝光、高木智子、大隅正子、木原章雄、五十嵐靖之
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  日本科学未来館(東京)JCBL48:271-274
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] スフィンゴ脂質研究を通して生体膜のきのう解明をめざす2006
- Author(s)
  五十嵐靖之
- Organizer
  東北薬科大学生体膜研究所設置記念シンポジウム
- Place of Presentation
  東北薬科大学(仙台)
- Year and Date
  2006-04-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] HL60の分化に伴うセラミドキナーゼの発現変動2006
- Author(s)
  館知美, 光武進、五十嵐靖之
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  日本科学未来館(東京)JCBL48:227-229
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050

1. INOKUCHI Jin-ichi (70131810)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. KIHARA Akio (50333620)

# of Collaborated Projects: 4 results

# of Collaborated Products: 36 results
3. MITSUTAKE Susumu (10344475)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
4. WADA Atsushi (00301953)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. HIDEYOSHI Harashima (00183567)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YATOMI Yutaka (60200523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MOTOHASHI Takeshi (90301952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SABURO Sone (40145024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAZUO Maruyama (30130040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MIZUTANI Yukiko (30396296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. IWAKI Soichiro (60399962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
12. 大熊芳明 (70192515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 篠原康雄 (60226157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 平林義雄 (90106435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小堤保則 (70205425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 永井克孝 (80072974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 清水孝雄 (80127092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 西島正弘 (60072956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 岡島史和 (30142748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 白浜勉 (90136862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 西山賢龍 (80264422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 坂上慎二 (50333604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YASUYUKI Igarashi 五十嵐 靖之

IGARASHI Yasuyuki 五十嵐 靖之

Research Projects

Research Products

Co-Researchers

Biological functions of Sphingolipids and their relevance to pathological phenomenaPrincipal Investigator

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Molecular Mechanism of production and secretion of platelet-derived bioactive lysolipidsPrincipal Investigator

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スフィンゴ脂質による生体膜ドメイン形成と多機能シグナリングPrincipal Investigator

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スフィンゴシン1-リン酸とその受容体の情報伝達機構と生理機能の解析Principal Investigator

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Biological functions of a lipid mediator, sphingosine 1-phosphatePrincipal Investigator

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[Book] Cell Growth Arrest by Sialic Acid Clusters in Ganglioside GM3 Mimetic Polymers.2007

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[Journal Article] The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry2008

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YASUYUKI Igarashi 五十嵐靖之

IGARASHI Yasuyuki 五十嵐靖之