FUJII Hisaichi 藤井寿一

Researcher Number	70107762
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Affiliation (Current)	2020: 東京女子医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2012: 東京女子医科大学, 医学部, 教授 2008 – 2010: 東京女子医科大学, 医学部, 教授 2005 – 2006: 東京女子医科大学, 医学部, 教授 2000 – 2003: 東京女子医科大学, 医学部, 教授 2001: Tokyo Women 's Medical University, Department of Transfusion Medicine, Professor, 医学部, 助教授 … More
Review Section/Research Field	Principal Investigator Hematology / Human genetics / Hematology Except Principal Investigator Hematology / Pediatrics / Hematology / Human genetics
Keywords	Principal Investigator 赤血球酵素異常症 / 溶血性貧血 / 変異酵素 / ミスセンス変異 / ピルビン酸キナーゼ異常症 / 遺伝性非球状性溶血性貧血 / 構造異常 / グルコース-6-リン酸脱水素酵素異常症 / 単一塩基置換 / 単一アミノ酸置換 … More Except Principal Investigator 赤血球酵素異常症 / ピルビン酸キナーゼ異常症 / 遺伝性溶血性貧血 / マラリア / TNF / PCR / hereditary hemolytic anemia / erythroenzymopathies / pyruvate kinase deficiency / 赤血球 / 解糖系 / 転写因子 / 分化誘導 / 細胞特異的発現 / 遺伝子治療 / PK異常症 / レンチウイルスベクター / siRNA / 先天性溶血性貧血 / 動物モデル / 造血幹細胞移植 / 単一遺伝子疾患 / ピリミジン5'-ヌクレオチダーゼ / アイソザイム / P5N異常症 / ピリミジン5'-ヌクレオチダーゼ異常症 / Pyrimidine 5'-nucleotidase / Isozymes / Pyrimidine 5'-nucleotidase deficiency / Purification / Hemolytic anemia / 疫学 / 理論疫学 / 血色素 / DNA診断 / 衛星画像 / 人類生態 / ソロモン諸島 / 血液型 / G6PD欠損 / パプアニューギニア / Malaria / Epidemiolgy / theoretical epidemiolgy / hemoglobin / DNA diagnosis / satellite image / hyman ecology / グルコース6リン酸脱水素酵素 / G6PD / プリマキン / 東南アジア / 疫学調査 / ゲノム遺伝子 / G6PD欠損症 / ミャンマー / インドネシア / red blood cell enzyme deficiency / glucose-6-phosphate dehydrogenase / malaria / primaquine / Southeast Asia / field study / genomic DNA / 遺伝性血性貧血 / ヒトL型PKcDNAクローン / L型PK遺伝子座 / human L-type PK cDNA / 赤血球酵素 / ピルビン酸キナ-ゼ / ピルビン酸キナ-ゼ異常(欠乏)症 / 溶血性貧血 / 遺伝子 / 三炭糖リン酸イソメラ-ゼ / ピルビン酸キナ-ゼ欠乏症 / 遺伝子解析 / 単一塩基置換 / 転写促進因子 / 病因解明 / ピルビン酸キナーゼ / ピルビン酸キナーゼ欠乏(異常)症 / 染色体 / red cell enzyme / pyruvate kinase / hemolytic anemia / gene / triosephosphate isomerase Less

Development of novel gene therapy for congenital blood disorders using induced pluripotent stem cells
- Principal Investigator
  
  KANNO Hitoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Women's Medical University
A novel gene therapy for pyruvate kinase deficiency.
- Principal Investigator
  
  UTSUGISAWA Taiju
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Women's Medical University
Screening for causative genes in unknown hemolytic anemiaPrincipal Investigator
- Principal Investigator
  
  FUJII Hisaichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Women's Medical University
MOLECULAR BASIS OF PYRIMIDINE 5'-NUCLEOTIDASE (P5N) DEFICIENCY AND FUNCTIONAL ANALYSIS OF P5NPrincipal Investigator
- Principal Investigator
  
  FUJII Hisaichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  TOKYO WOMEN'S MEDICAL UNIVERSITY
Diagnosis and molecular analysis of red cell enzyme anomalies and analysis of red cell deformabilitiesPrincipal Investigator
- Principal Investigator
  
  HISAICHI |Fujii
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Women 's Medical University
Molecular analysis of G6PD variants in Southeast Asia
- Principal Investigator
  
  MATSUOKA Hiroyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Molecular analysis of hereditary hemolytic anemia due to red cell enzyme anomaliesPrincipal Investigator
- Principal Investigator
  
  FUJII Hisaichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Women's Medical University
マラリア制圧に不可欠なグルコース・6ーリン酸脱水素酵素異常症の分子異常の同定Principal Investigator
- Principal Investigator
  
  藤井寿一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Women's Medical University
赤血球酵素異常症・発現したタンパクによる変異酵素の機能解析Principal Investigator
- Principal Investigator
  
  藤井寿一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Women's Medical University
赤血球酵素異常症の病因解明とモデルマウスを用いた新しい治療法の検討Principal Investigator
- Principal Investigator
  
  藤井寿一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Women's Medical University
赤芽球分化に伴う赤血球型ピルビン酸キナーゼの発現とその転写制御
- Principal Investigator
  
  KANNO Hitoshi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okinaka Memorial Institute for Medical Research
原因不明の遺伝性非球状性溶血性貧血の遺伝子レベルでの病因解明Principal Investigator
- Principal Investigator
  
  藤井寿一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Women's Medical University
Research on malaria and related hematological disorders in southwest Pacific region
- Principal Investigator
  
  ISHII Akira
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Jichi Medical School
  国立予防衛生研究所
赤血球酵素異常による遺伝性溶血性貧血の遺伝子レベルでの病因解明Principal Investigator
- Principal Investigator
  
  藤井寿一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Women's Medical University
Purification and cDNA cloning of human red cell pyrimidine 5'-nucleotidase isozymes
- Principal Investigator
  
  HIRONO Akira
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Okinaka Memorial Institute for medical Research
ピルビン酸キナ-ゼ異常による遺伝性溶血性貧血の病因解明Principal Investigator
- Principal Investigator
  
  藤井寿一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Women's Medical University
グルコ-スー6ーリン酸脱水素酵素変異種を指標としたわが国への遺伝子移子移込の検討Principal Investigator
- Principal Investigator
  
  藤井寿一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tokyo Women's Medical University
ヒト細胞におけるピルビン酸キナーゼアイソザイムの発現機構の解明Principal Investigator
- Principal Investigator
  
  藤井寿一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tokyo Women's Medical University
Erythroenzymopathies: Molecular analysis of pyruvate kinase deficiency
- Principal Investigator
  
  MIWA Shiro
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Okinaka Memorial Institute for Medical Research
グルコースー6-リン酸脱水素酵素異常症の遺伝子レベルでの病因解析Principal Investigator
- Principal Investigator
  
  藤井寿一
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tokyo Women's Medical University
Erythroenzymopathies: Mechanisms of isozyme switches and clarification of genetic abnormalities
- Principal Investigator
  
  MIWA Shiro
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tokyo

All 2013 2012 2011 2010 2007 2005

All Journal Article Presentation

[Journal Article] Enhanced expression of myogenic differentiation factors and skeletal muscle proteins in human amnion-derived cells via the forced expression of MYOD12013
- Author(s)
  Akizawa Y, Kanno H, Kawamichi Y, Matsuda Y, Ohta H, Fujii H, Matsui H, Saito K
- Journal Title
  
  Brain Dev
  
  Volume: 35 Pages: 349-355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591071
[Journal Article] Pyruvate supplementation enhances vascular endothelial growth factor production of bone marrow-derived mononuclear cells2012
- Author(s)
  Kanno H, Iribe Y, Aoki T, Ogura H, Fujii H
- Journal Title
  
  Jpn J Transf Cell Ther
  
  Volume: 58 Pages: 26-32
- NAID
  10030760776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591071
[Journal Article] An SNP in CYP39A1 is associated with severe neutropenia induced by docetaxel2012
- Author(s)
  Uchiyama T, Kanno H, Ishitani K, Fujii H, Ohta H, Matsui H, Kamatani N, Saito K
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 69 Pages: 1617-1624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591071
[Journal Article] Pyruvate supplementation enhanced vascular endothelial growth factor production by bone marrow-derived mononuclear cells2012
- Author(s)
  Kanno H, Iribe T, Aoki T, Ogura H, FujiiH.
- Journal Title
  
  Japanese Journal of Transfusion and Cell Therapy
  
  Volume: 58 Pages: 26-32
- NAID
  10030760776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591071
[Journal Article] High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma2011
- Author(s)
  Tsuruta T, Aihara Y, Kanno H, Kiyotani C, Maebayashi K, Sakauchi M, Osawa M, Fujii H, Kubo O, Okada Y
- Journal Title
  
  Childs Nerv Syst
  
  Volume: 27 Pages: 1019-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591071
[Journal Article] Shared molecular targets in pediatric gliomas and ependymomas2011
- Author(s)
  Tsuruta T, Aihara Y, Kanno H, Funase M,Murayama T, Osawa M, Fujii H, Kubo O, Okada Y.
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 57 Pages: 1117-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591071
[Journal Article] Double high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for primary disseminated medulloblastoma:a report of 3 cases2010
- Author(s)
  Aihara Y, Tsuruta T, Kawamata T, Kanno H, Maebayashi K, Wada E, Osawa M, Fujii H,Kubo O, Hori T.
- Journal Title
  
  J Pediatr Hematol Oncol
  
  Volume: 32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591071
[Journal Article] 寿命を終えた赤血球の処理機構-赤血球膜に出現する貪食目印分子に関する最近の知見-2007
- Author(s)
  菅野仁, 藤井寿一
- Journal Title
  
  Membrane 31・3(in press)
- NAID
  130005077797
- Data Source
  KAKENHI-PROJECT-17591013
[Journal Article] 寿命を終えた赤血球の処理機構~赤血球膜に出現する貪食目印分子に関する最近の知見~2007
- Author(s)
  菅野仁, 藤井寿一
- Journal Title
  
  Membrane 31・3(in press)
- NAID
  130005077797
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591013
[Journal Article] Ineffective erythropoiesis in mutant mice with deficient pyruvate kinase activity.2005
- Author(s)
  Aizawa S, Harada T, Kanbe E, Tsuboi I, Aisaki K, Fujii H, Kanno H
- Journal Title
  
  Exp.Hematol. 33(11)
  
  Pages: 1292-1298
- Data Source
  KAKENHI-PROJECT-17591013
[Journal Article] A novel homozygous mutation of PKLR gene in a pyruvate-kinase-deficient Korean family.2005
- Author(s)
  Park-Hah JO, Kanno H, Kim WD, Fujii H
- Journal Title
  
  Acta Haematol. 113(3)
  
  Pages: 208-211
- Data Source
  KAKENHI-PROJECT-17591013
[Presentation] Diamond Blackfan 貧血に関する新規の病因候補遺伝子同定2010
- Author(s)
  菅野仁、山本俊至, 大賀正一, 立石浩, 濱田貴子 , 槍澤大樹 , 小倉浩美 , 藤井寿一
- Organizer
  第72回日本血液学会総会
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-22591071
[Presentation] 免疫寛容導入療法におけるドナー、レシピエント細胞キメリズム解析2010
- Author(s)
  菅野仁, 槍澤大樹, 小倉浩美, 濱田貴子, 藤井寿一
- Organizer
  第58回日本輸血・細胞治療学会総会
- Year and Date
  2010-05-30
- Data Source
  KAKENHI-PROJECT-22591071
[Presentation] 薬物トランスポーター遺伝子多型を用いた薬理遺伝学的検査～ドセタキセル投与における好中球減少症予測2010
- Author(s)
  菅野仁、石谷健、相崎潤子、濱田貴子、内山智貴、浦野真理、近藤恵里、松井英雄、藤井寿一、太田博明、斎藤加代子
- Organizer
  第17回日本遺伝子診療学会大会
- Year and Date
  2010-08-07
- Data Source
  KAKENHI-PROJECT-22591071

1. MIWA Shiro (40034954)

# of Collaborated Projects: 12 results

# of Collaborated Products: 0 results
2. KANNO Hitoshi (70221207)

# of Collaborated Projects: 7 results

# of Collaborated Products: 14 results
3. HIRONO Akira (90181221)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. UTSUGISAWA Taiju (30337133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. ISHII Akira (40012752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAZAWA Minato (40251227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KANAZAWA Tamotsu (10194888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHTA Nobuo (10143611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAWABATA Masato (30175294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MATSUOKA Hiroyuki (10173816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAWAMOTOS Fumihiko (40115556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YOSHIDA Shigeto (10296121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IWAI Kuni (50271226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKIZAWA Takenori (40192158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KOIZUMI Tsutomu (40126579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MORISAKI Takayuki (30174410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 谷憲三朗 (00183864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. 内田ゆりジュリエッタ (40254908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. RZEPCZYK C

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. LEAFASIA J

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NIHEI Naoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. UCHIDA J

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KERE N.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 大保保康人

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

FUJII Hisaichi 藤井 寿一

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Screening for causative genes in unknown hemolytic anemiaPrincipal Investigator

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MOLECULAR BASIS OF PYRIMIDINE 5'-NUCLEOTIDASE (P5N) DEFICIENCY AND FUNCTIONAL ANALYSIS OF P5NPrincipal Investigator

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Diagnosis and molecular analysis of red cell enzyme anomalies and analysis of red cell deformabilitiesPrincipal Investigator

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Molecular analysis of hereditary hemolytic anemia due to red cell enzyme anomaliesPrincipal Investigator

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マラリア制圧に不可欠なグルコース・6ーリン酸脱水素酵素異常症の分子異常の同定Principal Investigator

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赤血球酵素異常症・発現したタンパクによる変異酵素の機能解析Principal Investigator

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赤血球酵素異常症の病因解明とモデルマウスを用いた新しい治療法の検討Principal Investigator

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原因不明の遺伝性非球状性溶血性貧血の遺伝子レベルでの病因解明Principal Investigator

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赤血球酵素異常による遺伝性溶血性貧血の遺伝子レベルでの病因解明Principal Investigator

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FUJII Hisaichi 藤井寿一

グルコ-スー6ーリン酸脱水素酵素変異種を指標としたわが国への遺伝子移子移込の検討Principal Investigator