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FUJII Hisaichi  藤井 寿一

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Researcher Number 70107762
Other IDs
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Affiliation (Current) 2021: 東京女子医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2012: 東京女子医科大学, 医学部, 教授
2008 – 2010: 東京女子医科大学, 医学部, 教授
2005 – 2006: 東京女子医科大学, 医学部, 教授
2000 – 2003: 東京女子医科大学, 医学部, 教授
2001: Tokyo Women 's Medical University, Department of Transfusion Medicine, Professor, 医学部, 助教授 … More
1998 – 1999: 東京女子医科大学, 医学部, 助教授
1994 – 1996: 東京女子医科大学, 医学部, 助教授
1994: 東京女子医大, 輸血部, 助教授
1993 – 1994: 東京女子医科大学, 輸血部, 助教授
1992: 東京女子医科大学輸血部, 助教授
1990 – 1992: 東京女子医科大学, 医学部, 助教授
1989: Tokyo Women's Medical College, Department of Transfusion Medicine, Associate Pro, 輸血部, 助教授
1987 – 1989: 東京女子医科大学, 輸血部, 助教授
1986: Lecturer, Institute of Medical Science, University of Yokyo, 医科学研究所, 講師 Less
Review Section/Research Field
Principal Investigator
Hematology / Human genetics / Hematology
Except Principal Investigator
Hematology / Pediatrics / Hematology / Human genetics
Keywords
Principal Investigator
赤血球酵素異常症 / 溶血性貧血 / 変異酵素 / ミスセンス変異 / ピルビン酸キナーゼ異常症 / 遺伝性非球状性溶血性貧血 / 構造異常 / グルコース-6-リン酸脱水素酵素異常症 / 単一塩基置換 / 単一アミノ酸置換 … More / 機能異常 / スプライシング変異 / フレームシフト変異 / トランスジェニックマウス / hereditary non-spherocytic hemolytic anemia / erythroenzymopathy / グリコ-スー6ーリン酸脱水素酵素異常症 / 遺伝子移入 / ピルビン酸キナ-ゼ異常症 / ホスホグリセリン酸キナーゼ異常症 / モデルマウス / 転写因子 / エリスロポエチン / グルコース-6ーリン酸脱水素・酵素異常症 / プリマキン / 藻剤惹起性溶血発作 / スクリーニング法 / PCR-SSCP法 / グルコースリン酸イソメラーゼ異常症 / 組み換え型酵素 / 融合タンパク / 遺伝性溶血性貧血 / グリコースー6-リン酸脱水素酵素異常症 / ピルビン酸キナーゼ / アイソザイム / 遺伝子発現。 / ヘキソナーゼ異常症 / エノラーゼ異常症 / 遺伝子内欠失 / ヘキソキナーゼ異常症 / ピリミジン5′-ヌクレオチダーゼ異常症 / hexokinase deficiency / enolase deficiency / intragenic deletion / missense mutation / 遺伝性非球状製溶血性貧血 / 赤血球変形能 / 塩基挿入 / glucose-6-phosphate dehydrogenase deficiency / pyruvate kinase deficiency / red cell deformability / 赤血球 / 遺伝子変異 / ハプロタイプ / ピリミジン-5'-ヌクレオチダーゼ異常症 / インフルエンザウイルス / 免疫応答 / HEMOLYTIC ANEMIA / MUTATION / PYRIMIDINE / RETICULOCYTES / ERYTHROCYTES / α-ヘモグロビン安定化タンパク / 急性溶血発作 / 遺伝子多型 / 酸化ストレス / アンチオキシダント / 疾患感受性遺伝子 / α-hemoglobin stabilizing protein / hemolytic anemia / acute hemolysis / single nucleotide polymorphisms (SNPs) / oxidative stress / antioxidant … More
Except Principal Investigator
赤血球酵素異常症 / ピルビン酸キナーゼ異常症 / 遺伝性溶血性貧血 / マラリア / TNF / PCR / hereditary hemolytic anemia / erythroenzymopathies / pyruvate kinase deficiency / 赤血球 / 解糖系 / 転写因子 / 分化誘導 / 細胞特異的発現 / 遺伝子治療 / PK異常症 / レンチウイルスベクター / siRNA / 先天性溶血性貧血 / 動物モデル / 造血幹細胞移植 / 単一遺伝子疾患 / ピリミジン5'-ヌクレオチダーゼ / アイソザイム / P5N異常症 / ピリミジン5'-ヌクレオチダーゼ異常症 / Pyrimidine 5'-nucleotidase / Isozymes / Pyrimidine 5'-nucleotidase deficiency / Purification / Hemolytic anemia / 疫学 / 理論疫学 / 血色素 / DNA診断 / 衛星画像 / 人類生態 / ソロモン諸島 / 血液型 / G6PD欠損 / パプアニューギニア / Malaria / Epidemiolgy / theoretical epidemiolgy / hemoglobin / DNA diagnosis / satellite image / hyman ecology / グルコース6リン酸脱水素酵素 / G6PD / プリマキン / 東南アジア / 疫学調査 / ゲノム遺伝子 / G6PD欠損症 / ミャンマー / インドネシア / red blood cell enzyme deficiency / glucose-6-phosphate dehydrogenase / malaria / primaquine / Southeast Asia / field study / genomic DNA / 遺伝性血性貧血 / ヒトL型PKcDNAクローン / L型PK遺伝子座 / human L-type PK cDNA / 赤血球酵素 / ピルビン酸キナ-ゼ / ピルビン酸キナ-ゼ異常(欠乏)症 / 溶血性貧血 / 遺伝子 / 三炭糖リン酸イソメラ-ゼ / ピルビン酸キナ-ゼ欠乏症 / 遺伝子解析 / 単一塩基置換 / 転写促進因子 / 病因解明 / ピルビン酸キナーゼ / ピルビン酸キナーゼ欠乏(異常)症 / 染色体 / red cell enzyme / pyruvate kinase / hemolytic anemia / gene / triosephosphate isomerase Less
  • Research Projects

    (21 results)
  • Research Products

    (14 results)
  • Co-Researchers

    (24 People)
  •  Development of novel gene therapy for congenital blood disorders using induced pluripotent stem cells

    • Principal Investigator
      KANNO Hitoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Women's Medical University
  •  A novel gene therapy for pyruvate kinase deficiency.

    • Principal Investigator
      UTSUGISAWA Taiju
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Women's Medical University
  •  Screening for causative genes in unknown hemolytic anemiaPrincipal Investigator

    • Principal Investigator
      FUJII Hisaichi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Women's Medical University
  •  MOLECULAR BASIS OF PYRIMIDINE 5'-NUCLEOTIDASE (P5N) DEFICIENCY AND FUNCTIONAL ANALYSIS OF P5NPrincipal Investigator

    • Principal Investigator
      FUJII Hisaichi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      TOKYO WOMEN'S MEDICAL UNIVERSITY
  •  Diagnosis and molecular analysis of red cell enzyme anomalies and analysis of red cell deformabilitiesPrincipal Investigator

    • Principal Investigator
      HISAICHI |Fujii
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Women 's Medical University
  •  Molecular analysis of G6PD variants in Southeast Asia

    • Principal Investigator
      MATSUOKA Hiroyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  Molecular analysis of hereditary hemolytic anemia due to red cell enzyme anomaliesPrincipal Investigator

    • Principal Investigator
      FUJII Hisaichi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Women's Medical University
  •  マラリア制圧に不可欠なグルコース・6ーリン酸脱水素酵素異常症の分子異常の同定Principal Investigator

    • Principal Investigator
      藤井 寿一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Women's Medical University
  •  赤血球酵素異常症・発現したタンパクによる変異酵素の機能解析Principal Investigator

    • Principal Investigator
      藤井 寿一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Women's Medical University
  •  赤血球酵素異常症の病因解明とモデルマウスを用いた新しい治療法の検討Principal Investigator

    • Principal Investigator
      藤井 寿一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Women's Medical University
  •  赤芽球分化に伴う赤血球型ピルビン酸キナーゼの発現とその転写制御

    • Principal Investigator
      KANNO Hitoshi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Okinaka Memorial Institute for Medical Research
  •  原因不明の遺伝性非球状性溶血性貧血の遺伝子レベルでの病因解明Principal Investigator

    • Principal Investigator
      藤井 寿一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Women's Medical University
  •  Research on malaria and related hematological disorders in southwest Pacific region

    • Principal Investigator
      ISHII Akira
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Jichi Medical School
      国立予防衛生研究所
  •  赤血球酵素異常による遺伝性溶血性貧血の遺伝子レベルでの病因解明Principal Investigator

    • Principal Investigator
      藤井 寿一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Women's Medical University
  •  Purification and cDNA cloning of human red cell pyrimidine 5'-nucleotidase isozymes

    • Principal Investigator
      HIRONO Akira
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Okinaka Memorial Institute for medical Research
  •  ピルビン酸キナ-ゼ異常による遺伝性溶血性貧血の病因解明Principal Investigator

    • Principal Investigator
      藤井 寿一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Women's Medical University
  •  グルコ-ス ー6ー リン酸脱水素酵素変異種を指標としたわが国への遺伝子移子移込の検討Principal Investigator

    • Principal Investigator
      藤井 寿一
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Tokyo Women's Medical University
  •  ヒト細胞におけるピルビン酸キナーゼアイソザイムの発現機構の解明Principal Investigator

    • Principal Investigator
      藤井 寿一
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Tokyo Women's Medical University
  •  Erythroenzymopathies: Molecular analysis of pyruvate kinase deficiency

    • Principal Investigator
      MIWA Shiro
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Okinaka Memorial Institute for Medical Research
  •  グルコースー6-リン酸脱水素酵素異常症の遺伝子レベルでの病因解析Principal Investigator

    • Principal Investigator
      藤井 寿一
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Tokyo Women's Medical University
  •  Erythroenzymopathies: Mechanisms of isozyme switches and clarification of genetic abnormalities

    • Principal Investigator
      MIWA Shiro
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      University of Tokyo

All 2013 2012 2011 2010 2007 2005

All Journal Article Presentation

  • [Journal Article] Enhanced expression of myogenic differentiation factors and skeletal muscle proteins in human amnion-derived cells via the forced expression of MYOD12013

    • Author(s)
      Akizawa Y, Kanno H, Kawamichi Y, Matsuda Y, Ohta H, Fujii H, Matsui H, Saito K
    • Journal Title

      Brain Dev

      Volume: 35 Pages: 349-355

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591071
  • [Journal Article] Pyruvate supplementation enhances vascular endothelial growth factor production of bone marrow-derived mononuclear cells2012

    • Author(s)
      Kanno H, Iribe Y, Aoki T, Ogura H, Fujii H
    • Journal Title

      Jpn J Transf Cell Ther

      Volume: 58 Pages: 26-32

    • NAID

      10030760776

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591071
  • [Journal Article] An SNP in CYP39A1 is associated with severe neutropenia induced by docetaxel2012

    • Author(s)
      Uchiyama T, Kanno H, Ishitani K, Fujii H, Ohta H, Matsui H, Kamatani N, Saito K
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 69 Pages: 1617-1624

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591071
  • [Journal Article] Pyruvate supplementation enhanced vascular endothelial growth factor production by bone marrow-derived mononuclear cells2012

    • Author(s)
      Kanno H, Iribe T, Aoki T, Ogura H, FujiiH.
    • Journal Title

      Japanese Journal of Transfusion and Cell Therapy

      Volume: 58 Pages: 26-32

    • NAID

      10030760776

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591071
  • [Journal Article] Shared molecular targets in pediatric gliomas and ependymomas2011

    • Author(s)
      Tsuruta T, Aihara Y, Kanno H, Funase M,Murayama T, Osawa M, Fujii H, Kubo O, Okada Y.
    • Journal Title

      Pediatr Blood Cancer

      Volume: 57 Pages: 1117-1123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591071
  • [Journal Article] High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma2011

    • Author(s)
      Tsuruta T, Aihara Y, Kanno H, Kiyotani C, Maebayashi K, Sakauchi M, Osawa M, Fujii H, Kubo O, Okada Y
    • Journal Title

      Childs Nerv Syst

      Volume: 27 Pages: 1019-1024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591071
  • [Journal Article] Double high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for primary disseminated medulloblastoma:a report of 3 cases2010

    • Author(s)
      Aihara Y, Tsuruta T, Kawamata T, Kanno H, Maebayashi K, Wada E, Osawa M, Fujii H,Kubo O, Hori T.
    • Journal Title

      J Pediatr Hematol Oncol

      Volume: 32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591071
  • [Journal Article] 寿命を終えた赤血球の処理機構-赤血球膜に出現する貪食目印分子に関する最近の知見-2007

    • Author(s)
      菅野 仁, 藤井寿一
    • Journal Title

      Membrane 31・3(in press)

    • NAID

      130005077797

    • Data Source
      KAKENHI-PROJECT-17591013
  • [Journal Article] 寿命を終えた赤血球の処理機構~赤血球膜に出現する貪食目印分子に関する最近の知見~2007

    • Author(s)
      菅野 仁, 藤井 寿一
    • Journal Title

      Membrane 31・3(in press)

    • NAID

      130005077797

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591013
  • [Journal Article] A novel homozygous mutation of PKLR gene in a pyruvate-kinase-deficient Korean family.2005

    • Author(s)
      Park-Hah JO, Kanno H, Kim WD, Fujii H
    • Journal Title

      Acta Haematol. 113(3)

      Pages: 208-211

    • Data Source
      KAKENHI-PROJECT-17591013
  • [Journal Article] Ineffective erythropoiesis in mutant mice with deficient pyruvate kinase activity.2005

    • Author(s)
      Aizawa S, Harada T, Kanbe E, Tsuboi I, Aisaki K, Fujii H, Kanno H
    • Journal Title

      Exp.Hematol. 33(11)

      Pages: 1292-1298

    • Data Source
      KAKENHI-PROJECT-17591013
  • [Presentation] Diamond Blackfan 貧血に関する新規の病因候補遺伝子同定2010

    • Author(s)
      菅野 仁、山本俊至, 大賀正一, 立石 浩, 濱田貴子 , 槍澤大樹 , 小倉浩美 , 藤井寿一
    • Organizer
      第72回日本血液学会総会
    • Year and Date
      2010-09-25
    • Data Source
      KAKENHI-PROJECT-22591071
  • [Presentation] 免疫寛容導入療法におけるドナー、レシピエント細胞キメリズム解析2010

    • Author(s)
      菅野 仁, 槍澤大樹, 小倉浩美, 濱田貴子, 藤井寿一
    • Organizer
      第58回日本輸血・細胞治療学会総会
    • Year and Date
      2010-05-30
    • Data Source
      KAKENHI-PROJECT-22591071
  • [Presentation] 薬物トランスポーター遺伝子多型を用いた薬理遺伝学的検査~ドセタキセル投与における好中球減少症予測2010

    • Author(s)
      菅野 仁、石谷 健、相崎 潤子、濱田 貴子、内山 智貴、浦野 真理、近藤 恵里、松井 英雄、 藤井寿一、太田 博明、斎藤加代子
    • Organizer
      第17回日本遺伝子診療学会大会
    • Year and Date
      2010-08-07
    • Data Source
      KAKENHI-PROJECT-22591071
  • 1.  MIWA Shiro (40034954)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 2.  KANNO Hitoshi (70221207)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 14 results
  • 3.  HIRONO Akira (90181221)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  UTSUGISAWA Taiju (30337133)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  ISHII Akira (40012752)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  NAKAZAWA Minato (40251227)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KANAZAWA Tamotsu (10194888)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  OHTA Nobuo (10143611)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KAWABATA Masato (30175294)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  MATSUOKA Hiroyuki (10173816)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KAWAMOTOS Fumihiko (40115556)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  YOSHIDA Shigeto (10296121)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  IWAI Kuni (50271226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TAKIZAWA Takenori (40192158)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KOIZUMI Tsutomu (40126579)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MORISAKI Takayuki (30174410)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  谷 憲三朗 (00183864)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 18.  内田 ゆりジュリエッタ (40254908)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  RZEPCZYK C
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  LEAFASIA J
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  NIHEI Naoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  UCHIDA J
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  KERE N.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  大保保 康人
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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