FUJIYAMA Yoshihide 藤山佳秀

… Alternative Names

藤山佳秀フジヤマヨシヒデ

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Researcher Number	70111896
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 医学部, その他
Affiliation (based on the past Project Information) *help	2003 – 2012: 滋賀医科大学, 医学部, 教授 2002: 滋賀医科大学, 医学部, 助教授 1997 – 1998: 滋賀医科大学, 医学部, 助教授 1994: Associate Professor, Shiga University of Medical Science, 医学部, 助教授 1988 – 1991: 滋賀医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator 炎症性腸疾患 / UGT / SEB / 分泌型IgA / mesenchymal cells / bone marrow transplantation / Stem cell / IL-17 / IL-22 / サイトカイン … More / 筋繊維芽細胞 / 組織再生 / 筋線維芽細胞 / 骨髄移植 / 骨髄細胞 / bile acid / intestinal micorbiota / IBD / hodeoxcholic acid / hyodeoxycholic acid / 胆汁酸 / 腸内細菌叢 / oral torelance / Vβ8T-cell / TCR α KO mice / DSS colitis / 炎症性腸疾患(IBD) / スーパー抗原 / 経口寛客 / 自己免疫疾患 / コラーゲン誘導関節炎 / TCRα鎖欠損マウス / 経口寛容 / DSS大腸炎 / TCRの鎖欠損マウス / 細菌性スーパー抗原 / 菌体凝集抗体 / 腸内細菌 / IgAプロテアーゼ / IL-23 / 樹状細胞 / 遺伝子・デリバリー / Schizophyllan / ドラッグデリバリーシステム / schizophyllan / Dectin-1 / パイエル板 / 成分栄養 / 消化管免疫 / 低蛋白栄養 / 低栄養 / 免疫グロブリン / 腸管粘膜免疫 / 成分栄養療法 … More Except Principal Investigator HCV-RNA / HCV / TTLS / RT-PCR / DNA probe / Endothelial function / Mesenteric artery / Vasorelaxation / RT-PCR法 / DNAプローブ法 / 内皮機能 / 腸間膜動脈 / 血管弛緩 / 小腸内視鏡 / 脂肪酸 / タローン病 / TNF-α / クローン病 / 脂肪乳剤 / 潰瘍性大腸炎 / 非特異的炎症性腸疾患 / 血中抗体 / 細菌外膜蛋白抗原 / Escherichia coli / Bacteroides vulgatus / 腸内細菌叢 / I.B.D. Less

Development of new therapeutic agents for inflammatory bowel disease based on the dendritic cell regulation via Dectin-1Principal Investigator
- Principal Investigator
  
  FUJIYAMA Yoshihide
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shiga University of Medical Science
Elucidation of the immunoresponse by direct stimulation of fatty acid in Crohn disease
- Principal Investigator
  
  TSUJIKAWA Tomoyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shiga University of Medical Science
Role of bone marrow-derivedcells in the intestinePrincipal Investigator
- Principal Investigator
  
  FUJIYAMA Yoshihide
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shiga University of Medical Science
Involvement of intestinal microbiota derived secondary bile acids in the patho-physiology of inflammatory baowel disease and the expression of UGT by intestinal epithelial cells.Principal Investigator
- Principal Investigator
  
  FUJIYAMA Yoshihide
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shiga University of Medical Science
Regulation of immune response in hole body and intestinal mucosa by oral administration of staphylococcal enterotoxin B (SEB)Principal Investigator
- Principal Investigator
  
  TSUJIKAWA Tomoyuki, 藤山佳秀
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shiga University of Medical Science
Gastrointestinal and hematologic diseases in Japan and China
- Principal Investigator
  
  OKADA Yoshio
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Shiga University of Medical Science
低栄養腸管粘膜免疫機構に対する成分栄養療法の功罪Principal Investigator
- Principal Investigator
  
  藤山佳秀
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shiga University of Medical Science
非特異性炎症性腸疾患(I.B.D.)の病因、病態への腸内細菌叢の関与ー病変粘膜細菌叢の解析結果を踏まえてー
- Principal Investigator
  
  細田四郎
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Shiga University of Medical Science
成分栄養療法の正常腸管粘膜免疫機構への功罪Principal Investigator
- Principal Investigator
  
  藤山佳秀
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shiga University of Medical Science
病原性発現機序へのIgAプロテアーゼの関与の解明ー粘膜局所免疫の攻撃因子かーPrincipal Investigator
- Principal Investigator
  
  藤山佳秀
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shiga University of Medical Science

All 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article

[Journal Article] Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn's disease using terminal restriction fragment length polymorphism analysis.2011
- Author(s)
  Andoh A, Imaeda H, Aomatsu T, Inatomi O, Bamba S, Sasaki M, Saito Y, Tsujikawa T, Fujiyama Y.
- Journal Title
  
  J Gastroenterol. 46(4)
  
  Pages: 479-486
- NAID
  10029028534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590739
[Journal Article] Energy metabolism in Japanese patients with Crohn's disease.2010
- Author(s)
  Sasaki M, Johtatsu T, Kurihara M, Iwakawa H, Tanaka T, Tsujikawa T, Fujiyama Y, Andoh A.
- Journal Title
  
  J Clin Biochem Nutr. 46(1)
  
  Pages: 68-72
- NAID
  130004466597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590739
[Journal Article] Alendronate improves low bone mineral density induced by steroid therapy in Crohn's disease.2009
- Author(s)
  Tsujikawa T, Andoh A, Inatomi O, Bamba S, Nakahara T, Sasaki M, Saito H, Fujiyama Y.
- Journal Title
  
  Intern Med. 48(12)
  
  Pages: 933-937
- NAID
  130000121886
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590739
[Journal Article] [Case report : periodical infliximab administration enabled closure of colostomy in fistulating perianal Crohn's disease].2008
- Author(s)
  Tsujikawa T, Imaeda H, Kobayashi Y, Oosaki R, Sonoda A, Senou K, Hayafuji K,Minematsu H, Ogawa A, Nakahara T, Hata K, Andoh A, Sasaki M, Saito Y, Fujiyama Y.
- Journal Title
  
  Nippon Shokakibyo Gakkai Zasshi. 105(6)
  
  Pages: 825-829
- NAID
  10021271741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590739
[Journal Article] [Small intestine : development, structure, function].2008
- Author(s)
  Tsujikawa T, Fujiyama Y.
- Journal Title
  
  Nippon Rinsho. 66(7)
  
  Pages: 1240-1242
- NAID
  40016117598
- Data Source
  KAKENHI-PROJECT-20590739
[Journal Article] Novel single-balloon enteroscopy for diagnosis and treatment of the small intestine : preliminary experiences.2008
- Author(s)
  Tsujikawa T, Saitoh Y, Andoh A, Imaeda H, Hata K, Minematsu H, Senoh K,Hayafuji K, Ogawa A, Nakahara T, Sasaki M, Fujiyama Y.
- Journal Title
  
  Endoscopy 40
  
  Pages: 11-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590739
[Journal Article] Interleukin 22 receptor 1 expression in pancreas islets2008
- Author(s)
  Shioya, M., Andoh, A., Kakinoki, S., Nishida, A., Fujiyama, Y
- Journal Title
  
  Pancreas 36(2)
  
  Pages: 197-9
- NAID
  10024367944
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590633
[Journal Article] Inflammatory responses induced by interleukin-17 family members in human colonic subepithelial myofibroblasts.2007
- Author(s)
  Yagi, Y, Fujiyama, Y, et. al.
- Journal Title
  
  J Gastroenterol. 42
  
  Pages: 745-753
- NAID
  10019816691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590633
[Journal Article] Therapeutic approaches targeting intestinal microflora in inflammatory bowel disease.2006
- Author(s)
  Andoh A, Fujiyama Y.
- Journal Title
  
  World J Gastroenterol. 12
  
  Pages: 4452-4460
- Data Source
  KAKENHI-PROJECT-17590633
[Journal Article] Interleukin-1beta and tumor necrosis factor-alpha upregulate interleukin-23 subunit p19 gene expression in human colonic subepithelial myofibroblasts.2005
- Author(s)
  Zhang Z他9名, Fujiyama Y(10番目)
- Journal Title
  
  Int J Mol Med. 15
  
  Pages: 79-83
- Data Source
  KAKENHI-PROJECT-14570462
[Journal Article] B1-B cells are the main antigen presenting cells in CpG-ODN-stimulated peritoneal exudate cells.2005
- Author(s)
  Bama H他5名, Fujiyama Y(5番目)
- Journal Title
  
  Microbiol Immunol. 49
  
  Pages: 89-95
- NAID
  10014377331
- Data Source
  KAKENHI-PROJECT-14570462
[Journal Article] Bile acid modulates transepithelial permeability via the generation of reactive oxygen species in the CaCo2 cell line2005
- Author(s)
  Araki A, Fujiyama Y(7番目)他6名
- Journal Title
  
  Free Radical Biology & Medicine 39
  
  Pages: 769-780
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570462
[Journal Article] Colonic subepithelial myofibroblasts in mucosal inflammation and repair : contribution of bone marrow-derived stem cells to the gut regenerative response2005
- Author(s)
  Andoh A, Bamba S, Fujiyama Y, Brittan M, Wright NA.
- Journal Title
  
  Journal of Gastroenterology 40
  
  Pages: 1089-1099
- NAID
  10016914041
- Data Source
  KAKENHI-PROJECT-17590633
[Journal Article] Clostridium butyricum, a probiotic derivative, suppresses dextran sulfate sodium-induced experimental colitis in rats.2004
- Author(s)
  Araki Y他4名, Fujiyama Y(5番目)
- Journal Title
  
  Int J Mol Med. 13
  
  Pages: 577-580
- Data Source
  KAKENHI-PROJECT-14570462
[Journal Article] Germinated barley foodstuff prolongs remission in patients with ulcerative colitis.2004
- Author(s)
  Hanai H他12名, Fujiyama Y(8番目)
- Journal Title
  
  Int J Mol Med. 13
  
  Pages: 643-647
- Data Source
  KAKENHI-PROJECT-14570462
[Journal Article] The analysis of pyridylamino-dextran sulfate oligomers by high-performance liquid chromatography and a novel detection system for sulfated polysaccharides.2004
- Author(s)
  Araki Y他5名, Fujiyama Y(6番目)
- Journal Title
  
  Oncol Rep. 12
  
  Pages: 363-367
- Data Source
  KAKENHI-PROJECT-14570462
[Journal Article] Suppression of interleukin-1beta- and tumor necrosis factor-alpha-induced inflammatory responses by leukocytapheresis therapy in patients with ulcerative colitis.2004
- Author(s)
  Andoh A他8名, Fujiyama Y(9番目)
- Journal Title
  
  J Gastroenterol. 39
  
  Pages: 1150-1157
- Data Source
  KAKENHI-PROJECT-14570462
[Journal Article] The cytotoxicity of hydrophobic bile acids is ameliorated by more hydrophilic bile acids in intestinal cell lines IEC-6 and CaCo-2.2003
- Author(s)
  Araki Y, Andoh A, Bamba H, Yoshikawa K, Doi H, Komai Y, Higuchi A, Fujiyama Y.
- Journal Title
  
  Oncology Report 10
  
  Pages: 1931-1936
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570462
[Journal Article] Combined effect of hydrogen peroxide induced oxidative stress and IL-1 alpha on IL-8 production in CaCo-2 cells.2003
- Author(s)
  Yamamoto K, Kushima R, Jusaju O, Fujiyama Y, Okebe H.
- Journal Title
  
  Inflammation 27
  
  Pages: 123-128
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570462
[Journal Article] The cytotoxicity of hydrophobic bile acids is ameliorated by more hydrophilic bile acids in intestinal cell lines IEC-6 and CaCo-2.2003
- Author(s)
  Araki Y, Fujiyama Y(8番目)他6名
- Journal Title
  
  Oncology Report 10
  
  Pages: 1931-1936
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570462
[Journal Article] Bild acid modulates transepithelial permeability via the generation of reactive oxygen species in the CaCo-2 cell line.
- Author(s)
  Araki Y, Katoh H, Ogawa A, Bamba S, Andoh A, Koyama S, Fujiyama Y, Bamba T
- Journal Title
  
  Free Radical Biology & Medicine 39
  
  Pages: 769-780
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570462

1. TSUJIKAWA Tomoyuki (80273407)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. ANDOH Akira (90252395)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. BAMBA Shigeki (40422901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OKADA Yoshio (10106825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. FUKANO Miya (50252383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. BANBA Tadao (40079819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TODA Noboru (50025590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 細田四郎 (00079807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 楊明燕

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 趙淑文

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YANG Mingyan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ZHAO Shuwen

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

FUJIYAMA Yoshihide 藤山 佳秀

藤山 佳秀 フジヤマ ヨシヒデ

Research Projects

Research Products

Co-Researchers

Development of new therapeutic agents for inflammatory bowel disease based on the dendritic cell regulation via Dectin-1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the immunoresponse by direct stimulation of fatty acid in Crohn disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of bone marrow-derivedcells in the intestinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of intestinal microbiota derived secondary bile acids in the patho-physiology of inflammatory baowel disease and the expression of UGT by intestinal epithelial cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of immune response in hole body and intestinal mucosa by oral administration of staphylococcal enterotoxin B (SEB)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gastrointestinal and hematologic diseases in Japan and China

Principal Investigator

Project Period (FY)

Research Category

Research Institution

低栄養腸管粘膜免疫機構に対する成分栄養療法の功罪Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

非特異性炎症性腸疾患(I.B.D.)の病因、病態への腸内細菌叢の関与ー病変粘膜細菌叢の解析結果を踏まえてー

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

成分栄養療法の正常腸管粘膜免疫機構への功罪Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

病原性発現機序へのIgAプロテアーゼの関与の解明ー粘膜局所免疫の攻撃因子かーPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn's disease using terminal restriction fragment length polymorphism analysis.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Energy metabolism in Japanese patients with Crohn's disease.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Alendronate improves low bone mineral density induced by steroid therapy in Crohn's disease.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] [Case report : periodical infliximab administration enabled closure of colostomy in fistulating perianal Crohn's disease].2008

FUJIYAMA Yoshihide 藤山佳秀

藤山佳秀フジヤマヨシヒデ