HIROHASHI Setsuo 廣橋説雄

… Alternative Names

廣橋説雄ヒロハシセツオ

広橋説雄ヒロハシセツオ

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Researcher Number	70129625
Affiliation (based on the past Project Information) *help	2009: 国立がんセンター 2000 – 2001: 国立がんセンター, 研究所, 所長 1995 – 1999: 国立がんセンター研究所, 副所長 1997 – 1998: 国立がんセンター, 研究所, 副所長 1996: 国立がんセンター研究所, 病理部, 副所長 … More 1990 – 1994: 国立がんセンター研究所, 病理部, 部長 1990 – 1993: 国立がんセンター, 病理部, 部長 1992: 国立がンセ, 研, 部長 1991: 国立がんセンター研究所, 病理, 部長 1990: 国立がんセンター研究所, 病理, 室長 1988 – 1989: 国立がんセンター, 病理部, 室長 1987 – 1989: 国立がんセンター研究所, 病理部, 室長 1988: 国立がんセンター, 研究所・病理, 室長 1988: Pathology Division, National Cancer Center Research Institute, 室長 1987: 国立ガンセンター研究所, 室長 1986: 国立ガンセンター, 研究所・病理部・実験病理, 室長 Less
Review Section/Research Field	Principal Investigator Human pathology Except Principal Investigator Biological Sciences / Public health/Health science
Keywords	Principal Investigator c-erbB-2 / カドヘリン / 浸潤・転移 / hepatitis B virus / oncogene amplification / DNA extraction / formalin-fixed paraffin-embedded tissue / hst / cーexbBー2 / Nーmyc … More / 予後因子 / 癌遺伝子の増幅 / ドットブロット法 / ホルマリン固定パラフィン包理組織 / B型肝炎ウイスル / 肝癌 / c-myc / sam / 胃癌 / Coxの重回帰分析 / がんの悪性度 / 乳癌の予後因子 / polymerase chain reaction / B型肝炎ウイルス / がん遺伝子増幅 / DNA抽出 / ホルマリン固定パラフィン包埋組織 / signal transduction / tyrosine phosphorylation / integrin / catenin / cadherin / invasion and metastasis / cell adhesion / DNAメチル化 / カドヘリン・カテニン / 多段階発がん / がん間質相互作用 / シグナル伝達 / チロシンリン酸化 / インテグリン / カテニン / 細胞接着 / 胃がん / モノクロ-ナル抗体 / 細胞接着分子 / がんの分化度 … More Except Principal Investigator Stomach cancer / 胃がん / モノクローナル抗体 / テネイシン / 多段階発癌 / がん抑制遺伝子 / 大腸がん / 癌遺伝子 / Cancer / 口腔がん / がん / Lung cancer / Genetic factors / Risk factor / Histology / Case-control study / Brazil / 病理学 / 分子生物学 / 生体指標 / 症例対照研究 / 発がん要因 / 日系移民 / サンパウロ / 糖鎖抗原 / 大腸発がん / β-catenin / カテニン / カドヘリン / がん遺伝子 / 偶発がん / 潜在がん / 乳がん / 前立腺がん / 乳癌 / マ-カ-酵素変異 / 発癌のプログレッション / 癌関連遺伝子 / DNA ploidy / 大腸腺腫 / 大腸癌 / America / Asai / Aerum estrogen / Colorectal Cancer / Werner syndrome / Oral squarmous cell Carcinomas / Cholangiocellular Carcinoma / 南アジア / 東アジア / ウェルナ-症候群 / アメリカ / アジア / 血清エストロゲン値 / ウェルナー症候群 / 肝内胆管癌 / Central-South America / South-East Asia / China / Skin cancer / Liver cancer / Esophageal cancer / ホンコン / 肺がん / インドネシア / マレーシア / ギリシャ / フランス / EBウイルス / 中南米 / 東南アジア / 中国 / 皮膚がん / 肝がん / 食道がん / Cancer Metastasis / DNA Repair / Signal Transduction / Tumor Suppressor Genes / Oncogenes / German-Japanese Collaborative Program in Cancer Research / French-Japanese Collaborative Program in Cancer Research / International Exchange Program / がん抑制遣伝子 / がん遣伝子 / 2国間共同研究 / ヒトゲノム / DNA修復 / がん転移 / がん細胞 / シグナル伝達 / histo-in situ hybridization / 細胞動態 / DNAploidy / 癌形質 / 大腸菌線毛蛋白質 / 黒色腫関連糖鎖 / シアリルLe^a / モノクローナル抗体による血清診断 / 癌胎児性糖鎖 / 血清診断 / メラノーマ / ムチン / ガングリオシド / 癌関連抗原 / 癌診断 / 複合糖質 / 糖蛋白質 / 糖脂質 / 腫瘍マーカー / 単クローン抗体 / 腫瘍関連抗原 / ウィルス / 細胞組織 / 遺伝子 / 細胞・組織 / ゲノム / 癌 / ウイルス / 遺伝学 / Wntシグナル / GeneChip / TCF4 / APC / c-Src / ARFGAP / p130Cas / チロシンリン酸化 / アクチン細胞骨格再構成 / membrane ruffle / RhoGAP / RhoA / paxillin / プラコグロビン / βカテニン / パキシリン / Rho-family GTPases / 浸潤性 / F9 / P120 / 浸潤 / 細胞運動 / インテグリン / 家族性大腸腺腫症 / T-cell factor-4 / multidrug resistance-1 (MDR1) gene / P-glycoprotein / 評価 / 外国側研究者 / ベトナム / ハンガリー / 北欧 / 胆嚢がん / 予備調査 / 計画研究 / 転写因子結合部位 / 転写調節領域 / 染色体7番 / CDDP / cisplatin / がん薬剤耐性 / Semaphorin E / 扁平上皮がん / BP180 / 類天疱瘡患者 / hemidesmosome / 基底膜 / 基底細胞 / 扁平上皮 / c-erbB-2 / インターフェロン / アポトーシス / HGF / lef / Tcr / β-カテニン / c-ERBB2遺伝子 / 6-16遺伝子 / ヒト消化器がん / cycloheximide / 5-FU / cytochrome c / caspase-3 / Bcl-2 / CIB / apoptosis / 6-16 gene / ホルモン / 癌抑制遺伝子 / nm23 / Ag-NOR / rasがん遺伝子 / p53癌抑制遺伝子 / アンドロゲン受容体 / AgーNOR / ras癌遺伝子 / 潜在癌 / 前立腺癌 / flat adenoma / インテグリン抗体 / 原因遺伝子 / 腎癌 / 肺癌 / 肝細胞癌 / 癌胎児性変化 / RNAスプライシング / フィブロネクチン / 細胞外基質 / UEAー1レセプター / 増殖帯 / allelic loss / 背景粘膜 Less

Genetic and Epigenetic Dysregulation in Cancer
- Principal Investigator
  
  NODA Tetsuo
- Project Period (FY)
  2004 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
  Tohoku University
TCF4とβ-catenin複合体により転写活性化される遺伝子の同定と機能解析
- Principal Investigator
  
  山田哲司
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
TCF4とβ-catenin複合体により転写活性化される遺伝子群の同定
- Principal Investigator
  
  山田哲司
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
細胞接着シグナルを介したがん細胞の浸潤制御機構
- Principal Investigator
  
  佐邊壽孝
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka Bioscience Institute
インターフェロン誘導6-16遺伝子の発現とその機能解析
- Principal Investigator
  
  田原榮一 (川原榮一)
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hiroshima University
がん特別調査に関する総括研究
- Principal Investigator
  
  OHNO Yoshiyuki
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya University
Semaphorin E誘導によるがん薬剤耐性機構の解明と臨床的意義の検討
- Principal Investigator
  
  山田哲司
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
Planning-Coordination Committe on Special Cancer Research
- Principal Investigator
  
  OHNO Yoshiyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Public health/Health science
- Research Institution
  NAGOYA UNIVERSITY
ヘミデスモゾーム蛋白BP180を介した扁平上皮の増殖分化制御とその癌化に伴う異常
- Principal Investigator
  
  YAMADA Tesshi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
Intercellular interaction and signal transduction in cancer morphogenesisPrincipal Investigator
- Principal Investigator
  
  HIROHASHI Setsuo
- Project Period (FY)
  1995 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  National Cancer Center Research Institute
General Studies on Special Cancer Research
- Principal Investigator
  
  TOMINAGA Suketami
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Aichi Cancer Center Research Institute
前立腺がんおよび乳がんにおける潜伏がんならびに微小がんの発生と進展
- Principal Investigator
  
  矢谷隆一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Mie University
Case-control study for gastric cancer among Japanese and non-Japanese groups in Brazil
- Principal Investigator
  
  WATANABE Shaw
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  National Cancer Center Research Institute
前立線がんおよび乳がんにおける潜伏がんならびに微小がんの発生と進展
- Principal Investigator
  
  矢谷隆一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Mie University
前立腺がんおよび乳がんにおける潜伏がんならびに微小がんの発生と進展
- Principal Investigator
  
  矢谷隆一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Mie University
Cooperation and information exchange with European countries.
- Principal Investigator
  
  KUROKI Toshio
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  University of Tokyo
Epidemiologic study on gastric cancer among Japanese and non-Japanese groups South America
- Principal Investigator
  
  WATANABE Shaw, 渡邉昌
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  National Cancer Center Research Institute
多段階発癌過程における癌関連遺伝子の変化
- Principal Investigator
  
  KITAGAWA Tomoyuki
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
ヒト固型がんの分化度と細胞接着分子の発現異常Principal Investigator
- Principal Investigator
  
  広橋説雄
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
多段階発癌過程における癌関連遺伝子の変化
- Principal Investigator
  
  北川知行
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
多段階発癌過程における癌関連遺伝子の変化
- Principal Investigator
  
  北川知行
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
ヒト大腸癌の発生と進展に関する細胞生物学的研究
- Principal Investigator
  
  森武貞
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
ヒト癌におけるalternative splicingの脱制御の検証
- Principal Investigator
  
  関口清俊
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Fujita Health University
ヒト大腸癌の発生と進展に関する細胞生物学的研究
- Principal Investigator
  
  森武貞
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
ヒト大腸癌の発生と進展に関する細胞生物学的研究
- Principal Investigator
  
  森武貞
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
腫瘍マーカーとしての糖鎖特異的単クローン抗体の作成とその応用
- Principal Investigator
  
  永井克孝
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Extraction of DNA from formalin-fixed paraffin-embedded tissues and its application to the study of molecular pathology.Principal Investigator
- Principal Investigator
  
  HIROHASHI Setsuo
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  National Cancer Center Research Institute
腫瘍マーカーとしての糖鎖特異的単クローン抗体の作成とその応用
- Principal Investigator
  
  永井克孝
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
腫瘍マーカーとしての糖鎖特異的単クローン抗体の作成とその応用
- Principal Investigator
  
  永井克孝
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo

All 2010 2009 2007 2006 2005 2004

All Journal Article

[Journal Article] Significance of PGP9. 5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma2010
- Author(s)
  Y. Akishima-Fukasawa, Y. Ino, Y. Nakanishi, A. Miura, Y. Moriya, T. Kondo, Y. Kanai, S. Hirohashi
- Journal Title
  
  Am. J. Clin. Pathol. 134
  
  Pages: 71-79
- Data Source
  KAKENHI-PROJECT-16059101
[Journal Article] Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma2009
- Author(s)
  T. Yamanashi, Y. Nakanishi, G. Fujii, Y. Akishima-Fukasawa, Y. Moriya, Y. Kanai, M. Watanabe, S. Hirohashi
- Journal Title
  
  Oncology. 77
  
  Pages: 53-62
- Data Source
  KAKENHI-PROJECT-16059101
[Journal Article] Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.2007
- Author(s)
  H. Katoh, S. Hirohashi, et. al. (total 11, 10th)
- Journal Title
  
  Gastroenterology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16059101
[Journal Article] Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancer proteomics2006
- Author(s)
  T.Kondo, S.Hirohashi
- Journal Title
  
  Nature Protocols 1(6)
  
  Pages: 2940-2956
- Data Source
  KAKENHI-PROJECT-16059101
[Journal Article] Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis : its association with clinicopathological features.2005
- Author(s)
  T.Shibata, S.Hirohashi et al.(total 13, last)
- Journal Title
  
  Clinical Cancer Res. 11(17)
  
  Pages: 6177-6185
- Data Source
  KAKENHI-PROJECT-16059101
[Journal Article] Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer.2005
- Author(s)
  S.Hirohashi.(他8名)
- Journal Title
  
  Gastroenterology 128(1)
  
  Pages: 51-62
- Data Source
  KAKENHI-PROJECT-16059101
[Journal Article] Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells.2004
- Author(s)
  S.Hirohashi.(他8名)
- Journal Title
  
  Cancer Res. 64(19)
  
  Pages: 6989-6995
- Data Source
  KAKENHI-PROJECT-16059101

1. KITAGAWA Tomoyuki (50085619)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. YAMADA Tesshi (30221659)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. KUROKI Toshio (90006073)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 加藤洋 (20010473)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 藤田哲也 (00079716)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. OHNO Yoshiyuki (10160590)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. YAMAMOTO Tadashi (40134621)

# of Collaborated Projects: 3 results

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8. HANAOKA Fumio (50012670)

# of Collaborated Projects: 3 results

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9. 森武貞 (60028496)

# of Collaborated Projects: 3 results

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10. 喜納勇 (60010211)

# of Collaborated Projects: 3 results

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11. 佐藤栄一 (60004579)

# of Collaborated Projects: 3 results

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12. 佐藤清美 (50006079)

# of Collaborated Projects: 3 results

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13. 小川勝洋 (50045514)

# of Collaborated Projects: 3 results

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14. 矢谷隆一 (80024636)

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15. 島崎淳 (10008229)

# of Collaborated Projects: 3 results

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16. 坂元吾偉 (80085620)

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17. 永井克孝 (80072974)

# of Collaborated Projects: 3 results

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18. 松本亮 (70046241)

# of Collaborated Projects: 3 results

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19. 内貴正治 (10020752)

# of Collaborated Projects: 3 results

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20. 谷口克 (80110310)

# of Collaborated Projects: 3 results

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21. 坂倉照好 (80073120)

# of Collaborated Projects: 2 results

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22. FUJIKI Hirota (60124426)

# of Collaborated Projects: 2 results

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23. ISHIKAWA Fuyuki (30184493)

# of Collaborated Projects: 2 results

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24. YAMAMOTO Masayuki (50166823)

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25. NAKAMURA Takuro (00180373)

# of Collaborated Projects: 2 results

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26. SHIMOTONO Kunitada (10000259)

# of Collaborated Projects: 2 results

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27. WATANABE Shaw (60051637)

# of Collaborated Projects: 2 results

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28. WAKABAYASHI Kenji (60158582)

# of Collaborated Projects: 2 results

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29. TSUGANE Shoichiro (40179982)

# of Collaborated Projects: 2 results

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30. YOSHIDA Mitsuaki (80012607)

# of Collaborated Projects: 2 results

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31. 白井智之 (60080066)

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32. 酒井正春 (50162269)

# of Collaborated Projects: 2 results

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33. 寺田信行 (50150339)

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34. 千谷晃一 (60179942)

# of Collaborated Projects: 2 results

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35. LAURENTI Ruy

# of Collaborated Projects: 2 results

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36. IRIYA Kiyoshi

# of Collaborated Projects: 2 results

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37. KOWALSKI Luiz

# of Collaborated Projects: 2 results

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38. TORLONI Humberto

# of Collaborated Projects: 2 results

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39. NODA Tetsuo (10183550)

# of Collaborated Projects: 1 results

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40. TAYA Youichi (60133641)

# of Collaborated Projects: 1 results

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41. HATAKEYAMA Masanori (40189551)

# of Collaborated Projects: 1 results

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42. TAKAI Yoshimi (60093514)

# of Collaborated Projects: 1 results

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43. NIWA Ohtsura (80093293)

# of Collaborated Projects: 1 results

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44. SAYA Hideyuki (80264282)

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45. NIKAIDO Osamu (60019669)

# of Collaborated Projects: 1 results

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46. SEKI Shuji (50032884)

# of Collaborated Projects: 1 results

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47. TANAKA Kiyoji (80144450)

# of Collaborated Projects: 1 results

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48. MAKI Hisaji (20199649)

# of Collaborated Projects: 1 results

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49. ISHIKAWA Takatoshi (30085633)

# of Collaborated Projects: 1 results

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50. SEKIGUCHI Mutsuo (00037342)

# of Collaborated Projects: 1 results

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51. TOMINAGA Suketami (30124530)

# of Collaborated Projects: 1 results

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52. FUJIYAMA Chihaya (30274814)

# of Collaborated Projects: 1 results

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53. IKEDA Noriaki (30150791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. SASAKI Ryuichiro (80131241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
55. ICHIHASHI Masamitsu (00030867)

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HIROHASHI Setsuo 廣橋 説雄

廣橋 説雄 ヒロハシ セツオ

広橋 説雄 ヒロハシ セツオ

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HIROHASHI Setsuo 廣橋説雄

廣橋説雄ヒロハシセツオ

広橋説雄ヒロハシセツオ