KUBOKAWA Manabu 久保川学

… Alternative Names

久保川学クボカワマナブ

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Researcher Number	70153327
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2011 – 2013: 岩手医科大学, 医学部, 教授 1998 – 2000: 岩手医科大学, 医学部, 教授 1998: Physiology II,Iwate Medical University Prof., 歯学部, 教授 1997: 大阪医科大学, 医学部, 助教授 1995: 大坂医科大学, 医学部, 講師 1991 – 1993: 大阪医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General physiology / General physiology Except Principal Investigator General physiology
Keywords	Principal Investigator K^+ channel / ATP / phosphorylation / proximal tubule / kidney / K^+channel / イオン輸送 / 腎尿細管 / パッチクランプ法 / cell pH … More / dephosphorylation / membrane potential / リン酸化酵素 / 細胞内Ca^<2+> / 膜電位 / 蛋白質脱リン酸化 / 蛋白質リン酸化 / 細胞内pH / K^+排泄 / cyclic GMP / protein kinase C / protein kinase A / ion transport / 蛋白脱燐酸化 / Gキナーゼ / Cキナーゼ / Aキナーゼ / 蛋白燐酸化 / 腎近位尿細管 / 二重還流装置 / インサート / MI細胞 / イオンチャネル / 集合管 / チャネル局在 / チャネル活性 / 膜発現 / 細胞膜極性 / 腎集合管細胞 / チャネル発現 / 遺伝子導入 / 腎集合管 / 管腔膜 / M-1細胞 / 遺伝子発現 / 膜蛋白質遺伝子発現 / Kチャネル / ROMK … More Except Principal Investigator Intracellular Ca / Intracellular pH / Ion channel / Urinary acidification / cyclic AMP / Tubular Na transport / Catecholamine / Angiotensin II / 腎尿細管細胞 / ノルエピネフリン / アンギオテンシンーII / 細胞内Na / 細胞内シグナル伝達 / 細胞容積調節 / Kチャネル / Clチャネル / パッチクランプ実験 / 単離尿細管細胞 / OK細胞 / 細胞内Ca / 細胞内pH / イオンチャネル / 尿酸性化 / サイクリックAMP / 尿細管ナトリウム輸送 / カテコラミン / アンギオテンシンII / 蛋白脱燐酸化 / Aキナーゼ / オポッサム腎培養細胞 / 食用蛙単離尿細管細胞 / パッチクランプ法 / ATP依存性K^+チャネル / pH感受性K^+チャネル Less

Molecular mechanisms for expression of renal potassium channels in doubly-perfused cultured collecting duct cells.Principal Investigator
- Principal Investigator
  
  KUBOKAWA Manabu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Iwate Medical University
Regulation and expression of ion channels in the renal tubule cellsPrincipal Investigator
- Principal Investigator
  
  KUBOKAWA Manabu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Iwate Medical University
Molecular Mechanisms for Regulation of Renal Ion ChannelsPrincipal Investigator
- Principal Investigator
  
  KUBOKAWA Manabu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Iwate Medical University
  Osaka Medical College
単離尿細管のpH感受性イオンチャネルの生理的意義
- Principal Investigator
  
  萩原暢子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kyoto Notre Dame University
Studies on intracellular signal transduction mechanism in renal tubular cells.
- Principal Investigator
  
  FUJIMOTO Mamoru
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Osaka Medical College

All 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] Patch-Clamp Technique2012
- Author(s)
  Kubokawa M, et al
- Total Pages
  108
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-23590264
[Book] PATCH CLAMP TECHNIQUE2012
- Author(s)
  Manabu Kubokawa
- Total Pages
  355
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-23590264
[Book] Recent Research Developments in Physiology2012
- Author(s)
  Manabu Kubokawa
- Total Pages
  191
- Publisher
  RESEARCH SIGNPOST
- Data Source
  KAKENHI-PROJECT-23590264
[Journal Article] Interleukin-1βsuppresses activity of an inwardly rectifying K^+ channel in human renal proximal tubule cells2013
- Author(s)
  Nakamura K, Komagiri Y, Kubokawa M
- Journal Title
  
  J Physiol Sci
  
  Volume: 63 Pages: 377-387
- NAID
  10031195391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590264
[Journal Article] Interleukin-1β suppresses activity of an inwardly rectifying K+ channel in human renal proximal tubule cells.2013
- Author(s)
  Nakamura K, Komagiri Y, Kubokawa M
- Journal Title
  
  J Physiol Sci
  
  Volume: 63 Issue: 5 Pages: 377-387
- DOI
  10.1007/s12576-013-0275-6
- NAID
  10031195391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590264
[Journal Article] Roles of Ca^<2+>-dependent phosphorylation and dephosphorylation in regulation of potassium channels in renal tubule cells2012
- Author(s)
  Kubokawa, M. Nakamura, K
- Journal Title
  
  Recent Res Devel Physi
  
  Volume: 5 Pages: 175-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590264
[Journal Article] Effects of cytokines on K^+ channels in renal tubular epithelia2012
- Author(s)
  Nakamura K, Komagiri Y, Kubokawa M
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 16 Pages: 55-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590264
[Journal Article] Functional relashionships between Ca2+/calmodulin-dependent kinases and phosphatase in regulation of K+ channel and intracellular Ca2+ in kidney tubules.2011
- Author(s)
  Kubokawa M, Nakamura K, Komagiri Y.
- Journal Title
  
  Journal of Iwate Medical Association
  
  Volume: 63 Pages: 209-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590264
[Journal Article] Functional relationships between Ca^<2+>/calmodulin-dependent kinases and phosphatase in regulation of K^+ channel activity and intracellular Ca^<2+> in kidney tubule cells2011
- Author(s)
  Kubokawa M, Komagiri Y, Nakamura K
- Journal Title
  
  J Iwate med Assoc
  
  Volume: 63 Pages: 209-218
- NAID
  110008665522
- Data Source
  KAKENHI-PROJECT-23590264
[Journal Article] Interaction between calcineurin and Ca^<2+>/calmodulin kinase-II in modulating cellular functions2011
- Author(s)
  Kubokawa M, Nakamura K, Komagiri Y
- Journal Title
  
  Enzyme Res
  
  Volume: 2011 Pages: 1-5
- DOI
  10.4061/2011/587359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] Characteristics of exogenous expression of ROMK K channels with EGFP fused to the different terminus in polarized and non-polarized membranes in cultured M-1 cells2014
- Author(s)
  Kubokawa M, Nakamura K, Mayanagi T, Sobue K
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] Expression of exogenously transfected ROMK K^+ channel activity favors the polarized apical membrane of cultured M-1 collecting duct cells2013
- Author(s)
  Kubokawa M, Nakamura K, Mayanagi T, Sobue K
- Organizer
  37th International Conference of Physiological Sciences (IUPS)
- Place of Presentation
  Birmingham, UK
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] Functional expression of transfected ROMK potassium channels in polarized and non-polarized membranes of cultured M1 cells.2013
- Author(s)
  Manabu Kubokawa
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] Functional expression of transfected ROMK potassium channels in polarized and non-polarized membranes of cultured M1 cells2013
- Author(s)
  Kubokawa M, Nakamura K, Mayanagi T, Sobue K
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] 培養M1集合管細胞へのROMK遺伝子導入によるチャネル活性発現と細胞膜極性との関連2013
- Author(s)
  久保川学, 中村一芳, 真柳平, 祖父江憲司
- Organizer
  第56回日本腎臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] Regulation of Renal ATP-dependent Potassium Channels by Phosphorylation and Dephosphorylation Processes2012
- Author(s)
  Kubokawa M, Nakamura K, Komagiri Y
- Organizer
  2012 International Ion Channel Conference
- Place of Presentation
  Jeju, Korea
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] Regulation of Renal ATP-dependent Potassium Channels by Phosphorylation and Dephosphorylation Processes.2012
- Author(s)
  Manabu Kubokawa
- Organizer
  2012 International Ion Channel Conference
- Place of Presentation
  Jeju, Korea,
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] ラット皮質集合管細胞における低浸透圧刺激に応答するCl-チャネルの探索
- Author(s)
  駒切　洋、中村一芳、久保川　学
- Organizer
  第56回日本腎臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] Expression of exogenously transfected ROMK K+ channel activity favors the polarized apical membrane of cultured M-1 collecting duct cells
- Author(s)
  Kubokawa M, Nakamura K, Mayanag T, Sobue K
- Organizer
  37th International Conference of Physiological Sciences (IUPS)
- Place of Presentation
  バーミンガム（英国）
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] 培養M1集合管細胞へのROMK遺伝子導入によるチャネル活性発現と細胞膜極性との関連
- Author(s)
  久保川　学、中村一芳、真柳　平、祖父江憲司
- Organizer
  第56回日本腎臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] Interleukin-1β reduces K+ channel activity through phosphorylation processes mediated by protein kinase C in human kidney proximal tubule cells.
- Author(s)
  Nakamura K, Komagiri Y, Kubokawa M
- Organizer
  37th International Conference of Physiological Sciences (IUPS)
- Place of Presentation
  バーミンガム（英国）
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] Involvement of K+ channel activity in the cytotoxicity of TNF-α in cultured human proximal tubule cells
- Author(s)
  Nakamura K, Komagiri Y, Kubokawa M
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23590264
[Presentation] 培養ヒト近位尿細管細胞のK+チャネル活性に対するtumor necrosis factor-aの促進作用
- Author(s)
  中村一芳、駒切　洋、久保川　学
- Organizer
  第56回日本腎臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590264

1. NAKAMURA Kazuyoshi (50237385)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
2. MAYANAGI Taira (20432544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. SOBUE Kenji (20112047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. FUJIMOTO Mamoru (70084803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KOTERA Kunihiko (00084905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MORI Yoshiaki (70268192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HIRANO Junko (40316352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 萩原暢子 (00164765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUBOKAWA Manabu 久保川 学

久保川 学 クボカワ マナブ

Research Projects

Research Products

Co-Researchers

Molecular mechanisms for expression of renal potassium channels in doubly-perfused cultured collecting duct cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation and expression of ion channels in the renal tubule cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Mechanisms for Regulation of Renal Ion ChannelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

単離尿細管のpH感受性イオンチャネルの生理的意義

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on intracellular signal transduction mechanism in renal tubular cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Patch-Clamp Technique2012

Author(s)

Total Pages

Publisher

Data Source

[Book] PATCH CLAMP TECHNIQUE2012

Author(s)

Total Pages

Publisher

Data Source

[Book] Recent Research Developments in Physiology2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Interleukin-1βsuppresses activity of an inwardly rectifying K^+ channel in human renal proximal tubule cells2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Interleukin-1β suppresses activity of an inwardly rectifying K+ channel in human renal proximal tubule cells.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Roles of Ca^<2+>-dependent phosphorylation and dephosphorylation in regulation of potassium channels in renal tubule cells2012

Author(s)

Journal Title

Data Source

[Journal Article] Effects of cytokines on K^+ channels in renal tubular epithelia2012

Author(s)

Journal Title

Data Source

[Journal Article] Functional relashionships between Ca2+/calmodulin-dependent kinases and phosphatase in regulation of K+ channel and intracellular Ca2+ in kidney tubules.2011

Author(s)

Journal Title

Data Source

[Journal Article] Functional relationships between Ca^<2+>/calmodulin-dependent kinases and phosphatase in regulation of K^+ channel activity and intracellular Ca^<2+> in kidney tubule cells2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Interaction between calcineurin and Ca^<2+>/calmodulin kinase-II in modulating cellular functions2011

Author(s)

KUBOKAWA Manabu 久保川学

久保川学クボカワマナブ