NOGUCHI Katsuhiko 野口克彦

Researcher Number	70156181
Other IDs
Affiliation (based on the past Project Information) *help	2017: 琉球大学, 医学部, 非常勤講師 2017: 琉球大学, 医学研究科, 准教授 2012 – 2016: 琉球大学, 医学(系)研究科(研究院), 准教授 2013: 琉球大学, 大学院医学研究科, 准教授 1999 – 2001: 琉球大学, 医学部, 助教授 1989 – 1990: 琉球大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology Except Principal Investigator 応用薬理学・医療系薬学 / Anesthesiology / General pharmacology
Keywords	Principal Investigator 血管内皮機能 / dihydrofolate reductase / テトラヒドロビオプテリン / ジヒドロビオプテリン / 酸化ストレス / 血管内皮細胞機能 / 一酸化窒素 / 遺伝子導入マウス / 血管内皮細胞 / ジヒドロ葉酸還元酵素 / 一酸化窒素合成酵素 / 動脈硬化 / 心血管 … More Except Principal Investigator … More マウス / 一酸化窒素合成酵素 / エストロゲン / 欠損 / 性差 / ミトコンドリア機能不全 / 酸化ストレス / テストステロン / 再灌流 / 脳虚血 / quercetin / reperfusion / ischemia / bactericidal action / hepatoprotection / antioxidants / reactive oxygen species / Okinawa / medicinal herb / グァバ / 健康食品 / ベニバナボロギク / フラボノイド / 虚血再灌流障害 / 抗菌作用 / タンニン / モモタマナ / iNOS / 抗酸化作用 / 薬草 / 再灌流傷害 / 虚血 / クロロゲン酸 / クェルセチン / 肝保護作用 / 抗菌活性 / 抗酸化物質 / 活性酸素 / 沖縄薬草 / Anesthetized dog / Coronary perfusion pressure / Pressure-flow relationship / Blood flow pattern / Myocardial blood flow / Microcirculation / Laser flowmeter / 摘出灌流ラット心臓 / ベ-タ受容体遮断薬 / 冠拡張薬 / 心筋虚血 / 冠血流量 / 臓器血流量 / 全身血行動態 / 麻酔開胸イヌ / レ-ザ組織血流計 / 麻酔開胸犬 / 冠潅流圧 / 圧一流量関係 / 血流波形 / 心筋組織血流量 / 微小循環 / レ-ザ組織血統計 / 遺伝子改変マウス / 急性心筋梗塞 / 骨髄前駆細胞 / 慢性腎臓病 / 動脈硬化 / 一酸化窒素 / ノックアウトマウス / 臓器連関 Less

Role of dihydrofolate reductase in the regulation of endothelial functionPrincipal Investigator
- Principal Investigator
  
  Noguchi Katsuhiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of the Ryukyus
An attempt to apply to new therapy the phenomenon that complete disruption of all nitric oxide synthase genes reduces cerebral infarct volume.
- Principal Investigator
  
  Kubota Haruaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  University of the Ryukyus
Evaluation of the role of dihydrobiopterin in the regulation of endothelial function in the normal and pathological statesPrincipal Investigator
- Principal Investigator
  
  NOGUCHI Katsuhiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of the Ryukyus
Basic research on the role of the nitric oxide synthase system in organ connection
- Principal Investigator
  
  TSUTSUI Masato
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of the Ryukyus
Chemical/pharmacological study for developing health promoting materials of natural antioxidants from Okinawa Islands.
- Principal Investigator
  
  ANIYA Yoko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  University of the Ryukyus
Changes in Myocardial Microcirculation Induced by Ischemia and Effects of Drugs on Them.
- Principal Investigator
  
  SAKANASHI Matao
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  University of the Ryukyus

All 2017 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.2017
- Author(s)
  Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M.
- Journal Title
  
  Diabetologia.
  
  Volume: 60 Issue: 6 Pages: 1138-1152
- DOI
  10.1007/s00125-017-4259-6
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04816, KAKENHI-PROJECT-15H06519, KAKENHI-PROJECT-15K15046, KAKENHI-PROJECT-15K21251, KAKENHI-PROJECT-15K08238, KAKENHI-PROJECT-15K10644, KAKENHI-PROJECT-16K09519, KAKENHI-PROJECT-16H00594, KAKENHI-PROJECT-17K09839
[Journal Article] Caffeine Contained in a Cup of Coffee Enhances Microvascular Endothelial Function in Healthy Subjects.2015
- Author(s)
  Noguchi K, Matsuzaki T, Sakanashi M, Hamadate N, Uchida T, Kina-Tanada M, Kubota H, Nakasone J, Sakanashi M, Ueda S, Masuzaki H, Ishiuchi S, Ohya Y, Tsutsui M
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 127 Issue: 2 Pages: 217-222
- DOI
  10.1016/j.jphs.2015.01.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590324, KAKENHI-PROJECT-24650168, KAKENHI-PROJECT-15H00594
[Journal Article] Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse.2014
- Author(s)
  Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M.
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 77 Pages: 29-41
- DOI
  10.1016/j.yjmcc.2014.09.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390352, KAKENHI-PROJECT-24590324, KAKENHI-PROJECT-24591245, KAKENHI-PROJECT-24591338, KAKENHI-PROJECT-24650168, KAKENHI-PROJECT-26500022
[Journal Article] Dihydrobiopterinによる内皮型一酸化窒素合成酵素機能障害2013
- Author(s)
  野口克彦、濱舘直史、松﨑俊博、坂梨まゆ子、仲宗根淳子、内田太郎、新垣久美子、久保田陽秋、石内勝吾、益崎裕章、須加原一博、大屋祐輔、坂梨又郎、筒井正人
- Journal Title
  
  琉球医学会誌
  
  Volume: 32 Pages: 7-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590324
[Journal Article] Long-Term Treatment With San’o-Shashin-To, a Kampo Medicine, Markedly Ameliorates Cardiac Ischemia-Reperfusion Injury in Ovariectomized Rats via the Redox-Dependent Mechanism2013
- Author(s)
  Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Sakanashi M, Uchida T, Kina-Tanada M, Kubota H, Arakaki K, Tanimoto A, Yanagihara N, Sakanashi M, Ohya Y, Masuzaki H, Ishiuchi S, Sugahara K, Tsutsui M
- Journal Title
  
  Circ J
  
  Volume: 77 Issue: 7 Pages: 1827-1837
- DOI
  10.1253/circj.CJ-12-1434
- NAID
  10031173765
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590660, KAKENHI-PROJECT-23390376, KAKENHI-PROJECT-23590159, KAKENHI-PROJECT-23590305, KAKENHI-PROJECT-23617035, KAKENHI-PROJECT-23790300, KAKENHI-PROJECT-24590324
[Journal Article] Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo.2011
- Author(s)
  Noguchi K, Hamadate N, Matsuzaki T, Sakanashi M, Nakasone J, Uchida T, Arakaki K, Kubota H, Ishiuchi S, Masuzaki H, Sugahara K, Ohya Y, Sakanashi M, Tsutsui M.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590305
[Journal Article] Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice: involvement of bone marrow-derived cells.2011
- Author(s)
  Furuno Y, Morishita T, Toyohira Y, Yamada S, Ueno S, Morisada N, Sugita K, Noguchi K, Sakanashi M, Miyata H, Tanimoto A, Sasaguri Y, Shimokawa H, Otsuji Y, Yanagihara N, Tamura M, Tsutsui M.
- Journal Title
  
  Nitric Oxide
  
  Volume: 25 Pages: 350-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590305
[Journal Article] Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice : Involvement of bone marrow-derived cells2011
- Author(s)
  Furuno Y., Morishita T., Toyohira Y., Yamada S., Ueno S., Morisada N., Sugita K., Noguchi K., Sakanashi M., Miyata H., Tanimoto A., Sasaguri Y., Shimokawa H., Otsuji Y., Yanagihara N., Tamura M., Tsuttsui M
- Journal Title
  
  Nitric Oxide
  
  Volume: 25 Issue: 3 Pages: 350-359
- DOI
  10.1016/j.niox.2011.06.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590159, KAKENHI-PROJECT-23590305, KAKENHI-PROJECT-23617035, KAKENHI-PROJECT-23617036
[Journal Article] Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo2011
- Author(s)
  Noguchi K, Hamadate N, Matsuzaki T, Sakanashi M, Nakasone J, Uchida T, Arakaki K, Kubota H, Ishiuchi S, Masuzaki H, Sugahara K, Ohya Y, Sakanashi M, Tsutsui M
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 301 Issue: 3 Pages: H721-H729
- DOI
  10.1152/ajpheart.01089.2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590305, KAKENHI-PROJECT-23790300
[Presentation] Long-term dietary nitrite and nitrate deficiency causes metabolic syndrome, endothelial dysfunction, and cardiovascular death in mice.2017
- Author(s)
  Tsutsui M, Kina-Tanada M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Shimokawa H, Ohya Y, Arasaki A.
- Organizer
  American Heart Association Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08238
[Presentation] Deleterious effect of all nitric oxide synthases in cerebral infarction in male mice: involvements of sex difference and testosterone.2017
- Author(s)
  Tsutsui M, Kubota H, Noguchi K, Matsuzaki T, Sakanashi M, Nakasone J, Shimokawa H, Ohya Y, Sugahara K, Kakinohana M.
- Organizer
  American Heart Association Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08238
[Presentation] 脳梗塞におけるNO合成酵素の有害な作用：性差およびテストステロンの関与2017
- Author(s)
  久保田陽秋、野口克彦、坂梨まゆ子、松崎俊博、仲宗根淳子、下川宏明、須加原一博、垣花　学、筒井正人
- Organizer
  第46回日本心脈管作動物質学会
- Data Source
  KAKENHI-PROJECT-15K08238
[Presentation] Sex difference in sudden death of 2/3 nephrectomized triple nitric oxide synthases-deficient mice.2017
- Author(s)
  Tsutsui M, Sakanashi M, Taira Y, Matsuzaki T, Noguchi K, Nakasone J, Ohya Y, Shimokawa H.
- Organizer
  IGM Congress 2017, The 8th Congress of the International Society for Gender Medicine.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08238
[Presentation] Development of an Experimentally Useful Model of Spontaneous Myocardial Infarction : 2/3 Nephrectomized Triple Nitric Oxide Synthases-Deficient Mouse2014
- Author(s)
  Uchida T, Furuno Y, Tanimoto H, Arakaki K, Kina M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Ohya Y, Yanagihara N, Shimokawa H, Tamura M, Otsuji Y, Tsutsui M.
- Organizer
  The 78th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Tokyo International Forum, Tokyo, Japan
- Year and Date
  2014-03-22
- Data Source
  KAKENHI-PROJECT-23590305
[Presentation] Development of an experimentally useful animal model of spontaneous myocardial infarction2013
- Author(s)
  Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Ohya Y, Yanagihara N, Shimokawa H, Tamura M, Otsuji Y, Tsutsui M
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Pacifico Yokohama, Yokohama, Japan
- Year and Date
  2013-03-15
- Data Source
  KAKENHI-PROJECT-23590305
[Presentation] ジヒドロビオプテリンのeNOS機能におよぼす影響2012
- Author(s)
  野口克彦、松崎俊博、坂梨まゆ子、浜館直史、仲宗根淳子、坂梨又郎、筒井正人
- Organizer
  第12回日本NO学会
- Place of Presentation
  兵庫県、神戸
- Data Source
  KAKENHI-PROJECT-24590324
[Presentation] Increasing dihydrobiopterin causese dysfunction of endothelial nitric oxide synthase in rats in vivo.2011
- Author(s)
  Tsutsui M, Noguchi K, Matsuzaki T, Sakanashi M, Nakasone J, Uchida T, Arakaki K, Kubota H, Sugahara K, Ohya Y.
- Organizer
  American Heart Association, Scientific Sessions 2011
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23590305
[Presentation] ジヒドロビオプテリンによる生体位ラットのeNOS機能障害
- Author(s)
  野口克彦、松崎俊博、坂梨まゆ子、浜館直史、仲宗根淳子、坂梨又郎、筒井正人
- Organizer
  第13回日本NO学会
- Place of Presentation
  那覇市
- Data Source
  KAKENHI-PROJECT-24590324
[Presentation] Development of an experimentally useful animal model of spontaneous myocardial infarction.
- Author(s)
  Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Ohya Y, Yanagihara N, Shimokawa H, Tamura M, Otsuji Y, Tsutsui M.
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Society.
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23590305
[Presentation] コーヒー1杯のカフェインのヒト微小血管内皮機能に対する急性効果
- Author(s)
  野口克彦、松崎俊博、坂梨まゆ子、浜館直史、仲宗根淳子、坂梨又郎、筒井正人
- Organizer
  第13回日本NO学会
- Place of Presentation
  那覇市
- Data Source
  KAKENHI-PROJECT-24590324
[Presentation] 内皮型一酸化窒素合成酵素（eNOS）の新しい活性調節機構の解明：DihydrobiopterinによるeNOS機能不全
- Author(s)
  野口克彦、松﨑俊博、坂梨まゆ子、仲宗根淳子、内田太郎、新垣久美子、久保田陽明、石内勝吾、益崎裕章、須加原一博、大屋祐輔、坂梨又郎、筒井正人
- Organizer
  第157回琉球医学会例会
- Place of Presentation
  沖縄県、西原
- Data Source
  KAKENHI-PROJECT-24590324

1. TSUTSUI Masato (70309962)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
2. MATSUZAKI Toshihiro (50244330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. SAKANASHI Mayuko (80363662)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. SAKANASHI Matao (80040252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HIGUCHI Makie (80040187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ANIYA Yoko (90045055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKAMINE Husae (80045062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Kubota Haruaki (10600421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 長嶺勝 (20189161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ICHIBA Toshio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SATOH Kimio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 柳原延章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 石内勝吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NOGUCHI Katsuhiko 野口 克彦

Research Projects

Research Products

Co-Researchers

Role of dihydrofolate reductase in the regulation of endothelial functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An attempt to apply to new therapy the phenomenon that complete disruption of all nitric oxide synthase genes reduces cerebral infarct volume.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of the role of dihydrobiopterin in the regulation of endothelial function in the normal and pathological statesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic research on the role of the nitric oxide synthase system in organ connection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical/pharmacological study for developing health promoting materials of natural antioxidants from Okinawa Islands.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Changes in Myocardial Microcirculation Induced by Ischemia and Effects of Drugs on Them.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Caffeine Contained in a Cup of Coffee Enhances Microvascular Endothelial Function in Healthy Subjects.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dihydrobiopterinによる内皮型一酸化窒素合成酵素機能障害2013

Author(s)

Journal Title

Data Source

[Journal Article] Long-Term Treatment With San&rsquo;o-Shashin-To, a Kampo Medicine, Markedly Ameliorates Cardiac Ischemia-Reperfusion Injury in Ovariectomized Rats via the Redox-Dependent Mechanism2013

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo.2011

Author(s)

Journal Title

Data Source

[Journal Article] Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice: involvement of bone marrow-derived cells.2011

Author(s)

Journal Title

Data Source

[Journal Article] Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice : Involvement of bone marrow-derived cells2011

Author(s)

Journal Title

DOI

Data Source

NOGUCHI Katsuhiko 野口克彦

[Journal Article] Long-Term Treatment With San’o-Shashin-To, a Kampo Medicine, Markedly Ameliorates Cardiac Ischemia-Reperfusion Injury in Ovariectomized Rats via the Redox-Dependent Mechanism2013