Yokomatsu Tsutomu 横松力

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YOKOMATSU Tsutomu 横松力

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Researcher Number	70158369
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2020: 東京薬科大学, その他部局等, 名誉教授 2013 – 2015: 東京薬科大学, 薬学部, 教授 2004 – 2011: Tokyo University of Pharmacy and Life Science, School of Pharmacy, Professor, 薬学部, 教授 2003: 東京薬科大学, 薬学部, 助教授 1998 – 1999: 東京薬科大学, 薬学部, 助教授 1989 – 1990: 東京薬科大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy / Basic Section 09050:Tertiary education-related
Keywords	Principal Investigator PNP阻害剤 / ジフルオロホスホン酸 / ヌクレオチドアナログ / スフィンゴミエリナーゼ / Sonogashira coupling / nucleotide analogues / 9-デアザグアニン / プリンヌクレオシドホスホリラーゼ / Alkynylation / Vinyl triflate … More / Cycloalkene oxide / Cyclic conjugate diynene / ホスフィン酸 / ジペプチドイソスター / fragment-based drug design / 計量的分析 / 検証 / 教育制度改革 / 学力評価 / インパクト / 薬学教育６年制 / 汎用能力 / 学業成績 / 高校ランク / 評定平均 / 間接評価 / 直接評価 / 役立ち度 / 満足度 / 医療法の改正 / 薬剤師職比率 / 統合学修期 / 基盤形成期 / 成長パターン / 薬学教育6年制 / 薬剤師 / 学修成果 / 薬学6年制教育 / 卒業時調査 / 卒業生調査 / phosphatase resistance / P2Y1 receptor antagonists / chemical modification / 9-deazaguanines / PNP inhibitors / difluoromethylenephosphonic acids / 核酸医薬 / ジフルオロホスフィン酸 / DNA / ジフロルオロホスホン酸 / ホスファターゼ抵抗性 / P2Y_1受容体アンタゴニスト / 化学修飾 / N-glycosylation / adenosine bisphosphates / short-chain analogues / N-palmitoylsphingosine-1-phosphate / inhibitors / sphingomyelinase / purine nucleoside phosphorylase / 酵素阻害剤 / MRS 2179 / P2Y1受容体拮抗剤 / イノシトールアナログ / アポトーシス / 神経細胞 / SMase阻害剤 / セラミド-1-ホスフェート / ジフルオロメチレンホスホン酸 / Structure-activity relation ship / Difluoromethylenephosphonic acids / Inhibitors / Protein-tyrosine phosphatase / Purine nucleoside phosphorylase / プロテインチロシンホスファターゼ / 構造活性相関 / ジフルホロホスホン酸 / 阻害薬 / プロティン・チロシンホスファターゼ / プリンヌクレシオドホスホリラーゼ / Bicyclo[3, 3, 1]nonane / ビシクロ[3,3,1]ノナン / 環状共役Diynene / アルキニル化 / ビニルトリフレ-ト / シクロアルケンオキシド / Bicyclo[3,3,1]nonane / プロテアーゼ / ホスホニル化反応 / 脱炭酸 / プロリン / ホスホプロリン / ジペプチド / 錯体形成 / トリアゾキノリン類 / プロテアーゼ阻害剤 / ミミック / 光学分割 / 結合定数 / 阻害形式 / 酵素選択性 / バイオイソスター / 生物活性 / ホスホン酸 / ジフルオロメチレンボスホン酸 / 速度論的光学分割 / X線構造解析 / 遷移状態アナログ / ペプチドイソスター / Huisen反応 / Huisgen反応 / TP阻害剤 / Huisgen 反応 / クリック反応 / TP 阻害剤 / PNP 阻害剤 Less

Impacts of 6-years educational systems on pharmaceutical university studentsPrincipal Investigator
- Principal Investigator
  
  Yokomatsu Tsutomu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09050:Tertiary education-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Application of phosphate mimetics to development of biologically active compoundsPrincipal Investigator
- Principal Investigator
  
  Yokomatsu Tsutomu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of biologically active compounds based on features of phosphonyl and phosphinyl functional groupsPrincipal Investigator
- Principal Investigator
  
  YOKOMATSU Tsutomu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of biologically active compounds based on features of fluoromethylene phosphonatesPrincipal Investigator
- Principal Investigator
  
  横松力
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Application of difluoromethylene phosphonic acids to development of biologically active nucleotidesPrincipal Investigator
- Principal Investigator
  
  YOKOMATSU Tsutomu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Study on synthesis of biologically active compounds based on modification of biological phosphatesPrincipal Investigator
- Principal Investigator
  
  YOKOMATSU Tsutomu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Synthesis and Biological Evaluation of Difluoromethylenephosphonic Acid DerivativesPrincipal Investigator
- Principal Investigator
  
  YOKOMATSU Tsutomu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  School of Pharmacy,Tokyo University of Pharmacy & Life Science
Studies on Synthesis of Cyclic Conjugate Diynene SystemsPrincipal Investigator
- Principal Investigator
  
  YOKOMATSU Tsutomu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo College of Pharmacy

[Journal Article] Studies on the Synthesis of Novel 4-Membered Cyclic Oxaphosphetanes via Intramolecular Mitsunobu Reaction of Bishydroxyalkylphosphinic acids2016
- Author(s)
  B. Kaboudin, H. Haghighat, and T. Yokomatsu
- Journal Title
  
  Synlett
  
  Volume: xx Issue: 10 Pages: 1537-1540
- DOI
  10.1055/s-0035-1560426
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460155
[Journal Article] Synthesis of 5-aminobenzoimidazo[1,2-a]quinoline derivatives through one-pot two-step cascade reaction2016
- Author(s)
  J. Kato, Y. Ito, R. Ijuin, H. Aoyama, and T. Yokomatsu
- Journal Title
  
  Heterocycles
  
  Volume: xx
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460155
[Journal Article] Hydroxy bisphosphinic acids: synthesis and complexation properties with transition metals and lanthanide ions in aqueous solution2016
- Author(s)
  B. Kaboudin, A. Ezzati, M. Reza Faghihi A. Barati, F.. Kazemi, H.. Abdollahi, and T.Yokomatsu
- Journal Title
  
  J Iran Chem. Soc.
  
  Volume: 13
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460155
[Journal Article] Resolution of Enantiomers of Novel C2-Symmetric Aminobisphosphinic Acids via Diastereomeric Salt Formation with Quinine2015
- Author(s)
  Babak Kaboudin, Mohammad R. Faghihi, Foad Kazemi, and Tsutomu Yokomatsu
- Journal Title
  
  Chirality
  
  Volume: 27 Issue: 1 Pages: 71-74
- DOI
  10.1002/chir.22391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460155
[Journal Article] Discovery of non-competitive thrombin inhibitor derived from competitive tryptase inhibitor skeleton: Shift in molecular recognition resulted from skeletal conversion of carboxylate into phosphonate2015
- Author(s)
  Hiroshi Aoyama, Ryosuke Ijuin, Jun-ya Kato, Sarasa Urushiyama, Masashi Tetsuhashi, Yuichi Hashimoto, Tsutomu Yokomatsu
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume: 25 Issue: 17 Pages: 3676-3680
- DOI
  10.1016/j.bmcl.2015.06.039
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08033, KAKENHI-PROJECT-25460155
[Journal Article] Analysis of Binding Interaction between N,N-Bis(phosphinomethyl)amines as a New Class of 1-Aminophosphinic Acids and Bovine Serum Albumin Using Fluorescence Spectroscopy2014
- Author(s)
  Babak Kaboudin, Mohammad R. Faghihi, Fakhrossadat Mohammadi, and Tsutomu Yokomatsu
- Journal Title
  
  Int J Biochem Biophysic
  
  Volume: 2 Pages: 19-30
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460155
[Journal Article] A Novel and Simple Method for the Preparation of (R)- and (S)-Pyrrolidine-2-phosphonic Acids: Phosphonic Acid Analogues of Proline2013
- Author(s)
  Babak Kaboudin, Jun-ya Kato, Hiroshi Aoyama, and Tsutomu Yokomatsu
- Journal Title
  
  Tetrahedron: Asymmetry
  
  Volume: 24 Issue: 24 Pages: 1562-1566
- DOI
  10.1016/j.tetasy.2013.10.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460155
[Journal Article] A Catalyst-free, Three-component Decarboxylative Coupling of Amino Acids with Aldehydes and H-dialkylphosphites for the Synthesis of α-Aminophosphonates2013
- Author(s)
  Babak Kaboudin, Leila Karami, Jun-ya Kato, Hiroshi Aoyama, and Tsutomu Yokomatsu
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Issue: 36 Pages: 4872-4875
- DOI
  10.1016/j.tetlet.2013.06.129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460155
[Journal Article] Synthesis of New Class of Phosphinic Acids : Synthesis of Novel 4-Membered Cyclic Oxaphosphetanes via Intramolecular Mitsunobu Reaction of Bishydroxyalkylphosphinic acids2011
- Author(s)
  B.Kaboudin, H.Haghighat, T.Yokomatsu
- Journal Title
  
  Synthesis
  
  Pages: 3185-3189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] A chemo-enzymatic synthesis of optically active 1, 1-diethoxyethyl(aminomethyl) phosphinates : useful chiral building blocks for phosphinyl dipeptide isosteres2011
- Author(s)
  T. Yamagishi, J. Mori, T. Haruki, and T. Yokomatsu
- Journal Title
  
  Tetrahedron : Asymmetry
  
  Volume: 22 Pages: 1358-1363
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Diastereoselective synthesis of the Leu-Pro type phosphinyl dipeptide isostere2011
- Author(s)
  T.Yamagishi, N.Tashiro, T.Yokomatsu
- Journal Title
  
  J.Org.Chem.
  
  Volume: 76 Issue: 13 Pages: 5472-5476
- DOI
  10.1021/jo200669r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] A chemo-enzymatic synthesis of optically active 1,1-diethoxyethyl(amino-methyl)phosphinates : useful chiral building blocks for phosphinyl dipeptide isosteres2011
- Author(s)
  T.Yamagishi, J.Mori, T.Haruki, T.Yokomatsu
- Journal Title
  
  Tetrahedron : Asymmetry
  
  Volume: 22 Issue: 12 Pages: 1358-1363
- DOI
  10.1016/j.tetasy.2011.06.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Diastereoselective synthesis of the Leu-Pro type phosphinyl dipeptide isostere2011
- Author(s)
  T. Yamagishi, N. Tashiro, and T. Yokomatsu
- Journal Title
  
  J. Org. Chem
  
  Volume: 76 Pages: 5472-5476
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] 9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase2010
- Author(s)
  K. Breer, L. Glavas-Obrovac, M. Suver, S. Hikishima, M. Hashimoto, T. Yokomatsu, B. Wielgus-Kutrowska, L. Magnowska, A. Bzowska
- Journal Title
  
  FEBS Journal
  
  Volume: 277 Pages: 1747-1760
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] 1.45A resolution crystal structure of recombinat PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of posutulated transition state2010
- Author(s)
  G. Chojnowski, K. Breer, M. Narczyk, B. Wielgus-Kutrowska, H. Czapinska, M. Hashimoto, S. Hikishima, T. Yokomatsu, M. Bochtler, A. Girstun, K. Staro., A. Bzowska
- Journal Title
  
  Biochem. Biophys. Res. Comm
  
  Volume: 391 Pages: 703-708
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] 9-Deazaguanine Derivatives Connected by a Linker to Difluoromethylene Phosphonic Acid Are Slow-binding Picomolar Inhibitors of Trimeric Purine Nucleoside Phosphorylase2010
- Author(s)
  K.Breer, L.Glavas-Obrovac, M.Suver, S.Hikishima, M.Hashimoto, T.Yokomatsu, B.Wielgus-Kutrowska, L.Magnowska, A.Bzowska
- Journal Title
  
  FEBS Journal
  
  Volume: 277 Pages: 1747-1760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Antiproliferative avtivity of purine nucleoside phosphorylase multisubstrate analogu inhibitors containing difluoromethyl phosphonic acid against leukaemia and lymphoma cells2010
- Author(s)
  L. Glava.-Obrovac, M. Suver, S. Hikishima, M. Hashimoto, T. Yokomatsu, L. Magnowska, A. Bzowska
- Journal Title
  
  Chem. Bio. Drug. Des
  
  Volume: 75 Pages: 392-399
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] 1.45Å resolution crystal structure of recombinat PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of posutulated transition state2010
- Author(s)
  T.Yokomatsu, A.Bzowska, 他
- Journal Title
  
  Biochem.Biophys.Res.Comm. 391
  
  Pages: 703-708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs2010
- Author(s)
  S.Hikishima, T.Yokomatsu, 他
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 2275-2284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Overexpressed protein may act as mops removing their ligands from host cells : A case study of calf PNP2010
- Author(s)
  K. Breer, B. Wielgus-Kutrowska, A. Girstun, K. Staro., M. Hashimoto, S. Hikishima, T. Yokomatsu, A. Bzowska
- Journal Title
  
  Biochem. Biophys. Res. Comm
  
  Volume: 391 Pages: 1203-1209
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Structural-based Design and Synthesis of Novel 9-Deazaguanine Derivatives having a Phosphate Mimic as Multi-substrate Analogue Inhibitors for Mammalian PNPs2010
- Author(s)
  S.Hikishima, M.Hashimoto, L.Magnowska, A.Bzowska, T.Yokomatsu
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 2275-2284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Antiproliferative Activity of Purine Nucleoside Phosphorylase Multisubstrate Analogue Inhibitors containing Difluoromethyl Phosphonic Acid against Leukaemia and Lymphoma Cells2010
- Author(s)
  L.Glavas-Obrovac, M.Suver, S.Hikishima, M.Hashimoto, T.Yokomatsu, L.Magnowska, A.Bzowska
- Journal Title
  
  Chem.Bio.Drug.Des.
  
  Volume: 75 Pages: 399-399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs2010
- Author(s)
  S. Hikishima, M. Hashimoto, L. Magnowska, A. Bzowska and T. Yokomatsu
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18 Pages: 2275-2284
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Overexpressed protein may act as mops removing their ligands from host cells : A case study of calf PNP2010
- Author(s)
  T.Yokomatsu, A.Bzowska, 他
- Journal Title
  
  Biochem.Biophys.Res.Comm. 391
  
  Pages: 1203-1209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Diastereoselective synthesis of γ-amino-δ-hydroxy-α, α-difluorophosphonates : A vehiclefor for the structure-activity relationship of SMA-7, a potent sphingomyelinase inhibitor2009
- Author(s)
  T. Yamagishi, S. Muronoi, S. Hikishima, H. Shimeno, S. Soeda, and T. Yokomatsu
- Journal Title
  
  J. Org. Chem
  
  Volume: 74 Pages: 6350-6353
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Diastereoselective synthesis of γ-amino-δ-hydroxy-α, α-difluorophosphonates : A vehiclefor for the structure-activity relationship of SMA-7, a potent sphingomyelinase inhibitor2009
- Author(s)
  T.Yamagishi, T.Yokomatsu, 他
- Journal Title
  
  J Org.Chem. 74
  
  Pages: 6350-6353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590126
[Journal Article] Sphingomyelinease inhibition suggests a possible new strategy for the treatment of inflammatory bowel disease2008
- Author(s)
  S. Soeda, A. Sakata, T. Ochiai, K. Yasuda, Y. Kuramoto, H. Shimeno, A. Toda, R. Eyanagi, S. Hikishima, T. Yokomatsu, and S. Shibuya
- Journal Title
  
  Curr. Drug Therapy 3
  
  Pages: 218-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Sphingomyelinease inhibition suggests a possible new strategy for the treatment of inflammatory bowel disease2008
- Author(s)
  S. Soeda, T. Yokomatsu, 他
- Journal Title
  
  Current Drug Therapy 3
  
  Pages: 218-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Inhibition of lipopolysaccharide-induced Release of Interleukin-8 from Intestinal Epithelial Cells by SMA, a Novel Inhibitor of Sphingomyelinase and its Therapeutic Effect on Dextran Sulphate Sodium-induced Colitis in Mice2007
- Author(s)
  A. Sakata, K. Yasuda, T. Ochiai, H. Shimeno, S. Hikishima, T. Yokomatsu, S. Shibuya, and S. Soeda
- Journal Title
  
  Cell Immunology 245
  
  Pages: 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Inhibitory Properties of Nucleotides with Difluoromethy lenephosphonic Acid as a Phosphate Mimic versus Calf Spleen Purine Nucleoside Phosphorylase and Effect of These Analogues on the Viability of Human Blood Lymphocytes2007
- Author(s)
  L. Glavas-Obrovac, M. Suver ; S. Hikishima, T. Yokomatsu, and A. Bzowska
- Journal Title
  
  ucleosides, Nucleotides & Nucleic Acids 26
  
  Pages: 989-993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Inhibitory properties of some acyclic nucleotides with difluoromethylenephosphonic acid as a phosphate mimic vs calf spleen purine nucleoside phosphorylase and effect of these analogues on the viability of human blood lymphocytes2007
- Author(s)
  L.Glavas-Obrovac, M.Suver, S.Hikishima, T.Yokomatsu, A.Bzowska
- Journal Title
  
  Nucleosides, Nucleotides ＆ Nucleic Acids (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590097
[Journal Article] Acid Sphingomyelinase Inhibition Suppresses Lipopolysaccharide-mediated Release of Inflammatory Cytokines from Macrophages and Protects against Disease Pathology in Dextran Sulphate Sodium-induced Colitis in Mices2007
- Author(s)
  A. Sakata, T. Ochiai, H. Shimeno, S. Hikishima, T. Yokomatsu, S. Shibuya, A. Toda, R. Eyanagi, and S. Soeda
- Journal Title
  
  Immunology 122
  
  Pages: 54-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a Linker to difluoromethylene phosphonic acid as multi-substrate analogue Inhibitors of PNP2007
- Author(s)
  S.Hikishima, M.Hashimoto, L.Magnowska, A.Bzowska, T.Yokomatsu
- Journal Title
  
  Bioorg. Med. Chem. Lett. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590097
[Journal Article] Synthesis and biological evaluation of 9-deazaguanine derivatives connec-ted by a Linker to difluoromethylene phosphonic acid as multi-substrate analogue Inhibitors of PNP2007
- Author(s)
  S. Hikishima, M. Hashimoto, L. Magnowska, A. Bzowska, andT. Yokomatsu
- Journal Title
  
  Bioorganic Medicinal Chemistry Letters 17
  
  Pages: 4173-4177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Synthesis and Biological Evalution of 9-Deazaguanine Derivatives connected by a Linker to Difluoromethylene phosphonic Acid as Multi-substrate Analogue Inhibitors of PNP2007
- Author(s)
  S. Hikishima, M. Hashimoto, L. Magnowska, A. Bzowska, and T. Yokomatsu
- Journal Title
  
  Bioorg. Med. Chem. Lett. 17
  
  Pages: 4173-4177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590109
[Journal Article] Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors2006
- Author(s)
  S.Hikishima, T.Yokomatsu et al.
- Journal Title
  
  Bioorg.Med.Chem 14
  
  Pages: 1660-1670
- Data Source
  KAKENHI-PROJECT-17590097
[Journal Article] Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors2006
- Author(s)
  S.Hikishima, M.Isobe, S.Koyanagi, S.Soeda, H.Shimeno, S.Shibuya, T.Yokomatsu
- Journal Title
  
  Bioorg. Med. Chem 14
  
  Pages: 1660-1670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590097
[Journal Article] Improved synthesis of 1,3-propanediol derivatives having a diethoxyphosphoryldifluoroethyl functional group at the 2-position. Application to chemo-enzymatic synthesis of novel acyclic nucleotide analogues of adenosine bisphosphates.2005
- Author(s)
  T.Murano, H.Kobayakawa, Y.Yuasa, T.Yokomatsu, S.Shibuya
- Journal Title
  
  Synthesis
  
  Pages: 187-192
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] Improved Synthesis of 1,3-Propanediol Derivatives having a Diethoxyphosphoryldifluoroethyl Functional Group at the 2-Position. Application to Chemo-enzymatic-----2005
- Author(s)
  T.Murano, H.Kobayakawa, Y.Yuasa, T.Yokomatsu, S.Shibuya
- Journal Title
  
  Synthesis
  
  Pages: 187-192
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] A practical synthesis of 8-hydroxyacyclovir and 9-(carbomethoxymethyl)guanine, metabolites of acyclovir2005
- Author(s)
  T.Kutsuma, T.Yokomatsu et al.
- Journal Title
  
  Heterocycles 65
  
  Pages: 1967-1973
- Data Source
  KAKENHI-PROJECT-17590097
[Journal Article] Improved Synthesis of 1,3-Propanediol Derivatives having a Diethoxyphosphoryldifluoroethyl Functional Group at the 2-Position. Application to Chemo-enzymatic Synthesis of Novel Acyclic Nucleotide Analogues of Adenosine Bisphosphates2005
- Author(s)
  T.Murano, H.Kobayakawa, Y.Yuasa, T.Yokomatsu, S.Shibuya
- Journal Title
  
  Synthesis
  
  Pages: 187-192
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] Inhibition of sphingomyelinase activity enables to prevent ischemic stress-induced death of neurons.2004
- Author(s)
  S.Soeda, Y.Tsuji, T.Ochiai, K.Mishima, K.Iwasaki, M.Fujiwara, T.Yokomatsu, T.Murano, S.Shibuya, H.Shimeno
- Journal Title
  
  Neurochem.Int. 45
  
  Pages: 619-626
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] Calf spleen purine-nucleoside phosphorylase : crystal structure of the binary complex with a potent multisubstrate analogue inhibitor.2004
- Author(s)
  M.Luic, G.Koellner, T.Yokomatsu, S.Shibuya, A.Bzowska
- Journal Title
  
  Acta Cryst., D 60
  
  Pages: 1417-1424
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] Inhibition of Sphingomyelinase Activity Helps to Prevent Neuron Death Caused by Ischemic Stress2004
- Author(s)
  S.Soeda, T.Yokomatsu, et al.
- Journal Title
  
  Neurochem.Int. 45
  
  Pages: 619-626
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] Inhibition of Sphingomyelinase Activity Helps to Prevent Neuron Death Caused by Isehemic Stress2004
- Author(s)
  S.Soeda, T.Yokomatsu, et al.
- Journal Title
  
  Neurochem.Int. 45
  
  Pages: 619-626
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] Calf Spleen Purine-nucleoside Phosphorylase : Crystal Structure of the Binary Complex with a Potent Multi Substrate Analogue Inhibitor2004
- Author(s)
  M.Luic, G.Koellner, T.Yokomatsu, S.Shibuya, A.Bzowska
- Journal Title
  
  Acta Cryst. D60
  
  Pages: 1417-1424
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity.2003
- Author(s)
  T.Yokomatsu, T.Murano, T.Akiyama, J.Koizumi, S.Shibuya, Y.Tsuji, S.Soeda, H.Shimeno
- Journal Title
  
  Bioorg.Med.Chem.Lett. 13
  
  Pages: 229-236
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] Stereoselective synthesis of highly-functionalized cyclohexene derivatives having a diethoxyphsphoryldifluoromethyl functionality from cyclohex-2-enyl-1-phosphates.2003
- Author(s)
  T.Yokomatsu, J.Kato, C.Sakuma, S.Shibuya
- Journal Title
  
  Synlett
  
  Pages: 1407-1410
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] N-Glycosylation of 2,3-dideoxyfuranose derivatives having a (diethoxyphosphorothioyl) difluoromethyl group at the 3α-position.2003
- Author(s)
  T.Murano, Y.Yuasa, S.Muroyama, T.Yokomatsu, S.Shibuya
- Journal Title
  
  Tetrahedron 59
  
  Pages: 9059-9073
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590101
[Journal Article] Synthesis of acyclic nucleotide analogues possessing a difluoromethylene phosphonyl group at the side chain.2003
- Author(s)
  T.Murano, Y.Yuasa, H.Kobayakawa, T.Yokomatsu, S.Shibuya
- Journal Title
  
  Tetrahedron 59
  
  Pages: 10223-10230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590101
[Presentation] 卒業時調査と教学データの統合による学修成果の可視化2020
- Author(s)
  横松　力
- Organizer
  AP事業報告会＿大学教育の質保証　卒業生調査の意義と有効性
- Data Source
  KAKENHI-PROJECT-18K02714
[Presentation] 卒業時調査と教学データの統合による学修成果の可視化2020
- Author(s)
  横松　力、日下田岳史、矢野眞和
- Organizer
  大学教育改革フォーラムin東海(2021)
- Data Source
  KAKENHI-PROJECT-18K02714
[Presentation] 卒業時調査と教学データの統合による学修成果の可視化2019
- Author(s)
  横松　力
- Organizer
  AP事業報告会（卒業生調査の意義と有効性）コロナ対応で中止
- Data Source
  KAKENHI-PROJECT-18K02714
[Presentation] 卒業時調査と教学データの統合による学修成果の可視化2019
- Author(s)
  横松　力、日下田岳史、矢野眞和
- Organizer
  大学教育改革フォーラムin東海(2020) 　コロナ対応で中止
- Data Source
  KAKENHI-PROJECT-18K02714
[Presentation] 理系小規模大学のIRの取り組み　東京薬科大学の在学生・卒業生調査から2018
- Author(s)
  岩井芙斗士、横松　力
- Organizer
  大学行政管理学会　第22回定期総会
- Data Source
  KAKENHI-PROJECT-18K02714
[Presentation] Synthesis of a-Aminophosphonates from a;-Amino Acids by Catalyst-free Three-component Decarboxylative Coupling Reactions2014
- Author(s)
  B． Kaboudin, L． Karami, J． Kato，H．Aoyama, and T. Yokomatsu
- Organizer
  20th International Conference on Phosphorus Chemistry
- Place of Presentation
  Ｄｏｕｂｌｉｎｅ，　Ｉｒｅｌａｎｄ
- Data Source
  KAKENHI-PROJECT-25460155
[Presentation] ホスフィニルジペプチイソスターの効率的合成を指向したアミノメチルホスフィナートの不斉アシル化反応2012
- Author(s)
  春木晶充, 森淳一郎, 山岸丈洋, 横松力
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590126
[Presentation] 非天然型の立体配置を有するホスフィニルジペプチドイソスターの合成研究2011
- Author(s)
  春木晶充, 山岸丈洋, 横松力
- Organizer
  日本薬学会第132年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21590126
[Presentation] SBDDを用いた新規PNP阻害剤の創製研究2010
- Author(s)
  谷津智之, 疋島貞雄, Agnieszka Bzowska, 横松力
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590126
[Presentation]2010
- Author(s)
  T. Haruki, H. Ichikawa, J. Mori, T. Yamagishi, T. Yokomatsu
- Organizer
  18^<th> International Conference on Phosphorus Chemistry
- Place of Presentation
  Wroclaw, Poland
- Data Source
  KAKENHI-PROJECT-21590126
[Presentation] SMase阻害剤を指向した機能性分子の創製研究2009
- Author(s)
  野田裕介, 疋島貞雄, 横松力
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] ベンゼン環をスキャホールドとする二基質類縁型PNP阻害剤の創製研究2009
- Author(s)
  谷津智之, 疋島貞雄, 横松力
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] ベンゼン環をスキャホールドとする二基質類縁型PNP 阻害剤の創製研究2009
- Author(s)
  谷津智之, 疋島貞雄, 横松力
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] SBDDを用いた新規PNP阻害剤の創製研究2009
- Author(s)
  谷津智之, 疋島貞雄, Agnieszka Bzowska, 横松力
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590126
[Presentation] SMase阻害剤を指向した新規SMA-7類縁体の合成研究2009
- Author(s)
  野田祐介, 室野井真, 疋島貞雄, 山岸丈洋, 横松力
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21590126
[Presentation] ホスホノジフルオロメチレン基を有するアジド誘導体と・-アルキニルピリミジン誘導体とのHuisgen反応2008
- Author(s)
  橘真純, 橋本真梨子, 疋島貞雄, 横松力
- Organizer
  第38回複素環化学討論会
- Place of Presentation
  福山
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] 9-Deazaguanine derivatives : synthesis and inhibitory properties as multi-substrate analogue inhibitors of mammalian PNPs Joint Symposium of the 18th International Roundtable on Nucleosides2008
- Author(s)
  T. Yatsu, M. Hashimoto, S. Hikishima, L. Magnowska, A. Bzowska, and T. Yokomatsu
- Organizer
  Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Huisgen 反応を用いた新規2基質複合類縁型TP阻害剤の創製研究2008
- Author(s)
  橘真純, 疋島貞雄, 横松力
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] ホスホノジフルオロメチレン基を有するアジト誘導体とω-アルキニルピリミジン誘導体とのHuisgen反応2008
- Author(s)
  橘真純, 橋本真梨子, 疋島貞雄, 横松力
- Organizer
  第38回複素環化学討論会
- Place of Presentation
  福山
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] リン酸等価体を有する新規2基質複合類縁型PNP阻害剤の創製研究2008
- Author(s)
  橋本真梨子, 疋島貞雄, 横松力
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] SMase阻害剤SMA-7誘導体の新規合成法の開発2008
- Author(s)
  室野井真, 山岸丈洋, 疋島貞雄, 横松力
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Huisgen反応を用いた新規2基質複合類縁型TP阻害剤の創製研究2008
- Author(s)
  橘真純, 疋島貞雄, 横松力
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] 9-Deazaguanine derivatives : synthesis and inhibitory properties as multi-substrate analogue inhibitors of mammalian PNPs2008
- Author(s)
  T. Yatsu, M. Hashimoto, A. Bzowska, T. Yokomatsu, 他
- Organizer
  Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  京都
- Year and Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Thermodynamic studies of interactions of calf spleen PNP with acyclic phosphonate inhibitors, Joint Symposium of the 18th International Roundtable on Nucleosides2008
- Author(s)
  K. Breer, B. Wielgus-Kutrowska, M. Hashimoto, S. Hikishima, T. Yokomatsu, R. H. Szczepanowski, M. Bochtler, A. Girstun, K. Staron, and A. Bzowska
- Organizer
  Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Synthesis and evaluation of 9-deazaguanine derivatives as multi-substrate analogue inhibitors of PNP2007
- Author(s)
  M. Hashimoto, S. Hikishima, L. Magnowska, A. Bzowska, and T. Yokomatsu
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Synthesis and evaluation of 9-deazaguanine derivatives as multi-substrate analogue inhibitors of PNP2007
- Author(s)
  Mariko Hashimoto, Sadao Hikishima, Lucyna Magnowska, Angieszka Bzowska, and Tsutomu Yokomatsu
- Organizer
  Fifth Inetrnational Symposium on Nucleic Acids Chemistry
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Synthesis and Biological Evaluation of 9-Deazaguanine Derivatives connected by a Linker to Difluoromethylene Phosphonic Acid2007
- Author(s)
  Sadao Hikishima, Mariko Hashimoto, Lucyna Magnowska, Agnieszka Bzowska, Tsutomu Yokomatsu
- Organizer
  6^<th> AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  イスタンブール(トルコ)
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Synthetic Studies for Difluoromethylenephosphonate Analogues of MRS2216, a Selective P2Y_1 Receptor Antagonist2007
- Author(s)
  Sadao Hikishima, Arihiro Takatori, Atsushi Kojima, and Tsutomu Yokomatsu
- Organizer
  6^<th> AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  イスタンブール(トルコ)
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] 脂肪細胞でのPPAR・2発現におけるセラミドシグナルの役割2007
- Author(s)
  鍋山卓志, 藏元佑嘉子, 落合敬史, 林田諭, 添田秦司, 疋島貞雄, 横松力, 渋谷皓, 占野廣司
- Organizer
  第24回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] T細胞受容体を介した・産生におけるセラミドシグナルの役割2007
- Author(s)
  東みお, 落合敬史, 藏元佑嘉子, 添田秦司, 坂田晃, 疋島貞雄, 横松力, 渋谷皓, 占野廣司
- Organizer
  第24回日本薬学会九州支部大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] PNP阻害剤を指向した新規ヌクレオチドアナログの設計と評価2007
- Author(s)
  疋島貞雄, 橋本真梨子, 添田秦司, 占野廣司, L. Magnowaka, A. Bzowska, 渋谷皓, 横松力
- Organizer
  日本ケミカルバイオロジー研究会第2回年会
- Place of Presentation
  京都
- Year and Date
  2007-05-09
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] 日本ケミカルバイオロジー研究会第2回年会2007
- Author(s)
  疋島貞雄, 橋本真梨子, 添田秦司, 占野廣司, Magnowaka Lucya, AgnieszkaBzowska, 渋谷皓, 横松力
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] Synthesis and Biological Evaluation of 9-Deazaguanine Derivatives connected by a Linker to Difluoromethylene Phosphonic Acid2007
- Author(s)
  S. Hikishima, M. Hashimoto, L. Magnowska, A. Bzowska, and T. Yokomatsu
- Organizer
  第6回 AFMC国際メディシナルケミストリーシンポジウム
- Place of Presentation
  イスタンブール(トルコ)
- Year and Date
  2007-07-08
- Data Source
  KAKENHI-PROJECT-19590109
[Presentation] 多置換[1,2,4]トリアゾロ[1,5-a]キノリン類の新規合成法の開発
- Author(s)
  加藤淳也、成瀬央、伊集院良祐、青山洋史、横松力
- Organizer
  第44回複素環討論会
- Place of Presentation
  札幌市
- Year and Date
  2014-09-10 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25460155
[Presentation] Synthesis of a-Aminophosphonates from a-Amino Acids by Catalyst-free Three-component Decarboxylative Coupling Reactions
- Author(s)
  B. Kaboudin, L. Karami, J. Kato, H. Aoyama, and T. Yokomatsu
- Organizer
  20th International Conference on Phosphorus Chemistry
- Place of Presentation
  Dublin, Ireland
- Year and Date
  2014-06-28 – 2014-07-02
- Data Source
  KAKENHI-PROJECT-25460155

1. HIKISHIMA Sadao (70398816)

# of Collaborated Projects: 2 results

# of Collaborated Products: 39 results
2. YAMAGISHI Takehiro (90297606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. ANGIESKA Bzowska

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SOEDA Shinji (20078695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. AOYAMA Hiroshi (40374699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 三浦典子 (30218036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 片野修一郎 (50814711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 緒方正裕 (90317082)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TACHIBANA Masumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. YATSU Tomoyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. NODA Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. KABOUDIN Babak

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
13. IJUIN Ryosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yokomatsu Tsutomu 横松 力

YOKOMATSU Tsutomu 横松 力

Research Projects

Research Products

Co-Researchers

Impacts of 6-years educational systems on pharmaceutical university studentsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Application of phosphate mimetics to development of biologically active compoundsPrincipal Investigator

Principal Investigator

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Development of biologically active compounds based on features of phosphonyl and phosphinyl functional groupsPrincipal Investigator

Principal Investigator

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Development of biologically active compounds based on features of fluoromethylene phosphonatesPrincipal Investigator

Principal Investigator

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Application of difluoromethylene phosphonic acids to development of biologically active nucleotidesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Study on synthesis of biologically active compounds based on modification of biological phosphatesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Synthesis and Biological Evaluation of Difluoromethylenephosphonic Acid DerivativesPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Studies on Synthesis of Cyclic Conjugate Diynene SystemsPrincipal Investigator

Principal Investigator

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[Journal Article] Studies on the Synthesis of Novel 4-Membered Cyclic Oxaphosphetanes via Intramolecular Mitsunobu Reaction of Bishydroxyalkylphosphinic acids2016

Author(s)

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DOI

Data Source

[Journal Article] Synthesis of 5-aminobenzoimidazo[1,2-a]quinoline derivatives through one-pot two-step cascade reaction2016

Author(s)

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Data Source

[Journal Article] Hydroxy bisphosphinic acids: synthesis and complexation properties with transition metals and lanthanide ions in aqueous solution2016

Author(s)

Journal Title

Data Source

[Journal Article] Resolution of Enantiomers of Novel C2-Symmetric Aminobisphosphinic Acids via Diastereomeric Salt Formation with Quinine2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of non-competitive thrombin inhibitor derived from competitive tryptase inhibitor skeleton: Shift in molecular recognition resulted from skeletal conversion of carboxylate into phosphonate2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of Binding Interaction between N,N-Bis(phosphinomethyl)amines as a New Class of 1-Aminophosphinic Acids and Bovine Serum Albumin Using Fluorescence Spectroscopy2014

Author(s)

Journal Title

Data Source

Yokomatsu Tsutomu 横松力

YOKOMATSU Tsutomu 横松力