Yamamoto Kojiro 山本康次郎

… Alternative Names

YAMAMOTO Koujirou 山本康次郎

山本康次郎ヤマモトコウジロウ

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Researcher Number	70174787
Other IDs
Affiliation (Current)	2025: 群馬大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 群馬大学, 大学院医学系研究科, 教授 2012 – 2015: 群馬大学, 医学(系)研究科(研究院), 教授 2014: 群馬大学, 医学部, 教授 2012: 群馬大学, 医学部, 教授 2008 – 2011: 群馬大学, 大学院・医学系研究科, 教授 … More 1998 – 2003: 群馬大学, 医学部, 助教授 1997: 東京大学, 医学部・附属病院, 助手 1994: 東京大学, 医学部(病), 助手 1986: 東京大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 / Basic Section 47060:Clinical pharmacy-related / 医薬分子機能学 Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / 応用薬理学・医療系薬学 / Natural medicines / Applied pharmacology / Laboratory medicine
Keywords	Principal Investigator 薬動力学解析 / 血小板 / 薬動力学 / 薬剤抵抗性 / プロテオーム解析 / 血液凝固 / Talin / 抗血小板薬 / ＰＫ－ＰＤ解析 / 薬物輸送担体 … More / PK-PD解析 / 細胞中薬物濃度 / 血中薬物濃度 / 薬力学 / 細胞内薬物動態 / 細胞内薬物濃度 / raspberry ketone / midazolam / St.John's wort / enzyme induction / セントジョンズウォート / ラズベリーケトン / ミダゾラム / セントジョンズワート / 酵素誘導 / ＴＤＭ / 微量定量法 / 血球移行 / 薬物治療モニタリング / 超微量分析 / 高感度定量法 / 高感度微量定量法 / 薬物濃度モニタリング / 臨床 / 薬剤反応性 / 遺伝子 / キサンチンオキシダーゼ / ビタミンKエポキシド還元酵素 / ITPA遺伝子 / 遺伝子多型 / ITPA / アザチオプリン / VKORC1 / ビタミンK / ワルファリン / トキシコダイナミクス / 消化管機能改善薬 / 薬力学モデル / ドンペリドン / 高プロラクチン血症 / メトクロプラミド / 酵素阻害薬 / 生理学的モデル / 5-α-reductase阻害薬 / testosterone 5α-reductase / FK143 / pharmacokinetics / pharmaco dynamics / animal scale up / フェモチジン / ニザチジン / ラニチジン / シメチジン / 中枢毒性 / H_2受容体遮断薬 … More Except Principal Investigator がん / 薬剤抵抗性 / 耐性 / SRC / 薬物抵抗性 / 抗体医薬 / プロテオーム / 抗腫瘍薬 / 獲得耐性 / 化学療法 / 抗体医薬品 / 分子標的薬 / 速度論モデル / 消化管移動 / 投与量依存性 / 有効表面積 / べき関数 / 粉末薬物 / 溶解速度論 / オピオイド / 和漢薬 / 疫学研究 / 処方調査 / ガスモチン / 大腸がん / 胃がん / カルテ調査 / モサプリドクエン酸塩 / 大建中湯 / 漢方薬の臨床薬理 / 副作用予防 / 有効性・安全性 / 西洋医薬品 / 漢方薬 / 東西医薬品の併用 / テーラーメード薬物治療 / テーラーメイド薬物治療 / 遺伝子多型 / 不可逆的阻害 / テーラーメード医療 / 個人差 / 薬物相互作用 / バイオテクノロジー / 薬剤反応性 / 肥満 / 糖尿病 / 一塩基多型 / 遺伝子 Less

Strategies for Overcoming Acquired Resistance to Molecular Targeted Anti-Tumor Drugs by Modulating SRC-Related Factors
- Principal Investigator
  
  荒木拓也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Gunma University
抗血小板薬による血小板凝集抑制作用の生理学的薬物動力学モデルによる解析Principal Investigator
- Principal Investigator
  
  山本康次郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Gunma University
Establishment of efficacy index and pharmacokinetic analysis of antiplatelet drugs based on proteomic analysisPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO KOUJIROU
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Gunma University
Mechanism of development of resistance to antitumor molecule-targeted drugs
- Principal Investigator
  
  Araki Takuya
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Gunma University
Drug resistance caused by intracellular pharmacokineticsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO KOUJIROU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Clinical pharmacological study for proper use in combination with Japanese traditional medicine and Western medicine
- Principal Investigator
  
  Nakamura Tomonori
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Keio University
Quantitative analysis of genetic factors affecting the extent of drug interactions via mechanism based inhibition of cytochrome P450
- Principal Investigator
  
  OHTANI Hisakazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Keio University
Development of non-invasive therapeutic drug monitoring method for pediatric patientsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Koujirou
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Mechanism of drug resistance and its rational treatment based on pharmacodynamic analysis.Principal Investigator
- Principal Investigator
  
  YAMAMOTO Kojiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Clinical application of a novel rapid gene analyzing method aiming at personalized medicine
- Principal Investigator
  
  MURAKAMI Masami
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Gunma University
Prediction of drug-drug interaction coused by xenobiotic metabolizing enzymes.Principal Investigator
- Principal Investigator
  
  YAMAMOTO Koujirou
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Gunma University
消化管機能改善薬による副作用発現の危険因子の定量的評価に基づく適正使用法の構築Principal Investigator
- Principal Investigator
  
  山本康次郎
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Gunma University
生体調節系のアニマルスケールアップに基づく酵素阻害薬の生理学的薬効動態解析Principal Investigator
- Principal Investigator
  
  山本康次郎
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Gunma University
  The University of Tokyo
ヒスタミンH_2遮断薬による中枢性副作用発現機構とその危険因子の薬物動態論的解明Principal Investigator
- Principal Investigator
  
  山本康次郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
難溶性薬物に関する系統的な溶解速度理論の構築と応用
- Principal Investigator
  
  中川富士雄
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Exploration of proteins involved in acquisition of resistance to cetuximab2019
- Author(s)
  Hironori Nakamura, Ayumu Nagamine, Hideaki Yashima, Takuya Araki, Koujirou Yamamoto
- Journal Title
  
  Indonesian Journal of Pharmaceutics
  
  Volume: 1 Issue: 1 Pages: 11-18
- DOI
  10.24198/idjp.v1i1.19582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06743
[Journal Article] L-Lactate dehydrogenase B may be a predictive marker for sensitivity to anti-EGFR monoclonal antibodies in colorectal cancer cell lines2019
- Author(s)
  Ayumu Nagamine, Takuya Araki, Daisuke Nagano, Mitsue Miyazaki, Koujirou Yamamoto
- Journal Title
  
  Oncology letters
  
  Volume: 17 Pages: 4710-4716
- DOI
  10.3892/ol.2019.10075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06743
[Journal Article] Raltegravir is safely used with long-term viral suppression for HIV-infected patients on hemodialysis: a pharmacokinetic study.2016
- Author(s)
  Kunio Yanagisawa, Daisuke Nagano, Yoshiyuki Ogawa, Hideki Uchiumia, Tetsuya Shigehara, Kazuhisa Saruki, Hiroshi Handa, Takuya Araki, Koujirou Yamamoto, Yoshihisa Nojima
- Journal Title
  
  ＡＩＤＳ
  
  Volume: 30 Issue: 6 Pages: 970-972
- DOI
  10.1097/qad.0000000000001012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08066
[Journal Article] Determination of Intracellular Darunavir by Liquid Chromatography Coupled with Fluorescence Detection.2014
- Author(s)
  Nagano D, Araki T, Nakamura T, Yamamoto K.
- Journal Title
  
  J Chromatogr Sci.
  
  Volume: 52 Issue: 9 Pages: 1021-1025
- DOI
  10.1093/chromsci/bmt147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659066, KAKENHI-PROJECT-25460116, KAKENHI-PROJECT-25670049
[Journal Article] Assessment of DDR2, BRAF, EGFR, and KRAS mutations as therapeutic markers in Japanese non-adenocarcinoma lung cancer patients.2014
- Author(s)
  Yashima H, Shimizu K, Araki T*, Aomori T, Ohtaki Y, Nagashima T, Enokida Y, Atsumi J, Nakamura T, Takeyoshi I, Yamamoto K
- Journal Title
  
  Mol Clin Oncol
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460116
[Journal Article] Assessment of DDR2, BRAF, EGFR and KRAS mutations as therapeutic targets in non-adenocarcinoma lung cancer patients.2014
- Author(s)
  Yashima H, Shimizu K, Araki T, Aomori T, Ohtaki Y, Nagashima T, Enokida Y, Atsumi J, Nakamura T, Takeyoshi I, Yamamoto K.
- Journal Title
  
  Mol Clin Oncol.
  
  Volume: 2 Pages: 714-718
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460116
[Journal Article] The Effect of a Dietary Supplement Containing Raspberry Ketone on CYP3A Activity.2014
- Author(s)
  Sekizuka M, Qi JW, Aomori T, Okada Y, Nakamura K, Araki T, Horiuchi R, Ohta S, Nakamura T, Yamamoto K
- Journal Title
  
  Pharmaceutica Analytica Acta
  
  Volume: 5 Issue: 06 Pages: 302-302
- DOI
  10.4172/2153-2435.1000302
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460116, KAKENHI-PROJECT-25670049
[Journal Article] Quantitative evaluation of biliary elimination of gadoxetate, a magnetic resonance imaging contrast agent, via geometrical isomer-specific transporting system in rats2014
- Author(s)
  Junji Ogawa, Azusa Yokota, Takuya Araki, Tohru Aomori, Tomonori Nakamura, Koujirou Yamamoto, Ichiro Koshiishi
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 35 Issue: 6 Pages: 362-371
- DOI
  10.1002/bdd.1907
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659015, KAKENHI-PROJECT-25460116, KAKENHI-PROJECT-25670049
[Journal Article] Case report: dose adjustment of warfarin using genetic information and plasma concentration monitoring.2014
- Author(s)
  Tohru Aomori*, Yukiyoshi Fujita, Kyoko Obayashi, Hiroaki Sato, Kazuma Kiyotani, Katsunori Nakamura, Tomonori Nakamura, Koujirou Yamamoto.
- Journal Title
  
  J Clin Pharm Ther
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460116
[Journal Article] Case report: dose adjustment of warfarin using genetic information and plasma concentration monitoring.2014
- Author(s)
  Aomori T, Fujita Y, Obayashi K, Sato H, Kiyotani K, Nakamura K, Nakamura T, Yamamoto K.
- Journal Title
  
  J Clin Pharm Ther
  
  Volume: 39 (3) Issue: 3 Pages: 319-321
- DOI
  10.1111/jcpt.12135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460116, KAKENHI-PROJECT-25460193, KAKENHI-PROJECT-25670049
[Journal Article] Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants.2013
- Author(s)
  114. T. Akiyoshi, M. Ito, S. Murase, M. Miyazaki, F.P. Guengerich, K. Nakamura, K. Yamamoto, H. Ohtani
- Journal Title
  
  Drug Metabol. Pharmacokinet
  
  Volume: 25(5) Pages: 411-415
- NAID
  130004933542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590668
[Journal Article] Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants2013
- Author(s)
  Takeshi Akiyoshi, Marie Ito, Saori Murase, Mitsue Miyazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto and Hisakazu Ohtani
- Journal Title
  
  Drug Metabol Pharmacokinet
  
  Volume: 28
- NAID
  130004933542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590668
[Journal Article] Risk of Falling and Hypnotic Drugs: Retrospective Study of Inpatients.2013
- Author(s)
  Kyoko Obayashi, Takuya Araki, Katsunori Nakamura, Masahiko Kurabayashi, Yoshihisa Nojima, Katsuyuki Hara, Tomonori Nakamura*, Koujirou Yamamoto.
- Journal Title
  
  Drugs in R&D
  
  Volume: 13 Issue: 2 Pages: 159-164
- DOI
  10.1007/s40268-013-0019-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460116, KAKENHI-PROJECT-25670049
[Journal Article] Influence of CYP2C9 and VKORC1 polymorphisms on time to determine the warfarin maintenance dose2011
- Author(s)
  Aomori T, Obayashi K, Fujita Y, Araki T, Nakamura K, Nakamura T, Kurabayashi M, Yamamoto K
- Journal Title
  
  Pharmazie
  
  Volume: 66 Pages: 222-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590150
[Journal Article] CYP4F2 gene polymorphism as a contributor to warfar in maintenance dose in Japanese subjects2011
- Author(s)
  Nakamura K, Obayashi K, Araki T, Aomori T, Fujita Y, Okada Y, Kurabayashi M, Hasegawa A, Ohmori S, Nakamura T, Yamamoto K
- Journal Title
  
  J. Pharmacy Ther
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590150
[Journal Article] Inosine triphosphate pyrophosphatase 94C>A polymorphism : clinical implications for patients with systemic lupus erythematosus treated with azathioprine2010
- Author(s)
  Yamamoto K, Okada Y, Nakamura K, Hiromura K, Nojima Y, Nakamura T
- Journal Title
  
  Exp Opin Drug Saf
  
  Volume: 9(3) Pages: 447-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590150
[Journal Article] Inosine triphosphate pyrophosphatase 94C>A polymorphism : clinical implications for patients with systemic lupus erythematosus treated with azathioprine.2010
- Author(s)
  山本康次郎, 岡田裕子, 中村智徳, et al.
- Journal Title
  
  Expert Opinion in Drug Safety (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590150
[Journal Article] Inosine triphosphate pyrophosphatase 94C>A polymorphism : clinical implications for patients with systemic lupus erythematosus treated with azathioprine.2010
- Author(s)
  Koujirou Yamamoto
- Journal Title
  
  Expert Opinion in Drug Safety
  
  Volume: 9 Pages: 447-457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590150
[Journal Article] 山本康次郎, 岡田裕子, 中村智徳2009
- Author(s)
  山本康次郎, 岡田裕子, 中村智徳
- Journal Title
  
  医薬ジャーナル
  
  Volume: 45(12) Pages: 3089-94
- Data Source
  KAKENHI-PROJECT-21590150
[Journal Article] Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2.2009
- Author(s)
  Aomori T, Yamamoto K, Oguchi-Katayama A, Kawai Y, Ishidao T, Mitani Y, Kogo Y, Lezhava A, Fujita Y, Obayashi K, Nakamura K, Kohnke H, Wadelius M, Ekstrom L, Skogastierna C, Rane A, Kurabayashi M, Murakami M, Cizdziel PE, Hayashizaki Y, Horiuchi R
- Journal Title
  
  Clin Chem 55
  
  Pages: 804-812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390164
[Journal Article] Rapid SNP detection of the cytochrome P450 (CYP) 2C9 and the vitamin K oxide reductase (VKOR) gene for the warfarin dose adjustment by SMart-Amplification Process2009
- Author(s)
  Aomori T, Yamamoto K, Oguchi-Katayama A, Kawai Y, Ishidao T, Mitani Y, Kogo Y, Lezhava A, Fujita Y, Obayashi K, Nakamura K, Kohnke H, Wadelius M, Ekstrom L, Skogastierna C, Rane A, Kurabayashi M, Murakami M, Cizdziel PE., Hayashizaki Y, Horiuchi R
- Journal Title
  
  Clin. Chem
  
  Volume: 55(4) Pages: 804-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590150
[Journal Article] Pro32Thr polymorphism of inosine triphosphate gene predicts efficacy of low-dose azathioprine for patients with systemic lupus erythematosus2009
- Author(s)
  Okada Y, Nakamura K, Hiromura K, Nojima K, Horiuchi R, Yamamoto K
- Journal Title
  
  Clin. Pharmacol. Ther
  
  Volume: 85(5) Pages: 527-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590150
[Journal Article] アザチオプリンの治療効果に対するITPA 94C>A遺伝子多型の影響2009
- Author(s)
  山本康次郎、岡田裕子、中村智徳, 他
- Journal Title
  
  医薬ジャーナル 45
  
  Pages: 3089-3094
- Data Source
  KAKENHI-PROJECT-21590150
[Journal Article] Sensitive and simple determination of vitamin K1 in human plasma by ultra-performance liquid chromatography coupled with a fluorescence detector
- Author(s)
  Ohno, I, Araki T, Kawano M, Nakamura T, Yamamoto K
- Journal Title
  
  J Liq Chromatogr & Related Tech.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] セツキシマブに対する後天的耐性を獲得した大腸癌に対する治療法の探索2019
- Author(s)
  荒木拓也, 中村浩規, 長嶺歩, 八島秀明, 山本康次郎
- Organizer
  第29回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-18K06743
[Presentation] ヒト大腸癌細胞株に対するセツキシマブの効果と LDH 発現量の関係2018
- Author(s)
  長嶺歩，荒木拓也，永野大輔，山本康次郎
- Organizer
  医療薬学フォーラム2018・第26回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06743
[Presentation] The influence of the genetic polymorphisms of efflux transporter on DRV levels in PBMC and plasma.2017
- Author(s)
  Daisuke Nagano, Takuya Araki, Kunio Yanagisawa, Yoshiyuki Ogawa, Hideki Uchiumi, Koujirou Yamamoto
- Organizer
  The 13th Congress of the European association for clinical pharmacology and therapeutics (EACPT).
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08066
[Presentation] The influence of the genetic polymorphisms of efflux transporter on DRV levels in PBMC and plasma.2017
- Author(s)
  Daisuke Nagano, Takuya Araki, Kunio Yanagisawa, Yoshiyuki Ogawa, Hideki Uchiumi, Yoshihisa Nojima, Koujirou Yamamoto
- Organizer
  American Society of Clinical Pharmacology and Therapeutics Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08066
[Presentation] 各種CYP3A4変異型分子種に対するベラパミルおよびその代謝物のMBI特性2015
- Author(s)
  秋好健志、大橋拓人、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] CYP3A4遺伝的variantsに対する各種競合阻害剤の阻害特性の比較2015
- Author(s)
  綾華奈子、小林由季、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] 各種CYP3A4変異型分子に対するグレープフルーツ果汁抽出物およびその成分のMBI特性.2014
- Author(s)
  秋好健志, 今岡鮎子, 日比野英幸, 荒木拓也, 宮崎光江, PeterGUENGERICH, 中村克徳, 中村智徳, 山本康次郎, 大谷寿一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-25460116
[Presentation] CYP3A4変異型分子種における testosterone 及び midazolam の代謝に対する競合阻害剤の阻害強度の比較2014
- Author(s)
  小縣淳子, 秋好健志, 今岡鮎子, 日比野英幸, 荒木拓也, 宮崎光江, F,P Guengerich, 中村克徳, 中村智徳, 山本康次郎, 大谷寿一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-25460116
[Presentation] 各種CYP3A4変異型分子に対するグレープフルーツ果汁およびその成分のMBI特性2014
- Author(s)
  秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、Guengerich FP、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] CYP3A4変異型分子種におけるtestosterone及びmidazolamの代謝に対する競合阻害剤の阻害強度の比較2014
- Author(s)
  小縣淳子、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、Guengerich FP、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] 果実成分によるCYP3A4のMBI特性に対する遺伝子変異の影響2013
- Author(s)
  鈴木恵美、日比野英幸、秋好健志、村瀬沙織、荒木拓也、宮崎光江、Peter Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] Intracellular concentration of Darunavir as an indicator for the clinical efficacy in HIV patients.2013
- Author(s)
  Nagano D, Araki T, Yanagisawa K, Hayashi T, Ogawa Y, Nojima Y, Nakamura T, Yamamoto K
- Organizer
  11th Conference of the European Association for Clinical Pharmacology and Therapeutics
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-24659066
[Presentation] Effect of Factor on concentration of darnavir in human plasma and PBMC in HIV patient.2012
- Author(s)
  Daiske Nagano, Takuya Araki, Kunio Yanagisana, Yoshiyuki Ogawa, Hideki Uchiumi, Yoshihisa Nojima, Tomonori Nakamura, Koujirou Yamamoto
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24659066
[Presentation] Comparison of the VKOR inhibitory activity by S-and R-warfarin2011
- Author(s)
  Kawano M, Araki T, Nakamura T, Yamamoto K
- Organizer
  2nd Asian Federation for Pharmaceutical Sciences
- Place of Presentation
  Kuala Lumpur, Malaysia
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] 肝ミクロソームを用いたSおよびRワルファリンによるVKOR阻害活性の比較検討2011
- Author(s)
  川野雅嗣, 荒木拓也, 中村智徳, 山本康次郎
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学、船橋
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] Association of genotype, pharmacokinetics of vitamin Ks, and response of warfarin2011
- Author(s)
  Takuya Araki, Masashi Kawano, Izumi Ohno, Tomonori Nakamura, Koujirou Yamamoto
- Organizer
  第5回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  名古屋大学病院
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] Effect of genetic polymorphisms on the efficacy of low-dose azathioprine therapy in patients with systemic lupus erythematosus2011
- Author(s)
  Aomori T, Nagamine A, Takenaka M, Okada Y, Hiromura K, Nojima Y, Araki T, Nakamura T, Yamamoto K
- Organizer
  10th Congress of the European Association for Clinical Pharmacology and Therapeutics
- Place of Presentation
  Budapest, Hungary
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] The Contribution of CYP3A5 and MDR1 (ABCB1) Polymorphisms on the pharmacokinetics of tacrolimus in patients with Rheumatoid arthritis and Lupus nephritis2010
- Author(s)
  Ayano Ito, Yuko Okada, Keiju Hiromura, Yoshihisa Nojima, Takuya Araki, Tomonori Nakamura, Koujirou Yamamoto
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] Contribution of genetic polymorphisms to the efficacy of low-dose azathioprine therapy in Japanese patients with systemic lupus erythematosus2010
- Author(s)
  Ayumu Nagamine, Miki Takenaka, Tohru Aomori, Yuko Okada, Keiju Hiromura, Yoshihisa Nojima, Takuya Araki, Tomonori Nakamura, Koujirou Yamamoto
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] ワルファリン維持投与量に対するCYP4F2遺伝子多型の影響の検討2010
- Author(s)
  中村克徳, 荒木拓也, 大林恭子, 川名純一, 倉林正彦, 中村智徳, 大森栄, 山本康次郎
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] Influence of CYP3A5 and MDR1 (ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in patients with rheumatoid arthritis and lupus nephritis2009
- Author(s)
  Tomonori Nakamura, Yuko Okada, Keiju Hiromura, Yoshihisa Nojima, Katsunori Nakamura, Koujirou Yamamoto
- Organizer
  30th American College of Clinical Pharmacy
- Place of Presentation
  Anaheim, CA, USA
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] CYP4F2 gene polymorphism as a contributor of warfarin dose in Japanese2009
- Author(s)
  Katsunori Nakamura, Kyoko Obayashi, Junichi Kawana, Hiroyasu Ogata, Kazuhiko Hanada, Masahiko Kurabayashi, Akira Hasegawa, Tomonori Nakamura, Koujirou Yamamoto
- Organizer
  16th International Conference on Cytochrome P450
- Place of Presentation
  Nago, Okinawa, Japan
- Year and Date
  2009-06-21
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] Individualization of Azathioprine dose for patients with Systemic Lupus Erythematosus 38th European Society of Clinical Pharmacy2009
- Author(s)
  Koujirou Yamamoto, Yuko Okada, Katsunori Nakamura, Tomonori Nakamura, Keiju Hiromura, Yoshihisa Nojima
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] ワルファリン維持投与量決定までの期間に対する VKOR および CYP2C9 遺伝子型の影響2009
- Author(s)
  青森達, 大林恭子, 中村克徳, 中村智徳, 倉林正彦, 三谷康正, 石田尾武文, 片山敦子, Alexander Lezhava, 林崎良英, 山本康次郎
- Organizer
  第16回日本遺伝子診療学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] Influence of CYP3A5 and MDR1 (ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in patients with rheumatoid arthritis and lupus nephritis2009
- Author(s)
  Tomonori Nakamura, Yuko Okada, Keiju Hiromura, Yoshihisa Nojima, Katsunori Nakamura, Koujirou Yamamoto
- Organizer
  3rd Asian Pacific Region ISSX Meeting
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] Individualization of Azathioprine dose for patients with Systemic Lupus Erythematosus.2009
- Author(s)
  山本康次郎, 岡田裕子, 中村智徳, 他
- Organizer
  38th European Society of Clinical Pharmacy
- Place of Presentation
  ジュネーブ(スイス)
- Data Source
  KAKENHI-PROJECT-21590150
[Presentation] 和漢薬と西洋薬の併用の適正性に関する疫学的研究
- Author(s)
  葛西良佳, 青森達, 坡下真大, 鈴木小夜, 小林典子, 中島綾, 荒木拓也, 山本康次郎, 中村智徳
- Organizer
  日本薬学会135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25460116

1. Araki Takuya (00568248)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. HASHITA Tadahiro (20613384)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. NAKAMURA Tomonori (30251151)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
4. AOMORI Tohru (40620802)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. 永野大輔 (90738387)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. 八島秀明 (60773512)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. MURAKAMI Masami (30241871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. NARA Makoto (80420165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OGIWARA Takayuki (80361377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MORIMURA Tadashi (20436306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSUNEKAWA Katsuhiko (30436307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. LEZHAVA Alexander (40443048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAMURA Katsunori (20361363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
14. OHTANI Hisakazu (70262029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
15. AKIYOSHI Takeshi (50399143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
16. YAMAZAKI Hiroshi (30191274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HORIUCHI Ryuya (90008342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐藤浩子 (50396652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 手塚淑人 (00433649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 鈴木小夜 (90424134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 小林典子 (90245449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 地引綾 (00746224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 中川富士雄 (70010220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 幸田幸直 (40143482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 齋藤侑也 (90162239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 今野裕子 (70311602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 長嶺歩 (00882622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. ALEXANDER Lezhava

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 輿石一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamamoto Kojiro 山本 康次郎

YAMAMOTO Koujirou 山本 康次郎

山本 康次郎 ヤマモト コウジロウ

Research Projects

Research Products

Co-Researchers

Strategies for Overcoming Acquired Resistance to Molecular Targeted Anti-Tumor Drugs by Modulating SRC-Related Factors

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抗血小板薬による血小板凝集抑制作用の生理学的薬物動力学モデルによる解析Principal Investigator

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Establishment of efficacy index and pharmacokinetic analysis of antiplatelet drugs based on proteomic analysisPrincipal Investigator

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Review Section

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Mechanism of development of resistance to antitumor molecule-targeted drugs

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Review Section

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Drug resistance caused by intracellular pharmacokineticsPrincipal Investigator

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Clinical pharmacological study for proper use in combination with Japanese traditional medicine and Western medicine

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Quantitative analysis of genetic factors affecting the extent of drug interactions via mechanism based inhibition of cytochrome P450

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Development of non-invasive therapeutic drug monitoring method for pediatric patientsPrincipal Investigator

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Mechanism of drug resistance and its rational treatment based on pharmacodynamic analysis.Principal Investigator

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Clinical application of a novel rapid gene analyzing method aiming at personalized medicine

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Prediction of drug-drug interaction coused by xenobiotic metabolizing enzymes.Principal Investigator

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消化管機能改善薬による副作用発現の危険因子の定量的評価に基づく適正使用法の構築Principal Investigator

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生体調節系のアニマルスケールアップに基づく酵素阻害薬の生理学的薬効動態解析Principal Investigator

Principal Investigator

Yamamoto Kojiro 山本康次郎

YAMAMOTO Koujirou 山本康次郎

山本康次郎ヤマモトコウジロウ