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Fujishita Akira  藤下 晃

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FUJISHITA Akira  藤下 晃

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Researcher Number 70190030
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2017: 済生会長崎院, 婦人科, 部長
2004 – 2005: 長崎大学, 大学院・医歯薬学総合研究科, 助教授
2003: Nagasaki University, School of Medicine, University Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師
2002: 長崎大学, 医学部附属病院, 講師
1999 – 2001: 長崎大学, 医学部・附属病院, 講師
1998: 長崎大学, 医学部・附属病院, 助手
Review Section/Research Field
Principal Investigator
Obstetrics and gynecology
Except Principal Investigator
Obstetrics and gynecology / Obstetrics and gynecology
Keywords
Principal Investigator
infertility / cytokines / macrophage / peritoneal fluid / angiogenic factor / growth factors / immunohistochemical study / endometriosis / 腹水中マクロファージ / サイトカイン … More / 膜水中マクロファージ / 血管新生因子 / 細胞増殖因子 / 免疫組織染色 / 子宮内膜症 … More
Except Principal Investigator
HGF / Endometriosis / 子宮内膜症 / Cytokine / マクロファージ / antibiotics / peritoneal fluid / bacteria / endometriosis / GnRHa / 細菌汚染仮説 / Toll様受容体4 / 腹水 / 月経血 / TLR4 / Endotoxin / Macrophages / Peritoneal fluid / TLR-4 / エンドトキシン / 増殖 / macrophage / growth factor / Dioxin / Morphological / c-Met / Macrophage / 増殖因子 / サイトカイン Less
  • Research Projects

    (4 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (5 People)
  •  Study of intrauterine microbial colonization in women with endometriosis

    • Principal Investigator
      Khan Khaleque
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Pathophysiology, Growth and Progression of Endometriosis

    • Principal Investigator
      KHAN Khaleque
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Nagasaki University
  •  Clnical and pathological investigation of pelvic endometriosis

    • Principal Investigator
      ISHIMARU Tadayuki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Nagasaki University
  •  The study of the pathophysiology of endometriosis and the relation between endometriosis and infertilityPrincipal Investigator

    • Principal Investigator
      FUJISHITA Akira
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      NAGASAKI UNIVERSITY

All 2017 2016 2015 2006 2005 2004 Other

All Journal Article Presentation

  • [Journal Article] Biological differences between functionalis and basalis endometria in women with and without adenomyosis2016

    • Author(s)
      Khan KN, Fujishita A, Kitajima M, Masuzaki H, Nakashima M, Kitawaki J.
    • Journal Title

      Eur J Obstet GYnecol REprod Biol

      Volume: in press Pages: 49-55

    • DOI

      10.1016/j.ejogrb.2016.05.012

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10675, KAKENHI-PROJECT-15K10674, KAKENHI-PROJECT-15K10681
  • [Journal Article] Biological differences between functionalis and basalis endometria in women with and without adenomyosis2016

    • Author(s)
      Khan KN, Fujishita A, Kitajima M, Masuzaki H, Nakashima M, Kitawaki J
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol

      Volume: 203 Pages: 49-55

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10675
  • [Journal Article] Role of bacterial contamination in endometriosis2016

    • Author(s)
      Khan KN, Kitajima M, Fujishita A, Nakashima M, Masuzaki H, Kitawaki J.
    • Journal Title

      J Endo Pelvic Pain Disorder

      Volume: in press Issue: 1 Pages: 2-7

    • DOI

      10.5301/je.5000229

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10675
  • [Journal Article] Molecular detection of intrauterine microbial colonization in women with endometriosis2016

    • Author(s)
      Khan KN, Fujishita A, Masumoto H, Muto H, Kitajima M, Masuzaki H, Kitawaki J
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol

      Volume: 199 Pages: 69-75

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10675
  • [Journal Article] Involvement of hepatocyte growth factor-induced epithelial-mesenchymal transition in human adenomyosis2015

    • Author(s)
      Khan KN, Nakashima M, et al
    • Journal Title

      Biol Reprod

      Volume: 92 Issue: 2 Pages: 35-35

    • DOI

      10.1095/biolreprod.114.124891

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590414, KAKENHI-PROJECT-24592474, KAKENHI-PROJECT-15K10674, KAKENHI-PROJECT-15K10675
  • [Journal Article] Peritoneal fluid and serum levels of hepatocyte growth factor may predict the activity of endometriosis2006

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Hiraki K, Miura S, Sekine I, Matsuyama T, Ishimaru T
    • Journal Title

      Acta Obsted Gynecol Scand (In press)

    • NAID

      120006986553

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Regulation of hcpatocyte growth factor by basal and stimulatcd macrophages in women with endometriosis2005

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Kohno T, Sekine I, Matsuyama T, Ishimaru T
    • Journal Title

      Human Reproduction 20(1)

      Pages: 49-60

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Detection of Escherichia coli in menstrual blood and endotoxin in peritoneal fluid : an implication in pelvic inflammation and toll-like rcccptor 4 (TLR41)-mediated growth of endometriosis2005

    • Author(s)
      Khan KN, Fujishita A, Kitajima M, Hiraki K, Masuzaki H, Sekine I, Matsuyama T, Ishimaru T
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol 123

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Interleukin-6 and tumor necrosis factor α-mcdiated expression of hepatocyte growth factor by stronal cells and its involvement in the growth of endometriosis2005

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Hiraki K, Sekine I, Matsuyama T, Ishimaru T
    • Journal Title

      Human Reproduction 20(10)

      Pages: 2715-2723

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Estrogen and progesterone receptor expression in macrophages and regulation of hepatocyte growth factor by ovarian steroids in women with endometriosis.2005

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Sekine I, Matsuyama T, Ishimaru T.
    • Journal Title

      Human Reproduction 20(7)

      Pages: 2004-2013

    • NAID

      120006986565

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Incrcased endotoxin conccntration in peritoneal fluid promotes toll-likc receptor 4 (TLR4)-mediated growth of endometriosis2005

    • Author(s)
      Khan KN, Fujishita A, Kitajima M, Hiraki K, Masuzaki H, Sekine I, Matsuyama T, Ishimaru T
    • Journal Title

      Am J Reprod Immunol 53

      Pages: 292-292

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Regulation of hepatocyte growth factor by basal and stimulated-macrophages in women with endometriosis2005

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Kohno T, Sekine I, Matsuyama T, Ishimaru T.
    • Journal Title

      Human Reproduction 20(1)

      Pages: 49-60

    • NAID

      120006986564

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Detection of Escherichia coli in menstrual blood and endotoxin in peritoneal fluid : an implication in pelvic inflammation and toll-like receptor 4 (TLR4)-mediated growth of endometriosis.2005

    • Author(s)
      Khan KN, Fujishita A, Kitajima M, Hiraki K, Masuzaki H, Sekine I, Matsuyama T, Ishimaru T.
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol 123

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Interleukin-6 and tumor necrosis factor α-mediated expression of hepatocte growth factor by stromal cells and its involvement in the growth of endometriosis.2005

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Hiraki K, Sekine I, Matsuyama T, Ishimaru T.
    • Journal Title

      Human Reproduction 20(10)

      Pages: 2715-2723

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Increased endotoxin concentration in peritoneal fluid promotes toll-like receptor 4 (TLR4)-mediated growth of endometriosis.2005

    • Author(s)
      Khan KN, Fujishita A, Kitajima M, Hiraki K, Masuzaki H, Sekine I, Matsuyama T, Ishimaru T.
    • Journal Title

      Am J Reprod Immunol 53

      Pages: 292-292

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Estrogen and progesterone receptor expression in macrophages and regulation of hepatocyte growth factor by ovarian steroids in women with endometriosis2005

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Sekine I, Matsuyama T, Ishimaru T
    • Journal Title

      Human Reproduction 20(7)

      Pages: 2004-2013

    • NAID

      120006986565

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Letter to the editor (Statistical analysis of endometriosis)2004

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Hamasaki T, Kitajima M, Ishimaru T
    • Journal Title

      Acta obstct Gynccol Scand 83(7)

      Pages: 693-693

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Histomorphometric alteration and cell-type specific modulation of arylhydrocarbon receptor and estrogen receptor expressio by 2,3,7,8-tetrachlorodibemzo-p-dioxin and 17b-estradiol in mouse experimental model of endometriosis.2004

    • Author(s)
      Kitajima M, Khan KN, Fujishita A, Masuzaki H, Ishimaru T.
    • Journal Title

      Reprod Toxicol. 18

      Pages: 793-801

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Letter to the editor (Statistical analysis of endometriosis).2004

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Hamasaki T, Kitajima M, Ishimaru T.
    • Journal Title

      Acta Obstet Gynecol Scand. 83(7)

      Pages: 693-693

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Modified reduction surgery for adenomyosis : a preliminary report of the transverse H incision technique2004

    • Author(s)
      Fujishita A, Masuzaki H, Khan KN, Kitajima M, Ishimaru T
    • Journal Title

      Gynecol Obsted Invest. 57(3)

      Pages: 132-138

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Histomorphometric alteration and cell-type specific modulation of arylhydrocarbon receptor and estrogen receptor expression by 2, 3, 7, 8-tctrachlorodibemzo-p-dioxin and 17b-estradiol in mousc expcrimcntal model of elldometriosis2004

    • Author(s)
      Kitajima M, Khan KN, Fujishita A, Masuzaki H, Ishimaru T.
    • Journal Title

      Reprod Toxicol 18

      Pages: 793-801

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Higher activity by opaque endometriotic lesions than nonopaque lesions.2004

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Sekine I, Ishimaru T.
    • Journal Title

      Acta Obstet Gynecol Scand. 83(4)

      Pages: 375-382

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Hepatocyte growth factor may be involved in cellular changes to the peritoneal mesothelium adjacent to pelvic endometriosis.2004

    • Author(s)
      Ishimaru T, Khan KN, Fujishita A, Kitajima M, Masuzaki H.
    • Journal Title

      Fertility and Sterility. 81 (suppl.1)

      Pages: 810-818

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Laparoscopic salpingotomy for tubal pregnancy : comparison of linear salpingotomy with and without suturing.2004

    • Author(s)
      Fujishita A, Masuzaki H, Khan KN, Kitajima M, Hiraki K, Ishimaru T.
    • Journal Title

      Human Reproduction. 19(5)

      Pages: 1195-1200

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Higher activity by opaque endometriotic lesions than nonopaque lesions2004

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Sekine I, Ishimaru T
    • Journal Title

      Acta obstet Gynccol Scand 83(4)

      Pages: 375-382

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Differential macrophage infiltration in early and advanced endometriosis and adjacent peritoneum2004

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Sekine I, Ishimaru T
    • Journal Title

      Fcrtility and Sterility 81(3)

      Pages: 652-661

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Expression of the arylhydrocarbon rcceptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation2004

    • Author(s)
      Kitajima M, Khan KN, Fujishita A, Masuzaki H, Ishimaru T.
    • Journal Title

      Arch Histol Cytol 67

      Pages: 465-474

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Laparoscopic salpingotomy for tubal pregnancy : comparison of linear salpingotomy with and without suturing2004

    • Author(s)
      Fujishita A, Masuzaki H, Khan KN, Kitajima M, Hiraki K, Ishimaru T
    • Journal Title

      Human Reproduction 19(5)

      Pages: 1195-1200

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Hepatocyte growth factor may be involved in cellular changes to the peritoneal mesothelium adjacent to pelvic endometriosis2004

    • Author(s)
      Ishimaru T, Khan KN, Fujishita A, Kitajima M, Masuzaki H
    • Journal Title

      Fertility and Sterility 81(suppl.1)

      Pages: 810-818

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Differential macrophage infiltration in early and advanced endometriosis and adjacent peritoneum.2004

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Sekine I, Ishimaru T.
    • Journal Title

      Fertility and Sterility. 81(3)

      Pages: 652-661

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Modified reduction surgery for adenomyosis : a preliminary report of the transverse H incision technique.2004

    • Author(s)
      Fujishita A, Masuzaki H, Khan KN, Kitajima M, Ishimaru T.
    • Journal Title

      Gynecol Obstet Invest. 57(3)

      Pages: 132-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Expression of the arylhydrocarbon receptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation.2004

    • Author(s)
      Kitajima M, Khan KN, Fujishita A, Masuzaki H, Ishimaru T.
    • Journal Title

      Arch Histol Cytol 67

      Pages: 465-474

    • NAID

      10014483340

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Journal Article] Peritoneal fluid and serum levels of hepatocyte growth factor may predict the activity of endometriosis.

    • Author(s)
      Khan KN, Masuzaki H, Fujishita A, Kitajima M, Hiraki K, Miura S, Sekine I, Matsuyama T, Ishimaru T.
    • Journal Title

      Acta Obstet Gynecol Scand. (in press)

    • NAID

      120006986553

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591671
  • [Presentation] Adolescent endometriosis: current status and its problems in Asia2017

    • Author(s)
      han KN, Fujishita A, Kitajima Y, Kitawaki J
    • Organizer
      The 38th Japan Endometriosis Congress
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2017-01-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K10675
  • [Presentation] GnRHa療法が子宮腔内への細菌コンタミネーションおよび子宮内膜炎の発生に及ぼす影響2016

    • Author(s)
      カーン カレク,北島道夫,平木宏一,藤下 晃, 増崎英明, 北脇 城
    • Organizer
      第 37回エンドメトリオーシス学会
    • Place of Presentation
      熊本
    • Year and Date
      2016-01-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K10675
  • [Presentation] Role of EMT in adenomyosis2015

    • Author(s)
      Khan KN, Kitajima M, Hiraki K, Fujishita A, Nakashima M, Masuzaki H
    • Organizer
      The 1st Symposium on Reproductive Diseases
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2015-12-12
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K10675
  • [Presentation] 子宮内膜症腹膜病変の形成におけるFOXP3+Treg細胞の役割2015

    • Author(s)
      カーン カレク,北島道夫,井上統夫1,平木宏一、藤下 晃、増崎英明
    • Organizer
      第30回日本生殖免疫学会
    • Place of Presentation
      熊本
    • Year and Date
      2015-11-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K10675
  • [Presentation] 子宮内膜症に対するGnRHa療法が子宮腔内の細菌コンタミネーションおよび子宮内膜炎に及ぼす影響に関する検討2015

    • Author(s)
      カーン カレク,北島道夫,平木宏一,藤下 晃, 中島正洋, 増崎英明
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-10
    • Data Source
      KAKENHI-PROJECT-15K10675
  • [Presentation] 子宮腺筋症の病態とEpithelial-Mesenchymal Transition (EMT):hepatocyte growth factor (HGF)とエストロゲンの役割2015

    • Author(s)
      カーン カレク,北島道夫, 平木宏一、藤下 晃,中島正洋, 増崎英明
    • Organizer
      7th Japan Endometriosis Forum (JEF)
    • Place of Presentation
      東京
    • Year and Date
      2015-11-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K10675
  • 1.  KHAN Khaleque newaz (60336162)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 37 results
  • 2.  ISHIMARU Tadayuki (20039580)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  KOJI Takehiko (30170179)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  北島 道夫 (50380845)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 5.  中島 正洋
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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