YOKOYAMA Takahiko 横山尚彦

… Alternative Names

横山高彦ヨコヤマタカヒコ

Less

Researcher Number	70191525
External Links
Affiliation (based on the past Project Information) *help	2012 – 2016: 京都府立医科大学, 医学(系)研究科(研究院), 教授 2003 – 2005: 京都府立医科大学, 医学研究科, 教授 2004: 京都府立医科大学, 大学院・医学研究科, 教授 2002: 京都府立医科大学, 医学部, 教授 1996 – 2001: 東京女子医科大学, 医学部, 助手 1998: 東京女子医科大学, 医学部 1997: 東京女子医大, 医学部, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Developmental biology / Developmental biology / General anatomy (including Histology/Embryology) / Kidney internal medicine / General anatomy (including Histology/Embryology) Except Principal Investigator Kidney internal medicine / General medical chemistry / General medical chemistry
Keywords	Principal Investigator inv / カルシウム / 左右非対称性 / 繊毛 / 遺伝子 / 内臓逆位 / ankyrin / 腎臓 / 嚢胞腎 / カルモデュリン … More / intracellular localization / right asymmetry / left / Xenopus / microarray / kidney / cyst / policystin / 遺伝子発現 / inv (3) situs inversus / xenopus / IQモティフ / situs inversus / 細部内局在 / 細胞内局在 / アンキリン / gene / mutant / sirus inversus / asymmetry / トランスジェニックマウス / YAC / マウス / 変異体 / 非対称 / Fucci / 嚢胞 / アポトーシス / 細胞周期 / 細胞増殖 / 腎嚢胞 / シグナル / 機械的刺激 / 核移行 / アンキリン・ドメイン / 変異 / ヒト / アンキリン・モティフ / トランスフェクション … More Except Principal Investigator ノックアウトマウス / 形態形成 / 心臓 / Ankyrin / Transgenic mouse / Polystic kidney / K ATPase / Na / NalkATPase / モノクロナル抗体 / アンキリン / トランスジェニックマウス / 嚢胞腎 / メダカ突然変異体 / 神経堤細胞 / 細胞移動 / 大動脈 / 突然変異 / 発生工学 / 分子遺伝学 / 先天性奇形 / 大血管 Less

Mechanisms to develop renal cyst formation and progression by disruption of cilia/centriole and cell cycle relationshipsPrincipal Investigator
- Principal Investigator
  
  yokoyama Takahiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Establishiment of calcium influx and detection system in the ciliaPrincipal Investigator
- Principal Investigator
  
  YOKOYAMA Takahiko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kyoto Prefectural University of Medicine
物理的刺激による発生・細織形態制御機構Principal Investigator
- Principal Investigator
  
  横山尚彦
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Prefectural University of Medicine
心臓大血管の形態形成の分子機構の解明
- Principal Investigator
  
  三浦直行
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
Involvement of inv-calmodulin pathway for left-right asymmetry formationPrincipal Investigator
- Principal Investigator
  
  YOKOYAMA Takahiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  Kyoto Prefectural University of Medicine
Xenopusの左右非対称性形成におけるinv遺伝子機能の解明Principal Investigator
- Principal Investigator
  
  横山尚彦
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Prefectural University of Medicine
左右非対称性決定機構の解明 -カルシウムは左右決定因子か?-Principal Investigator
- Principal Investigator
  
  横山尚彦
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Women's Medical University
心大血管発生の分子機構と先天性疾患のメカニズム
- Principal Investigator
  
  三浦直行
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
左右非対称性決定機構の解明Principal Investigator
- Principal Investigator
  
  横山尚彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Women's Medical University
Functional analysis of left-right determining (inv) gene'-''Principal Investigator
- Principal Investigator
  
  YOKOYAMA Takahiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Tokyo Women's Medical University
左右非対称性決定機構の解明Principal Investigator
- Principal Investigator
  
  横山尚彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Women's Medical University
左右非対称性決定機構の解明Principal Investigator
- Principal Investigator
  
  横山尚彦
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Women's Medical University
Functional analysis of left-right determining (inv) genePrincipal Investigator
- Principal Investigator
  
  YOKOYAMA Takahiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Tokyo Women's Medical University
左右を決定する遺伝子（inv）のクローニングPrincipal Investigator
- Principal Investigator
  
  横山尚彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Women's Medical University
Molecular analysis of cystic kidney formed transgenic mouse generated by insertional mutation
- Principal Investigator
  
  TSUCHIYA Ken
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Women's Medical University
Cloning of left-right determining (inv) genePrincipal Investigator
- Principal Investigator
  
  YOKOYAMA Takahiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Tokyo Women's Medical College

All 2017 2016 2015 2014 2013 2012 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] Cardiovasucular Development and Congenital Malformation -Molecular and Genetic Mechanisms-2005
- Author(s)
  Takahiko Yokoyama, Yukuto Yasuhiko
- Total Pages
  292
- Publisher
  Blackwell & Futura
- Data Source
  KAKENHI-PROJECT-16027245
[Journal Article] Ciliary subcompartments and cysto-proteins.2017
- Author(s)
  Yokoyama T
- Journal Title
  
  Anat Sci Int.
  
  Volume: 92 Issue: 2 Pages: 207-214
- DOI
  10.1007/s12565-015-0302-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461235
[Journal Article] Structural basis of the Inv compartment and ciliary abnormalities in Inv/nphp2 mutant mice.2016
- Author(s)
  Tsuji T, Matsuo K, Nakahari T, Marunaka Y, Yokoyama T.
- Journal Title
  
  Structural basis of the Inv compartment and ciliary abnormalities in Inv/nphp2 mutant mice.
  
  Volume: 73 Issue: 1 Pages: 45-56
- DOI
  10.1002/cm.21264
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870691, KAKENHI-PROJECT-26461235, KAKENHI-PROJECT-15K15034
[Journal Article] 嚢胞性腎疾患と繊毛2014
- Author(s)
  横山尚彦
- Journal Title
  
  腎と透析
  
  Volume: 77 Pages: 705-710
- Data Source
  KAKENHI-PROJECT-26461235
[Journal Article] Blockade of Death Ligand TRAIL Inhibits Renal Ischemia Reperfusion Injury2013
- Author(s)
  Adachi T, Sugiyama N, Gondai T, Yagita H, Yokoyama T
- Journal Title
  
  Act Histochem Cytodhem
  
  Pages: 161-170
- NAID
  130003381870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659089
[Journal Article] 繊毛は身体の「右と左」を決める2013
- Author(s)
  小林大介、横山尚彦
- Journal Title
  
  京都府立医科大学雑誌
  
  Volume: 6 Pages: 371-375
- Data Source
  KAKENHI-PROJECT-24659089
[Journal Article] Blockade of Death Ligand TRAIL Inhibits Renal Ischemia Reperfusion Injury2013
- Author(s)
  Adachi T, Sugiyama N, Gondai T, Yagita H, Yokoyama T.
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 46 Issue: 6 Pages: 161-170
- DOI
  10.1267/ahc.13022
- NAID
  130003381870
- ISSN
  0044-5991, 1347-5800
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591197, KAKENHI-PROJECT-24659089
[Journal Article] 繊毛は体の「右と左」を決める2013
- Author(s)
  小林大介, 横山尚彦
- Journal Title
  
  京都府立医科大学雑誌
  
  Volume: 112 Pages: 371-379
- Data Source
  KAKENHI-PROJECT-24659089
[Journal Article] 繊毛運動を制御する分子メカニズム2013
- Author(s)
  茂田昌樹、横山尚彦
- Journal Title
  
  The Lung perspectives
  
  Volume: 21 Pages: 57-60
- Data Source
  KAKENHI-PROJECT-24659089
[Journal Article] The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish2012
- Author(s)
  Fukui H, Shiba D, Asakawa K, Kawakami K, Yokoyama T
- Journal Title
  
  FEBS Lett
  
  Volume: 586(16) Pages: 2273-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659089
[Journal Article] Roles of the Foxjl and Inv genes in left-right determination of internal organs in mice2006
- Author(s)
  Tomoki Tamakoshi Tatsuo Itakural Absheck Chandra, Tadayoshi Uezatol, Zhi Yang, Xiao-Dong Xue, Bo Wang, Brian P.Hackett, Tatsuhiko Yokoyama, Naovuki Miura
- Journal Title
  
  Biochemical and Biophysical Research Communications 339(3)
  
  Pages: 932-938
- Data Source
  KAKENHI-PROJECT-16027245
[Journal Article] Primary cilia of inv/inv mouse renal epithelial cells sense physiological fluid flow : Bending of primary cilia and Ca2+ influx2005
- Author(s)
  Shiba D, Takamatsu T, Yokoyama T
- Journal Title
  
  Cell Structure and Function 30(2)
  
  Pages: 93-100
- NAID
  130004137502
- Data Source
  KAKENHI-PROJECT-16027245
[Journal Article] 繊毛:その新たな機能2005
- Author(s)
  横山尚彦
- Journal Title
  
  細胞 37(7)
  
  Pages: 284-287
- Data Source
  KAKENHI-PROJECT-16027245
[Journal Article] 遺伝的変異体作成とその形態形成機構解明への応用2005
- Author(s)
  横山尚彦
- Journal Title
  
  関西実験動物研究会会報 26
  
  Pages: 24-28
- Data Source
  KAKENHI-PROJECT-16027245
[Journal Article] Motor or sensor : a new aspect of primary cilia function.2004
- Author(s)
  Yokoyama T
- Journal Title
  
  Anat.Sci. Int 79・2
  
  Pages: 47-54
- NAID
  10014025727
- Data Source
  KAKENHI-PROJECT-15370095
[Journal Article] Motor or sensor : a new aspect of primary cilia function.2004
- Author(s)
  Yokoyama T
- Journal Title
  
  Anat.Sci.Int 79・2
  
  Pages: 47-54
- NAID
  10014025727
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370095
[Journal Article] Motor or sensor : a new aspect of primary cilia function2004
- Author(s)
  Yokoyama T
- Journal Title
  
  Anat.Sci.Int 79(2)
  
  Pages: 47-54
- NAID
  10014025727
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370095
[Journal Article] Motor or sensor: a new aspect of primary cilia function.2004
- Author(s)
  Yokoyama T
- Journal Title
  
  Anat. Sci. Int 79・2
  
  Pages: 47-54
- NAID
  10014025727
- Data Source
  KAKENHI-PROJECT-16027245
[Journal Article] 繊毛運動を制御する分子メカニズム
- Author(s)
  辻琢磨、横山尚彦
- Journal Title
  
  The Lung perspective秋季号
  
  Pages: 57-60
- Data Source
  KAKENHI-PROJECT-24659089
[Presentation] Inv compartment lnephrocystins2017
- Author(s)
  T Yokoyama
- Organizer
  The Kitasato-Yale Fluid Symposium 2017: Molecular Control of Cellular and Epithelial Function
- Place of Presentation
  Shirakane, Tokyo
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461235
[Presentation] 一次繊毛に局在するNephrocystin-3の機能解析2016
- Author(s)
  中島由朗、陳琳、横山尚彦
- Organizer
  第121回日本解剖学会
- Place of Presentation
  福島
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26461235
[Presentation] 尿細管形成と嚢胞発生機構2016
- Author(s)
  横山尚彦
- Organizer
  『上皮膜輸送調節蛋白の異常と病態生理学の融合』
- Place of Presentation
  自然科学研究機構生理学研究所
- Year and Date
  2016-11-24
- Invited
- Data Source
  KAKENHI-PROJECT-26461235
[Presentation] 若年性ネフロン癆(NPHP)原因遺伝子Inv/Nphp2の網膜およひ;気管上皮における機能解析2016
- Author(s)
  松尾和彦、中張隆司、丸中良典、横山
- Organizer
  第121回日本解剖学会
- Place of Presentation
  福島
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26461235
[Presentation] Analysis of the medaka intestinal atresia mutant2016
- Author(s)
  Kobayashi D and Yokoyama T
- Organizer
  第121回日本解剖学会
- Place of Presentation
  福島
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26461235
[Presentation] Structural base of the Inv compartment and ciliary abnormality in the inv mutant mice2015
- Author(s)
  Matsuo K, Tuji T and Yokoyama T
- Organizer
  FASEB meeting
- Place of Presentation
  Snowmass, Corolado
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461235
[Presentation] Cilia localization signal of nephrocystin-3 is crucial for the kidney morphogenesis, but not situs determination.2015
- Author(s)
  Nakajima Y and Yokoyama T
- Organizer
  FASEB meeting
- Place of Presentation
  Snowmass, Corolado
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461235
[Presentation] 一次繊毛の微細構造と繊毛病の関係2014
- Author(s)
  茂田昌樹、横山尚彦
- Organizer
  第119回解剖学会総会
- Place of Presentation
  自治医科大学
- Data Source
  KAKENHI-PROJECT-24659089
[Presentation] 繊毛／繊毛蛋白異常と嚢胞性腎疾患2014
- Author(s)
  横山尚彦
- Organizer
  第119回解剖学会総会
- Place of Presentation
  自治医科大学
- Invited
- Data Source
  KAKENHI-PROJECT-24659089
[Presentation] 一次繊毛の微細構造と繊毛病の関係2014
- Author(s)
  辻琢磨、横山尚彦
- Organizer
  第119回日本解剖学会総会
- Place of Presentation
  自治医科大学
- Data Source
  KAKENHI-PROJECT-24659089
[Presentation] 繊毛/繊毛蛋白異常と嚢胞性腎疾患2014
- Author(s)
  横山尚彦
- Organizer
  第119回解剖学会総会(解剖学会/生理学会合同シンポジウム)
- Place of Presentation
  自治医科大学
- Data Source
  KAKENHI-PROJECT-24659089
[Presentation] A three step process of Nphp3 ciliary localization2013
- Author(s)
  Shiba D, Nakata K, Fukui H, Kobayashi D and Yokoyama T
- Organizer
  CILIA2012 1^<st> International Science Conference
- Place of Presentation
  London
- Data Source
  KAKENHI-PROJECT-24659089
[Presentation] A three-step process of Nphp3 ciliary localization.2013
- Author(s)
  Shiba D, Nakata K, Fukui H, Kobayashi D and Yokoyama T.
- Organizer
  CILIA 2012-1st International Scientific Conferenc
- Place of Presentation
  London
- Data Source
  KAKENHI-PROJECT-24659089
[Presentation] 繊毛病としての嚢胞性腎疾患2013
- Author(s)
  横山尚彦
- Organizer
  第21回嚢胞性腎疾患研究会
- Place of Presentation
  杏林大学
- Year and Date
  2013-09-21
- Invited
- Data Source
  KAKENHI-PROJECT-24659089
[Presentation] Ciliary subdomains and abnormality in the kidney of inv mutant mice
- Author(s)
  横山尚彦、辻琢磨
- Organizer
  第120回解剖学会総会第92回生理学会合同大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-26461235
[Presentation] Roles of a ciliary gene, Nphp2/inv in cell cycle control
- Author(s)
  茂田昌樹、中島由郎、横山尚彦
- Organizer
  第120回解剖学会総会第92回生理学会合同大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-26461235

1. SHIBA Dai (50360722)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. SUGIYAMA Noriyuki (90381954)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 三浦直行 (40165965)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 栗原裕基 (20221947)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 竹内隆 (70197268)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TSUCHIYA Ken (00246472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MOCHIZUKI Toshio (00277120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IIJIMA Norio (00285248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 里方一郎 (70170800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 瀧原義宏 (60226967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小椋利彦 (60273851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 田中誠 (00271007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 鳴瀬善久 (00326216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 大橋憲太郎 (50332953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MATSUO Kazuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOKOYAMA Takahiko 横山 尚彦

横山 高彦 ヨコヤマ タカヒコ

Research Projects

Research Products

Co-Researchers

Mechanisms to develop renal cyst formation and progression by disruption of cilia/centriole and cell cycle relationshipsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishiment of calcium influx and detection system in the ciliaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

物理的刺激による発生・細織形態制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

心臓大血管の形態形成の分子機構の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of inv-calmodulin pathway for left-right asymmetry formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Xenopusの左右非対称性形成におけるinv遺伝子機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

左右非対称性決定機構の解明 -カルシウムは左右決定因子か?-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

心大血管発生の分子機構と先天性疾患のメカニズム

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

左右非対称性決定機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Functional analysis of left-right determining (inv) gene'-''Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

左右非対称性決定機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

左右非対称性決定機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Functional analysis of left-right determining (inv) genePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

YOKOYAMA Takahiko 横山尚彦

横山高彦ヨコヤマタカヒコ