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NISHIYAMA Tsutomu  西山 勉

ORCIDConnect your ORCID iD *help
… Alternative Names

西山 勉  ニシヤマ ツトム

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Researcher Number 70208239
Other IDs
Affiliation (based on the past Project Information) *help 2009 – 2014: Niigata University, 医歯学系, 准教授
1991: 新潟大学, 医学部附属病院, 講師
1989: 新潟大学, 医学部附属病院, 講師
Review Section/Research Field
Principal Investigator
Urology / Urology
Except Principal Investigator
Urology
Keywords
Principal Investigator
アンドロゲン受容体 / アンドロゲン抑制療法 / 前立腺癌 / 活性化共役因子 / アンドロゲンん / NKX3.1 / 共役因子 / アゴニスト / アンタゴニスト / アンドロゲン … More / 下垂体-副腎内分泌軸 / 3αアンドロスタンディオール / HSD17B6 / デヒドロエピアンドロステロン / ジヒドロテストステロン / 細胞内アンドロゲン代謝 / 細胞内分泌学 / アンドロゲン代謝 / in vitro / PNA-ricinA / 膀胱癌 / Tn抗原 / T抗原 / targeting therapy … More
Except Principal Investigator
フロ-サイトメトリ- / 腎細胞癌 / 細胞間接着因子 Less
  • Research Projects

    (4 results)
  • Research Products

    (42 results)
  • Co-Researchers

    (2 People)
  •  Elucidation of agonistic changes of the antagonists of androgen receptor of prostate cancerPrincipal Investigator

    • Principal Investigator
      NISHIYAMA Tsutomu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Niigata University
  •  Development of intracrine androgen deprivation therapy for prostate cancerPrincipal Investigator

    • Principal Investigator
      NISHIYAMA Tsutomu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Niigata University
  •  腎細胞癌上におけるICAMー1の表現とサイトカインによる発現の調節(宿主免疫担当細胞に対する感受性の変化)

    • Principal Investigator
      佐藤 昭太郎
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Niigata University
  •  ヒト膀胱癌関連T抗原、Tn抗原特異的バイオミサイル療法の基礎的研究Principal Investigator

    • Principal Investigator
      西山 勉
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Niigata University

All 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

  • [Book] Androgens: Production, Functions and Disorders. Chapter 1: Androgen deprivation therapy for advanced prostate cancer on the ground of androgen milieu in the prostate2012

    • Author(s)
      Nishiyama T
    • Publisher
      NOVA SCIENCE PUBLISHERS, INC.
    • Data Source
      KAKENHI-PROJECT-24592380
  • [Book] Paradigm shift in the concept of hormonal milieu of prostate cancer.In Spiess PE ed.PROSTATE CANCER FROM ENCH TO BEDSIDE.Croatia, InTech, 20112011

    • Author(s)
      Tsutomu Nishiyama
    • Publisher
      InTech
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Book] Paradigm shift in the concept of hormonal milieu of prostate cancer. In Prostate Cancer-From Bench to Bedside.(Spiess PE ed.)2011

    • Author(s)
      Nishiyama T
    • Publisher
      In Tech. Croatia
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Androgen metabolic pathway involved in current and emerging treatment for men with castration resistant prostate cancer: intraprostatic androgens as therapeutic targets and endocrinological biomarkers.2014

    • Author(s)
      Hara N, Nishiyama T.
    • Journal Title

      Curr Drug Targets.

      Volume: 15 Pages: 1215-1224

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592380
  • [Journal Article] Serum testosterone levels after medical or surgical androgen deprivation: A comprehensive review of the literature.2014

    • Author(s)
      Nishiyama T,
    • Journal Title

      Urol Oncol.

      Volume: 32 Issue: 1 Pages: 38.e17-38.e28

    • DOI

      10.1016/j.urolonc.2013.03.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592380
  • [Journal Article] Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer.2013

    • Author(s)
      Ishizaki F, Nishiyama T, Kawasaki T, Miyashiro Y, Hara N, Takizawa I, Naito M, Takahashi K.
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 1528-1528

    • DOI

      10.1038/srep01528

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592380
  • [Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer.2012

    • Author(s)
      Nishiyama T.
    • Journal Title

      J Steroid Biochem Mol Biol.

      Volume: 129 Issue: 3-5 Pages: 179-190

    • DOI

      10.1016/j.jsbmb.2011.12.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592380
  • [Journal Article] Deficiency in androgens and upregulation of insulin-like growth factor-1 are involved in high bone turnover in men receiving androgen deprivation therapy for prostate cancer.2012

    • Author(s)
      Ishizaki F, Hara N, Takizawa I, Nishiyama T, Isahaya E, Kawasaki T, Takahashi K.
    • Journal Title

      Growth Horm IGF Res.

      Volume: 22 Issue: 3-4 Pages: 122-128

    • DOI

      10.1016/j.ghir.2012.04.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592380
  • [Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer2012

    • Author(s)
      Nishiyama T
    • Journal Title

      J steroid Biochem Mol Biol.2012 Apr; 129(3-5) : 179-90

      Volume: 129 Pages: 179-190

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer2012

    • Author(s)
      Nishiyama T
    • Journal Title

      J Steroid Biochem Mol Biol

      Volume: 129(3-5) Pages: 179-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤2011

    • Author(s)
      西山勉
    • Journal Title

      日本臨床

      Volume: 69 Suppl 5 Pages: 511-515

    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy.2011

    • Author(s)
      Komatsu S, Hara N, Ishizaki F, Nishiyama T, Takizawa I, Isahaya E, Kawasaki T, Takahashi K.
    • Journal Title

      Prostate

      Volume: (In press) Issue: 11 Pages: 1207-1213

    • DOI

      10.1002/pros.22471

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035, KAKENHI-PROJECT-21791493, KAKENHI-PROJECT-24592380
  • [Journal Article] II臨床6)内分泌療法c.内分泌療法の新展開d)アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤日本臨牀69巻増刊号5前立腺癌(第2版)2011

    • Author(s)
      西山勉
    • Journal Title

      日本臨牀

    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] 前立腺癌ホルモン環境概念のパラダイムシフト2011

    • Author(s)
      西山勉
    • Journal Title

      新潟医学会雑誌

      Volume: 125 Pages: 581-601

    • NAID

      120006748441

    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Insulin-like growth factorl is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer.2011

    • Author(s)
      Hara N, Takizawa I, Isahaya E, Nishiyama T, Hoshii T, Ishizaki F, Takahashi K.
    • Journal Title

      Urol Oncol.2011 Mar 30

      Volume: (電子版 Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer2011

    • Author(s)
      Hara N, Takizawa I, Isahaya E, Nishiyama T, Hoshii T, Ishizaki F, Takahashi K
    • Journal Title

      Urol Oncol

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Adrenocorticotropic hormone is involved in regulation of androgen synthesis in men receiving androgen deprivation therapy for localized prostate cancer.2010

    • Author(s)
      Takizawa I, Hara N, Nishiyama T, Isahaya E, Hoshii T, Takahashi K.
    • Journal Title

      JUrol.184(5), 2010.

      Volume: 184 Pages: 1971-1976

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu.2010

    • Author(s)
      Takizawa I, Nishiyama T, Hara N, Isahaya E, Hoshii T, Takahashi K.
    • Journal Title

      Prostate.70(13)1395-401, 2010.

      Volume: 70 Pages: 1395-1401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Decline of the red blood cell count in patients receiving androgen deprivation therapy for localized prostate cancer : impact of ADT on insulin-like growth factor-1 and erythropoiesis2010

    • Author(s)
      Hara N, Nishiyama T, Takizawa I, Saito T, Kitamura Y, Takahashi K
    • Journal Title

      Urology

      Volume: 75(6) Pages: 1441-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy(ADT): impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis2010

    • Author(s)
      Isahaya E, Hara N, Nishiyama T, Hoshii T, Takizawa I, Takahashi K
    • Journal Title

      Prostate

      Volume: 70(2) Pages: 155-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Prostate cancer and androgens : new strategies of androgen deprivation therapy2010

    • Author(s)
      Nishiyama T
    • Journal Title

      Curr Top Steroid Res

      Volume: 7 Pages: 35-45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu2010

    • Author(s)
      Takizawa I, Nishiyama T, Hara N, Isahaya E, Hoshii T, Takahashi K
    • Journal Title

      Prostate

      Volume: 70(13) Pages: 1395-401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Decline of the Red Blood Cell Count in Patients Receiving Androgen Deprivation Therapy for Localized Prostate Cancer : Impact of ADT on Insul in-like Growth Factor-1 and Erythropoiesis.2010

    • Author(s)
      Hara N, Nishiyama T, Takizawa I, Saito T, Kitamura Y, Takahashi K.
    • Journal Title

      Urology. 75(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells.2010

    • Author(s)
      Takizawa I, Nishiyama T, Hara N, Hoshii T, Ishizaki F, Miyashiro Y, Takahashi K.
    • Journal Title

      Cancer Lett.297(2)226-30, 2010.

      Volume: 297 Pages: 226-230

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Adrenocorticotropic hormone is involved in regulation of androgen synthesis in men receiving androgen deprivation therapy for localized prostate cancer2010

    • Author(s)
      Takizawa I, Hara N, Nishiyama T, Isahaya E, Hoshii T, Takahashi K
    • Journal Title

      J Urol

      Volume: 184(5) Pages: 1971-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells2010

    • Author(s)
      Takizawa I, Nishiyama T, Hara N, Hoshii T, Ishizaki F, Miyashiro Y, Takahashi K. Trilostane
    • Journal Title

      Cancer Lett

      Volume: 297(2) Pages: 226-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Bone metabolic disorder in patients with prostate cancer receiving and rogen deprivation therapy(ADT) : impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis.2010

    • Author(s)
      Isahaya E, Hara N, Nishiyama T, Hoshii T, Takizawa I, Takahashi K.
    • Journal Title

      Prostate. 2010 Feb 1 ; 70(2): 70

      Pages: 155-161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] 前立腺癌とアンドロゲン-アンドロゲン抑制療法の新たな挑戦2009

    • Author(s)
      西山勉
    • Journal Title

      Urology Today

      Volume: 16(2) Pages: 50-54

    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy

    • Author(s)
      Komatsu S, Hara N, Ishizaki F, Nishiyama T, Takizawa I, Isahaya E, Kawasaki T, Takahashi K
    • Journal Title

      Prostate.2011 Dec 27.doi : 10.1002/pros.22471

      Volume: (Epub ahead of print)(未定)(Online先行掲載)(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Journal Article] Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer

    • Author(s)
      Hara N, Takizawa I, Isahaya E, Nishiyama T, Hoshii T, Ishizaki F, Takahashi K.
    • Journal Title

      Urol Oncol.2011 Mar 30

      Volume: (Epub ahead of print)(未定)(Online先行掲載)(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] 前立腺癌アンドロゲンレセプターに対する抗アンドロゲン剤のアゴニスト化のメカニズム:共調節因子の発現および機能の変化2015

    • Author(s)
      武田啓介、西山勉
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      金沢、ホテル日航金沢
    • Year and Date
      2015-04-19
    • Data Source
      KAKENHI-PROJECT-24592380
  • [Presentation] スポンサードセミナー「前立腺組織内環境からみた前立腺癌アンドロゲン抑制療法」2011

    • Author(s)
      西山勉
    • Organizer
      第63回日本泌尿器科学会西日本総会
    • Place of Presentation
      久留米
    • Year and Date
      2011-11-12
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] 5 a-androstane-3a 17b-diol will be a p otential precursor of the most active androgen 5a-dihydrotestosterone in prostate cancer2011

    • Author(s)
      Nishiyama T, Ishizaki F, Hara N, K awasaki T, Miyashiro Y, Takizawa I, Hoshii T, Naito M, Takahashi K
    • Organizer
      AUA annual meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-05-15
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] 5 α ANDROSTANE-3 α 17 β-DIOL WILL BE A POTENTIAL PRECURSOR OF THE MOST ACTIVE ANDROGEN 5 α-DIHYDROTESTOSTERONE IN PROSTATE CANCER2011

    • Author(s)
      Tsutomu Nishiyama, Fumio Ishizaki, Itsuhiro Takizawa, Kazutoshi Yamana, Noboru Hara, Kota Takahashi
    • Organizer
      American Urological Association 2011 annual meeting
    • Place of Presentation
      Washington, USA. Walter E.Washington Convertion Center
    • Year and Date
      2011-05-15
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] ホルモン抵抗性前立腺癌概念のparadigm shift2010

    • Author(s)
      西山勉
    • Organizer
      日本泌尿器科学会東部総会教育講演
    • Place of Presentation
      宇都宮
    • Year and Date
      2010-09-17
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] ホルモン抵抗性前立腺癌概念のparadigm shift2010

    • Author(s)
      西山勉
    • Organizer
      第75回日本泌尿器科学会東部総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2010-09-17
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] an inhibitor of 3β-HSD, has an agonistic activity for androge n receptors in the prostate cancer ce lls2010

    • Author(s)
      Nishiyama T, Takizawa I, Hoshii T, Kasahara T, Hara N, Takahashi K, Trilostane
    • Organizer
      AUA annual meeting
    • Place of Presentation
      San Franci sco, USA
    • Year and Date
      2010-05-30
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] Trilostane, an inhibitor of 3β-HSD, has an agonistic activity for androgen receptors in the prostate cancer cells.2010

    • Author(s)
      Nishiyama T, Takizawa I, Hoshii T, Kasahara T, Hara N, Takahashi K
    • Organizer
      アメリカ泌尿器科学会年次総会
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2010-05-30
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤2010

    • Author(s)
      西山勉
    • Organizer
      第17回東京前立腺がんフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] The expression features o f androgen-metabolic genes involving intracrine production of androgens i n the prostate cancer cells2009

    • Author(s)
      Nishiyama T, Hara N, Yamana K, K Suzuki K, Hoshii T, Takizawa I, Ta kahashi K.
    • Organizer
      AUA annual meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-04-26
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] The expression features of androgen- metabolic genes involving intracrine production of androgens in the prostate cancer cells2009

    • Author(s)
      西山勉
    • Organizer
      アメリカ泌尿器科学会年次総会
    • Place of Presentation
      シカゴ
    • Year and Date
      2009-04-26
    • Data Source
      KAKENHI-PROJECT-21592035
  • [Presentation] NKX3-1 and RAB3B as possible major coactivators inducing agonistic effects in androgen receptor-androgen receptor antagonist interaction

    • Author(s)
      Nishiyama T, Takeda K, Hara H, Ishizaki F, Takahashi K
    • Organizer
      SIU annual meeting
    • Place of Presentation
      Vancouver, Canada
    • Data Source
      KAKENHI-PROJECT-24592380
  • 1.  佐藤 昭太郎 (30018288)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  富田 善彦 (90237123)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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