HARA Shuichi 原修一

Researcher Number	70208651
Other IDs
Affiliation (based on the past Project Information) *help	2009 – 2018: Tokyo Medical University, 医学部, 准教授 2003 – 2008: 東京医科大学, 医学部, 講師 2000 – 2001: 東京医科大学, 医学部, 講師 1997 – 1998: 東京医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Legal medicine / Legal medicine / 応用薬理学・医療系薬学 Except Principal Investigator Legal medicine
Keywords	Principal Investigator ラット / 線条体 / ヒドロキシルラジカル / ラット線条体 / 一酸化炭素 / 一酸化窒素 / 一酸化炭素中毒 / pO_2 / ヒドロキシラジカル / Hypoxia … More / Carbon monoxide / テトロドトキシン / 低酸素 / ドパミン / Nitric oxide / Wet dog shakes / 7-Nitroindazole / Nω-Nitro-L-arginine / NADPH oxidase / 酸化ストレス / 活性酸素 / dual oxidase / アンジオテンシン / アンジオテンシンII / nitric oxide system / respiratory chain / mitochondria / striatum / rat / hydroxyl radical / carbon monoxide / MPP+ / シアン化ナトリウム / マロン酸 / ミトコンドリア呼吸鎖 / cGMP / 一酸化窒素合成酵素 / 呼吸鎖 / ミトコンドリア / Blood flow / Rat striatum / Calcium ion / Glutamate / Hydroxyl radical / 酸素分圧 / 血流量 / カルシウムイオン / グルタミン酸 / Rat / Striatum / Microdialysis / Dopamine / ノミフェンシン / クロルジリン / モノアミンオキシダーゼ / ドパミン代謝物 / マイクロダイアリシス / Vasopressin / Naloxone / Paraquat / バソプレッシン受容体 / オピオイド受容体 / バンプレッシン / バソプレッシン / ナロキソン / パラコート / siRNA / Dual oxidase / mRNA / dual oxidase 2 / H89 / H7 / forskolin / 8-bromo-cAMP / dibutyryl-cAMP / プリン受容体 / exchange protein directly activated by cAMP(Epac) / protein kinase A(PKA) / cAMP / 脳 / 鉄 / デヒドロアスコルビン酸 / 細胞外アスコルビン酸 / 遊離鉄 / アスコルビン酸 … More Except Principal Investigator セロトニン / 動物モデル / 病態 / 中毒 / 異常行動 / カンナビノイド系薬物 / 薬物中毒 / 不整脈 / 心不全 / 薬毒物スクリーニング / セロトニン受容体 / カンナビノイド受容体 / 網羅的薬物分析 / 突然死 / 横紋筋融解症 / 行動異常 / 毒性 / ゼブラフィッシュ / 薬物スクリーニング / 合成カンナビノイド / 危険ドラッグ Less

Systematic analyses on the pathogenesis of neuro-psychoactive substances using zebrafish
- Principal Investigator
  
  Yoshida Ken-ichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical University
Role of NADPH oxidase on brain damage due to carbon monoxidePrincipal Investigator
- Principal Investigator
  
  Hara Shuichi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical University
Study on the threshold for brain damage due to carbon monoxide poisoningPrincipal Investigator
- Principal Investigator
  
  HARA SHUICHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical University
Study on oxidative stress induced by carbon monoxide poisoning in the brainPrincipal Investigator
- Principal Investigator
  
  HARA Shuichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical University
Study on the mechanism of hydroxyl radical generation in the brain due to carbon monoxide poisoningPrincipal Investigator
- Principal Investigator
  
  HARA Shuichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical University
Role of mitochondrial respiratory chain in neuronal toxicity due to carbon monoxide poisoningPrincipal Investigator
- Principal Investigator
  
  HARA Shuichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical University
Study on carbon monoxide toxicity independent of hypoxiaPrincipal Investigator
- Principal Investigator
  
  HARA Shuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical University
Study on the mechanism of carbon monoxide-induced damage to the central nervous systemPrincipal Investigator
- Principal Investigator
  
  HARA Shuichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical University
Role of nitric oxide and opioid receptors in the regulation of blood brain barrier permeabilityPrincipal Investigator
- Principal Investigator
  
  HARA Shuichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo Medical University

All 2018 2017 2015 2014 2012 2011 2010 2009 2008 2007 2004

All Journal Article Presentation

[Journal Article] Hydroxyl radical production via NADPH oxidase in rat striatum due to carbon monoxide poisoning2018
- Author(s)
  Hara S, Kobayashi M, Kuriiwa F, Ikematsu K, Mizukami H.
- Journal Title
  
  Toxicology
  
  Volume: 394 Pages: 63-71
- DOI
  10.1016/j.tox.2017.12.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08885
[Journal Article] Gene expression in rat striatum following carbon monoxide poisoning2017
- Author(s)
  Hara S, Kobayashi M, Kuriiwa F, Kurosaki K, Mizukami H
- Journal Title
  
  Genomics Data
  
  Volume: 12 Pages: 74-75
- DOI
  10.1016/j.gdata.2017.03.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08885
[Journal Article] The psychoactive drug 25B-NBOMe recapitulates rhabdomyolysis in zebrafish larvae2017
- Author(s)
  Kawahara G, Maeda H, Kikura-Hanajiri R, Yoshida K, Hayashi Y.
- Journal Title
  
  Forensic Toxicol
  
  Volume: 印刷中 Issue: 2 Pages: 1-7
- DOI
  10.1007/s11419-017-0366-9
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05274, KAKENHI-PROJECT-16K09218, KAKENHI-PROJECT-17H06112
[Journal Article] Different mechanisms of hydroxyl radical production susceptible to purine P2 receptor antagonists between carbon monoxide poisoning and exogenous ATP in rat striatum2014
- Author(s)
  Hara S, Kobayashi M, Kuriiwa F, Mukai T, Mizukami H.
- Journal Title
  
  Free Radical Research
  
  Volume: 48 Issue: 11 Pages: 1322-1333
- DOI
  10.3109/10715762.2014.951842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590866
[Journal Article] Dual contradictory roles of cAMP signaling pathways in hydroxyl radical production in the rat striatum2012
- Author(s)
  Hara S, Kobayashi M, Kuriiwa F, Mukai T, Mizukami H
- Journal Title
  
  Free Radical Biology & Medicine
  
  Volume: 52巻 Issue: 6 Pages: 1086-1092
- DOI
  10.1016/j.freeradbiomed.2012.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590747
[Journal Article] Existence of a threshold for hydroxyl radical generation independent of hypoxia in rat striatum during carbon monoxide poisoning2011
- Author(s)
  Hara S, Mizukami H, Kurosaki K, Kuriiwa F, Mukai T
- Journal Title
  
  Archives of Toxicology
  
  Volume: 85巻 Issue: 9 Pages: 1091-1099
- DOI
  10.1007/s00204-010-0637-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590747
[Journal Article] cAMP production mediated through P2Y11-like receptors in rat striatum due to severe, but not moderate, carbon monoxide poisoning2011
- Author(s)
  Hara S, Mizukami H, Kuriiwa F, Mukai T
- Journal Title
  
  Toxicology
  
  Volume: 288巻 Issue: 1-3 Pages: 49-55
- DOI
  10.1016/j.tox.2011.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590747
[Journal Article] Hydroxyl radical generation dependent on extracellular ascorbate in rat striatum, as determined by microdialysis2009
- Author(s)
  Shuichi Hara
- Journal Title
  
  Toxicology 258
  
  Pages: 10-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590681
[Journal Article] Hydroxyl radical generation dependent on extracellular ascorbate in rat striatum2009
- Author(s)
  Hara S, Mizukami H, Kuriiwa F, Endo T
- Journal Title
  
  as determined by microdialysis Toxicology 258巻
  
  Pages: 10-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590681
[Journal Article] Nittric oxide-independent cGMP efflux in the striatum of rats exposed to carbon monoxide, as determined by microdialysis2007
- Author(s)
  Hara S.et al.
- Journal Title
  
  Journal of Pharmacological Sciences (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590586
[Journal Article] Nitric oxide-independent cGMP efflux in the striatum of rats exposed to carbon monoxide, as determined by microdialysis2007
- Author(s)
  Hara S, Mukai T, Mizukami H, Kuriiwa F, Watanabe T, Endo T
- Journal Title
  
  Journal of Pharmacological Sciences (in press)
- NAID
  10024314115
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590586
[Journal Article] Characterization of hydroxyl radical generation in the striatum of free-moving rats due to carbon monoxide poisoning, as determined by in vivo microdialysis2004
- Author(s)
  Shuichi Hara, Toshiji Mukai, Kunihiko Kurosaki, Fumi Kuriiwa, Takahiko Endo
- Journal Title
  
  Brain Research 1016 (2)
  
  Pages: 281-284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590590
[Journal Article] Different response to exogenous L-arginine in nitric oxide production between hippocampus and striatum of conscious rats ; a microdialysis study2004
- Author(s)
  Shuichi Hara, Toshiji Mukai, Kunihiko Kurosaki, Fumi Kuriiwa, Takahiko Endo
- Journal Title
  
  Neuroscience Letters 366 (3)
  
  Pages: 302-307
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590590
[Journal Article] Different response to exogenous L-arginine in nitric oxide production between hippocampus and striatum of conscious rats ; a microdialysis study2004
- Author(s)
  Shuichi Hara
- Journal Title
  
  Neuroscience Letters 366・3
  
  Pages: 302-307
- Data Source
  KAKENHI-PROJECT-15590590
[Journal Article] Different response to exogenous L-arginine in nitric oxide production between hippocampus and striatum of conscious rats : a microdialysis study2004
- Author(s)
  Shuichi Hara
- Journal Title
  
  Neuroscience Letters 366
  
  Pages: 302-307
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590590
[Journal Article] Characterization of hydroxyl radical generation in the striatum of free-moving rats due to carbon monoxide poisoning, as determined by in vivo microdialysis2004
- Author(s)
  Shuichi Hara
- Journal Title
  
  Brain Research 1016
  
  Pages: 281-284
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590590
[Journal Article] Characterization of hydroxyl radical generation in the striatum of free-moving rats due to carbon monoxide poisoning, as determined by in vivo microdialysis2004
- Author(s)
  Shuichi Hara
- Journal Title
  
  Brain Research 1016・2
  
  Pages: 281-284
- Data Source
  KAKENHI-PROJECT-15590590
[Presentation] Microarray analysis of gene expression in rat striatum exposed to carbon monoxide and hypoxic hypoxia2018
- Author(s)
  K. Kobayashi, S. Hara, F. Kuriiwa, K. Kurosaki, H. Mizukami
- Organizer
  24th Congress of the International Academy of Legal Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08885
[Presentation] A new psychoactive designer drug 2-(4-Bromo-2,5-dimethoxyphenyl)-N-N-Benzyl-substituted phenethylamine (25B-NBOMe) induces rhabdomyolysis in zebrafish: A new mode for rhabdomyolysis and serotonin syndrome2017
- Author(s)
  Ken-ichi Yoshida, Genri Kawahara, Hideyuki Maeda, Ruri
- Organizer
  0th International Symposium Advances in Legal Medicine (ISALM)
- Data Source
  KAKENHI-PROJECT-16H05274
[Presentation] 25B-NBOMeはゼブラフィッシュに横紋筋融解症を惹起する2017
- Author(s)
  川原玄理　前田秀将　花尻（木倉）瑠理　吉田謙一　林由起子
- Organizer
  日本筋学会第３回学術集会
- Data Source
  KAKENHI-PROJECT-16H05274
[Presentation] 5B-NBOMeはゼブラフィッシュに横紋筋融解症を惹起する2017
- Author(s)
  川原玄理　前田秀将　花尻（木倉）瑠理　林由起子　○吉田謙一
- Organizer
  日本法中毒学会　第36年会
- Data Source
  KAKENHI-PROJECT-16H05274
[Presentation] 合成カンナビノイド系薬物MDMB-CHMICAは、ラットに徐脈・昇圧作用と行動異常を惹起する2017
- Author(s)
  前田秀将　永嶋瑛利香　川原玄理　花尻（木倉）瑠理　林由起子　吉田謙一
- Organizer
  日本法中毒学会　第36年会
- Data Source
  KAKENHI-PROJECT-16H05274
[Presentation] 急性一酸化炭素中毒時のヒドロキシルラジカル生成におけるNADPH oxidaseの関与2015
- Author(s)
  原　修一、小林正宗、栗岩ふみ、池松和哉、向井敏二、水上　創
- Organizer
  第99次日本法医学会学術全国集会
- Place of Presentation
  高知市文化プラザ　かるぽーと
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-24590866
[Presentation] ラット線条体ヒドロキシルラジカル生成におけるcAMPの役割2011
- Author(s)
  原修一
- Organizer
  第95次日本法医学会学術全国集会
- Place of Presentation
  コラッセふくしま(福島)
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-21590747
[Presentation] ラット線条体ヒドロキシルラジカル生成におけるcAMPの役割2011
- Author(s)
  原修一
- Organizer
  第95次日本法医学会学術全国集会
- Place of Presentation
  コラッセ福島(福島)
- Year and Date
  2011-06-15
- Data Source
  KAKENHI-PROJECT-21590747
[Presentation] 一酸化炭素によるラット線条体cAMP増加におけるプリン受容体の関与2010
- Author(s)
  原修一, 他4名
- Organizer
  第94次日本法医学会学術全国集会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-21590747
[Presentation] 一酸化炭素によるラット線条体cAMP増加におけるプリン受容体の関与2010
- Author(s)
  原修一
- Organizer
  第94次日本法医学会学術全国集会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-21590747
[Presentation] 一酸化炭素曝露によるラット線条体cAMPの増加とヒドロキシルラジカル生成2009
- Author(s)
  原修一
- Organizer
  第93次日本法医学会学術全国集会
- Place of Presentation
  千里ライフサイエンスセンター(大阪)
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-21590747
[Presentation] 一酸化炭素曝露によるラット線条体cAMPの増加とヒドロキシルラジカル生成2009
- Author(s)
  原修一, 向井敏二, 水上創, 栗岩ふみ, 荒川礼次郎, 遠藤任彦
- Organizer
  第93次日本法医学会学術全国集会
- Place of Presentation
  大阪千里ライフセンター
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-21590747
[Presentation] 一酸化炭素曝露によるラット線条体のヒドロキシルラジカル生成におけるアスコルビン酸および鉄の関与2008
- Author(s)
  原修一, 向井敏二, 水上創, 栗岩ふみ, 遠藤任彦
- Organizer
  第92次日本法医学会総会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-19590681
[Presentation] ラット線条体における細胞外アスコルビン酸に依存したヒドロキシルラジカル生成 : マイクロダイアリシスによる検討2008
- Author(s)
  原修一, 向井敏二, 水上創, 栗岩ふみ, 遠藤任彦
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590681

1. KURIIWA Fumi (30468665)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. MIZUKAMI Hajime

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. MUKAI Toshiji

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. KOBAYASHI Masamune

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. Yoshida Ken-ichi (40166947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 花尻瑠理 (10224916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 川原玄理 (40743331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. 林由起子 (50238135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 前田秀将 (60407963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. IKEMATSU Kazuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

HARA Shuichi 原 修一

Research Projects

Research Products

Co-Researchers

Systematic analyses on the pathogenesis of neuro-psychoactive substances using zebrafish

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of NADPH oxidase on brain damage due to carbon monoxidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the threshold for brain damage due to carbon monoxide poisoningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on oxidative stress induced by carbon monoxide poisoning in the brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the mechanism of hydroxyl radical generation in the brain due to carbon monoxide poisoningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of mitochondrial respiratory chain in neuronal toxicity due to carbon monoxide poisoningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on carbon monoxide toxicity independent of hypoxiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the mechanism of carbon monoxide-induced damage to the central nervous systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of nitric oxide and opioid receptors in the regulation of blood brain barrier permeabilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hydroxyl radical production via NADPH oxidase in rat striatum due to carbon monoxide poisoning2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene expression in rat striatum following carbon monoxide poisoning2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The psychoactive drug 25B-NBOMe recapitulates rhabdomyolysis in zebrafish larvae2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different mechanisms of hydroxyl radical production susceptible to purine P2 receptor antagonists between carbon monoxide poisoning and exogenous ATP in rat striatum2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual contradictory roles of cAMP signaling pathways in hydroxyl radical production in the rat striatum2012

Author(s)

HARA Shuichi 原修一