Shigenobu Tone 刀袮重信

… Alternative Names

Researcher Number	70211399
Other IDs
External Links
Affiliation (Current)	2020: 東京電機大学, 理工学研究科, 特別専任教授
Affiliation (based on the past Project Information) *help	2016 – 2020: 東京電機大学, 理工学研究科, 特別専任教授 2016: 東京電機大学, 理工学部生命理工学系分子発生生物学研究室, 教授 2015: 川崎医科大学, 医学部, 准教授 2008 – 2013: Kawasaki Medical School, 医学部, 准教授 1998 – 2005: 川崎医科大学, 医学部, 助教授 … More
Review Section/Research Field	Principal Investigator Experimental pathology / General anatomy (including Histology/Embryology) / Morphology/Structure Except Principal Investigator General medical chemistry / Biological Sciences / Obstetrics and gynecology / Nerve anatomy/Neuropathology / Cell biology / Obstetrics and gynecology / General surgery … More
Keywords	Principal Investigator アポトーシス / 核 / ES細胞 / 核移植 / 臓器移植 / FS細胞 / 再生 / 細胞工学 / 細胞融合 / メチル化 … More Except Principal Investigator アポトーシス / インドールアミン酸素添加酵素 / ラット / c-fos / トリプトファン代謝 / IFN-γ / トリプトファン / IDO / 分子生物学 / 細胞死 / 形態形成 / 誘導酵素 / ノックアウトマウス / 免疫寛容 / 酸素添加酵素 / 胎盤 / 神経突起 / 変性 / 生殖医学 / 胎児-母体間免疫 / Medaka / Spermatogenesis / Culture / Hormones / cDNA / Protamine / Northern hybridization / 転写制御因子 / 細胞内情報伝達機構 / pseudorabies virus / IRF-1 / tryptophan metabolism / apoptosis / p53 / 軟X線顕微鏡 / リン酸基 / プログラム細胞死 / 生理的細胞死 / 奇形 / 細胞交替 / 免疫レパートリ形成 / 免疫不全 / amblyopia / 視覚遮断 / 視覚野 / 発達 / 大脳皮質視覚野 / 暗所飼育 / 直早期遺伝子 / Zif268 / 抗細胞内寄生虫活性 / TDO / 胎児 / 妊娠 / 母体 / カスパーゼ / 顆粒細胞 / Ca^<2+>チャネル / レドックス制御 / 脱分極 / ネクローンス / コルヒチン / ワーラー変性 / ES細胞 / 細胞融合 / 細胞脱核法 / サイトプラスト / 核移植 / インドールアミン酸素添加素 / トリプトファン誘導体 / 静電ポテンシャル / 構造活性相関 / インドール環 / 転写調節因子 / 免疫調節因子 / NF-kBシグナリング / 必須アミノ酸 / 絨毛膜羊膜炎 / indoleamine 2,3-dioxygnase / 早産 / 絨毛膜羊膜炎(CAM) / プロスタグランジン / Western blot法 / ガン細胞 / 細胞増殖 / タンパク質高次構造変化 / 抗がん剤 / ケミカルライブラリー / レポーターアッセイ / タンパク質高次構造 / Arginine / メダカ / 精子形成 / 培養 / プロタミン / プロタミン遺伝子 / mRNA / ノーザンハイブリダイゼーション / ホルモン / 抗プロタミン抗体 / 遺伝子解析 / 精母細胞 / 精巣断片 / 機能的精子分化 / BrdU / 免疫組織化学 / Arginnine / サイトカイン / インターフェロン-γ / インターフェロンーγ / 細胞内情報伝達 / Oxygenase / Interferon-gamma / Trans-acting factor / Signal transduction / Cytokine / Tryptophan metabolism / 偽狂犬病ウィルス / トランスニューロナル・トレーサー / 遺伝子導入 / 咬筋 / 三叉神経運動核 / 三叉神経中脳路核 / 逆行性輸送 / トランスフェクション / 神経細胞 / トレーサー / 後根神経節 / Pseudorabies virus / Transneuronal tracer / neuron / ウイルス / pseudorabies / ペプチド / transneuronal tracer / gene-delivery / masseter / motor trigeminal nucleus / mesencephalic trigeminal nucleus / retrograde transport / 細胞性癌遺伝子 / c‐fos / NGFI‐A(zif268) / 脳 / ストレス / 心臓 / 角膜 / NGFI-A / 視床下部室傍核 / Proto-oncogenes / NGFI-A (zif268) / Rat / Brain / Stress / Heart / Cornea / 酵素誘導 / STAT1 / STAT 1 / interferon-gamma / indoleamine 2,3-dioxygenase / transcriptional factor / cytokine / ISRE / 損傷 / ネクローシス / TNF-2 / TNF-α / 細胞死機構 / Injury / Cell Death / Apoptosis / Necrosis / TNF alpha / 肢芽 / 遺伝子 / DNA切断 / 胚芽 / limb-bud / gene / DNA fragmentation / 細胞骨格 / ビメンチン / アンカー機能 / 核内移行反応 / 機能ドメイン解析 / 核移行反応 / cytoskeleton / vimentin / anchoring function / nuclear translocation / functional domain / キヌレニン化 / アルツハイマー病 / インターフェロンガンマ / 興奮性神経毒 / 翻訳語蛋白修飾 / 感染防御機構 / 翻訳後蛋白修飾 / Kynurenylation / Alzheimer's disease / knockout mouse / INF-γ / excitatory neurotoxin / post-translational modification / quinolinic acid / 再生医療 / 腸管分化誘導 / iPS細胞 / 胚様体 / 人工腸管 / iPS cell / tissue engineering / smooth muscle / gut / activin A / short bowel syndrome / 脳小血管病 / 脳梗塞 / バイオマーカー / 脈波 / 脈波伝播速度 / 脳卒中 / 血管内皮機能障害 / 水の窓 / UTA放射 / 反射多層膜 / レーザープラズマ光源 / ヌクレオチド / P-L2,3吸収端 / LPP光源 / 軟Ｘ線顕微鏡 / レーザー励起プラズマ光源 / Ⅹ線 / 量子ビーム / 軟Ⅹ線顕微鏡 / レーザー生成プラズマ光源 / 吸収端構造 / コンフォメーション / 電子構造 / 脊髄損傷 / 造精機能障害 / 無精子症 Less

Development of a new treatment for the patients with spinal injury accompanied by defective spermatogenesisOngoing
- Principal Investigator
  
  原綾英
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kawasaki Medical School
リン酸基結合分子の変化によるリン吸収端構造変化とそのクロマチン可視化応用Ongoing
- Principal Investigator
  
  江島丈雄
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 80040:Quantum beam science-related
- Research Institution
  Tohoku University
Development of soft X-ray microscope in Water window wavelength region using Flash LPP light source
- Principal Investigator
  
  Ejima Takeo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Quantum beam science
- Research Institution
  Tohoku University
New approach to treat stroke by assessing cerebral small vessel dysfunction indicated by pulse wave velocity and biomarkers
- Principal Investigator
  
  SAJI Naoki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
  Cardiovascular medicine
- Research Institution
  National Center for Geriatrics and Gerontology
  Kawasaki Medical School
Initinal research for tissue engineering intestine using iPS cells
- Principal Investigator
  
  Yoshida Atsushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatric surgery
- Research Institution
  Kawasaki Medical School
Genome-wide analysis of nuclear condensation factors during apoptosisPrincipal Investigator
- Principal Investigator
  
  TONE Shigenobu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphology/Structure
- Research Institution
  Kawasaki Medical School
Fundamental studies for development of a novel anti-tumor drug based on perchloric acid-soluble protein
- Principal Investigator
  
  KANOUCHI HIROAKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Kagoshima University
Role of tryptophan analogue and clarification of its action mechanism in the immunity between embryo-mother's bodies
- Principal Investigator
  
  OKAMOTO Takeaki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Ehime University
  Kawasaki Medical School
Molecular Cell Biological Analysis of Nuclear Condensation in ApoptosisPrincipal Investigator
- Principal Investigator
  
  TONE Shigenobu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kawasaki Medical School
Role of tryptophan and clarification of its action mechanism in the immunity between embryo-mother's bodies
- Principal Investigator
  
  OKAMOTO Takeaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kawasaki Medical School
体細胞を脱核幹細胞と融合して幹細胞化する試み
- Principal Investigator
  
  四宮貴久
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  National Research Institute for Child Health and Development
Generation of indoleamine 2,3-dioxygenase-dificient mouse
- Principal Investigator
  
  TAKIKAWA Osamu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  HOKKAIDO UNIVERSITY
神経突起変性により誘導されるカスケードとその神経変性疾患モデルにおける解析
- Principal Investigator
  
  小池達郎
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
神経突起変性により誘発される細胞内カスケードの解明
- Principal Investigator
  
  小池達郎
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
胚性幹細胞に体細胞の核を移植する試み-臓器移植をめざした基礎的研究-Principal Investigator
- Principal Investigator
  
  刀袮重信 (刀祢重信)
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Kawasaki Medical School
胎盤でのトリプトファン酸素添加酵素阻害は果して流産の原因となるか?
- Principal Investigator
  
  河野一郎
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kawasaki Medical School
NUCLEAR PROTEIN-ANCHORING FUNCTION OF CYTOSKELETON AND ITS ANTI-APOPTOTIC EFFECTS AGAINST P53-DEPENDENT APOPTOSIS.
- Principal Investigator
  
  NISHIO Koji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  NAGOYA UNIVERSITY
幼若ラット視覚野の回路発達に関する遺伝子群の検索とその役割の検討
- Principal Investigator
  
  仙波恵美子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Wakayama Medical University
IFN−γで誘導されるトリプトファン分解酵素のノックアウトマウスの作製
- Principal Investigator
  
  TAKIKAWA Osamu
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka Bioscience Institute
Molecular mechanism of programmed cell death.Principal Investigator
- Principal Investigator
  
  KURIHARA Keiko, 刀祢重信
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  生物形態・構造
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science
光刺激による幼若ラット視覚野の回路発達に関する遺伝子群の検索
- Principal Investigator
  
  SENBA Emiko
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Wakayama Medical University
Cell-Biological Study on Medicolegal Diagnosis of Injury
- Principal Investigator
  
  TSUJI Tsutomu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  Wakayama Medical College
The roles and regulatory mechanisms of expression of proto-oncogenes in the nervous system
- Principal Investigator
  
  SENBA Emiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Wakayama Medical College
Molecular cloning of cDNAs for transcriptional factors of indoleamine 2,3-dioxygenase induced by IFN-gamma
- Principal Investigator
  
  TAKIKAWA Osamu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka Bioscience Institute
アポトーシスの機能と分子機構
- Principal Investigator
  
  山田武
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Toho University
The development of viral vector for in vivo gene-delivery and its applications
- Principal Investigator
  
  SENBA Emiko, 野口光一
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Wakayama Medical College
Molecular cloning of trans-acting factor cDNA for IFN-gamma-inducible indoleamine 2,3-dioxygenase
- Principal Investigator
  
  TAKIKAWA Osamu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Osaka Bioscience Institute
In vitro analysis of spermatogenesis in the medaka, Oryzias latipes.
- Principal Investigator
  
  ONITAKE Kazuo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  動物発生・生理学
- Research Institution
  Yamagata University

All 2019 2018 2017 2016 2014 2013 2012 2011 2010 2009 2007 Other

All Journal Article Presentation Book

[Book] 細胞死実験プロトコル2011
- Author(s)
  刀祢重信, (編集及び共著)
- Total Pages
  223
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23570083
[Book] 細胞死解析プロトコル2011
- Author(s)
  刀祢重信
- Total Pages
  224
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23570083
[Book] Methods in Molecular Biology : imaging of mitotic cell division and apoptotic intra-nuclear processes in multicolor2009
- Author(s)
  Sugimoto K, Tone S. (in press)
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-20590203
[Book] Down-regulation of the indoleamine 2,3-dioxygenase (IDO) transcription by tryptophan analogue2007
- Author(s)
  Takeaki Okamoto, Sigenobu Tone,Hiroaki Kanouchi,Fumio Ohyama,Yohsuke Minatogawa
- Publisher
  The interdisciplinary conference on tryptophan
- Data Source
  KAKENHI-PROJECT-19791177
[Book] Induction of indoleamine2,3-dioxygenase in small intestine of ,mouse infected with parasitic helminth, hymenolepis nana2007
- Author(s)
  Fumio Ohyama, Shigenobu Tone, Takeaki Okamotoほか2名
- Publisher
  The interdisciplinary conference on tryptophan
- Data Source
  KAKENHI-PROJECT-19791177
[Journal Article] Quantitative Distribution of DNA, RNA, Histone and Proteins Other than Histone in Mammalian Cells, Nuclei and a Chromosome at High Resolution Observed by Scanning Transmission Soft X-Ray Microscopy (STXM)2019
- Author(s)
  K. Shinohara, S. Tone, T. Ejima, T. Ohigashi, A. Ito
- Journal Title
  
  Cells
  
  Volume: 8 Pages: 164-164
- DOI
  10.3390/cells8020164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K05000, KAKENHI-PROJECT-16H03902, KAKENHI-PROJECT-17H03013, KAKENHI-PROJECT-16K05021, KAKENHI-PROJECT-16K05022
[Journal Article] Cilostazol May Decrease Plasma Inflammatory Biomarkers in Patients with Recent Small Subcortical Infarcts: A Pilot Study2018
- Author(s)
  Saji N, Tone S, Murotani K, Yagita Y, Kimura K, Sakurai T.
- Journal Title
  
  Journal of Stroke and Cerebrovascular Diseases
  
  Volume: S1052-3057 Pages: 1639-1645
- DOI
  10.1016/j.jstrokecerebrovasdis.2018.01.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03902
[Journal Article] Discrimination of DNA and RNA distribusion in a mammalian cell by scanning transmission soft X-ray microscopy2018
- Author(s)
  Shinohara Kunio、Ito Atsushi、Ohigashi Takuji、Kado Masataka、Tone Shigenobu
- Journal Title
  
  X-Ray Science and Technology
  
  Volume: 26 Pages: 877-884
- DOI
  10.3233/xst-180392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03902, KAKENHI-PROJECT-16K05021, KAKENHI-PROJECT-16K05022
[Journal Article] Development of laboratory-type soft X-ray microscope, CXRM, in Water-window using LPP light source2018
- Author(s)
  Ejima Takeo、Ono Yuichi、Ito Keisuke、Kawasaki Hiromu、Higashiguchi Takeshi、Tone Shigenobu、Hatano Tadashi
- Journal Title
  
  Microscopy and Microanalysis
  
  Volume: 24 Pages: 214-215
- DOI
  10.1017/s1431927618013417
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19021, KAKENHI-PROJECT-16H03902
[Journal Article] hemical Bonding State Change of Phosphodiester Bonds in Plasmid DNA2018
- Author(s)
  T. Ejima, T. Ohigashi, M. Kado, and S. Tone
- Journal Title
  
  UVSOR Activity Report
  
  Volume: 2017 Pages: 157-157
- Data Source
  KAKENHI-PROJECT-16H03902
[Journal Article] 人工海水の止水飼育下でのベニクラゲの若返り, クラゲ芽形成,　並びに第２回目の若返りの初記録2018
- Author(s)
  大塚玲桜,　藤瀬弦汰,　久保田信,　刀祢重信
- Journal Title
  
  日本生物地理学会会報
  
  Volume: 73 Pages: 1901-94
- NAID
  40021767302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03902
[Journal Article] Quantitative analysis of mammalian chromosome by scanning transmission soft X-ray microscopy2018
- Author(s)
  K. Shinohara, T. Ohigashi, S. Tone, M. Kado, A. Ito
- Journal Title
  
  Ultramicroscopy
  
  Volume: 194 Pages: 1-6
- DOI
  10.1016/j.ultramic.2018.07.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K05000, KAKENHI-PROJECT-16H03902, KAKENHI-PROJECT-17H03013, KAKENHI-PROJECT-16K05021
[Journal Article] Intracellular morphological changes in Staphylococcus aureus induced by treatment with sodium hypochlorite2017
- Author(s)
  Ujimine S, Tone S, Saito M, Yamada S.
- Journal Title
  
  Med Mol Morphol.
  
  Volume: 50 Pages: 178-184
- DOI
  10.1007/s00795-017-0159-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03902
[Journal Article] 赤外顕微分光法によるアポトーシスを起こした細胞核の解析2017
- Author(s)
  加道雅孝, 江島丈雄、刀祢重信、篠原邦夫
- Journal Title
  
  SPring-8利用研究成果集 Section A
  
  Volume: 5 Pages: 35-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03902
[Journal Article] Role of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase in Patients with Recurrent Miscarriage2016
- Author(s)
  Yuki Obayashi, Yasuhiko Ozaki, Satomi Kurakane, Shinobu Goto, Kyoko Kumagai, Tamao Kitaori, Suzumori Nobuhiro, Mayumi Sugiura
- Journal Title
  
  Am J Reprod Immunol.
  
  Volume: 75 Pages: 69-77
- DOI
  10.1111/aji.12434
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K20154, KAKENHI-PROJECT-24592478, KAKENHI-PROJECT-25462571, KAKENHI-PROJECT-16K11100, KAKENHI-PROJECT-16H03902
[Journal Article] Distribution of DNA and Protein in Mammalian Cell Nuclei calculated using NEXAFS profiles at the N-K and O-K edges2016
- Author(s)
  A. Ito, T. Ohigashi, K. Shinohara, S. Tone, M. Kado, Y. Inagaki and N. Kosugi
- Journal Title
  
  UVSOR Activity Report
  
  Volume: 2015 Pages: 143-143
- Data Source
  KAKENHI-PROJECT-16H03902
[Journal Article] Novel and Robust Transplantation Reveals the Acquisition of Polarized Processes by Cortical Cells Derived from Mouse and Human Pluripotent Stem Cells2014
- Author(s)
  Nagashima F, Suzuki IK, Shitamukai A, Sakaguchi H, Iwashita M, Kobayashi T, Tone S, Toida K, Vanderhaeghen P, Kosodo Y.
- Journal Title
  
  Stem Cells Dev.
  
  Volume: E-Pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570083
[Journal Article] Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability show poor prognosis in the relapse-free survival.2013
- Author(s)
  Rezano A, Kuwahara K, Yamamoto-Ibusuki M, Kitabatake M, Moolthiya P, Phimsen S, Suda T, Tone S, Yamamoto Y, Iwase H, Sakaguchi N
- Journal Title
  
  BMC Cancer. 2013 Dec 1;13:562. doi:
  
  Volume: 13 Pages: 562-562
- DOI
  10.1186/1471-2407-13-562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390122, KAKENHI-PROJECT-23570083, KAKENHI-PROJECT-24590388, KAKENHI-PROJECT-24659224, KAKENHI-PROJECT-25860813
[Journal Article] A Novel Mutation of Human Liver Alanine:Glyoxylate Aminotransferase Causes Primary Hyperoxaluria Type 1 -Immunological quantification and subcellular distribution-2012
- Author(s)
  Kawai C, Minatogawa Y, Akiyoshi H, Hirose S, Suehiro T, Tone S
- Journal Title
  
  Acta Histochemica et Cytochemica
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570083
[Journal Article] Selective cell death of p53-insufficient cancer cells is induced by knockdown of the mRNA export molecule GANP.2012
- Author(s)
  Phimsen S, Kuwahara K, Nakaya T, Ohta K, Suda T, Rezano A, Kitabatake M, Vaeteewoottacharn K, Okada S, Tone S, Sakaguchi N.
- Journal Title
  
  Apoptosis
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570083
[Journal Article] The actin family member Arp6 and the histone variant H2A.Z are required for spatial positioning of chromatin in chicken cell nuclei.2012
- Author(s)
  Maruyama E., Hori T., Tanabe H., Kitamura H., Matsuda R., Tone S., Pavel H., Habermann FA., Hase JV, Cremer C., Fukagawa T, and Harata(equal first authors)
- Journal Title
  
  Jounal of Cell Science
  
  Volume: 125 Pages: 3739-3743
- DOI
  10.1242/jcs.103903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J05962, KAKENHI-PROJECT-22570008, KAKENHI-PROJECT-23570083, KAKENHI-PROJECT-23658281, KAKENHI-PROJECT-23810015, KAKENHI-PROJECT-24380183, KAKENHI-PUBLICLY-23114702, KAKENHI-PUBLICLY-23114722, KAKENHI-PUBLICLY-23125505
[Journal Article] Selective cell death ofp53-insufficient cancer cells isinduced by knockdown of the mRNA exportmolecule GANP2012
- Author(s)
  Phimsen S, et al
- Journal Title
  
  Apoptosis
  
  Volume: (印刷中) Pages: 679-690
- DOI
  10.1007/s10495-012-0711-8
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021036, KAKENHI-PROJECT-23390122, KAKENHI-PROJECT-23570083, KAKENHI-PROJECT-23791116, KAKENHI-PROJECT-24590388
[Journal Article] A Novel Mutation of Human Liver Alanine:Glyoxylate Aminotransferase Causes Primary Hyperoxaluria Type 1: Immunohistochemical Quantification and Subcellular Distribution2012
- Author(s)
  Kawai C, Minatogawa Y, Akiyoshi H, Hirose S, Suehiro T, Tone S
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 45((2)) Issue: 2 Pages: 121-129
- DOI
  10.1267/ahc.11042
- NAID
  130001854237
- ISSN
  0044-5991, 1347-5800
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249062, KAKENHI-PROJECT-23570083, KAKENHI-PROJECT-23659529
[Journal Article] The actin family member Arp6 and the histone variant H2A.Z are required for spatial positioning of chromatin in chicken cell nuclei.2012
- Author(s)
  Maruyama EO, Hori T, Tanabe H, Kitamura H, Matsuda R, Tone S, Hozak P, Habermann FA, von Hase J, Cremer C, Fukagawa T, Harata M
- Journal Title
  
  J Cell Sci.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570083
[Journal Article] Clostridium perfringens iota-toxin b induces rapid cell necrosis.2011
- Author(s)
  Masahiro Nagahama
- Journal Title
  
  Infect and Immun. 79(11):4353-60. (2011)
  
  Volume: 79 Pages: 4353-43
- DOI
  10.1128/iai.05677-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590500, KAKENHI-PROJECT-23570083
[Journal Article] Possible involvement of caspase-6 and -7 but not caspase-3 in the regulation of hypoxia-induced apoptosis in tube-forming endothelial cells.2009
- Author(s)
  Eguchi R, Tone S, et al
- Journal Title
  
  Exp.Cell Res 315
  
  Pages: 327-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590203
[Journal Article] Imaging of mitotic cell division and apoptotic intra-nuclear processes in multicolor.2009
- Author(s)
  Sugimoto K, Tone S
- Journal Title
  
  Methods in Molecular Biology 591
  
  Pages: 135-146
- Data Source
  KAKENHI-PROJECT-20590203
[Journal Article] Transcriptional regulation of indoleamine 2,3-dioxygenase (IDO) by tryptophan and its analogue2007
- Author(s)
  Takeaki Okamoto, Shigenobu Tone, Hiroaki Kanouchi, Chie Miyawaki, Sayuri Ono, Yohsuke Minatogawa
- Journal Title
  
  Cytotechnology 54
  
  Pages: 107-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791177
[Presentation] Development of laboratory-type soft X-ray microscope, CXRM, in Water-window using LPP light source2018
- Author(s)
  Takeo Ejima, Yuichi Ono, Keisuke Ito, Hiromu Kawasaki, Takeshi Higashiguchi, Shigenobu Tone and Tadashi Hatano
- Organizer
  14th International conference on x-ray microscopy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03902
[Presentation] BiターゲットLPP光源を用いた軟Ｘ線顕微鏡CXRM2018
- Author(s)
  江島丈雄、小野祐一、伊藤圭祐、川崎大夢、羽多野忠、刀祢重信、東口武史
- Organizer
  第79回応用物理学会秋季学術講演会
- Data Source
  KAKENHI-PROJECT-16H03902
[Presentation] Analysis of apoptosis induced by actin C-terminal 15 kDa fragment2018
- Author(s)
  Kamiyama H, Ito N, Tone S, Tanaka M
- Organizer
  American Society of Cell Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03902
[Presentation] C-terminal 15kDa fragment from β-actin causes apoptotic cell death.2017
- Author(s)
  Ito, N., Tone, S. and Tanaka, M.
- Organizer
  Annual Meeting 2017 of American Society for Biochemistry and Molecular Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03902
[Presentation] プロフィリンはβ-アクチンの15kDa-C末端側断片が引き起こす細胞死を抑制する2017
- Author(s)
  伊東奈那子、本多弘幸、刀祢重信、田中眞人
- Organizer
  第26回日本Cell Death 学会学術集会
- Data Source
  KAKENHI-PROJECT-16H03902
[Presentation] アポトーシス研究におけるエレクトロポレーション法の優位性について2017
- Author(s)
  刀祢重信
- Organizer
  第１２２回日本解剖学会
- Place of Presentation
  長崎大学、長崎県長崎市
- Year and Date
  2017-03-30
- Data Source
  KAKENHI-PROJECT-16H03902
[Presentation] βアクチンのC末端側断片は細胞死を誘起する2017
- Author(s)
  伊東奈那子、刀祢重信、田中眞人
- Organizer
  第26回日本Cell Death 学会学術集会
- Data Source
  KAKENHI-PROJECT-16H03902
[Presentation] Profilins suppress the apoptosis induced by cytoskeletal 15kDa-β-actin in cancer cell lines2016
- Author(s)
  N. Ito, H. Honda, S. Tone, M. Tanaka
- Organizer
  The American Society for Cell Biology Annual Meeting
- Place of Presentation
  Moscone Center, San Francisco, US
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03902
[Presentation] QUANTITATIVE STUDY OF MAMMALIAN CELLS BY SCANNING TRANSMISSION SOFT X-RAY MICROSCOPY2016
- Author(s)
  篠原邦夫, 大東琢治, 刀祢重信, 加道雅孝, 伊藤敦
- Organizer
  X-Ray Microscopy Conference 2016
- Place of Presentation
  Oxford University, UK
- Year and Date
  2016-08-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03902
[Presentation] アポトーシスに見る自己集合現象ワークショップ「生命における自己組織化のメカニズム」2013
- Author(s)
  刀祢重信
- Organizer
  第36回分子生物学会年会
- Place of Presentation
  神戸市
- Year and Date
  2013-12-06
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] アポトーシスにおける核凝縮の3つの素過程リング、ネックレス、核崩壊をそれぞれ誘導する因子の解析2012
- Author(s)
  刀祢重信, 杉本憲治, 網代廣三, 栗林太
- Organizer
  第21回日本Cell Death学会
- Place of Presentation
  名古屋市
- Year and Date
  2012-07-27
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] アポトーシスにおける核凝縮の3つの素過程リング、ネックレス、核崩壊をそれぞれ誘導する因子の解析- Cell-free系を用いて2012
- Author(s)
  刀祢重信, 杉本憲治, 網代廣三, 栗林太
- Organizer
  第35回日本分子生物学年会
- Place of Presentation
  福岡市
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] アポトーシスにおける核凝縮の3つの素過程リング、ネックレス、核崩壊を試験管内で再現する2012
- Author(s)
  刀祢重信, 杉本憲治, 網代廣三, 栗林太
- Organizer
  第53回日本生化学会中四国支部例会
- Place of Presentation
  岡山市
- Year and Date
  2012-05-18
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] アポトーシスにおける核凝縮の分子機構2011
- Author(s)
  刀祢重信
- Organizer
  第67回日本顕微鏡学会シンポジウム
- Place of Presentation
  福岡市
- Year and Date
  2011-05-16
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] Proapoptotic Role of DNA-PK System in DT40 Apoptosis Induced by X-ray2010
- Author(s)
  Tone S, Kuribayashi F, Takata M, Ishiai M
- Organizer
  UV or Hydrogen Peroxide American Society for Cell Biology Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-20590203
[Presentation] 特別講演プログラムされた細胞死アポトーシス2010
- Author(s)
  刀祢重信
- Organizer
  大阪府立大学ライブセルイメージング研究所設立4周年記念シンポジウム
- Place of Presentation
  大阪府堺市
- Year and Date
  2010-02-01
- Data Source
  KAKENHI-PROJECT-20590203
[Presentation] Proapoptotic Role of DNA-PK System in DT40 Apoptosis Induced by X-ray, UV or Hydrogen Peroxide2010
- Author(s)
  Tone S, Kuribayashi F, Takata M, Ishiai M.
- Organizer
  American Society of Cell Biology
- Place of Presentation
  フィラデルフィア(米国)
- Year and Date
  2010-12-13
- Data Source
  KAKENHI-PROJECT-20590203
[Presentation] Ku70 and DNA-PKcs are essential in DT40 apoptosis inducedby X-ray, UV or H2O2.2009
- Author(s)
  Tone S
- Organizer
  Keystone Symposium on "Cell Death Pathways"
- Place of Presentation
  Wistler (Canada)
- Data Source
  KAKENHI-PROJECT-20590203
[Presentation] Ku70 and DNA-PKcs are essential in DT40 apoptosis induced by X-ray2009
- Author(s)
  Tone S, Tanda K Takata M Ishiai M
- Organizer
  UV or H2O2 Keystone Symposia Conference "Cell Death Pathways"
- Place of Presentation
  Whistler, Canada
- Data Source
  KAKENHI-PROJECT-20590203
[Presentation] 細胞を救うはずのDNA修復酵素DNA-PKは、細胞自らが死ぬために必要である2009
- Author(s)
  刀祢重信
- Organizer
  第8回核ダイナミクス研究会
- Place of Presentation
  静岡県伊豆市
- Year and Date
  2009-06-19
- Data Source
  KAKENHI-PROJECT-20590203
[Presentation] 細胞死関連マルチパラメーターの自動連続測定法-Image Xpress を用いて2009
- Author(s)
  刀祢重信
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20590203
[Presentation] ワークショップアポトーシス検出法 ―初歩から最先端まで 1)アポトーシスの検出法まずこれをやってみたら?2009
- Author(s)
  刀祢重信
- Organizer
  第18回日本アポトーシス研究会学術集会
- Place of Presentation
  長崎市
- Year and Date
  2009-08-01
- Data Source
  KAKENHI-PROJECT-20590203
[Presentation] Dynamic aspects of nuclear condensation revealed by time-lapse imaging, biochemical and electron microscopy analysis of cell-free apoptosis.2007
- Author(s)
  Tone S, Tanda K Sugimoto K Suda T Uehira K, Kanouchi H Samejima K Minatogawa Y, Earnshaw W C
- Organizer
  EMBO Conference Series on Nuclear Structure & Dynamics.
- Place of Presentation
  Montpelier, France
- Data Source
  KAKENHI-PROJECT-20590203
[Presentation] アポトーシスにおける核凝縮の３つの素過程リング、ネックレス、核崩壊をそれぞれ誘導する因子の解析　- Cell-free系を用いて
- Author(s)
  刀祢重信,　杉本憲治, 網代廣三,　栗林太
- Organizer
  第３５回日本分子生物学会
- Place of Presentation
  福岡国際会議場（福岡市）
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] アポトーシスにおける核凝縮の３つの素過程リング、ネックレス、核崩壊をそれぞれ誘導する因子の解析
- Author(s)
  刀祢重信,　杉本憲治, 網代廣三,　栗林太
- Organizer
  第２１回　日本Cell Death 学会
- Place of Presentation
  名古屋大学（名古屋市）
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] アポトーシスにおける核凝縮の分子形態学的アプローチ
- Author(s)
  刀祢重信
- Organizer
  第６７回日本顕微鏡学会　シンポジウム　細胞死の分子機構(招待講演)
- Place of Presentation
  福岡国際会議場（福岡）
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] Semi-complete reconstitution of apoptotic nuclear machinery
- Author(s)
  Tone, S, Norimoto, T, Sugimoto, K, Ajiro, K, Kuribayashi, F
- Organizer
  53rd American Society for Cell Biology Annual Meeting
- Place of Presentation
  Morial Center（ニューオリンズ市）
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] 細胞死のプログラムの解読　死のシグナルから死の実行まで
- Author(s)
  刀祢重信
- Organizer
  鹿児島大学第１回分子病態学セミナー
- Place of Presentation
  鹿児島大学（鹿児島市）
- Invited
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] アポトーシスに見る自己集合現象
- Author(s)
  刀祢重信
- Organizer
  第３6回日本分子生物学会年会ワークショップ　「生命における自己組織化のメカニズム」
- Place of Presentation
  神戸国際会議場（神戸市）
- Invited
- Data Source
  KAKENHI-PROJECT-23570083
[Presentation] Analysis of factors involving three distinct stages during apoptotic nuclear condensation using a cell-free system
- Author(s)
  Tone S, Sugimoto K, Ajiro K, Kuribayashi F
- Organizer
  52th American Society for Cell Biology (ASCB )
- Place of Presentation
  Moscone Center (サンフランシスコ, USA)
- Data Source
  KAKENHI-PROJECT-23570083

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Shigenobu Tone 刀袮 重信

刀袮 重信 トネ シゲノブ

TONE Shigenobu 刀祢 重信

刀根 重信 トネ シゲノブ

TONE Sigenobu 刀禰 重信

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Development of a new treatment for the patients with spinal injury accompanied by defective spermatogenesisOngoing

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リン酸基結合分子の変化によるリン吸収端構造変化とそのクロマチン可視化応用Ongoing

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Genome-wide analysis of nuclear condensation factors during apoptosisPrincipal Investigator

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Molecular Cell Biological Analysis of Nuclear Condensation in ApoptosisPrincipal Investigator

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Shigenobu Tone 刀袮重信

刀袮重信トネシゲノブ

TONE Shigenobu 刀祢重信

刀根重信トネシゲノブ

TONE Sigenobu 刀禰重信