AOYAGI Yutaka 青柳裕

… Alternative Names

青柳裕アオヤギユタカ

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Researcher Number	70212389
External Links
Affiliation (Current)	2025: 金城学院大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2011 – 2012: 金城学院大学, 薬学部, 教授 2010: 東京薬科大学, 薬学部, 准教授 2005 – 2006: 東京薬科大学, 薬学部, 講師 2002 – 2003: 東京薬科大学, 薬学部, 講師 1999 – 2000: 東京薬科大学, 薬学部, 講師 1992: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Chemical pharmacy / Chemical pharmacy
Keywords	Principal Investigator ジテルペン / リパーゼTL / 構造活性相関 / GE3 / マイクロウェーブ / 光学分割 / 速度論的光学分割 / structure-activity relationship / cytotoxicity / diterpene … More / biologically active natural products / Green chemistry / triptolide / ent-kaurene / grandione / 環状ヘキサデプシペプチドGE3 / NF-κB / 生理活性 / 細胞毒活性 / 生理活性天然物 / グリーンケミストリー / SAR / Piperazic acid / Antitumor / Glycerols / Asymmetric Synthesis / Hexadepsipeptides / Lipase TL / 低温活性酵素 / 光学活性ピペラジン酸 / グリセロール / 2級アルコール / ピペラジン酸 / 抗腫瘍活性 / グリセロール誘導体 / 不斉合成 / ヘキサデプシペプチド / トリプドライドアナログ / ent-カウレン / トリプトライドアナログ / salvileucalin類 / ent-カウレンアナログ / 環境調和型 / マイクロ波 / 抗炎症 / 抗トリパノソーマ / 創薬シーズ / 生物活性 / 創薬 / 環境調和型化学 / リパーゼ / 合成 / Pkaloside A / 全合成 / リパーゼ TL / 免疫抑制活性 / plakoside A / スフィンゴ糖脂質 … More Except Principal Investigator 抗腫瘍性 / 抗菌性 / ネオリグナン / モノテルペンアルカロイド / ヒドロキサム酸 / インドール / ピペラチン / ピラチン Less

Synthesis and Structure-Activity Relationship of Biologically ActiveNatural Products and their Analogues Based on Green ChemistryPrincipal Investigator
- Principal Investigator
  
  AOYAGI Yutaka
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kinjo Gakuin University
  Tokyo University of Pharmacy and Life Science
Green chemistry oriented synthesis of biologically active natural products and structure-activity relationshipsPrincipal Investigator
- Principal Investigator
  
  AOYAGI Yutaka
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Sciences
Chemoenzymatic Synthesis of Biologically Active Natural products via Lipase TL -Mediated Kinetic Resolution as a Key Step and their Structure Activity RelationshipPrincipal Investigator
- Principal Investigator
  
  AOYAGI Yutaka
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
強力な免疫抑制活性を有するスフィンゴ糖脂質Plakoside Aの合成研究Principal Investigator
- Principal Investigator
  
  青柳裕
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
N,0一複系環を有する天然物の合成と薬理作用に関する研究
- Principal Investigator
  
  太田明廣
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2013 2012 2011 2010 2006 2005 Other

All Journal Article Presentation

[Journal Article] Salvileucalin Ca novel rearranged neo- clerodane diterpene from Salvia leucantha2011
- Author(s)
  Yutaka Aoyagi, Akira Yamazaki, ReikoKato, Fukuya Tobe, Haruhiko Fukaya, Tadateru Nishikawa, Atsufumi Nakahashi, Nobuaki Miura, Kenji Monde, Koichi Takeya
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 52巻 No 16 Issue: 16 Pages: 1851-1853
- DOI
  10.1016/j.tetlet.2011.02.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590019
[Journal Article] Synthesis of rabdokunmin Canalogues and their inhibitory effect onNF-κB activation2011
- Author(s)
  Yutaka Aoyagi, Yoshiyuki Adachi, KeiOzawa, Chihiro Yokomizo, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li, Naohito Ohno, Koichi Takeya
- Journal Title
  
  Bioorganic & MedicinalChemistry
  
  Volume: No 7 Issue: 7 Pages: 2450-2457
- DOI
  10.1016/j.bmc.2011.02.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590019
[Journal Article] Semisynthesis of triptolide analogues: Effect of〓actone and C-14 substituents oncytotoxic activities2011
- Author(s)
  Yutaka Aoyagi, Yukio Hitotsuyanagi,Tomoyo Hasuda, Haruhiko Fukaya, Koichi Takeya, Ritsuo Aiyama, Takeshi Matsuzaki, Shusuke Hashimoto
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 21巻, No 10 Issue: 10 Pages: 3046-3049
- DOI
  10.1016/j.bmcl.2011.03.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590019
[Journal Article] Salvileucalin C, a novel rearranged neoclerodane diterpene from Salvia leucantha2011
- Author(s)
  Yutaka Aoyagi, Koichi Takeya, 他8名
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 52 Pages: 1851-1853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590019
[Journal Article] Semisynthesis of Isetexane Diterpenoid Analogues and their Cytotoxic Activity2006
- Author(s)
  Yutaka Aoyagi
- Journal Title
  
  Chemical Pharmaceutical Bulletin 54
  
  Pages: 1602-1604
- NAID
  110004836485
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Semisynthesis of C-ring Modified Triptolide Analogues and their Cytotoxic Activities2006
- Author(s)
  Yutaka Aoyagi
- Journal Title
  
  Bioorganic Medicinal Chemistry Letters 16
  
  Pages: 1947-1949
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Semisynthesis of 1-O-Monoacyl or 12-0-monoacyl, 1,12-O-Diacyl, and 11, 12-Dehydrated Excisanin A 7,14-Acetonides and their Cytotoxic Activity2006
- Author(s)
  Yutaka Aoyagi
- Journal Title
  
  Bioorganic Medicinal Chemistry 14
  
  Pages: 5802-5811
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Efficient Synthesis of Pyrroles and 4,5,6,7-Tetrahydro- indoles via Palladium-Catalyzed Oxidation of Hydroxy-examines2006
- Author(s)
  Yutaka Aoyagi
- Journal Title
  
  Tetrahedron 62
  
  Pages: 8533-8538
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthesis analogues2006
- Author(s)
  Yutaka Aoyagi et al.
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 14・15
  
  Pages: 5285-5291
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Semisynthesis of icetexane diterpenoid analogues and their cytotoxic activity2006
- Author(s)
  Yutaka Aoyagi et al.
- Journal Title
  
  Chemical ＆ Pharmaceutical Bulletin 54・11
  
  Pages: 1602-1604
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Efficient Synthesis of Pyrroles and 4,5,6,7-Tetrahydroindoles via Palladium-Catalyzed Oxidation of Hydroxy-enamines2006
- Author(s)
  Yutaka Aoyagi
- Journal Title
  
  Tetrahedron 62
  
  Pages: 8533-8538
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Effecient synthesis of pyrroles and 4,5,6,7-tetrahydroindoles via palladium-catalyzed oxidation of hydroxyl-enamines2006
- Author(s)
  Yutaka Aoyagi et al.
- Journal Title
  
  Tetrahedron 62・36
  
  Pages: 8533-8538
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Synthesis of 1-0-monoacyl or 12-0-monoacyl, 1-,12-0-diacyl- and 11,12-dehydrated excisanin A 7,14-acetonides and their cytotoxic activity2006
- Author(s)
  Yutaka Aoyagi et al.
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 14・15
  
  Pages: 5802-5811
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Semisynthesis and SAR study of C-ring modified cytotoxic triptolide analogues2006
- Author(s)
  Yutaka Aoyagi et al.
- Journal Title
  
  Bioorg.Med.Chem.Lett. 16
  
  Pages: 1947-1949
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Semisynthesis of Isetexane Diterpenoid Analogues and their Cytotoxic Activity2006
- Author(s)
  Yutaka Aoyagi
- Journal Title
  
  Chemical ＆ Pharmaceutical Bulletin 54
  
  Pages: 1602-1604
- NAID
  110004836485
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Semisynthesis of 1-O-Monoacyl or 12-O-monoacyl, 1,12-O-Diacyl, and 11,12-Dehydrated Excisanin A 7,14-Acetonides and their Cytotoxic Activity2006
- Author(s)
  Yutaka Aoyagi
- Journal Title
  
  Bioorganic Medicinal Chemistry 14
  
  Pages: 5802-5811
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Cytotoxicity of Abietane Diterpenoids from Perovskia abrotanoides and of their Semisynthetic Analogues2006
- Author(s)
  Yutaka Aoyagi
- Journal Title
  
  Bioorganic Medicinal Chemistry 14
  
  Pages: 5285-5291
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Biomimetic Synthesis of Grandione from De-methylsalvicanol via Hetero-Diels-Alder Type Dimerization and Structure Division of Grandione2005
- Author(s)
  Yutaka Aoyagi
- Journal Title
  
  Tetrahedron Letters 46
  
  Pages: 7885-7887
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Biomimetic synthesis of grandione from demethylsalvicanol via hetero Diels-Alder type dimerization and structural revision of grandione2005
- Author(s)
  Yutaka Aoyagi et al.
- Journal Title
  
  Tetrahedron Lett. 46
  
  Pages: 7885-7887
- Data Source
  KAKENHI-PROJECT-17590014
[Journal Article] Biomimetic Synthesis of Grandione from Demethylsalvicanol via Hetero-Diels-Alder Type Dimerization and Sructure Dvision of Grandione2005
- Author(s)
  Yutaka Aoyagi
- Journal Title
  
  Tetrahedron Letters 46
  
  Pages: 7885-7887
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590014
[Presentation] 狗日草(コウジツソウ)ジテルベン類のモルモットにおける心機能作用2013
- Author(s)
  頼実舞,澄川彩音、川根誉代、日比千尋、平出瑞紀、斉藤久美子、青柳裕、一柳幸生、竹谷孝一、杉本由美、山田潤、福沢嘉孝、野々垣常正、堀田芳弘
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] アビエタン系ジテルペン類のモルモット心臓に対する作用2013
- Author(s)
  青柳　裕
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] アビエタン系ジテルベン類のモルモット心臓に対する作用2013
- Author(s)
  川根誉代、澄川彩音、頼実舞、斎藤久美子、青柳裕、一柳幸生、竹谷孝一、杉本由美、山田潤、酒井淳一、野々垣常正、堀田芳弘
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] 抗トリパソノーマ活性化合物SalviandulinEアナログの合成と構造活性相関に関する研究2012
- Author(s)
  青柳裕、冨士原浩次、山崎朗、菅原直子、深谷晴彦、一柳幸生、竹谷孝一、矢野玲子、石山亜紀、岩月正人、乙黒一彦、山田陽城、大村智
- Organizer
  第58回日本薬学会東海支部大会
- Place of Presentation
  静岡
- Year and Date
  2012-07-07
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] お茶カテキンガレート基のモルモット心機能に対する影響2012
- Author(s)
  齊藤久美子、澄川彩音、日比千尋、頼実舞、青柳裕、酒井淳一、福沢嘉孝、野々垣常正、中井由実、杉本由美、山田潤、堀田芳弘
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] 細胞毒活性トリプトライドアナログの合成と構造活性相関2011
- Author(s)
  青柳裕、一柳幸生、蓮田知代、深谷晴彦、松山沙樹、竹谷孝一、相山律男、松崎健、橋本秀介
- Organizer
  第57回日本薬学会東海支部大会
- Place of Presentation
  名古屋
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] リュウキュウマユミより得られたテルペン化合物の構造2011
- Author(s)
  稲葉靖典、蓮田知代、青柳裕、一柳幸生、木下武司、竹谷孝一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] マキ属植物由来ジテルペンのアナログ合成及び細胞毒活性に関する研究2011
- Author(s)
  菅原直子、鈴木直樹、佐藤公彦、朴〓宣、青柳裕、一柳幸生、秋山敏行、小山鐵夫、竹谷孝一
- Organizer
  日本生薬学会第58回年会
- Place of Presentation
  東京
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] 細胞毒活性トリプトライドアナログの合成と構造活性相関2011
- Author(s)
  青柳裕
- Organizer
  第57回日本薬学会東海支部総会・大会
- Place of Presentation
  愛知県名古屋市・金城学院大学
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] リュウキュウマユミより得られたジテルペノイド化合物について2011
- Author(s)
  藤川尚子、稲葉靖典、蓮田知代、青柳裕、一柳幸生、竹谷孝一、木下武司
- Organizer
  日本生薬学会第58回年会
- Place of Presentation
  東京
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] Podocarpus属植物由来ジテルペンのアナログ合成とそれらの細胞毒活性2011
- Author(s)
  鈴木直希、菅原直子、佐藤公彦、朴〓宣、秋山敏行、小山鐵夫、青柳裕、竹谷孝一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] ガレート型カテキン類のモルモット心臓における陽性変力作用2011
- Author(s)
  川麗子、竹内裕子、出口賀奈子、齊藤久美子、青柳裕、中川秀彦、宮田直樹、野々垣常正、堀田芳弘
- Organizer
  第57回日本薬学会東海支部大会
- Place of Presentation
  名古屋
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] NF-κB活性化阻害作用を有するent-カウレンアナログの創製研究2010
- Author(s)
  青柳裕、安達禎之、横溝千尋、桂明玉、金永日、李諸文、大野尚仁、竹谷孝一
- Organizer
  第18回天然薬物の開発と応用シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] NF-κB活性化阻害作用を有するent-カウレンアナログの創製研究2010
- Author(s)
  青柳裕, 他7名
- Organizer
  第18回天然薬物の開発と応用シンポジウム
- Place of Presentation
  東京、北里大学
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-22590019
[Presentation] 抗トリパソノーマ活性 Salviandulin E アナログの合成と構造活性相関に関する研究
- Author(s)
  青柳　裕
- Organizer
  第58回日本薬学会東海支部大会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22590019

1. 太田明廣 (90057307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 後藤美紀子 (60225662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 島崎眞 (80187426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山田健二 (30057351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AOYAGI Yutaka 青柳 裕

青柳 裕 アオヤギ ユタカ

Research Projects

Research Products

Co-Researchers

Synthesis and Structure-Activity Relationship of Biologically ActiveNatural Products and their Analogues Based on Green ChemistryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Green chemistry oriented synthesis of biologically active natural products and structure-activity relationshipsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemoenzymatic Synthesis of Biologically Active Natural products via Lipase TL -Mediated Kinetic Resolution as a Key Step and their Structure Activity RelationshipPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

強力な免疫抑制活性を有するスフィンゴ糖脂質Plakoside Aの合成研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

N,0一複系環を有する天然物の合成と薬理作用に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Salvileucalin Ca novel rearranged neo- clerodane diterpene from Salvia leucantha2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of rabdokunmin Canalogues and their inhibitory effect onNF-κB activation2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Semisynthesis of triptolide analogues: Effect of〓actone and C-14 substituents oncytotoxic activities2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Salvileucalin C, a novel rearranged neoclerodane diterpene from Salvia leucantha2011

Author(s)

Journal Title

Data Source

[Journal Article] Semisynthesis of Isetexane Diterpenoid Analogues and their Cytotoxic Activity2006

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Semisynthesis of C-ring Modified Triptolide Analogues and their Cytotoxic Activities2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Semisynthesis of 1-O-Monoacyl or 12-0-monoacyl, 1,12-O-Diacyl, and 11, 12-Dehydrated Excisanin A 7,14-Acetonides and their Cytotoxic Activity2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Efficient Synthesis of Pyrroles and 4,5,6,7-Tetrahydro- indoles via Palladium-Catalyzed Oxidation of Hydroxy-examines2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthesis analogues2006

Author(s)

Journal Title

Data Source

[Journal Article] Semisynthesis of icetexane diterpenoid analogues and their cytotoxic activity2006

Author(s)

AOYAGI Yutaka 青柳裕

青柳裕アオヤギユタカ