sasaki motoko 佐々木素子

… Alternative Names

佐々木素子ササキモトコ

SASAKI Motoko 佐々木素子

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Researcher Number	70225895
Other IDs
External Links
Affiliation (Current)	2025: 金沢大学, 医学系, 准教授
Affiliation (based on the past Project Information) *help	2025: 金沢大学, 医学系, 准教授 2022 – 2023: 金沢大学, 医学系, 准教授 2008 – 2020: Kanazawa University, 医学系, 准教授 2007: Kanazawa University, 医学系研究科, 准教授 2003 – 2006: 金沢大学, 医学系研究科, 助教授 … More 2002: 金沢大学, 医学系研究科, 講師 2002: Kanazawa Univ., Graduate School of Medical Science, Assitant Prof., 大学院・医学系研究科, 助教授 2001: 金沢大学, 大学院・医学研究科, 講師 2001: 金沢大学, 大学院・医学系研究科, 講師 2000: 金沢大学, 医学部, 講師 1998: 金沢大, 医学部, 講師 1996 – 1997: Kanazawa University School of Medicine, 2nd Department of Pathology, Assistant P, 医学部, 講師 1992 – 1996: 金沢大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Human pathology / Human pathology / Basic Section 49020:Human pathology-related Except Principal Investigator Human pathology / Human pathology
Keywords	Principal Investigator 細胞老化 / 病理学 / 免疫組織化学 / 生体分子 / 自己免疫性疾患 / 原発性胆汁性肝硬変 / 肝内胆管癌 / 肝内結石症 / 原発性胆汁性胆管炎 / trefoil factor family (TFF) … More / オートファジー / 胆管上皮細胞 / 再生医学 / ムチンコア蛋白 / 胆管細胞 / 組織透明化 / ライトシート顕微鏡 / PD-L1 / cGAS-STING経路 / cellular senescence / immunohistochemistry / biliary epithelial cell / intrahepatic bile duct / primary biliary cirrhosis / bile duct vanishing syndrome / deleted in malignant brain tumor-1 (DMBT1) / 原発性硬化性胆管炎 / trefoil factor family(TFF) / 肝内小型胆管 / 肝内胆管消失症候群 / 混合型肝癌 / ウイルス性慢性肝炎 / 肝内胆管 / アポムチン / In situ hybridization法 / ディスプラジア / Ki-67抗原 / p53蛋白 / 境界病変 / 肝硬変 / 肝細胞癌 / ルイスY抗原 / CEA / ウェスタンブロッテイング / 粘液糖蛋白 / 糖鎖坑原 / 胆汁 … More Except Principal Investigator HBV / HCV / chronic hepatitis C / aly / PBC / primary biliary cirrhosis / 原発性胆汁性肝硬変 / 胆管系 / self defence / signal transduction / biliary tract / Toll-like receptor / microorganism / innate immunity / culture / リポポリサッカライド / トル様レセプタ / リポタイコ酸 / シグナル伝達系 / 細菌感染 / 自然免役 / 肝内胆管系 / フラクタルカイン / 生体防御 / シグナル伝達 / トル様受容体 / 微生物 / 自然免疫 / 培養 / PCK Rat / Animal Model / Caroli's Disease / Congenital Hepatic Fibrosis / Molecular Biology / Pathology of Liver / Human Pathology / TGF-βファミリー / cDNAマイクロアレイ / アポトーシス / 体染色体性劣性遺伝 / 肝内胆管 / 細胞増殖 / 細胞内シグナル伝達 / 上皮成長因子 / サイトケラチン20 / PCKラット / 動物モデル / カロリ病 / 先天性肝線維症 / 分子生物学 / 肝臓病理 / 人体病理学 / inflammatory cells / intrahepatic small vessels / interferon / cell injury / hemosiderin / 肝細胞 / 細胞接着因子 / 炎症細胞 / 肝内小血管 / インターフェロン / 細胞障害 / ヘモジデリン / 慢性C型肝炎 / aly mouse / hepatitis associated bile duct damage / サイトカイン / MUC1アポムチン / alyマウス / aly alyマウス / 肝炎性胆管障害 / C型慢性肝炎 / Immunopathological / immunohistochemistry / ALY mouse / bile / pyruvate dehydrogenase / confocal lazer microscope / interlobular bile duct / antimitochodrial antibodies / ALYマウス / 免疫組織化学 / ピルビン酸脱水素酵素 / 胆汁 / 小葉間胆管 / 共焦点レーザー顕微鏡 / 抗ミトコンドリア抗体 / anti-oncogenes) / oncogenes / immunophenotypes / carcinogenesis / cell kinetics / cirrhosis / adenomatous hyperplasia / hepatocellular carcinoma / 血行動態 / 病理組織計測 / 病理組織像 / 類洞 / 細胞動態 / 前癌病変 / 銅 / 臨床病理 / 組織計測 / 肝腺腫様過形成 / 肝細胞癌 / 肝 / サイトケラチン / ras / p53 / 肝発癌 / 嚢胞腫瘍 / 浸潤 / 襄胞腫瘍 / 膵管腫瘍 / 表現型 / 粘液産生 / 胆管上皮 / 細胞・組織 / 病理学 / 臨床 / 遺伝子 / 癌 / 通常型胆管癌 / 粘液癌 / 乳頭状腫瘍 / 上皮内腫瘍 / 胆管癌 / 管腔内乳頭状腫瘍 / 膵腫瘍 / 胆管 / 幹細胞 / 肝臓 / 多分化能 / c-kit / stem cell factor Less

老化細胞の多様性に着目した肝臓病の病態解明と新規治療薬候補の探索Principal Investigator
- Principal Investigator
  
  佐々木素子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kanazawa University
老化細胞を標的とした原発性胆汁性胆管炎の新しい治療法開発Principal Investigator
- Principal Investigator
  
  佐々木素子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kanazawa University
Development of new therapy for liver disease by regulating cellular senescencePrincipal Investigator
- Principal Investigator
  
  Sasaki Motoko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kanazawa University
Involvement of dysregulated autophagy in autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  Sasaki Motoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
Novel approach to primary biliary cirrhosis putting focus on deregulated autophagyPrincipal Investigator
- Principal Investigator
  
  SASAKI Motoko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
Novel approach to liver disease from aspect of cellular senescencePrincipal Investigator
- Principal Investigator
  
  SASAKI Motoko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
Proposal of intraductal papillary neoplasm of the bile duct and molecular pathological study on its development and progression
- Principal Investigator
  
  NAKANUMA Yasuni
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
Pathogenesis of progressive bile duct loss in primary biliary cirrhosis : A possible involvement of cellular senescencePrincipal Investigator
- Principal Investigator
  
  SASAKI Motoko
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
Expression of Toll-like Receptor on Biliary Mucosa and its Dysregulation: Molecular Pathological Study by Using Cultured Biliary Epithelial Cells and Hepato-Biliary Tissue
- Principal Investigator
  
  NAKANUMA Yasuni
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
The molecular mechanism of the impaired regeneration of biliary epithelial cells in bile duct vanishing syndrome.Principal Investigator
- Principal Investigator
  
  SASAKI Motoko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
ヒト肝臓の幹細胞の研究:c-kit 受容体-stem cell factor系の発現を中心に
- Principal Investigator
  
  常山幸一
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
Pathological and biological analysis of congenital hepatic fibrosis and Caroli's disease -A comparative study using an animal model for the disease
- Principal Investigator
  
  NAKANUMA Yasuni
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
増生細胆管でのアポムチンサブタイプの発現とその意義：増生細胆管は肝ステムセルか？Principal Investigator
- Principal Investigator
  
  佐々木素子
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
肝内胆管系におけるムチンコア蛋白の正常分布と疾患に伴う変動-肝内結石症を中心に-Principal Investigator
- Principal Investigator
  
  佐々木素子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
HEMOSIDERIN DEPOSITION IN INTRAHEPATIC SMALL VESSELS IN CHRONIC HEPATITIS C : PATHOLOGICAL SIGNIFICANCE AND ITS PREDICTING ROLE IN RESPONSE TO INTERFERON
- Principal Investigator
  
  NAKANUMA Yasuni
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  KANAZAWA UNIVERSITY SCHOOL OF MEDICINE
ウイルス性肝硬変の再生結節内の“ルイスY抗原陰性巣":新しい癌関連病巣かPrincipal Investigator
- Principal Investigator
  
  佐々木素子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
Immunopathological and Molecular Biological Study of Primary Biliary Cirrhosis
- Principal Investigator
  
  NAKANUMA Yasuni
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KANAZAWA UNIVERSITY
Immunohistochemical Study of Hepatitis Associated Bile Duct Damage in Chronic Hepatitis C,Contrasted with Chronic Bile duct Damage of Primary Biliary Cirrhosis
- Principal Investigator
  
  HOSO Masahiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
胆汁中粘液糖蛋白の解析:肝内胆管病変との対比を中心にPrincipal Investigator
- Principal Investigator
  
  佐々木素子
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
肝内結石症に合併する肝内胆管癌の発生の進展に関する免疫組織化学的検討Principal Investigator
- Principal Investigator
  
  佐々木素子
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Human pathology
- Research Institution
  Kanazawa University
CARCINOGENESIS OF HUMAN HEPATOCELLULAR CARCINOMA : COMPARISON BETWEEN HISTOPATHOLOGICAL FEATURES AND CELL KINETICS,CYTOPLASMIC PHENOTYPES AND GENETIC FEATURES.
- Principal Investigator
  
  TERADA Tadashi
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  KANAZAWA UNIVERSITY

[Book] 膵臓を診る医師のための膵臓病理テキスト　（中沼安二, 古川　徹, 福村由紀　編）III章　腫瘍性疾患の病理. 1. 嚢胞性腫瘍.2020
- Author(s)
  佐々木素子
- Total Pages
  6
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-18K06985
[Book] 腫瘍病理鑑別診断アトラス肝癌第２版　（坂元享宇, 原田憲一　編）　第２部　組織型と診断の実際　II. 胆管細胞系腫瘍　6. 胆管腺腫および類似病変.2020
- Author(s)
  佐々木素子
- Total Pages
  5
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-18K06985
[Book] Cellular senescence and biliary disorders. Book chapter; In Nakanuma Y eds. Pathology of the bile duct.2017
- Author(s)
  Sasaki M.
- Total Pages
  16
- Publisher
  BD-book springer
- Data Source
  KAKENHI-PROJECT-15K08341
[Book] Chapter 10. Mucinous Cystic Neoplasm of the Liver and Pancreas In: Nakanuma Y eds. Biliary Diseases with Pancreatic Counterparts: A New Disease Concept.2017
- Author(s)
  Sasaki M.
- Total Pages
  16
- Publisher
  Nova Science publishers.
- Data Source
  KAKENHI-PROJECT-15K08341
[Journal Article] 病理組織学的なMetastatic carcinomatous cirrhosisをきたした浸潤性小葉癌の１症例2023
- Author(s)
  金守良, 金秀基, 小林久人, 奥田豊一, 中井敦史, 藤井友実, 早雲孝信, 佐々木素子, 狛雄一朗, 朝井章, 西川　浩
- Journal Title
  
  肝臓
  
  Volume: 64 Pages: 575-582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] 限局性結節性過形成 focal nodular hyperplasia（FNH）の病理診断2023
- Author(s)
  佐々木素子
- Journal Title
  
  肝臓クリニカルアップデート
  
  Volume: 9 Pages: 75-79
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] Drug-induced sarcoidosis-like reaction three months after BNT162b2 mRNA COVID-19 vaccination: A case report and review of literature2023
- Author(s)
  Kim Soo Ryang、Kim Soo Ki、Fujii Takako、Kobayashi Hisato、Okuda Toyokazu、Hayakumo Takanobu、Nakai Atsushi、Fujii Yumi、Suzuki Ryuji、Sasase Noriko、Otani Aya、Koma Yu-ichiro、Sasaki Motoko、Kumabe Tsutomu、Nakashima Osamu
- Journal Title
  
  World Journal of Clinical Cases
  
  Volume: 11 Issue: 1 Pages: 177-186
- DOI
  10.12998/wjcc.v11.i1.177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] Identification of a Transmembrane Protein Involved in Shear Stress Signaling and Hepatocarcinogenesis After a Sustained Virological Response to Hepatitis C Virus2023
- Author(s)
  Nishikawa Masashi、Okada Hikari、Kawaguchi Kazunori、Shimakami Tetsuro、Nio Kouki、Arai Kuniaki、Yamashita Tatsuya、Sasaki Motoko、Kaneko Shuichi、Yamashita Taro、Honda Masao
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 16 Issue: 2 Pages: 263-286
- DOI
  10.1016/j.jcmgh.2023.04.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06957, KAKENHI-PROJECT-21K07940, KAKENHI-PROJECT-21K07905, KAKENHI-PROJECT-21H04823
[Journal Article] An involvement of Hippo-yes-associated protein pathway in biliary epithelial senescence in primary biliary cholangitis.2023
- Author(s)
  Sasaki M, Sato Y, Nakanuma Y
- Journal Title
  
  Clin Res Hepatol Gastroenterol
  
  Volume: － Issue: 4 Pages: 102106-102106
- DOI
  10.1016/j.clinre.2023.102106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] Hepatic Inflammatory Pseudotumor?Focusing on Its Heterogeneity2023
- Author(s)
  Kim Soo Ryang、Kim Soo Ki、Koma Yu-ichiro、Sasaki Motoko、Asai Akira、Nishikawa Hiroki
- Journal Title
  
  Diagnostics
  
  Volume: 13 Issue: 17 Pages: 2857-2857
- DOI
  10.3390/diagnostics13172857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] Bile duct adenoma and small‐sized small duct type intrahepatic cholangiocarcinoma show distinct differences in genetic alterations, expression of IMP3 and EZH2 and stromal and inflammatory components2023
- Author(s)
  Sasaki Motoko、Sato Yasunori、Nakanuma Yasuni
- Journal Title
  
  Histopathology
  
  Volume: 83 Issue: 2 Pages: 298-309
- DOI
  10.1111/his.14932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] Nestin may be a candidate marker for differential diagnosis between small duct type and large duct type intrahepatic cholangiocarcinomas.2023
- Author(s)
  Sasaki M, Sato Y, Nakanuma Y.
- Journal Title
  
  Pathol Res Pract
  
  Volume: in press Pages: 155061-155061
- DOI
  10.1016/j.prp.2023.155061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] 転移性肝腫瘍の病理診断とゲノム検査を依頼するときのポイント2022
- Author(s)
  佐々木素子
- Journal Title
  
  肝臓クリニカルアップデート
  
  Volume: 8 Pages: 185-191
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] 肝細胞腺腫2022
- Author(s)
  佐々木素子
- Journal Title
  
  臨床検査
  
  Volume: 66 Pages: 726-733
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] Is Nestin a diagnostic marker for combined hepatocellular-cholangiocarcinoma?2022
- Author(s)
  Sasaki M, Sato Y, Nakanuma Y
- Journal Title
  
  Histopathology
  
  Volume: 80 Issue: 5 Pages: 859-868
- DOI
  10.1111/his.14622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] 画像診断と病理・薬物療法後のpseudoprogression：組織所見2022
- Author(s)
  佐々木素子
- Journal Title
  
  肝臓クリニカルアップデート
  
  Volume: 8 Pages: 73-77
- Data Source
  KAKENHI-PROJECT-22K06957
[Journal Article] MET amplification results in heterogeneous responses to osimertinib in EGFR ‐mutant lung cancer treated with erlotinib2020
- Author(s)
  Nishiyama Akihiro、Takeuchi Shinji、Adachi Yuta、Otani Sakiko、Tanimoto Azusa、Sasaki Motoko、Matsumoto Shingo、Goto Koichi、Yano Seiji
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 10 Pages: 3813-3823
- DOI
  10.1111/cas.14593
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08516, KAKENHI-PROJECT-19H03665, KAKENHI-PROJECT-18K06985
[Journal Article] Immunosuppressive tumor microenvironment in occupational cholangiocarcinoma: Supportive evidence for the efficacy of immune checkpoint inhibitor therapy2020
- Author(s)
  Sato Yasunori, Tanaka Shogo, Kinoshita Masahiko, Takemura Shigekazu, Shinkawa Hiroji, Kokudo Takashi, Hasegawa Kiyoshi, Tanaka Hiromu, Yoshimoto Hidero, Mori Akira, Yamamura Minako, Sasaki Motoko, Harada Kenichi, Kubo Shoji
- Journal Title
  
  Journal of Hepato-Biliary-Pancreatic Sciences
  
  Volume: 27 Issue: 11 Pages: 860-869
- DOI
  10.1002/jhbp.788
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06985, KAKENHI-PROJECT-18K08654
[Journal Article] 【消化器腫瘍II　新WHO分類のポイント　肝胆膵編】混合型肝癌2020
- Author(s)
  佐々木素子
- Journal Title
  
  病理と臨床
  
  Volume: 38 Pages: 1088-1092
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] 特集：　自己免疫性肝疾患. II. 基礎　胆管上皮細胞2020
- Author(s)
  佐々木素子
- Journal Title
  
  日本臨床
  
  Volume: 78 Pages: 27-33
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] Fulminant myocarditis and pulmonary cavity lesion induced by disseminated mucormycosis in a chronic hemodialysis patient: Report of an autopsied case.2020
- Author(s)
  Fujisawa Y, Hara S, Zoshima T, Maekawa N, Inoue D, Sasaki M, Gamou T, Nagata Y, Hayashi K, Takeji A, Ito K, Mizushima I, Fujii H, Kawano M.
- Journal Title
  
  Pathol Int.
  
  Volume: Aug;70(8) Issue: 8 Pages: 557-562
- DOI
  10.1111/pin.12943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08129, KAKENHI-PROJECT-18K06985, KAKENHI-PROJECT-18K08100
[Journal Article] 画像診断と病理・肝内胆管癌の病理　ここがポイント！WHO分類第5版2020
- Author(s)
  佐々木素子
- Journal Title
  
  肝臓クリニカルアップデート
  
  Volume: 6 Pages: 101-104
- NAID
  40022300939
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] Clinical features and diagnostic imaging of cholangiolocellular carcinoma compared with other primary liver cancers: a surgical perspective2020
- Author(s)
  Takamura Hiroyuki, Gabata Ryousuke, Obatake Yoshinao, Nakanuma Shinichi, Hayashi Hironori, Kozaka Kazuto, Sasaki Motoko, et al.
- Journal Title
  
  Technology in Cancer Research & Treatment
  
  Volume: 19
- DOI
  10.1177/1533033820948141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] The cyclin-dependent kinase pathway involving CDK1 is a potential therapeutic target for cholangiocarcinoma.2020
- Author(s)
  Yamamura M, Sato Y, Takahashi K, Sasaki M, Harada K.
- Journal Title
  
  Oncol Rep.
  
  Volume: 43 Pages: 306-317
- DOI
  10.3892/or.2019.7405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern May Be Characterized by ARID1A Genetic Alterations.2019
- Author(s)
  Sasaki M, Sato Y, Nakanuma Y.
- Journal Title
  
  Am J Surg Pathol.
  
  Volume: 43 Issue: 3 Pages: 352-360
- DOI
  10.1097/pas.0000000000001201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] 特集　胆嚢癌診療の現況　2. 胆嚢癌の病理2019
- Author(s)
  佐々木素子
- Journal Title
  
  臨床消化器内科
  
  Volume: 34 Pages: 139-145
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] Increased p16INK4a-expressing senescent bile ductular cells are associated with inadequate response to ursodeoxycholic acid in primary biliary cholangitis.2019
- Author(s)
  Sasaki M, Sato Y, Nakanuma Y.
- Journal Title
  
  J Autoimmun.
  
  Volume: Epub ahead of print Pages: 102377-102377
- DOI
  10.1016/j.jaut.2019.102377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] Asymptomatic giant cell hepatitis: a subtype of post-infantile giant cell hepatitis?2019
- Author(s)
  Zenda T, Araki I, Sasaki M.
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: 12 Issue: 4 Pages: 367-371
- DOI
  10.1007/s12328-019-00950-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] 画像診断と病理・肝炎ウイルス消失後の画像診断と病理　病理2019
- Author(s)
  佐々木素子
- Journal Title
  
  肝臓クリニカルアップデート
  
  Volume: 5 Pages: 85-89
- NAID
  40022088450
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] 胆道疾患におけるオートファジーの関与2018
- Author(s)
  佐々木素子
- Journal Title
  
  胆と膵
  
  Volume: 39 Pages: 165-171
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] Blockade of Hedgehog Signaling Attenuates Biliary Cystogenesis in the Polycystic Kidney (PCK) Rat.2018
- Author(s)
  Sato Y, Yamamura M, Sasaki M, Harada K
- Journal Title
  
  Am J Pathol.
  
  Volume: 188 Issue: 10 Pages: 2251-2263
- DOI
  10.1016/j.ajpath.2018.06.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] 画像診断と病理・C 型肝炎ウイルス消失後の肝線維化の評価病理2018
- Author(s)
  佐々木素子
- Journal Title
  
  肝臓クリニカルアップデート
  
  Volume: 4 Pages: 85-89
- NAID
  40021605831
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports2018
- Author(s)
  Tsuda Toyonobu、Tada Hayato、Tanaka Yoshihiro、Nishida Naoto、Yoshida Taiji、Sawada Takeshi、Sakata Kenji、Hayashi Kenshi、Kawashiri Masa-aki、Oyama Takeru、Sasaki Motoko、Kurose Nozomu、Yamagishi Masakazu
- Journal Title
  
  Journal of Medical Case Reports
  
  Volume: 12 Issue: 1 Pages: 95-95
- DOI
  10.1186/s13256-018-1629-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08748, KAKENHI-PROJECT-18K06985, KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-16K08687
[Journal Article] Increased expression of senescence-associated cell cycle regulators in the progression of biliary atresia: an immunohistochemical study2018
- Author(s)
  Sasaki Motoko, Kuo Fang-Ying, Huang Chao-Cheng, Swanson Paul E, Chen Chao-Long, Chuang Jiin-Haur, Yeh Matthew M
- Journal Title
  
  Histopathology
  
  Volume: (in press) Issue: 7 Pages: 1164-1171
- DOI
  10.1111/his.13476
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08341, KAKENHI-PROJECT-18K06985
[Journal Article] An impaired biliary bicarbonate umbrella may be involved in dysregulated autophagy in primary biliary cholangitis2018
- Author(s)
  Sasaki Motoko, Sato Yasunori, Nakanuma Yasuni
- Journal Title
  
  Laboratory Investigation
  
  Volume: (in press) Issue: 6 Pages: 745-754
- DOI
  10.1038/s41374-018-0045-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08341, KAKENHI-PROJECT-18K06985
[Journal Article] 誌上デイベート　「IPNB」は胆管癌の前癌病変か」　①前癌病変であるとする立場から2018
- Author(s)
  佐々木素子
- Journal Title
  
  膵・胆道FRONTIER
  
  Volume: 7 Pages: 14-17
- Data Source
  KAKENHI-PROJECT-18K06985
[Journal Article] Bile Acids and Deregulated Cholangiocyte Autophagy in Primary Biliary Cholangitis.2017
- Author(s)
  Sasaki M, Nakanuma Y.
- Journal Title
  
  Dig Dis
  
  Volume: 35 Issue: 3 Pages: 210-216
- DOI
  10.1159/000450913
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08341
[Journal Article] Stress-induced cellular responses and cell death mechanisms during inflammatory cholangiopathies2017
- Author(s)
  Sasaki Motoko, Nakanuma Yasuni
- Journal Title
  
  Clin Res Hepatol Gastroenterol
  
  Volume: 41 Issue: 2 Pages: 129-138
- DOI
  10.1016/j.clinre.2016.08.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08341
[Journal Article] Autophagy and senescence in fibrosing cholangiopathies.2015
- Author(s)
  Nakanuma Y, Sasaki M, Harada K.
- Journal Title
  
  J Hepatol.
  
  Volume: 62 Issue: 4 Pages: 934-945
- DOI
  10.1016/j.jhep.2014.11.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590409, KAKENHI-PROJECT-15K08341
[Journal Article] In recurrent primary biliary cirrhosis after liver transplantation, biliary epithelial cells show increased expression of mitochondrial proteins.2015
- Author(s)
  Sasaki M, Hsu M, Yeh MM, Nakanuma Y
- Journal Title
  
  Virchows Arch.
  
  Volume: 467 Issue: 4 Pages: 417-25
- DOI
  10.1007/s00428-015-1819-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08341
[Journal Article] Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions.2015
- Author(s)
  Sasaki M, Nakanuma Y.
- Journal Title
  
  Histol Histopathol
  
  Volume: 30 Pages: 267-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590409
[Journal Article] A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis.2015
- Author(s)
  Sasaki M, Yoshimura-Miyakoshi M, Sato Y, Nakanuma Y.
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Issue: 9 Pages: 984-95
- DOI
  10.1007/s00535-014-1033-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08341
[Journal Article] A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis.2015
- Author(s)
  Sasaki M, Yoshimura-Miyakoshi M, Sato Y, Nakanuma Y
- Journal Title
  
  J Gastroenterol
  
  Volume: [Epub ahead of print] Pages: 000-000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590409
[Journal Article] Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and in biliary epithelial layer may be involved in the pathogenesis in primary biliary cirrhosis.2014
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Journal of Clinical Pathology
  
  Volume: in press Issue: 6 Pages: 470-6
- DOI
  10.1136/jclinpath-2013-201917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590409
[Journal Article] Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis.2014
- Author(s)
  Kobayashi M, Kakuda Y, Harada K, Sato Y, Sasaki M, Ikeda H, Terada M, Mukai M, Kaneko S, Nakanuma Y.
- Journal Title
  
  World J Gastroenterol.
  
  Volume: 20 Issue: 13 Pages: 3597-608
- DOI
  10.3748/wjg.v20.i13.3597
- NAID
  120007139982
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590409, KAKENHI-PROJECT-26460416
[Journal Article] Chemokine-Chemokine Receptor CCL2-CCR2 and CX3CL1-CX3CR1 Axis May Play a Role in the Aggravated Inflammation in Primary Biliary Cirrhosis.2014
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Dig Dis Sci
  
  Volume: 59 Issue: 2 Pages: 358-364
- DOI
  10.1007/s10620-013-2920-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590409
[Journal Article] Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis.2013
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Liver International
  
  Volume: 33 Issue: 2 Pages: 312-20
- DOI
  10.1111/liv.12049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590409
[Journal Article] Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis2012
- Author(s)
  Sasaki M, et al
- Journal Title
  
  Dig Dis Sci
  
  Volume: 57 Pages: 660-666
- NAID
  120003497596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis2012
- Author(s)
  Sasaki M, et al
- Journal Title
  
  Liver Int
  
  Volume: 32 Issue: 3 Pages: 487-499
- DOI
  10.1111/j.1478-3231.2011.02656.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Autophagy may precede cellular senescenceof bile ductular cells in ductular reaction inprimary biliary cirrhosis2012
- Author(s)
  Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y
- Journal Title
  
  Dig Dis Sci
  
  Volume: 57 Pages: 660-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] A possible involvement of p62/sequestosome-1 in the process of biliary epithelialautophagy and senescence in primary biliarycirrhosis2012
- Author(s)
  Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y
- Journal Title
  
  Liver Int
  
  Volume: 32 Pages: 487-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Novel approach to bile duct damage in primary biliary cirrhosis : participation of cellular senescence and autophagy2012
- Author(s)
  Sasaki M, et al
- Journal Title
  
  Int J Hepatol
- NAID
  120004186277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Novel approach tobile duct damage in primary biliary cirrhosis : participation of cellular senescence andautophagy2012
- Author(s)
  Sasaki M, Nakanuma Y
- Journal Title
  
  Int J Hepatol
  
  Volume: 2012 Pages: 452143-452143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Participation ofbile ductular cells in the pathological progressionof non-alcoholic fatty liver disease2011
- Author(s)
  Chiba M, Sasaki M
- Journal Title
  
  J Clin Pathol
  
  Volume: 64 Pages: 564-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease2011
- Author(s)
  Chiba M, Sasaki M, et al
- Journal Title
  
  J Clin Pathol
  
  Volume: 64 Pages: 564-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Autophagy mediates the process of cellularsenescence characterizing bile duct damages inprimary biliary cirrhosis2010
- Author(s)
  Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y
- Journal Title
  
  Lab Invest
  
  Volume: 90 Pages: 835-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] 肝内結石症と肝内胆管癌-実態と発癌の病理学的検討-2010
- Author(s)
  中沼安二、原田憲一、木村康、佐藤保則、佐々木素子、池田博子
- Journal Title
  
  胆と膵 31(2)
  
  Pages: 185-192
- NAID
  120005478847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] 肝内胆管癌(胆管細胞癌)2010
- Author(s)
  中沼安二、佐々木素子、佐藤保則、池田博子、原田憲一
- Journal Title
  
  肝胆膵画像 12(9)
  
  Pages: 54-521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Bile ductular cells undergoing cellular senescence increase in chronic liver diseases along with fibrous progrerssion2010
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Am J Clin Pathol 133
  
  Pages: 212-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] 胆道癌の分子生物学的特性2010
- Author(s)
  中沼安二、原田憲一、佐々木素子、佐藤保則、池口博子
- Journal Title
  
  胆と膵 31(4)
  
  Pages: 379-386
- NAID
  120005478848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors : an immunohistochemical approach.2010
- Author(s)
  Nakanuma Y, Zen Y, Harada K, Ikeda H, Sato Y, Uehara T, Sasaki M.
- Journal Title
  
  J Hepatobiliary Pancreat Sci 17(3)
  
  Pages: 211-222
- NAID
  10027422376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Modulation of the microenvironment by senescentbiliary epithelial cells may be involved in thepathogenesis of primary biliary cirrhosis2010
- Author(s)
  Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y
- Journal Title
  
  J Hepatol
  
  Volume: 53 Pages: 318-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Application of a new histological stagingand grading system for primary biliary cirrhosis toliver biopsy specimens : Interobserver agreement2010
- Author(s)
  Nakanuma Y, Zen Y, Harada K, Sasaki M, (他26名)
- Journal Title
  
  Pathol Int
  
  Volume: 60 Pages: 167-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis2010
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Lab Invest
  
  Volume: 90 Pages: 835-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Intraductal tubular neoplasm of the common bile duct : Case Report2010
- Author(s)
  Sato Y, Osaka K, Harada K, Sasaki M, Nakanuma Y
- Journal Title
  
  Pathol Int 60(7)
  
  Pages: 516-519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Bileductular cells undergoing cellular senescenceincrease in chronic liver diseases along withfibrous progrerssion2010
- Author(s)
  Sasaki M, Ikeda H, Sato Y, Nakanuma Y
- Journal Title
  
  Am J Clin Pathol
  
  Volume: 133 Pages: 212-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Modulation of microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis2010
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  J Hepatol
  
  Volume: 53 Pages: 319-325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens : Interobser veragreement.2010
- Author(s)
  Nakanuma Y, Sasaki M, et al.
- Journal Title
  
  Pathol Int
  
  Volume: 60 Pages: 167-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Biliary epithelialapoptosis, autophagy, and senescence in primarybiliary cirrhosis2010
- Author(s)
  Sasaki M, Nakanuma Y
- Journal Title
  
  Hepat Res Treat
  
  Pages: 205128-205128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma.2010
- Author(s)
  Yamaguchi J, Sasaki M, Sato Y, Itatsu K, Harada K, Zen Y, Ikeda H, Nimura Y, Nagino M, Nakanuma Y.
- Journal Title
  
  Cancer Sci 101(2)
  
  Pages: 355-362
- NAID
  10026587662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Biliary epithelial apoptosis, autophagy, and senescence in primarybiliary cirrhosis2010
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Hepat Res Treat
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile cucts2009
- Author(s)
  Nakanuma Y, Sasaki M, Sato Y, Ren X, Ikeda H, Harada K
- Journal Title
  
  World J Hepatol 1(1)
  
  Pages: 35-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] 肝, 胆管発癌における cancer stem cell の役割2009
- Author(s)
  中沼安二, 佐々木素子, 佐藤保則, 原田憲一, 冨士井孝彦, 池田博子
- Journal Title
  
  肝胆膵 59(4)
  
  Pages: 639-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-{alpha}2009
- Author(s)
  Itatsu, K., Sasaki, M., Nakanuma, Y., (他11名)
- Journal Title
  
  Am J Pathol 174(3)
  
  Pages: 829-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion2009
- Author(s)
  Ikeda H, Sasaki M, et al.
- Journal Title
  
  Hum Pathol 40
  
  Pages: 1774-1782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Bile ductularcell reaction with senescent hepatovcytes inchronic viral hepatitis is lost duringhepatocarcinogenesis2009
- Author(s)
  Ikeda H, Sasaki M, (他5名)
- Journal Title
  
  Pathol Int
  
  Volume: 59 Pages: 471-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Large cellchange of hepatocytes in chronic viral hepatitisrepresents a senescent-related lesion2009
- Author(s)
  Ikeda H, Sasaki M, (他5名)
- Journal Title
  
  Hum Pathol
  
  Volume: 40 Pages: 1774-1782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Bile ductular cell reaction with senescent hepatovcytes in chronic viral hepatitis is lost during hepatocarcinogenesis2009
- Author(s)
  Ikeda H, Sasaki M, et al
- Journal Title
  
  Pathol Int 59
  
  Pages: 471-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Intraductal papillary-mucinous neoplasm of the pancreas associated with polycystic liver and kidney disease2009
- Author(s)
  Sato Y, Mukai M, Sasaki M, Kitao A, Yoneda N, Kobayashi D, Imamura Y, Nakanuma Y.
- Journal Title
  
  Pathol Int 59(3)
  
  Pages: 201-4
- NAID
  10027379586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Intraductal papillary-mucinous neoplasm of the pancreas associated with polycystic liver and kidney disease2009
- Author(s)
  Sato, Y., Mukai, M., Sasaki, M., Kitao, A., Nakanuma, Y., (他5名)
- Journal Title
  
  Pathol Int 59(3)
  
  Pages: 201-4
- NAID
  10027379586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Cyclooxygenase-2 is involved in the up-regulation of matrix metalloprote inase-9 in cholangiocarcinoma induced by tumor necrosis factor-{alpha}2009
- Author(s)
  Itatsu K, Sasaki M, Yamaguchi J, Ohira S, Ishikawa A, Ikeda H, Sato Y, Harada K, Zen Y, Sato H, Ohta T, Nagino M, Nimura Y, Nakanuma Y.
- Journal Title
  
  Am J Pathol 174(3)
  
  Pages: 829-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Histone deacetylase inhibitor (SAHA) and repression ofEZH2 synergistically inhibit proliferation of gallbladder carcinoma2009
- Author(s)
  Yamaguchi J, Sasaki M, et al.
- Journal Title
  
  Cancer Sci (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Polycomb group protein Bmil is overexpressed and essential in anchorage-independent colony formation, proliferation and repression of cell ular senescence in cholangiocarinoma : tissue and culture studies2009
- Author(s)
  Sasaki M, et al
- Journal Title
  
  Hum Pathol 40
  
  Pages: 1723-1730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Papillary hyperplasia of the gallbladder in pancreaticobiliary malfunction represents a senescence-related lesion induced by lysolecithin2009
- Author(s)
  Yamaguchi J, Sasaki M, Harada K, Zen Y, Sato Y, Ikeda H, Itatsu K, Yokoyama Y, Ando H, Ohta T, Kubota A, Shimizu K, Nimura Y, Nagino M, Nakanuma Y.
- Journal Title
  
  Lab Invest 89(9)
  
  Pages: 1018-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha2009
- Author(s)
  Itatsu K, Sasaki M, et al
- Journal Title
  
  Am J Pathol 174
  
  Pages: 829-841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] 胆道癌の病理診断2009
- Author(s)
  中沼安二, 原田憲一, 木村康, 佐藤保則, 佐々木素子, 池田博子
- Journal Title
  
  消化器外科 32
  
  Pages: 1715-25
- NAID
  120005308286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Papillary hyperplasia of the gallbladder in pancreatobiliary maljunction represents a senescence-related lesion induced by lysolecithin2009
- Author(s)
  Yamaguchi J, Sasaki M, et al.
- Journal Title
  
  Lab Invest 89
  
  Pages: 1018-1031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Polycomb group protein Bmil is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in cholangiocarcinoma Tissue and culture studies2009
- Author(s)
  Sasaki M, Yamaguchi J, Ikeda H, Itatsu K, Nakanuma Y.
- Journal Title
  
  Hum Pathol 40(12)
  
  Pages: 1723-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors : an immunohistochemical approach2009
- Author(s)
  Nakanuma Y, Zen Y, Harada K, Ikeda H, Sato Y, Uehara T, Sasaki M.
- Journal Title
  
  J Hepatobiliary Pancreat Surg (In press)
- NAID
  10027422376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Polycomb group proteinBmi1 is overexpressed and essential inanchorage-independent colony formation, proliferation and repression of cellularsenescence in cholangiocarinoma : tissue andculture studies2009
- Author(s)
  Sasaki M, (他5名)
- Journal Title
  
  Hum Pathol
  
  Volume: 40 Pages: 1723-1730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590366
[Journal Article] Phosphorylation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and nuclear translocation of nuclear factor-kB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-α2009
- Author(s)
  Itatsu, K., Sasaki, M., Nakanuma, Y., (他8名)
- Journal Title
  
  Liver Int 29(2)
  
  Pages: 291-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Phosphorylation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and nuclear translocation of nuclear factor-kB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-α2009
- Author(s)
  Itatsu K, Sasaki M, Harada K, Yamaguchi J, Ikeda H, Sato Y, Ohta T, Sato H, Nagino M, Nimura Y, Nakanuma Y.
- Journal Title
  
  Liver Int 29(2)
  
  Pages: 291-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Over-expression of polycomb group protein EZH2 relates to decreased expression of p16(INK4a) in cholangiocarcinogenesis in hepatolithiasis2008
- Author(s)
  Sasaki, M., Yamaguchi, J., Nakanuma, Y., (他2名)
- Journal Title
  
  J Pathol 215(2)
  
  Pages: 175-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence2008
- Author(s)
  Sasaki M, Ikeda H, Yamaguchi J, et.al.
- Journal Title
  
  Hepatology 48
  
  Pages: 186-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression andaggressive biological behavior of hepatocellular carcinoma2008
- Author(s)
  Sasaki M, Ikeda H, Itatsu K, et.al.
- Journal Title
  
  Lab Invest 88
  
  Pages: 873-882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway : a culture study2008
- Author(s)
  Sasaki M, Ikeda H, Sato Y, et.al.
- Journal Title
  
  Free Radic Res 42
  
  Pages: 625-632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis2008
- Author(s)
  Sasaki M, Yamaguchi J, Itatsu K, et.al.
- Journal Title
  
  J Pathol 215
  
  Pages: 175-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p^<21WAF1/Cip1> in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis : an immunohistochemical study.2008
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  J Autoimmun 31
  
  Pages: 73-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence2008
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Hepatology 48
  
  Pages: 186-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mitoinhibitory p^<21WAF1/Cip1> in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis : an immunohistochemical study2008
- Author(s)
  Sasaki M, Ikeda H, Nakanuma Y
- Journal Title
  
  J Autoimmun 31
  
  Pages: 73-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Tumor necrosis factor-alpha induces the aberrant expression of mucus core protein-2 in non-neoplastic biliary epithelial cells via the upregulation of CDX2 in chronic cholangitis2008
- Author(s)
  Ikeda H, Sasaki M, Ohira S, et.al.
- Journal Title
  
  Hepatol Res 38
  
  Pages: 1006-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Express of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts.2008
- Author(s)
  Itatsu K, Zen Y, Yamaguchi J, Ohira S, Ishikawa A, IKeda H, Sato Y, Harada K, Sasaki M, Sasaki M, Sakamoto H, Nagino M, Nimufa Y, Ohta T, Nakanuma Y.
- Journal Title
  
  Hum Pathol. 39
  
  Pages: 710-719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21^<WAF1/Cip1> in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study2008
- Author(s)
  Sasaki M, Ikeda H, Nakanuma Y.
- Journal Title
  
  J Autoimmun 31
  
  Pages: 73-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress andactivation of ATM pathway : a culture study.2008
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Free Radic Res 42
  
  Pages: 625-632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Over-expresaon of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis.2008
- Author(s)
  Sasaki M, Yamaguchi J, Itatsu K, Ikeda H, Nakanuma Y.
- Journal Title
  
  J Pathol. 215
  
  Pages: 175-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] 粘液産生胆管腫瘍と粘液性嚢胞性胆管腫瘍-両者の鑑別と膵と比較しての問題点-2008
- Author(s)
  中沼安二、佐々木素子、全陽
- Journal Title
  
  胆と膵 29(6)
  
  Pages: 479-485
- NAID
  120005478846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliarv system: Physiological disfribution and pathobgical significance2007
- Author(s)
  M. Sasaki, H. lkeda, Y. Nakanuma
- Journal Title
  
  Prog Histochem Cytochem 42
  
  Pages: 61-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Naturally-occurring regulatory T cells are increased in infl.amed portal tracts with cholangiopathy in primary biliary cirrho-sis2007
- Author(s)
  Sasaki M, et. al.
- Journal Title
  
  J CIin Pathol 60
  
  Pages: 1102-1107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture2007
- Author(s)
  Ikeda, H., Sasaki, M., Nakanuma, Y., (他5名)
- Journal Title
  
  Lab Invest 87(6)
  
  Pages: 559-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture2007
- Author(s)
  Ikeda H, Sasaki M, Ishikawa A, et.al.
- Journal Title
  
  Lab Invest 87
  
  Pages: 559-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis2007
- Author(s)
  Sasaki M, Ikeda H, Sawada S, et.al.
- Journal Title
  
  J Clin Pathol 60
  
  Pages: 1102-1107
- NAID
  120001716662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis.2007
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  Journal of Clinical Pathology (in press)
- NAID
  120001716662
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Expression profiles of MUC mucins and trefoil factor family (TFF)peptides in the intrahepatic biliary system:physiologi-cal distribution and pathblogical significance2007
- Author(s)
  Sasaki M, et. al.
- Journal Title
  
  Prog Histochem Cytochem 42
  
  Pages: 61-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] ntraductal papillary cholangiocarcinoma and atypical biliary epithelial lesions confused with intrabiliary extension of metastatic colorectal carcinoma2007
- Author(s)
  K. ltatsu, T. Fujii, M. Sasaki, Y. Zen, Y. Nakanuma
- Journal Title
  
  Hepatogastroenterology 54
  
  Pages: 677-680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390098
[Journal Article] Hepatocellular carcinoma arising in primary biliary cirrhosis presenting with nodular regenerative hyperplasia : report of an autopsy case.2006
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  Journal of Gastroenterology and Hepatology 21・12
  
  Pages: 1866-1868
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Augmented expression of hepatocytes growth factor activator inhibitor type 1 (HAI-1) in intrahepatic small bile ducts in primary biliary cirrhosis2006
- Author(s)
  Sasaki M, Ikeda H, Kataoka H, et.al.
- Journal Title
  
  Virchows Arch 449
  
  Pages: 462-471
- NAID
  120000809447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Augmented expression of hepatocytes growth factor activator inhibitor type 1(HAI-1)in intrahepatic small bile ducts in primaly biliary cirrhosis.2006
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  Virchows Archieves 449・4
  
  Pages: 462-471
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Decreased expression of bmil is closely associated with cellular senescence in small bite ducts in primary biliary cirrhosis.2006
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  American Journal of Pathology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Decreased expression of bmil is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis2006
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  American Journal of Pathology (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Decreased expression of Bmil is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis.2006
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  American Journal of Pathology 169・3
  
  Pages: 831-845
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis2006
- Author(s)
  Sasaki M, Ikeda H, Sato Y, et.al.
- Journal Title
  
  Am J Pathol 169
  
  Pages: 831-845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590325
[Journal Article] Expression profiles of MUC mucin core protein in the intrahepatic biliary system : Physiological distribution and pathological significance.2005
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Acta Histochemica et Cytochemica 38(5)
  
  Pages: 295-303
- NAID
  110003502638
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Are bile duct lesions of primary biliary cirrhosis distinguishable from those of autoimmune hepatitis and chronic viral hepatitis? Interobserver histological agreement on trimmed bile ducts.2005
- Author(s)
  Zen Y, Harada K, Sasaki M, et al.
- Journal Title
  
  Journal of Gastroenterology 40(2)
  
  Pages: 164-170
- NAID
  10014513650
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Expression profiles of MUC mucin core protein in the intrahepatic biliary system : Physiological distribution and pathological significance2005
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  Acta Histochemica et Cytochemica 38・5
  
  Pages: 295-303
- NAID
  110003502638
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Frequent cellular senescence in small bile ducts in primary biliary cirrhosis : a possible role in bile duct loss.2005
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Journal of Pathology 205(4)
  
  Pages: 451-459
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Frequent cellular senescence in small bile ducts in primary biliary cirrhosis : a possible role in bile duct loss.2005
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  Journal of Pathology 205・4
  
  Pages: 451-459
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss2005
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  Journal of Pathology 205・4
  
  Pages: 451-459
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Expression profiles of MUC mucin core protein in the intrahepatic biliary system: Physiological distribution and pathological significance2005
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  Acta Histochemica et Cytochemica 38・5
  
  Pages: 295-303
- NAID
  110003502638
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] 原発性胆汁性肝硬変(PBC)における胆管消失の分子機構: 胆管消失は再生不良によるか?2004
- Author(s)
  佐々木素子
- Journal Title
  
  十全医学会雑誌 113・2
  
  Pages: 61-65
- NAID
  110002966229
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Expression of trefoil factor family-1, 2, and 3 is augmented in hepatolithiasis2004
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  Peptides 25・5
  
  Pages: 763-770
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] The molecular mechanism for the bile duct loss in primary biliary cirrhosis. (in Japanese)2004
- Author(s)
  Sasaki M
- Journal Title
  
  Journal of the Juzen Medical Society 113(2)
  
  Pages: 61-65
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] The destruction of bile duct may be related to the cellular senescence in primary biliary cirrhosis.2004
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Kan Tan Sui 49(8)
  
  Pages: 185-190
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology.2004
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Liver International 24(1)
  
  Pages: 29-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] PBCの胆管破壊: Cellular senescenceとの関連性2004
- Author(s)
  佐々木素子. 他
- Journal Title
  
  肝胆膵 49・8
  
  Pages: 185-190
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Expression of Trefoil factor family-1,2, and 3 is Augmented in Hepatolithiasis2004
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  Peptides 25・5
  
  Pages: 763-770
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and DMBT1 in normal and diseased intrahepatic bile ducts relates to biliary2004
- Author(s)
  Motoko Sasaki, et al.
- Journal Title
  
  Liver International 24・1
  
  Pages: 29-37
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] Expression of trefoil factor family 1, 2, and 3 peptide is augmented in hepatolithiasis.2004
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Peptides 25(5)
  
  Pages: 763-770
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] PBCの胆管破壊:Cellular senescenceとの関連性2004
- Author(s)
  佐々木素子, 他
- Journal Title
  
  肝胆膵 49・8
  
  Pages: 185-190
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] 原発性胆汁性肝硬変(PBC)における胆管消失の分子機構:胆管消失は再生不良によるか?2004
- Author(s)
  佐々木素子
- Journal Title
  
  十全医学会雑誌 113・2
  
  Pages: 61-65
- NAID
  110002966229
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] The role of trefoil factor family-1,2,3 in the intrahepatic biliary mucosa. (in Japanese)2003
- Author(s)
  Sasaki M, et al.
- Journal Title
  
  Digestive organ and Molecular Immunology 40
  
  Pages: 89-92
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Journal Article] 肝内胆管粘膜免疫における粘膜再生因子 Trefoil factor family-1,2,3の役割2003
- Author(s)
  佐々木素子, 中沼安二
- Journal Title
  
  消化器と免疫 40
  
  Pages: 89-92
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590297
[Presentation] 混合型肝癌, 肝内胆管癌におけるFGFR2発現：臨床病理学的解析2023
- Author(s)
  佐々木素子佐藤　保則　中沼安二
- Organizer
  第59回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] Expression and clinicopathological significance of fibroblast growth factor receptor 2 (FGFR2) in combined hepatocellular-cholangiocarcinoma.2023
- Author(s)
  Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
- Organizer
  The Liver Meeting 2023 (November 9-13, Boston) Nov 13, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] A heterogeneous subtype of biliary epithelial senescence may be involved in the pathogenesis of primary biliary cholangitis.2023
- Author(s)
  Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
- Organizer
  The Liver Meeting 2023 (November 9-13, Boston) Nov 13, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] 教育講演33　胆道疾患の病理2023
- Author(s)
  佐々木素子
- Organizer
  第59回臨床放射線学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] 胆管系肝腫瘍におけるmethylthioadenosine phosphorylase (MTAP)発現欠失の臨床病理学的意義2023
- Author(s)
  佐々木素子佐藤保則　中沼安二
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] 小型胆管型肝内胆管癌の前癌/早期癌病変の確立：臨床病理学的検討2023
- Author(s)
  佐々木素子佐藤保則　中沼安二
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] 胆管腺腫における遺伝子異常の解析：小型胆管型肝内胆管癌の前癌病変の同定を目指して2022
- Author(s)
  佐々木　素子, 佐藤　保則　中沼安二
- Organizer
  第58回肝癌研究会（5/12-13, 虎ノ門ヒルズフォーラム, 東京）
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] 原発性胆汁性胆管炎の胆管病変におけるHippo-yes-associated protein (YAP)経路の関与と細胞老化との関連2022
- Author(s)
  佐々木　素子佐藤　保則　中沼安二
- Organizer
  第58回日本肝臓学会総会（6/2, 3, パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] Nestinは肝内胆管癌の亜分類（小型胆管型 vs大型胆管型）に有用か？2022
- Author(s)
  佐々木　素子, 佐藤　保則
- Organizer
  第58回胆道学会　(10/13, 14 パシフィコ横浜)
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] AASLD/JSH Symposium: Women's Health. Liver Masses in Women: Adenomas & HCC.2022
- Author(s)
  Motoko Sasaki
- Organizer
  The Liver Meeting 2022 (November 4-8, Washington D.C.)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] 画像上悪性腫瘍と鑑別困難であったが, 肝腫瘍生検により診断し得た良性病変の４症例2022
- Author(s)
  金秀基, 藤井貴子, 金守良, 小林久人, 奥田豊一, 中島収, 隈部力, 佐々木素子, 狛雄一朗
- Organizer
  第58回肝癌研究会（5/12-13, 虎ノ門ヒルズフォーラム, 東京）
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] 原発性肝癌の背景肝における多発胆管腺腫の臨床病理学的意義2022
- Author(s)
  佐々木　素子佐藤　保則　中沼安二
- Organizer
  第111回日本病理学会総会（4/14-16; 神戸国際会議場, 神戸）
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] An involvement of hippo-yes-associated protein (yap) pathway and its association with biliary epithelial senescence in the pathogenesis of primary biliary cholangitis2022
- Author(s)
  Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
- Organizer
  The Liver Meeting 2022 (November 4-8, Washington D.C.)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06957
[Presentation] 特別講演　胆道腫瘍アップデート　-WHO分類2019と新規約のポイント-2020
- Author(s)
  佐々木　素子
- Organizer
  第24回日本病理学会中部支部スライドセミナー (2021年 3月 6日　愛知県がんセンター (WEB))
- Invited
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 胆管生検の良悪性診断に有用なバイオマーカーの探索2020
- Author(s)
  佐々木　素子, 佐藤　保則
- Organizer
  第１０9回日本病理学会総会（会期4/16-18; 福岡国際会議場；WEB開催）
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 胆道癌におけるLong interspersed nucleotide factor-1 （LINE-1）ORF1p発現とその臨床病理学的意義の検討2020
- Author(s)
  佐々木素子　佐藤保則
- Organizer
  第56回胆道学会総会　（会期10/1-2; WEB開催）
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 原発性肝癌におけるNestin発現と臨床病理学的意義の検討2020
- Author(s)
  佐々木素子　佐藤保則中沼安二
- Organizer
  第56回肝癌研究会2020　（会期12/22-23; WEB開催）
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] Increased expression of interferon- induced protein with tetratricopeptide repeats 3 (Ifit3) in senescent biliary epithelial cells may play a role in the pathogenesis of primary biliary cholangitis2020
- Author(s)
  Motoko Sasaki, Yasunori Sato and Yasuni Nakanuma
- Organizer
  AASLD The Liver Meeting Digital Experience; 2020.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 胆管腺腫は小型胆管型（small duct type）肝内胆管癌の前癌病変か？2020
- Author(s)
  佐々木素子　佐藤保則中沼安二
- Organizer
  第56回日本肝臓学会総会（8/28, 29 大阪国際会議場/WEB）
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] Increased p16INK4a-expressing senescent biliary epithelial cells in ductular reactions is associated with inadequate response to ursodeoxycholic acid and could be a target of senolytic elimination in primary biliary cholangitis2019
- Author(s)
  Motoko Sasaki, Yasunori Sato and Yasuni Nakanuma
- Organizer
  AASLD The Liver Meeting 2019 (Boston, November 8-12)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] Altered expression of various inflammation and immune-related genes in senescent biliary epithelial cells relating to primary biliary cholangitis2019
- Author(s)
  Motoko Sasaki, Yasunori Sato
- Organizer
  Asian Pacific Association for the Study of the Liver Single Topic Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 原発性胆汁性胆管炎における胆管細胞老化と臨床病理学的特徴の関連2019
- Author(s)
  佐々木素子　佐藤保則
- Organizer
  第55回日本肝臓学会総会（会期5/30-31; 京王プラザホテル）
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 胆管検体の病理診断におけるInsulin-like growth factor II mRNA-binding protein 3 (IMP3)　免疫染色の有用性2019
- Author(s)
  佐々木素子　佐藤保則
- Organizer
  第55回胆道学会 (2019年10月3, 4日　名古屋)
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 末梢型-肝内胆管癌の前癌病変の探索2019
- Author(s)
  佐々木　素子, 佐藤　保則
- Organizer
  第１０８回日本病理学会総会（会期5/9-11; 東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] パネルディスカッション4「混合型肝癌の亜分類」　混合型肝癌・細胆管癌の組織学的分類と遺伝子異常2019
- Author(s)
  佐々木素子
- Organizer
  第55回肝癌研究会 (2019年7月4, 5日　東京)
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 肝癌の背景肝における胆管腺腫, 胆管微小過誤腫/von Meyenburg complexの発生状況と臨床病理学的意義の検討2019
- Author(s)
  佐々木素子　佐藤保則　中沼安二
- Organizer
  第55回肝癌研究会 (2019年7月4, 5日　東京)
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 自己免疫性肝疾患の診断と治療の進歩」原発性胆汁性胆管炎の病態における胆管細胞老化の意義と治療標的としての可能性2018
- Author(s)
  佐々木素子
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 遺伝子異常を基盤とした胆管系分化を伴う肝癌の組織亜分類2018
- Author(s)
  佐々木素子　佐藤保則　中沼安二
- Organizer
  第54回肝癌研究会
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 混合型肝癌・細胆管癌におけるSWI/SNFクロマチンリモデリング遺伝子群異常の臨床病理学的意義2018
- Author(s)
  佐々木素子　佐藤保則　中沼安二
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] Biliary epithelial senescence may play a critical role in the pathogenesis and could be a target of senolytic therapy in primary biliary cholangitis2018
- Author(s)
  Motoko Sasaki, Yasunori Sato and Yasuni Nakanuma
- Organizer
  AASLD The Liver Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 混合型肝癌・細胆管癌の遺伝子異常と臨床病理学的特徴との関連2018
- Author(s)
  佐々木素子　佐藤保則　中沼安二
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 低分子デキストラン製剤が骨髄に沈着し貧血の原因と考えられた維持透析症例の解析2018
- Author(s)
  杉森尚美, 中村万理, 原田憲一, 佐々木素子, 経田克則, 中川詩織, 原章規, 古市賢吾
- Organizer
  第 80 回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] ARID1A alterations may be related to “ductal plate malformation” pattern in cholangiolocellular carcinoma and combined hepatocellular carcinoma-cholangiocarcinoma2018
- Author(s)
  Motoko Sasaki, Yasunori Sato and Yasuni Nakanuma
- Organizer
  AASLD The Liver Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 若年男性に発症したbeta-catenin活性化型肝細胞腺腫の1例2018
- Author(s)
  米田憲秀, 北尾梓, 小坂一斗, 出雲崎晃, 小森隆弘, 井上大, 蒲田敏文, 小林聡, 山口貴久, 高村博之, 太田哲生, 大坪公士郎, 中村律子, 佐々木素子
- Organizer
  第 32 回日本腹部放射線学会
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] AT-rich interactive domain-containing protein 1A (ARID1A)発現消失を示す胆管性結節は肝内胆管癌の前癌病変か？2018
- Author(s)
  佐々木素子　佐藤保則
- Organizer
  第54回日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06985
[Presentation] 胆道閉鎖症の進展における胆管細胞老化の関与2017
- Author(s)
  佐々木素子　佐藤保則
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-15K08341
[Presentation] Impaired biliary bicarbonate umbrella may play a central role in deregulated autophagy and cellular senescence in cholangiocytes in primary biliary cholangitis2017
- Author(s)
  Motoko Sasaki, Yasuni Nakanuma
- Organizer
  AASLD The Liver Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08341
[Presentation] Bile acids and cholangiocyte autophagy2016
- Author(s)
  Sasaki M, Nakanuma Y
- Organizer
  The XXIV International Bile Acid Meeting“Bile Acids in Health and Disease”
- Place of Presentation
  Dusseldorf, Germany
- Year and Date
  2016-06-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08341
[Presentation] WS3-9　自己免疫性肝疾患の今後の展開：原発性胆汁性肝硬変における胆管病変の発生進展機序：胆管細胞老化,オートファジー異常, 重炭酸アンブレラ破綻の関与2016
- Author(s)
  佐々木素子
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  千葉
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K08341
[Presentation] Impaired biliary bicarbonate umbrella may play a central role in deregulated autophagy and cellular senescence in cholangiocytes in primary biliary cholangitis2016
- Author(s)
  Motoko Sasaki, Yasuni Nakanuma
- Organizer
  AASLD The Liver Meeting 2016
- Place of Presentation
  Boston, USA
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08341
[Presentation] シンポジウム1「PBC（原発性胆汁性肝硬変）」原発性胆汁性肝硬変の胆管オートファジー異常発生における小胞体ストレスの役割2015
- Author(s)
  佐々木素子,　吉村茉沙美, 佐藤保則, 中沼安二
- Organizer
  第52回消化器免疫学会総会
- Place of Presentation
  京王プラザホテル, 東京
- Year and Date
  2015-07-30
- Data Source
  KAKENHI-PROJECT-15K08341
[Presentation] Increased expression of ORM1-like protein 3 (ORMDL3) in biliary epithelial cells may be related to the pathogenesis of primary biliary cirrhosis.2015
- Author(s)
  Motoko Sasaki, Yasunori Sato and Yasuni Nakanuma
- Organizer
  The Liver Meeting 2015
- Place of Presentation
  Moscone West Convention Center, San Francisco
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-15K08341
[Presentation] 原発性胆汁性肝硬変の胆管上皮におけるORM1-like protein 3(ORMDL3)発現とその意義2015
- Author(s)
  佐々木　素子, 吉村茉沙美　佐藤保則　中沼　安二.
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本, 熊本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K08341
[Presentation] 肝内小型胆管のミトコンドリア蛋白異常発現は原発性胆汁性肝硬変の移植後再発の有用な診断マーカーである。2015
- Author(s)
  佐々木　素子, 　中沼　安二
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  ホテル日航熊本, 熊本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K08341
[Presentation] ミトコンドリア蛋白陽性炎症細胞と原発性胆汁性肝硬変の胆管病変との関連2013
- Author(s)
  佐々木　素子, 角田　優子, 佐藤　保則, 中沼　安二
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル, 東京
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] 原発性胆汁性肝硬変の胆管病変におけるautophagy異常、ミトコンドリア蛋白発現亢進と細胞老化の関与2013
- Author(s)
  佐々木　素子, 中沼　安二
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京グランドプリンスホテル新高輪, 東京
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] 原発性胆汁性肝硬変におけるミトコンドリア蛋白陽性炎症細胞の分布とその意義2013
- Author(s)
  佐々木素子
- Organizer
  第99回消化器病学会
- Place of Presentation
  かごしま県民交流センター（鹿児島市)
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] 原発性胆汁性肝硬変(PBC)における肝幹細胞/前駆細胞と病期との関連について2013
- Author(s)
  角田　優子, 原田　憲一, 池田　博子, 岡藤　啓史, 佐藤　保則, 佐々木　素子, 水腰　英四郎, 金子　周一, 中沼　安二
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル, 東京
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and intraepithelial layer may be involved to the pathogenesis in primary biliary cirrhosis2013
- Author(s)
  Sasaki M, et al.
- Organizer
  102nd Annual Meeting of the United States 　and Canadian Academy of Pathology
- Place of Presentation
  Baltimore Convention Center. (Baltimore, USA)
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] 原発性胆汁性肝硬変におけるORM1-like protein 3 (ORMDL3) 発現細胞と胆管病変との関連2013
- Author(s)
  佐々木　素子, 角田優子,　佐藤保則,　中沼安二
- Organizer
  肝臓学会西部会
- Place of Presentation
  長良川国際会議場、岐阜市
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] Infiltration of macrophages and plasma cells with coarse granular expression of mitochondrial proteins around bile ducts and intraepithelial layer may be involved in the pathogenesis of bile duct lesions in primary biliary cirrhosis2013
- Author(s)
  Sasaki M, Kakuda Y, Miyakoshi M, Sato Y, Nakanuma Y
- Organizer
  AASLD: The Liver Meeting 2013
- Place of Presentation
  Walter E. Washington convention center. Washington DC, USA
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] Correlation of destruction of canals of Hering with the progression of the primary biliary cirrhosis stage2013
- Author(s)
  Kakuda Y, Harada K, Ikeda H, Sato Y, Sasaki M, Nakanuma Y
- Organizer
  AASLD: The Liver Meeting 2013
- Place of Presentation
  Walter E. Washington convention center. Washington DC, USA
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] 原発性胆汁性肝硬変の胆管病変におけるCCL2/CCR2, CX3CL1/CX3CR1系の関与2013
- Author(s)
  佐々木素子
- Organizer
  第99回消化器病学会
- Place of Presentation
  かごしま県民交流センター（鹿児島市)
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] Chemokines CCL2 and CX3CL1 as senescence-associated secretory phenotypes may play a role in aggravated inflammation in primary biliary cirrhosis2012
- Author(s)
  Sasaki M, et al.
- Organizer
  63th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes convention center (Boston, USA)
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] 原発性胆汁性肝硬変の胆管病変におけるミトコンドリア蛋白発現の亢進とオートファジー異常2012
- Author(s)
  佐々木素子
- Organizer
  第48回肝臓学会総会
- Place of Presentation
  石川県立音楽堂 (金沢市)
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] The deregulated autophag y of mitochondria may be involved in the pa thogenesis in primary biliary cirrhosis2012
- Author(s)
  Sasaki M, et al
- Organizer
  101st Annual Meeting of the United States and Canadian Academy of Pathology
- Place of Presentation
  Vancouver convention center, Canada
- Year and Date
  2012-03-19
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] The deregulated autophagy of mitochondria may be involved in the pathogenesis in primary biliary cirrhosis2012
- Author(s)
  Sasaki M, et al
- Organizer
  101st Annual Meeting of the United States and Canadian Academy of Pathology
- Place of Presentation
  Vancouver convention center (Vancouver, Canada)
- Year and Date
  2012-03-19
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 原発性胆汁性肝硬変の胆管病変に特徴的なミトコンドリアのオートファジーは胆管上皮細胞特異的か？2012
- Author(s)
  佐々木素子
- Organizer
  第16回肝臓学会大会
- Place of Presentation
  神戸国際会議場　（神戸市）
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] Intraepithelial infiltration of ORM1-like protein 3 (ORMDL3) –expressing cells may be closely related to the pathogenesis of primary biliary cirrhosis2012
- Author(s)
  Sasaki M, et al.
- Organizer
  63th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes convention center (Boston, USA)
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] パネルデスカッション2:自己免疫性肝疾患の病態と治療:原発性胆汁性肝硬変の胆管病変におけるsenescence-associated secretory phenotypes (SASP)の関与2011
- Author(s)
  佐々木素子
- Organizer
  第39回肝臓学会西部会
- Place of Presentation
  岡山コンベンションセンター(岡山)
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 原発性胆汁性肝硬変の細胆管反応におけるオートファジーの関与2011
- Author(s)
  佐々木素子
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] Increased expression of mitochondrial proteins associated with autophagy in the biliary epithelial lesions in primary biliary cirrhosis2011
- Author(s)
  Sasaki M, et al
- Organizer
  62th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Moscone West convention center, USA
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] ワークショップ11「自己免疫性肝疾患upgrade」原発性胆汁性肝硬変の胆管病変におけるオートファジー異常2011
- Author(s)
  佐々木素子
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  ホテルグランパシフィック・LE DAIBA(東京)
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] パネルデスカッション2 :自己免疫性肝疾患の病態と治療:原発性胆汁性肝硬変の胆管病変におけるsenescence-associated secretory phenotypes(SASP)の関与2011
- Author(s)
  佐々木素子
- Organizer
  第39回肝臓学会西部会
- Place of Presentation
  岡山コンベンションセンター,岡山
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 非アルコール性脂肪性肝炎における線維性隔壁及び門脈域の線維化の進展と細胆管反応:細胞老化との関連性2011
- Author(s)
  千葉真由美, 佐々木素子
- Organizer
  第48回消化器免疫学会総会
- Place of Presentation
  エクセルホテル金沢(石川)
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] Increased expression of mitochondrial proteins associated with autophagy in the biliary epithelial lesions in primary biliary cirrhosis2011
- Author(s)
  Sasaki M, et al
- Organizer
  62th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Moscone West convention cencer (San Francisco, USA)
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 原発性胆汁性肝硬変の胆管病変におけるミトコンドリア蛋白の発現2011
- Author(s)
  佐々木素子
- Organizer
  第48回消化器免疫学会総会
- Place of Presentation
  エクセルホテル金沢,石川
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] ワークショップ11「自己免疫性肝疾患upgrade」原発性胆汁性肝硬変の胆管病変におけるオートファジー2011
- Author(s)
  佐々木素子
- Organizer
  異常第47回日本肝臓学会総会
- Place of Presentation
  ホテルグランパシフィック・LE DAIBA,東京
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 原発性胆汁性肝硬変の胆管病変におけるミトコンドリア蛋白の発現2011
- Author(s)
  佐々木素子
- Organizer
  第48回消化器免疫学会総会
- Place of Presentation
  エクセルホテル金沢(石川)
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 細胞老化に着日した肝胆道系疾患の解明2010
- Author(s)
  佐々木素子
- Organizer
  第46回肝形態科学研究会
- Place of Presentation
  ホテルメトロポリタン山形(山形)
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 肝臓学会特別企画「肝臓病理1日コース4-1」細胆管反応と肝疾患2010
- Author(s)
  佐々木素子
- Organizer
  第14回日本肝臓学会大会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] シンポジウム2「肝胆膵疾患の免疫病態の新たな展開」原発性胆汁性肝硬変での老化胆管細胞による免疫調節2010
- Author(s)
  佐々木素子, ら
- Organizer
  第47回消化器免疫学会総会
- Place of Presentation
  大津プリンスホテル(滋賀)
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] Autophagy may precede cellular senescence of bile ductular cells in ductuar reaction in primary biliary cirrhosis2010
- Author(s)
  Sasaki M, et al.
- Organizer
  61th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes convention center(Boston, USA)
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis2010
- Author(s)
  Sasaki M, et al
- Organizer
  61th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes convention center, USA
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis2010
- Author(s)
  Sasaki M, et al.
- Organizer
  61th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes convention center(Boston, USA)
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 原発性胆汁性肝硬変の老化胆管細胞によるケモカイン発現とその意義2010
- Author(s)
  佐々木素子, ら
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2010-04-28
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] Autophagy may precede cellular senescence of bile ductular cells in ductuar reaction in primary biliary cirrhosis2010
- Author(s)
  Sasaki M, et al
- Organizer
  61th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes convention center, USA
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 画像と病理の対比からみた肝内胆管系疾患の診断・病態解析画像と病理の対比からみた嚢胞形成性胆管腫瘍の臨床病理学的検討.2010
- Author(s)
  佐々木素子、米田憲秀、中沼安二
- Organizer
  第14回日本肝臓学会大会.
- Place of Presentation
  横浜パシフィコ(神奈川県)
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-19390098
[Presentation] 肝胆膵での上皮内腫瘍:病態解明と治療戦略胆道癌多段階発癌課程における細胞老化機構の制御異常.2010
- Author(s)
  佐々木素子、山口淳平、中沼安二
- Organizer
  第14回日本肝臓学会大会.
- Place of Presentation
  横浜パシフィコ(神奈川県)
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-19390098
[Presentation] WS2「自己免疫性肝疾患研究の進歩」原発性胆汁性肝硬変の胆管細胞老化におけるオートファジーの関与2010
- Author(s)
  佐々木素子, ら
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  ホテルメトロポリタン山形(山形)(招待講演)
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] A modulation of microenvironment by senescent biliary epithelial cells in the pathogenesis of bile duct lesions in primary biliary cirrhosis2009
- Author(s)
  佐々木素子, et al.
- Organizer
  60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
- Place of Presentation
  John B. Hynes Convention Center, Boston, USA
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 細胞老化に着目した肝胆道系疾患の発生・進展機構の解明2009
- Author(s)
  佐々木素子
- Organizer
  第55回日本病理学会秋期特別総会
- Place of Presentation
  京王プラザホテル,東京
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] ヒストン脱アセチル化酵素阻害剤 (SAHA) およびEZH2抑制による胆嚢癌増殖抑制効果2009
- Author(s)
  山口淳平, 佐々木素子, 原田憲一, 佐藤保則, 池田博子, 梛野正人, 中沼安二
- Organizer
  第45回日本胆道学会学術集会
- Place of Presentation
  アパホテル&リゾート東京ベイ幕張 (千葉県)
- Year and Date
  2009-09-19
- Data Source
  KAKENHI-PROJECT-19390098
[Presentation] ピストン脱アセチル化酵素阻害剤(SAHA)およびEZH2抑制による胆嚢癌増殖抑制効果2009
- Author(s)
  山口淳平、佐々木素子、原田憲一、佐藤保則、池田博子、椰野正人、中沼安二
- Organizer
  第45回日本胆道学会学術集会
- Place of Presentation
  東京ベイ幕張(千葉県)
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-19390098
[Presentation] 胆管癌の浸潤・転移機構における上皮-間葉転換(EMT)の関与2009
- Author(s)
  佐藤保則、下村修治、角田優子、池田博子、佐々木素子、原田憲一、中沼安二
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸ポートピアホテル(兵庫県)
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-19390098
[Presentation] 肝内胆管癌におけるポリコーム群蛋白 Bmil の発現とその意義2009
- Author(s)
  佐々木素子, ら
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都国際会議場, 京都
- Year and Date
  2009-05-01
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] A modulation of microenvironment by senescent biliary epithelial cells in the pathogenesis of bile duct lesions in primary biliary cirrhosis2009
- Author(s)
  Sasaki M, et al
- Organizer
  60th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes convention center, USA
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] A possible involvement of autophagy in the process of biliary epithelial senescence in primary biliary cirrhosis2009
- Author(s)
  Sasaki M, et al
- Organizer
  60th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes convention center, USA
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] ヒストン脱アセチル化酵素阻害剤 (SAHA) およびEZH2抑制による胆嚢癌増殖抑制効果2009
- Author(s)
  山口淳平, 佐々木素子, ら
- Organizer
  第45回胆道学会
- Place of Presentation
  アパホテル&リゾート, 東京ベイ幕張, 千葉
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 酸化ストレス、胆汁酸による障害胆管細胞における細胞老化、オートファジー、アポトーシスの関連の検討2009
- Author(s)
  宮腰茉沙美, 佐々木素子, ら
- Organizer
  第38回肝臓学会西部会
- Place of Presentation
  米子コンベンションセンター鳥取
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 肝疾患の細胆管反応 Ductular reaction における細胞老化の関与2009
- Author(s)
  佐々木素子, ら
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸ポートピアホテル, 兵庫
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 細胞老化に着目した肝胆道系疾患の発生・進展機構の解明2009
- Author(s)
  佐々木素子
- Organizer
  第55回日本病理学会秋期特別総会
- Place of Presentation
  九段会館, 東京
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 嚢胞形成性肝内胆管腫瘍の臨床病理学的検討2009
- Author(s)
  佐々木素子、中沼安二
- Organizer
  第45回日本胆道学会学術集会
- Place of Presentation
  東京ベイ幕張(千葉県)
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-19390098
[Presentation] A possible involvement of autophagy in the process of biliary epithelial senescence in primary biliary cirrhosis2009
- Author(s)
  佐々木素子, et al.
- Organizer
  60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
- Place of Presentation
  John B. Hynes Convention Center, Boston, USA
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-21590366
[Presentation] 肝内胆管癌におけるポリコーム群蛋白 Bmil の発現とその意義2009
- Author(s)
  佐々木素子, 山口淳平, 池田博子, 佐藤保則, 中沼安二
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館 (京都府)
- Year and Date
  2009-05-01
- Data Source
  KAKENHI-PROJECT-19390098
[Presentation] 肝内胆管癌におけるポリコーム群蛋白Bmi1の発現とその意義2009
- Author(s)
  佐々木素子、山口淳平、池田博子、佐藤保則、中沼安二
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2009-05-01
- Data Source
  KAKENHI-PROJECT-19390098
[Presentation] Cellular senescence of bile ductular cells may be involved in the pathophysiology in ductular reactions in chronicliver diseases. 59th Annual Meeting of the American Association for the Study of Liver Diseases2008
- Author(s)
  Sasaki M, et.al.
- Organizer
  AASLD
- Place of Presentation
  San Francisco
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] 原発性胆汁性肝硬変の傷害胆管におけるテロメア長短縮とその意義2008
- Author(s)
  佐々木素子ら
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-03
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] 老化機構解明のための病理学的アプローチ肝疾患における細胞老化の関与自己免疫性疾患から発癌まで.2008
- Author(s)
  佐々木素子ら
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢
- Year and Date
  2008-05-14
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] Cellular senescence of biliary epithelial cells characterizes the damaged small bile ducts in primary biliary cirrhosis.2008
- Author(s)
  Sasaki M, et al.
- Organizer
  59th Annual Meeting of the American Association for the study of Liver Diseases(AASLD)
- Place of Presentation
  San Francisco, USA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] Cellular senescence of bile ductular cells may be involved in the pathophysiology in ductular reactions in chronic liver diseases2008
- Author(s)
  Sasaki M, et.al.
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
- Place of Presentation
  San Francisco
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] 自己免疫性肝疾患研究に創流を求めて自己免疫性肝疾患の胆管病変(PBC, PSC, AIPの胆管病変).2008
- Author(s)
  佐々木素子ら
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-04
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] 老化機構解明のための病理学的アプローチ肝疾患における細胞老化の関与自己免疫性疾患から発癌まで2008
- Author(s)
  佐々木素子ら
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢
- Year and Date
  2008-05-14
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] Cellular senescence of bile ductular cells may be involved in thepathophysiology in ductular reactions in chronic liver diseases.2008
- Author(s)
  Sasaki M, et al.
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD)
- Place of Presentation
  San Francisco, USA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] MMP-7は大型胆管癌の予後不良因子である2008
- Author(s)
  板津慶太、全陽、池田博子、佐藤保則、原田憲一、佐々木素子、中沼安二
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  石川県立音楽堂(石川県)
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19390098
[Presentation] Cellular senescence of biliary epithelial cells characterizes the damaged small bile ducts in primary biliary cirrhosis2008
- Author(s)
  Sasaki M, et.al.
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
- Place of Presentation
  San Francisco
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] 自己免疫性肝疾患研究に創流を求めて自己免疫性肝疾患の胆管病変 (PBC, PSC, AIP の胆管病変)2008
- Author(s)
  佐々木素子ら
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-04
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] Cellular senescence of biliary epithelial cells characterizes the damaged small bile ducts in primary biliary cirrhosis. 59th Annual Meeting of the American Association for the Study of Liver Diseases2008
- Author(s)
  Sasaki M, et.al.
- Organizer
  AASLD
- Place of Presentation
  San Francisco
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] 慢性胆管炎のgoblet cell metaplasiaにおけるMUC2(腸型ムチン)発現の分子機構 tumor necrosisfactor(TNF)-αはCDX2発現を介してMUC2を誘導する2008
- Author(s)
  池田博子, 佐々木素子ら
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-03
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] 原発性胆汁性肝硬変の胆管細胞老化におけるATM (ataxiatelangiectasiamutated)/p53/p21経路の関与2007
- Author(s)
  佐々木素子ら
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] シンポジュム:胆道癌の発生機序胆道癌多段階発癌過程における癌遺伝子誘導性細胞老化(oncogene-inducedsenescence)と細胞老化エスケープ機構の関与2007
- Author(s)
  佐々木素子, 山口淳平, 板津慶太, 池田博子, 中沼安二
- Organizer
  第43回日本胆道学会学術集会
- Place of Presentation
  東京ドームホテル
- Year and Date
  2007-09-26
- Data Source
  KAKENHI-PROJECT-19390098
[Presentation] 慢性肝疾患における肝細胞め細胞老化(cellular senescence)とその意義2007
- Author(s)
  佐々木素子ら
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] 原発性胆汁性肝硬変の胆管細胞老化におけるATM(ataxia-telangiectasia mutated)1p53/p21経路の関与2007
- Author(s)
  佐々木素子ら
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-18590325
[Presentation] 原発性胆汁性肝硬変(PBC)の病期と肝前駆細胞
- Author(s)
  角田　優子, 原田　憲一, 池田　博子, 岡藤　啓史, 佐藤　保則, 佐々木　素子, 水腰　英四郎, 金子　周一, 中沼　安二
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ, 東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] WS4: 自己免疫性肝障害の病態と治療をめぐる問題点原発性胆汁性肝硬変の胆管病変発生機序における小胞体ストレス, オートファジー, 細胞老化の関与
- Author(s)
  佐々木素子　中沼安二
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ, 東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] A possible involvement of endoplasmic reticulum stress in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis.
- Author(s)
  Sasaki M, Yoshimura-Miyakoshi M, Sato Y, Nakanuma Y.
- Organizer
  The 65th Annual Meeting of American Association for the Study of Liver Diseases (AASLD)
- Place of Presentation
  Boston, Hynes convention center, USA.
- Year and Date
  2014-11-08 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590409
[Presentation] 原発性胆汁性肝硬変(PBC)の肝生検における新病期分類を用いた薬物治療反応性・予後予測の可能性
- Author(s)
  角田　優子, 原田　憲一, 北村　星子, 池田　博子, 佐藤　保則, 佐々木　素子, 中沼　安二
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場, 広島
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590409

1. NAKANUMA Yasuni (10115256)

# of Collaborated Projects: 10 results

# of Collaborated Products: 61 results
2. SATO Yasunori (30324073)

# of Collaborated Projects: 9 results

# of Collaborated Products: 45 results
3. HARADA Kenichi (30283112)

# of Collaborated Projects: 5 results

# of Collaborated Products: 18 results
4. TERADA Tadashi (30188677)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. TERASAKI Syuuichi (10251943)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OHTA Tetsuo (40194170)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. ZEN You (90377416)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. HOSO Masahiro (20219182)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SAITO Katsuhiko (10205635)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 常山幸一 (10293341)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. GERSHWIN M E

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MERIC Gershwin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKEUCHI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. OYAMA Takeru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 井上大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

sasaki motoko 佐々木 素子

佐々木 素子 ササキ モトコ

SASAKI Motoko 佐々木 素子

Research Projects

Research Products

Co-Researchers

老化細胞の多様性に着目した肝臓病の病態解明と新規治療薬候補の探索Principal Investigator

Principal Investigator

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Research Institution

老化細胞を標的とした原発性胆汁性胆管炎の新しい治療法開発Principal Investigator

Principal Investigator

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Review Section

Research Institution

Development of new therapy for liver disease by regulating cellular senescencePrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Involvement of dysregulated autophagy in autoimmune diseasesPrincipal Investigator

Principal Investigator

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Research Institution

Novel approach to primary biliary cirrhosis putting focus on deregulated autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel approach to liver disease from aspect of cellular senescencePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Pathogenesis of progressive bile duct loss in primary biliary cirrhosis : A possible involvement of cellular senescencePrincipal Investigator

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The molecular mechanism of the impaired regeneration of biliary epithelial cells in bile duct vanishing syndrome.Principal Investigator

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増生細胆管でのアポムチンサブタイプの発現とその意義：増生細胆管は肝ステムセルか？Principal Investigator

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sasaki motoko 佐々木素子

佐々木素子ササキモトコ

SASAKI Motoko 佐々木素子

[Book] 膵臓を診る医師のための膵臓病理テキスト　（中沼安二, 古川　徹, 福村由紀　編）III章　腫瘍性疾患の病理. 1. 嚢胞性腫瘍.2020

[Book] 腫瘍病理鑑別診断アトラス肝癌第２版　（坂元享宇, 原田憲一　編）　第２部　組織型と診断の実際　II. 胆管細胞系腫瘍　6. 胆管腺腫および類似病変.2020