OKOSHI SHOGO 大越章吾

… Alternative Names

OHKOSHI Shogo 大越章吾

OHGOSHI Shogo 大越章吾

OHKOSHI Showgo 大越章吾

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Researcher Number	70231199
Other IDs
Affiliation (Current)	2025: 日本歯科大学, 新潟生命歯学部, 教授 2025: 昭和大学, 医学部, 兼任講師
Affiliation (based on the past Project Information) *help	2014 – 2024: 日本歯科大学, 新潟生命歯学部, 教授 2013: 昭和大学, 医学部, 准教授 2011 – 2012: 昭和大学, 医学部, 講師 2008 – 2011: 新潟大学, 医歯学系, 講師 2010: 新潟大学, 医歯学総合病院, 講師 … More 2004 – 2006: 新潟大学, 医歯学総合病院, 講師 1999: NIIGATA UNIVERSITY, University Medical Hospital, ASSISTANT, 医学部・附属病院, 助手 1998: 新潟大学, 医学部附属病院, 助手 1993 – 1994: NIIGATA UNIVERSITY, HOSPITAL BLOOD TRANSFUSION DIVISON ASSISTANT, 医学部・附属病院, 助手 1992: 新潟大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 57040:Regenerative dentistry and dental engineering-related / Gastroenterology / Applied pharmacology / Gastroenterology Except Principal Investigator Basic Section 52010:General internal medicine-related / Gastroenterology / Gastroenterology / Respiratory organ internal medicine
Keywords	Principal Investigator 再生医療 / 肝細胞 / 間葉系幹細胞 / 歯髄バンク / 歯髄幹細胞 / ヒト細胞特異的PCR / 歯の細胞バンク / 歯髄細胞 / インターフェロン / 低酸素 … More / 免疫不全ラット / 組織生着率 / ヒト特異的プライマー / 肝炎モデル / 細胞動態 / 定量PCR / 免疫調節効果 / 細胞生着率 / 肝炎 / ヒトmRNA特異的PCR / 人工バイオ肝臓 / 脱落歯 / 薬剤スクリーニング / 動物モデル / 重症肝障害 / テーラーメード医療 / 薬剤毒性スクリーニング / ヒトDNA特異的PCR / 劇症肝炎 / テーラーメイド医療 / 肝脂肪化 / RBP4 / リバビリン / C型慢性肝炎 / Insulin抵抗性 / IFN / インスリン抵抗性 / Peg-IFN / RBP-4 / HCV / トランスジェニックマウス / ATM / HBx遺伝子 / DNA修復機構 / ウイルス発癌 / 肝細胞癌 / DNA修復 / 発癌予防 / IFNβ / 分子機序 / 発がん抑制 / 細胞内局在 / p21 / HBV / 肝癌 / 肝臓学 / 変異 / 慢性化 / qaasispecies / 輸血 / C型肝炎ウイルス … More Except Principal Investigator 睡眠時無呼吸症候群 / 肝細胞癌 / 脂肪肝 / 持続陽圧呼吸療法 / 非アルコール性脂肪性肝疾患 / 慢性間欠的低酸素 / 閉塞性睡眠時無呼吸症 / 動脈硬化 / 肝線維化 / NASH / 低酸素血症 / 非アルコール性脂肪肝炎 / In situ hybridization / HCV-RNA / フコース転移酵素 / 糖鎖 / 間欠的低酸素血症 / 睡眠時無呼吸 / RANTES / 非アルコール性脂肪肝疾患 / 持続陽圧呼吸 / 炎症 / SAS / 無呼吸指数 / 吹田スコア / ＳＡＳ / 血小板マイクロパーティクル / IL-18 / 血小板活性化 / マクロファージ / 動脈硬化リスク / トランスレーショナル研究 / 活性血小板 / 睡眠時無呼吸症 / CCL5 / 食道pH/インピーダンス検査 / 胃食道逆流症 / M2BPGi / フィブロスキャン / 肝障害 / NAFLD / 持続的陽圧呼吸療法 / CPAP / 夜間低酸素血症 / glycosyltransferase / gene therapy / sugar chain / Hepatocellular carcinoma / AFP / 糖鎖転移酵素 / 遺伝子治療 / treatment / Lens culinaris agglutinin / antisense oligonucleotide / hepatocellular carcinoma / fucosylation / Alpha 1-6 fucosyltransferase / 治療 / アンチセンス / HCV core protein / Hepatitis C virus / in situ hybridization / polymerase chain reaction / HCVエンベロープ / HCVコア / HCVコア蛋白 / HCVコア抗原 / HCVコア抗体 / HCV抗体 / C型肝炎ウイルス / FUT8 / フコシル化AFP / アルファフェトプロテイン / α1-6フコース転位酵素(FUT8) / アミノ酸一次構造 / アルファフェトプロテイン(AFP) Less

睡眠時無呼吸症に着目した、脂肪肝と動脈硬化ネットワークの解明とその改善法の提案
- Principal Investigator
  
  廣野玄
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  The Nippon Dental University
歯の細胞バンクが繋ぐ、口腔と消化器の歯科医科横断的再生医療Principal Investigator
- Principal Investigator
  
  大越章吾
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  The Nippon Dental University
消化管逆流の視点から考える、誤嚥性肺炎に対する新しい予防戦略の確立
- Principal Investigator
  
  渡邉和彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  The Nippon Dental University
Exploration of new clinical markers for arteriosclerosis that contribute the inhibition of vascular events induced by obstructive sleep apnea
- Principal Investigator
  
  Hasegawa Katsuhiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  The Nippon Dental University
Identification of NASH patients who obtain therapeutic benefit from the improvement of nocturnal intermittent hypoxia and its application for clinical practice.
- Principal Investigator
  
  Hirono Haruka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  The Nippon Dental University
Dissemination of messages for clinical application of dental pulp stem cells that have been stored in cell bank.Principal Investigator
- Principal Investigator
  
  Ohkoshi Shogo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  The Nippon Dental University
Establishment of new treatment strategy for sleep apnea syndrome with less burden on patients
- Principal Investigator
  
  Watanabe Kazuhiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  The Nippon Dental University
Regenetative medicine using decidouous teeth preparing for future diseasesPrincipal Investigator
- Principal Investigator
  
  Shogo Ohkoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  The Nippon Dental University
Establishment of new treatment strategy for NASH by elucidating the mechanisms of fibrosis progression due to nocturnal intermittent hypoxia.
- Principal Investigator
  
  HIRONO Haruka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The Nippon Dental University
Discovery of new insulin-resistance marker which determines the effect of IFN for chronic hepatitis CPrincipal Investigator
- Principal Investigator
  
  Ohkoshi Shogo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The Nippon Dental University
  Showa University
Development of new IFN-strategy that based on DNA repair mechanismPrincipal Investigator
- Principal Investigator
  
  OHKOSHI Shogo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Showa University
  Niigata University
Development of treatment strategy for patients with hepatocellular carcinoma using serum glycosylation modification
- Principal Investigator
  
  AOYAGI Yutaka (AOYGI Yutaka)
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Niigata University
TREATMENT OF PTIENTS WITH HEPATOCELLULAR CARCINOMA BY THE MODIFICATION OF SUGAR CHAIN.
- Principal Investigator
  
  AOYAGI Yutaka
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Niigata University
ALPHA-1-6 FUCOSYLTRANSFERASE ANTISENSE-OLIGONUCLEOTIDE THERAPY FOR HEPATOCELLULAR CARCINOMA.
- Principal Investigator
  
  AOYAGI Yutaka
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  NIIGATA UNIVERSITY
AFP遺伝子構造解析と高分化型微小肝癌の遺伝子診断に関する研究
- Principal Investigator
  
  AOYAGI Yutaka
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Niigata University
C型慢性肝疾患進展機構の解明Principal Investigator
- Principal Investigator
  
  大越章吾
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Niigata University
STUDY ON HEPATITIS C VIRUS ASSOCIATED PROTEIN AND GENOME IN THE HEPATOCYTES
- Principal Investigator
  
  KAMIMURA Tomoteru
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  NIIGATA UNIVERSITY

[Book] 専門医から伝えたい　歯科医院に知ってほしい　肝疾患のこと2019
- Author(s)
  大越　章吾
- Total Pages
  112
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-16K09564
[Book] 比較的若年の女性に起こった肝静脈閉塞症の一例,臨床消化器内科2006
- Author(s)
  塙孝泰, 大越章吾, 青木洋平, 竹内学, 山際訓, 松田康伸, 野本実, 青柳豊
- Total Pages
  6
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-16590582
[Journal Article] Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea2021
- Author(s)
  Hirono H、Watanabe K、Hasegawa K、Kohno M、Terai S、Ohkoshi　S
- Journal Title
  
  World J Clinical Cases
  
  Volume: 9 Pages: 5112-5125
- Open Access
- Data Source
  KAKENHI-PROJECT-21K07329
[Journal Article] Detection and quantification of human-specific mRNA from hepatocyte-like cells derived from dental pulp using real-time polymerase chain reaction2021
- Author(s)
  Shimamura N, Fujii K, Ohkoshi S
- Journal Title
  
  J Oral Biosci .
  
  Volume: 63 Issue: 3 Pages: 298-305
- DOI
  10.1016/j.job.2021.07.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10019
[Journal Article] Differentiation of Dental Pulp-Derived MSCs into Hepatocyte-Like Cells and Their Therapeutic Use for Chemical Liver Injuries of Rats2020
- Author(s)
  Hara H,Sano K, Ishikawa H, Ohkoshi S
- Journal Title
  
  J. hard tissue biol.
  
  Volume: 29 Issue: 4 Pages: 215-222
- DOI
  10.2485/jhtb.29.215
- NAID
  130007930684
- ISSN
  1341-7649, 1880-828X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10019, KAKENHI-PROJECT-19K24106
[Journal Article] Anti-Dementia Drugs and Hepatotoxicity Report of Two Cases2018
- Author(s)
  Hirono Haruka、Watanabe Kazuhiko、Hasegawa Katsuhiko、Hiroyasu Kazuhiko、Shibasaki Koichi、Ohkoshi Shogo
- Journal Title
  
  International Journal of Gerontology
  
  Volume: 1 Issue: 3 Pages: 1-3
- DOI
  10.1016/j.ijge.2018.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08966
[Journal Article] Dental pulp cell bank as a possible future source of individual hepatocytes2018
- Author(s)
  Ohkoshi S, Hirono H, Nakahara T, Ishikawa H.
- Journal Title
  
  World J Hepatol.
  
  Volume: 10 Issue: 10 Pages: 702-707
- DOI
  10.4254/wjh.v10.i10.702
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08966, KAKENHI-PROJECT-18K09733, KAKENHI-PROJECT-16K09564
[Journal Article] 閉塞性睡眠時無呼吸症候群と脂肪肝　－肝フィブロスキャン検査を用いたアプローチー2017
- Author(s)
  大越章吾、廣野玄、渡邉和彦、長谷川勝彦、斎藤満美子、安井浩美
- Journal Title
  
  歯学
  
  Volume: 105 Pages: 21-25
- Data Source
  KAKENHI-PROJECT-16K09564
[Journal Article] Evaluation of Hepatic Steatosis with Controlled Attenuation Parameter (CAP) Technology2017
- Author(s)
  Ohkoshi S, Hirono H, Watanabe K and Hasegawa K
- Journal Title
  
  Journal of Gastroenterology, Hepatology and Endoscopy
  
  Volume: 2 Pages: 1-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09564
[Journal Article] 睡眠時無呼吸症候群における夜間間欠的低酸素血症の改善が肝線維化・脂肪化に及ぼす影響の解析2017
- Author(s)
  廣野玄、渡邉和彦、長谷川勝彦、河野正己、大越章吾
- Journal Title
  
  新潟県医師会報
  
  Volume: 802 Pages: 7-8
- Data Source
  KAKENHI-PROJECT-16K09564
[Journal Article] Retinol binding protein 4, an insulin-resistance marker, induces interferon resistance in chronic hepatitis C.2016
- Author(s)
  Takahashi H, Ohkoshi S, Matsuda Y, et al.
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 未定
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461012
[Journal Article] Contributions of transgenic mouse studies on the research of hepatitis B virus and hepatitis C virus-induced hepatocarcinogenesis.2015
- Author(s)
  Ohkoshi S, Hirono H, Watanabe K, et al.
- Journal Title
  
  World J Hepatol
  
  Volume: 7 Issue: 28 Pages: 2834-40
- DOI
  10.4254/wjh.v7.i28.2834
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461012
[Journal Article] Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy2015
- Author(s)
  Ohkoshi S, Yano M, Matsuda Y.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 21 Issue: 42 Pages: 12150-6
- DOI
  10.3748/wjg.v21.i42.12150
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461012
[Journal Article] Direct antiviral agent treatment of decompensated hepatitis C virus-induced liver cirrhosis.2015
- Author(s)
  Ohkoshi S, Hirono H, Yamagiwa S
- Journal Title
  
  World J Gastrointest Pharmacol Ther
  
  Volume: 6 Issue: 4 Pages: 114-9
- DOI
  10.4292/wjgpt.v6.i4.114
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461012
[Journal Article] Retinol binding protein 4, an insulin- resistance marker, induces interferon resistance in chronic hepatitis C2015
- Author(s)
  Hiromichi Takahashi, Shogo Ohkoshi, Masahiko Yano, Satoshi Yamagiwa, Masanori Ikeda, Nobuyuki Kato, Yasunobu Matsuda, Yutaka Aoyagi
- Journal Title
  
  Hepatogastroenterology
  
  Volume: In Press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461012
[Journal Article] Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase.2014
- Author(s)
  Matsuda Y, Sanpei A, Wakai T, Kubota M, Osawa M, Hirose Y, Sakata J, Kobayashi T, Fujimaki S, Takamura M, Yamagiwa S, Yano M, Ohkoshi S, Aoyagi Y
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 7 Pages: 2032-43
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461012
[Journal Article] Double staining with crystal violet and methylene blue is appropriate for colonic endocytoscopy: an in vivo prospective pilot study.2014
- Author(s)
  Ichimasa K, Kudo SE, Mori Y, Wakamura K, Ikehara N, Kutsukawa M, Takeda K, Misawa M, Kudo T, Miyachi H, Yamamura F, Ohkoshi S, Hamatani S, Inoue H
- Journal Title
  
  Dig Endosc
  
  Volume: 14 Issue: 3 Pages: 403-8
- DOI
  10.1111/den.12164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461012, KAKENHI-PROJECT-25860564
[Journal Article] Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis2013
- Author(s)
  Yano M
- Journal Title
  
  Liv Int
  
  Volume: in press Issue: 8 Pages: 2018-2029
- DOI
  10.1111/liv.12176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590722, KAKENHI-PROJECT-25461012
[Journal Article] Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up-regulation of cytoplasmic p21 expression2013
- Author(s)
  Yano M, Ohkoshi S, Aoki YH, Takahashi H, Kurita S, Yamazaki K, Suzuki K, Yamagiwa S, Sanpei A, Fujimaki S, Wakai T, Kudo SE, Matsuda Y,Aoyagi Y
- Journal Title
  
  Liver Int
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Blockade of ataxia telangiectasia mutated sensitizes hepatoma eell lines to sorafenib by interfering with Akt signaling2012
- Author(s)
  Fujimaki S, Matsuda Y, Ohkoshi S, et al
- Journal Title
  
  Cancer Lett
  
  Volume: 319 Pages: 98-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence2012
- Author(s)
  Kamimura H, Yamagiwa S, Tsuchiya A, Takamura M, Matsuda Y, Ohkoshi S, Inoue M, Wakai T, Shirai Y, Nomoto M, Aoyagi Y.
- Journal Title
  
  J. Hepatol.
  
  Volume: 56(2) Pages: 381-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling2012
- Author(s)
  Fujimaki S, Matsuda Y, Wakai T, Sanpei A, Kubota M, Takamura M, Yamagiwa S, Yano M, Ohkoshi S, Aoyagi Y
- Journal Title
  
  Cancer Lett
  
  Volume: 319(1) Pages: 98-108
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis2011
- Author(s)
  Kawai H, Nomoto M, Suda T, Kamimura K, Tsuchiya A, Tamura Y, Yano M, Takamura M, Igarashi M, Wakai T, Yamagiwa S, Matsuda Y, Ohkoshi S, Kurosaki I, Shirai Y, Okada M, Aoyagi Y
- Journal Title
  
  Polyhedron
  
  Volume: 3(1) Pages: 15-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] A case with chronic hepatitis C who developed liver cirrhosis due to liver dysfunction caused by pegylated interferon plus ribavirin treatment despite negativity of serum HCV RNA, during therapy2011
- Author(s)
  Ohkoshi S, Morita S, Tanaka Y, Yano M, Takeuchi M, Takahashi H, Ikeda H, Yamagiwa S, Matsuda Y, Nomoto M, Aoyagi Y
- Journal Title
  
  Nihon Shokakibyo Gakkai Zasshi
  
  Volume: 108(2) Pages: 267-74
- NAID
  10029388211
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Failure to achieve 2-log_<10> viral decrease in first 4 weeks of peg-IFN α 2b plus ribavirin therapy for chronic hepatitis C with genotype lb and high viral titer is useful in predictingnon-response-Evaluation of response-guided therapy-2011
- Author(s)
  Ohkoshi S, et al.
- Journal Title
  
  Hepatogas troenterology
  
  Volume: In Press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Failure to achieve 2-log10 viral decrease in first four weeks of peg-IFNalpha-2b plus ribavirin therapy for chronic hepatitis C with genotype 1b and high viral titer is useful in predicting non-response: evaluation of response-guided therapy2011
- Author(s)
  Ohkoshi S, Yamagiwa S, Yano M, Takahashi H, Aoki YH, Waguri N, Igarashi K, Sugitani S, Takahashi T, Ishikawa T, Kamimura T, Wakabayashi H, Watanabe T, Matsuda Y,Aoyagi Y.
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 58(107-108) Pages: 965-70
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Characterization of elevated alanine aminotransferase levels during pegylated-interferon α-2b plus ribavirin treatment for chronic hepatitis C2011
- Author(s)
  Aoki YH, Ohkoshi S, Yamagiwa S, Yano M, Takahashi H, Waguri N, Igarashi K, Sugitani S, Takahashi T, Ishikawa T, Kamimura T, Wakabayashi H, Watanabe T, Matsuda Y,(2)Nomoto M, Aoyagi Y
- Journal Title
  
  Hepatol Res
  
  Volume: 41(2) Pages: 118-25
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Failure to achieve 2-log10 viral decrease in first four weeks of peg-IFNa lpha-2b plus ribavirin therapy for chronic hepatitis C with genotype 1b and high viral titer is useful in predicting non-response : evaluation of response-guided therapy2011
- Author(s)
  Ohkoshi S
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 68 Pages: 965-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis2011
- Author(s)
  Kawai H, Nomoto M, Suda T, Kamimura K, Tsuchiya A, Tamura Y, Yano M, Takamura M, Igarashi M, Wakai T, Yamagiwa S, Matsuda Y, Ohkoshi S, (4)Kurosaki I, Shirai Y, Okada M, Aoyagi Y
- Journal Title
  
  World J Hepatol
  
  Volume: 3(1) Pages: 15-23
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Very-Low-Dose Pegylated Interferon a2a Plus Ribavirin Therapy for Advanced Liver Cirrhosis Type C : A Possible Therapeutic Alternative without Splenic Intervention.2010
- Author(s)
  Ohkoshi S
- Journal Title
  
  Case Rep Gastroenterol
  
  Volume: 4 Pages: 261-266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Very low-dose pegylated interferon a2a plus ribavirin therapy for advanced liver cirrhosis type C-A possible therapeutic alternative without splenic intervention2010
- Author(s)
  Ohkoshi S, et al.
- Journal Title
  
  Case Report in Gastroenterology
  
  Volume: 4 Pages: 261-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590722
[Journal Article] Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase.2009
- Author(s)
  Yano M, Ikeda M, Abe KI, Kawai Y, Kuroki M, Mori K, Dansako H, Ariumi Y, Ohkoshi S, Aoyagi Y, Kato N.
- Journal Title
  
  Hepatology. 50(3)
  
  Pages: 678-688
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Serum alpha-fetoprotein levels during and after interferon therapy and the development of hepatocellular carcinoma in patients with chronic hepatitis C.2009
- Author(s)
  Tamura Y, Yamagiwa S, Aoki Y, Kurita S, Suda T, Ohkoshi S, Nomoto M, Aoyagi Y.
- Journal Title
  
  Dig Dis Sci. 54(11)
  
  Pages: 2530-2537
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Serum alpha-fetoprotein levels during and after interferon therapy and the development of hepatocellular carcinoma in patients with chronic hepatitis C2009
- Author(s)
  Tamura Y, Yamagiwa S, Aoki Y, Kurita S, Suda T, Ohkoshi S, Nomoto M, Aoyagi Y.
- Journal Title
  
  Dig Dis Sci.
  
  Volume: 54(11) Pages: 2530-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Progression of hypermethylation of the p16(INK4A) gene from normal liver to nontumorous liver and hepatocellular carcinoma : an evaluation using quantitative PCR analysis2009
- Author(s)
  Kurita S, Ohkoshi S, Yano M, Yamazaki K, Suzuki K, Aoki YH, Matsuda Y, Wakai T, Shirai Y, Ichida T, Aoyagi Y.
- Journal Title
  
  Dig Dis Sci.
  
  Volume: 54(1) Pages: 80-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase2009
- Author(s)
  Yano M, Ikeda M, Abe KI, Kawai Y, Kuroki M, Mori K, Dansako H, Ariumi Y, Ohkoshi S, Aoyagi Y, Kato N.
- Journal Title
  
  Hepatology.
  
  Volume: 50(3) Pages: 678-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Sucessful treatment with lamivudine may correlate with reduction of serum ferritin levels in the patients with chronic hepatitis and liver cirrhosis type B2008
- Author(s)
  Ohkoshi S
- Journal Title
  
  Hepatol Int 2
  
  Pages: 382-387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells2008
- Author(s)
  Yamagiwa S, Matsuda Y, Ichida T, Honda Y, Takamura M, Sugahara S, Ishikawa T, Ohkoshi S, Sato Y, Aoyagi Y.
- Journal Title
  
  Hepatol Res.
  
  Volume: 38(7) Pages: 664-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Comprehensive Analysis of the Effects of Ordinary Nutrients on Hepatitis C Virus RNA Replication in Cell Culture,2007
- Author(s)
  Yano M, Ikeda M, Abe KI, Dansako H, Ohkoshi S, Aoyagi Y, Kato N.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy (印刷中)
- Data Source
  KAKENHI-PROJECT-16590582
[Journal Article] Temporal treatment with interferon-b prevents hepatocellular carcinoma in hepatitis B virus-X gene transgenic mice.2007
- Author(s)
  Yamazaki K, Suzuki K, Ohkoshi S, Yano M, Kurita S, Aoki Y, Toba K, Takamura M, Yamagiwa S, Matsuda Y, Aoyagi Y.
- Journal Title
  
  J Hepatol. 48
  
  Pages: 255-265
- Data Source
  KAKENHI-PROJECT-20390205
[Journal Article] Decompensated lamivudine-resistant Hepatitis B virus related cirrhosis treated successfully with adefovir dipivoxil allowin surgery for hepatocellular carcinoma2007
- Author(s)
  Takamura M, Ichida T, Ohkoshi S, Tsubata S, Osaki A,.Aoyagi T, Nomoto M, Uehara K, Terada H, Aoyagi Y.
- Journal Title
  
  Intern Med. 46(7)
  
  Pages: 367-371
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590582
[Journal Article] Decompensated lamivudine-resistant Hepatitis B virus related cirrhosis treated successfully with adefovir dipivoxil allowin surgery for hepatocellular carcinoma.2007
- Author(s)
  Takamura M, Ichida T, Ohkoshi S, Tsubata S, Osaki A, Aoyagi T, Nomoto M, Uehara K, Terada H, Aoyagi Y.
- Journal Title
  
  Intern Med. 46・7
  
  Pages: 367-371
- Data Source
  KAKENHI-PROJECT-16590582
[Journal Article] Comprehensive Analysis of the Effects of Ordinary Nutrients on Hepatitis C Virus RNA Replication in Cell Culture.2007
- Author(s)
  Yano M, Ikeda M, Abe KI, Dansako H, Ohkoshi S, Aoyagi Y, -Kato N.
- Journal Title
  
  Antimicrob Agents Chemother.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590582
[Journal Article] Common clinicopathological features of the patients with chronic hepatitis B virus infection who developed hepatocellular carcinoma after seroconversion to anti-HBs--a consideration of the pathogenesis of HBV-induced hepatocellular carcinoma and a strategy to inhibit it.2006
- Author(s)
  Tsuboi Y, Ohkoshi S, Yano M, Suzuki K, Tsubata SS, Ishihara K, Ichida T, Sugitani S, Shibazaki K, Aoyagi Y.
- Journal Title
  
  Hepato-Gasroenterology 53・67
  
  Pages: 110-4
- Data Source
  KAKENHI-PROJECT-16590582
[Journal Article] Absence of pretreatment markers that predict the emergence of YMDD mutants during lamivudine treatment-the results of a prospective multi-center study.2006
- Author(s)
  Yano M, Ohkoshi S, Suzuki K, Ito S, Wakabayashi H, Sugiyama M, Watanabe T, Maeda H, Hatakeyama SA, Hatano T, Kobayashi Y, Takei S, Kohjiro H, Tsuboi Y, Takahashi T, Ishikawa T, Kamimura T, Ichida T, Aoyagi Y.
- Journal Title
  
  Hepato-Gasroenterology 53・67
  
  Pages: 124-7
- Data Source
  KAKENHI-PROJECT-16590582
[Journal Article] Absence of pretreatment markers that predict the emergence of YMDD mutants during lamivudine treatment-the results of a prospective multi-center study.2006
- Author(s)
  Yano M, Ohkoshi S, Suzuki K, Ito S, Wakabayashi H, Sugiyama M, Watanabe T, Maeda H, Hatakeyama SA, Hatano T, Kobayashi Y, Takei S, Kohjiro H, Tsuboi Y, Takahashi T, Ishikawa T, Kamimura T, Ichida T, Aoyagi Y.
- Journal Title
  
  Hepato-Gasroenterology. Jan-Feb 53(67)
  
  Pages: 124-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590582
[Journal Article] Common clinicopathological features of the patients with chronic hepatitis B virus infection who developed hepatocellular carcinoma after seroconversion to anti-HBs a consideration of the pathogenesis of HBV-induced hepatocellular carcinoma and a strategy to inhibit it.2006
- Author(s)
  Tsuboi Y, Ohkoshi S, Yano M, Suzuki K, Tsubata SS, Ishihara K, Ichida T, Sugitani S, Shibazaki K, Aoyagi Y.
- Journal Title
  
  Hepato-Gasroenterology. Jan-Feb 53(67)
  
  Pages: 110-4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590582
[Journal Article] Comparative study of genotype B and C hepatitis B virus-induced chronic hepatitis in relation to the basic core promoter and precore mutations.2005
- Author(s)
  Watanabe K, Takahashi T, Takahashi S, Okoshi S, Ichida T, Aoyagi Y.
- Journal Title
  
  J Gastroenterol Hepatol. 20 (3)
  
  Pages: 441-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590582
[Journal Article] Effect of Interferon arfa and cell cycle progression on translation mediated' by hepatitis C virus 5' untranslated region : A study using a transgenic mouse model..2004
- Author(s)
  Takeda Y, Okoshi S, Suzuki K, Yano M, Gangen J-D, Jay G, Asakura H, Aoyagi Y.
- Journal Title
  
  J Viral Hepatitis. 11
  
  Pages: 33-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590582
[Presentation] 夜間睡眠ポリグラフと食道pH/インピーダンス同時測定から検討した、閉塞性睡眠時無呼吸症候群と胃食道逆流症の関連性2021
- Author(s)
  渡辺和彦、廣野玄、長谷川勝彦、大越章吾、河野茜、猪子芳美、河野正己
- Organizer
  日本睡眠学会第46回定期学術集会
- Data Source
  KAKENHI-PROJECT-18K07429
[Presentation] 閉塞性睡眠時無呼吸症候群における夜間の一過性下部食道括約筋弛緩(TLESR)の発生には、わずかな嚥下反応が関与する可能性がある-PSG・食道pH/インピーダンス同時測定からの考察-2021
- Author(s)
  渡辺和彦、廣野玄、長谷川勝彦、大越章吾
- Organizer
  第63回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-18K07429
[Presentation] 改訂Fスケール問診を用いた、閉塞性睡眠時無呼吸症候群と胃食道逆流症の関連性及び治療効果の検討2020
- Author(s)
  渡辺和彦、廣野玄、長谷川勝彦、大越章吾
- Organizer
  第62回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-18K07429
[Presentation] 歯髄間葉系幹細胞から肝細胞への分化とIn Vivoにおける細胞動態.2019
- Author(s)
  大越章吾
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K08966
[Presentation] Differentiation of dental pulp-derived mesenchymal stem cells into hepatocytes and their repopulation in nude rat liver.2018
- Author(s)
  Ohkoshi S
- Organizer
  26th United European Gastroentetrology Week, Vienna
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09564
[Presentation] Differentiation of dental pulp stem cells into hepatocytes and their repopulation in nude rat liver2018
- Author(s)
  Ohkoshi S, Hara H, et al.
- Organizer
  UEGW
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08966
[Presentation] いびき症に潜む動脈硬化危険因子　～睡眠から発する検診メッセージ～　（肝フィブロスキャン検査を用いたアプローチ）2018
- Author(s)
  廣野玄、渡邉和彦、長谷川勝彦、大越章吾、河野正己
- Organizer
  2017年度　新潟市医師会地域医療研究助成発表会
- Data Source
  KAKENHI-PROJECT-16K09564
[Presentation] 睡眠時無呼吸症候群（SAS）と脂肪肝の関係　～フィブロスキャンを用いて～2017
- Author(s)
  廣野玄、渡邉和彦、長谷川勝彦、大越章吾、猪子芳美、河野正己
- Organizer
  第14回　新潟睡眠呼吸障害研究会
- Data Source
  KAKENHI-PROJECT-16K09564
[Presentation] Differentiation of mesenchymal dental pulp stem cells into hepatocytes2017
- Author(s)
  Hara H, Sano K, Ishikawa H, Ohkoshi H
- Organizer
  World Dntal Congress (FDI 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08966
[Presentation] C型慢性肝炎とインスリン抵抗性因子RBP4RBP4 はインターフェロン治療抵抗性をもたらす2012
- Author(s)
  高橋弘道, 大越章吾, 矢野雅彦, 山際訓, 松田康伸, 池田正徳, 加藤宣之, 青柳豊
- Organizer
  日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] Retinol Binding Protein 4 induces interferon resistance in cells and it’s serum levels can be a good marker to predict SVR in chronic hepatitis C patients treated by PegIFN/ RIB2012
- Author(s)
  Shogo　Ohkoshi
- Organizer
  全米肝臓学会（AASLD)
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] Retinol Binding Protein 4 induces interferon resistance in cells and it's serum levels can be a good marker to predict SVR in chronic hepatitis C patients treated by PegIFN/ RIB2012
- Author(s)
  Ohkoshi S
- Organizer
  全米肝臓学会総会
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] p21細胞内局在制御によるIFN-βのシスプラチン制癌効果増強機構2012
- Author(s)
  矢野雅彦, 大越章吾, 高橋弘道, 藤巻隼, 松田康伸, 青柳豊, 工藤進英
- Organizer
  日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] DNA傷害修復因子ATMによる肝癌細胞の細胞死抑制機構の解析2011
- Author(s)
  藤巻隼, 松田康伸, 矢野雅彦, 大越章吾, 若井俊文, 白井良夫, 三瓶歩, 平野茂樹
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] Interferon-B Prevents HBX-Triggered Hepatococarcinogenesis By Down-Regulating Cytoplasmic P21 Over expression.2011
- Author(s)
  Yano M, Ohkoshi S, Aoki Y, Matsuda Y, Aoyagi Y
- Organizer
  46^<th> Annual Meeting Of The European Association For The Study Of The Liver(EASL 2011)
- Place of Presentation
  国際会議場122ベルリン
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-20390205
[Presentation] HBx誘導性肝発癌に対するIFN-βの制御機構の分子学的解析2010
- Author(s)
  矢野雅彦, 大越章吾, 青木洋平, 山崎和秀, 栗田聡, 鈴木健太, 三瓶歩, 松田康伸, 青柳豊
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22590722
[Presentation] Oxidative Stress Induces Anti-HCV Status via the Activation of MEK-ERK1/2 Signaling Pathway.2009
- Author(s)
  Yano M, Matsuda K, Ohkoshi S, Aoyagi Y.
- Organizer
  2009 AASLD.
- Place of Presentation
  Hynes Convention Center
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-20390205
[Presentation] ペグインターフェロン+リバビリン療法の治療成績とその効果予測に関与する因子の解析2008
- Author(s)
  大越章吾
- Organizer
  日本肝臓学会総会
- Place of Presentation
  松山市
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-20390205
[Presentation] B型慢性肝疾患に対する抗ウイルス療法(ラミブジン)投与の成否と血清フェリチン値の低下との関係2008
- Author(s)
  大越章吾
- Organizer
  JDDW2008日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-20390205

1. HIRONO Haruka (80386268)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. AOYAGI Yutaka (00142266)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
3. MATSUDA Yasunobu (40334669)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
4. Hasegawa Katsuhiko (60328870)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
5. Watanabe Kazuhiko (70742758)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
6. 石川博 (30089784)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
7. 河野正己 (20170201)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
8. ODANI Shohji (60018702)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SUDA Takeshi (10361916)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
10. YAMAGIWA Satoshi (10419327)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
11. YANO Masahiko (70529693)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
12. 猪子芳美 (50386265)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
13. 中原貴 (10366768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. UCHIUMI Toshio (50143764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KAMIMURA Tomoteru (70018894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SUZUKI Kenji (00303123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. IGARASHI Masato (00401745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 鈴木康史 (50270939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 小方則夫 (70204063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 白野美和 (60318558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 道川誠 (40270912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 島村直宏 (40908125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKOSHI SHOGO 大越 章吾

OHKOSHI Shogo 大越 章吾

OHGOSHI Shogo 大越 章吾

OHKOSHI Showgo 大越 章吾

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歯の細胞バンクが繋ぐ、口腔と消化器の歯科医科横断的再生医療Principal Investigator

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Dissemination of messages for clinical application of dental pulp stem cells that have been stored in cell bank.Principal Investigator

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Regenetative medicine using decidouous teeth preparing for future diseasesPrincipal Investigator

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Discovery of new insulin-resistance marker which determines the effect of IFN for chronic hepatitis CPrincipal Investigator

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Development of new IFN-strategy that based on DNA repair mechanismPrincipal Investigator

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OKOSHI SHOGO 大越章吾

OHKOSHI Shogo 大越章吾

OHGOSHI Shogo 大越章吾

OHKOSHI Showgo 大越章吾

[Book] 専門医から伝えたい　歯科医院に知ってほしい　肝疾患のこと2019

[Journal Article] 閉塞性睡眠時無呼吸症候群と脂肪肝　－肝フィブロスキャン検査を用いたアプローチー2017