TEZUKA Yasuhiro 手塚康弘

Researcher Number	70236975
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2014 – 2016: 北陸大学, 薬学部, 教授 2010 – 2013: 富山大学, 和漢医薬学総合研究所, 准教授 2005 – 2006: 富山大学, 和漢医薬学総合研究所, 助教授 2000 – 2004: 富山医科薬科大学, 和漢薬研究所, 助教授 1991 – 1996: Toyama Medical and Pharmaceutical University, Research Institute for Wakan-Yaku,, 和漢薬研究所, 助手
Review Section/Research Field	Principal Investigator Bioorganic chemistry / Natural medicines / Drug development chemistry Except Principal Investigator Chemical pharmacy / 医薬分子機能学 / Chemical pharmacy / Science and Engineering / Bioorganic chemistry
Keywords	Principal Investigator 抗がん剤 / 膵臓がん / 和漢薬 / 穿心蓮 / 活性成分 / 栄養飢餓耐性解除 / PANC-1 / アルクチゲニン / 栄養飢餓耐性 / 癌 … More / 医薬品化学 / α‐Aminoisobutylic acid(Aib) / Calcium Channel Acitivator / MS) / Tandem MS(MS / Ion‐spray ionization MS(ISI‐MS) / Trichokonin(TK) / Mycoparasitic Fungi / Trichodermakoningii / Peptaibol / 逆転写酵素阻害活性 / リグナン / インドネシア産薬用植物 / ヘリクテレス・イソラ / MS / FAB-MS / ペプタイボール / Trichoderma koningii / 霊芝寄生菌 … More Except Principal Investigator ビオチン / ジアジリン / 光アフィニティーラベル / 薬草栽培 / Panax zinziberensis / Panax vietnamensis / Aquilaria crassna / 伝統医学 / 沈香 / DNA / diazirine / 化学発光 / Menispermum dauricum / Curcuma xanthorrhiza / Swietenolide / Limonoid / Swietenia mahagoni / 固相合成 / アビジン / カルベン / Field investigation / Gout / BDNF / Pancreatic cancer / Agar wood / anti-malaria / Ethnic minority / Traditional medicine / 抗癌 / 抗炎症 / Aquilaria属植物 / チャンパ民族 / ミャンマー / ベトナム / 三七人参 / インドネシア / オシン族 / フィールド調査 / 脳由来神経因子 / 膵臓癌 / 痛風 / 抗マラリア / 少数民族 / Orthosiphon stamineus / anti-narcotic action / liver disease / traditional medicine / agarwood / マトリックスメタロプロテアーゼ / アーティチョーク / 薬用人参 / 癌転移 / Orthosiphon stamineous / 抗麻薬作用 / 肝臓疾患 / drug discover and development / proteomics / peptide / oligosaccharide / Solid phase synthesis / potoaffinity labeling / 非放射性検出 / ハイスループット / 固相プローブ / 光アフィニティ-ラベル / 無保護合成 / フェニルアラニン / ジアリジン / 糖鎖リガンド / ペプチドリガンド / ライブラリー / 構造生物学 / プローブライブラリー / 個相合成 / 創薬 / プロテオミクス / ペプチド / 糖鎖 / structure-function relation ship / biotin / avidin / chemiluminescence / carbene / opioid receptor / photoaffinity labeling / 微生物代謝成分 / アジド / 構造機能相関 / オピオイドレセプター / Sedative Effect / Protein kinase C activation / Synthesis / Musclide-B / Musclide-A2 / Musclide-A1 / Cardiotonic Effect / Musk / Protein kinase-C isozyme / Protein kinase C活性化 / ムスクライド / 鎮静作用 / プロテインキナーゼC活性化 / 合成 / ムスクライド-B / ムスクライド-A_2 / ムスクライド-A_1 / 強心作用 / 麝香 / Veratrum nigrum var. ussuriense / Swietamahonin / Anti-PAF / Meliaceae / secomahoganin / anti-PAF / Curcuma xantholiza / 2D NMR / Maliaceae / tetranortriterpenoid / mahagonin / swietemahonin A / swietenolide / swietemahonin / limonoid / antiーPAF / Swietenia mshagoni / Veratrum nigrum var.ussuriense / Swietemahonin / AntiーPAF / 木蝴蝶 / 和羌活 / Tram Bau / ポジティブスクリーニング / Ca^<2+>シグナル伝達 / 酵母 / 糖鎖工学 / アミノ基の保護 / 水酸基の保護 / 光異性化 / 光反応基 / 生理活性天然物 / 光制御 / シアリルトランスフェラーゼ / ガラクトシルトランスフェラーゼ / 糖転移酵素 Less

Search for a lead compound based on antiausteric activityPrincipal Investigator
- Principal Investigator
  
  Tezuka Yasuhiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Hokuriku University
  University of Toyama
Development of a new pancreatic cancer curative medicine from arctigenin, an ingredient of Wakan-yaku "Burdock Fruit (Seeds of Arctium lappa)"Principal Investigator
- Principal Investigator
  
  TEZUKA Yasuhiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Toyama
東南アジアの天然薬物から酵母Ca^<2+>シグナル伝達阻害物質の探索と医薬への応用
- Principal Investigator
  
  KADOTA Shigetoshi
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  University of Toyama
Investigation on Traditional Medicine system and Natural Drug Resources in Vietnam, Myanmar and Indoneisa
- Principal Investigator
  
  KADOTA Shigetoshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  University of Toyama
  Toyama Medical and Pharmaceutical University
Investigation of Natural Drug Resouces in Lam Dong Province, Vietnam and Shan State, Myanmar
- Principal Investigator
  
  KADOTA Shigetoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Rapid and Sensitive Photoaffinity Labeling of Drug Receptors with Immobilized Probes
- Principal Investigator
  
  HATANAKA Yasumaru
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
カルシウムチャネル活性化作用を有するペプタイボール類に関する生物有機化学的研究Principal Investigator
- Principal Investigator
  
  手塚康弘
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Toyama Medical and Pharmaceutical University
新しい光応答性基による生理活性分子の光制御
- Principal Investigator
  
  KIKUCHI Tohru
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Toyama Medical and Pharmaceutical University
インドネシア産薬用植物ヘリクテレス・イソラの逆転写酵素阻害活性成分の研究Principal Investigator
- Principal Investigator
  
  手塚康弘
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Toyama Medical and Pharmaceutical University
Analysis of the Binding Sites of Opioid Receptor by Photoaffinity Labeling
- Principal Investigator
  
  HATANAKA Yasumaru
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
糖転移酵素および関連蛋白質の光アフィニティーラベリング
- Principal Investigator
  
  HATANAKA Yasumaru
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Toyama Medical and Pharmaceutical University
霊芝寄生菌の産製する抗真菌活性物質の研究Principal Investigator
- Principal Investigator
  
  手塚康弘
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Toyama Medical and Pharmaceutical University
Chemical and Pharmacological Studies on Cardiotonic and Sedative Effects of Musk
- Principal Investigator
  
  KIKUCHI Tohru
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
A Chemical Study on Crude Drugs with an Activity to Eliminate Blood Stagnation
- Principal Investigator
  
  KIKUCHI Tohru
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Toyama Medical and Pharmaceutical University

All 2015 2013 2012 2011 2006 2005 2004

All Journal Article Presentation

[Journal Article] Preferential cytotoxicity of crude drugs used in Japanese Kampo medicines against human pancreatic cancer PANC-1 and PSN-1 cells2015
- Author(s)
  S. Lee, D.F. Dibwe, F. Li, H. Morita, Y. Tezuka
- Journal Title
  
  Traditional & Kampo Medicine
  
  Volume: なし Issue: 2 Pages: 1-8
- DOI
  10.1002/tkm2.1016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25108710, KAKENHI-PROJECT-25242067, KAKENHI-PROJECT-25460117, KAKENHI-PROJECT-26282210
[Journal Article] Preferentially Cytotoxic Constituents of Andrographis paniculata and their Preferential Cytotoxicity against Human Pancreatic Cancer Cell Lines2015
- Author(s)
  Lee S., Morita H., Tezuka Y.
- Journal Title
  
  Nat. Prod. Commun.
  
  Volume: 10
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460117
[Journal Article] Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy2013
- Author(s)
  Kudou N., Taniguchi A., Sugimoto A., Matsuya Y., Kawasaki M., Toyooka N., Miyoshi C., Awale S., Dibwe D.F., Esumi H., Kadota S., and Tezuka Y
- Journal Title
  
  Eur. J. Med. Chem
  
  Volume: 60 Pages: 76-88
- DOI
  10.1016/j.ejmech.2012.11.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590098
[Journal Article] Anti-austeric Activity of Phenolic Constituents of Seeds of Arctium lappa2013
- Author(s)
  Tezuka Y., Yamamoto K., Awale S., Li F., Yomoda S., Kadota S.
- Journal Title
  
  Nat. Prod. Commun.
  
  Volume: 8 Pages: 463-466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590098
[Journal Article] Anti-austeric Activity of Phenolic Constituents of Seeds of Arctium lappa2013
- Author(s)
  Tezuka Y., Yamamoto K., Awale S., Li F., Yomoda S., and Kadota S
- Journal Title
  
  Nat. Prod. Commun
  
  Volume: 8(4) Pages: 463-466
- URL
  http://www.naturalproduct.us/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590098
[Journal Article] Identification of arctigenin as an Anti-tumor Agent having activity to Eliminate Cancer Cell's Tolerance to Nutrient Starvation2006
- Author(s)
  Awale S., Lu J., Kalauni S.K., Kurashima Y., Tezuka Y., Kadota S., Esumi H.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 1751-1753
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Xanthine Oxidase Inhibitors from the Flowers of Chrysanthemum sinense2006
- Author(s)
  Nguyen M.T., Awale S., Tezuka Y., Ueda J., Tran Q.L., Kadota S.
- Journal Title
  
  Planta med. 72
  
  Pages: 46-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Antimalarial Activity of Cassane- and Norcassane-type Diterpenes from Caesalpinia Crista and Their Structure-Activity Relationship2006
- Author(s)
  Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Asih P.B.S., Syafruddin D., Kadota S.
- Journal Title
  
  Biol.Pharm.Bull. 29
  
  Pages: 1050-1052
- NAID
  110005602240
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Angelmarin, a Novel Anticancer Agent Able to Eliminate the Tolerance of Cancer Cells to Nutrition Starvation2006
- Author(s)
  Awale S., Nakashima E.M.N., Kalauni S.K., Tezuka Y., Lu J., Kurashima Y., Esumi H., Kadota S.
- Journal Title
  
  Bioorg.Med.Chem.Lett. 16
  
  Pages: 581-583
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA expression in vitro2006
- Author(s)
  Ueda J., Imamura L., Tezuka Y., Tran A.L., Tsuda M., Kadota S.
- Journal Title
  
  Bioorg.Med.Chem. 14
  
  Pages: 3571-3574
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] New Cassane- and Norcassane-type Diterpenes from Caesalpinia crista of Indonesia and Their Antimalarial Activity against the Growth of Plasmodium falciparum2005
- Author(s)
  Linn T.Z., Awale S., Tezuka Y., Banskota A.H., Kalauni S.K., Attamimi F., Ueda J., Asih P.B.S., Syafruddin D., Tanaka K., Kadota S.
- Journal Title
  
  J.Nat.Prod. 68
  
  Pages: 706-710
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Methyl Migrated Cassane-Type Furanoditerpenes of Caesalpinia crista from Myanmar2005
- Author(s)
  Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Kadota S.
- Journal Title
  
  Chem.Pharm.Bull. 53
  
  Pages: 1300-1304
- NAID
  110003666262
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Hypouricemic Effects of Acacetin and 4,5-O-Dicaffeoylquinic Acid Methyl Ester on Serum Uric Acid Levels in Potassium Oxonate-Pretreated Rats2005
- Author(s)
  Nguyen M.T., Awale S., Tezuka Y., Shi L., Zaidi S.F.H., Ueda J., Tran Q.L., Murakami Y., Matsumoto K., Kadota S.
- Journal Title
  
  Biol.Pharm.Bull. 28
  
  Pages: 2231-2234
- NAID
  110004049121
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] New Cassane-type Diterpenes of Caesalpinia crista from Myanmar2005
- Author(s)
  Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Kadota S.
- Journal Title
  
  Chem.Pharm.Bull. 53
  
  Pages: 214-218
- NAID
  10016652259
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Xanthine Oxidase Inhibitors from the Heartwood of Vietnamese Caesalpinia sappan2005
- Author(s)
  Nguyen M.T., Awale S., Tezuka Y., Tran Q.L., Kadota S.
- Journal Title
  
  Chem.Pharm.Bull. 53
  
  Pages: 984-988
- NAID
  10016655946
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Flavanoids from Nepalese Propolis and Their Nitric Oxide Production Inhibitory Activity2005
- Author(s)
  Awale S., Shrestha S.P., Tezuka Y., Ueda J., Matsushige K., Kadota S.
- Journal Title
  
  J.Nat.Prod. 68
  
  Pages: 858-864
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Neosappanone A, a Xanthine Oxidase (XO) Inhibitory Dimeric Methanodibenzoxocinone with a New Carbon Skeleton from Caesalpinia sappan2004
- Author(s)
  Nguyen M.T., Awale S., Tezuka Y., Tran Q.L., Kadota S.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 8519-8522
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Staminane-and Isopimarane-type Diterpenes from Orthosiphon stamineus of Taiwan and Their Nitric Oxide Inhibitory Activity2004
- Author(s)
  Nguyen M.T., Awale S., Tezuka Y., Chien-Hsiung C., Kadota S.
- Journal Title
  
  J.Nat.Prod. 67
  
  Pages: 654-658
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Neoorthosiphonone A, a Nitric oxide (NO) Inhibitory Diterpene with a New Carbon Skeleton from Orthosiphon stamineus2004
- Author(s)
  Awale S., Tezuka Y., Kobayashi M., Ueda J., Kadota S.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 1359-1362
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants2004
- Author(s)
  Nguyen M.T., Awale S., Tezuka Y., Tran Q.L., Watanabe H., Kadota S.
- Journal Title
  
  Biol.Pharm.Bull. 27
  
  Pages: 1414-1421
- NAID
  110003608986
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Journal Article] Cassane- and Norcassane-type Diterpenes from Caesalpinia crista from Myanmar2004
- Author(s)
  Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Kadota S.
- Journal Title
  
  J.Nat.Prod. 67
  
  Pages: 1859-1863
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406002
[Presentation] 穿心蓮中の栄養飢餓状態選択的な殺細胞活性成分2015
- Author(s)
  李　雪林，森田洋行，手塚康弘
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25460117
[Presentation] 栄養飢餓耐性解除に基づく新規膵臓がん治療薬の開発研究2012
- Author(s)
  谷口瑛,工藤直紀,松谷裕二,杉本健士,友廣岳則,畑中保丸,川崎正志,Suresh Awale,李峰,手塚康弘,門田重利,三好千香,江角浩安,豊岡尚樹
- Organizer
  第42回複素環化学討論会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590098
[Presentation] 栄養飢餓耐性解除に基づく新規膵臓がん治療薬の開発研究2011
- Author(s)
  谷口瑛,工藤直紀,松谷裕二,杉本健士,川崎正志,Suresh Awale,手塚康弘,門田重利,三好千香,江角浩安,豊岡尚樹
- Organizer
  平成23年度有機合成化学北陸セミナー
- Place of Presentation
  福井県坂井市
- Data Source
  KAKENHI-PROJECT-22590098

1. HATANAKA Yasumaru (30111181)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KADOTA Shigetoshi (90115163)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
3. KIKUCHI Tohru (40025680)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SURESH Awale (00377243)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
5. SAIKI Ikuo (80133776)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TOYOOKA Naoki (10217565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. KIMURA Ikuko (70019131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KIMURA Masayasu (60019099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WATANABE Hiroshi (10012642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. A.H. Banskota (40333497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSUDA Masaaki (80132736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 宮川都吉 (10116676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MORITA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TEZUKA Yasuhiro 手塚 康弘

Research Projects

Research Products

Co-Researchers

Search for a lead compound based on antiausteric activityPrincipal Investigator

Principal Investigator

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Development of a new pancreatic cancer curative medicine from arctigenin, an ingredient of Wakan-yaku "Burdock Fruit (Seeds of Arctium lappa)"Principal Investigator

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Review Section

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カルシウムチャネル活性化作用を有するペプタイボール類に関する生物有機化学的研究Principal Investigator

Principal Investigator

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Principal Investigator

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インドネシア産薬用植物ヘリクテレス・イソラの逆転写酵素阻害活性成分の研究Principal Investigator

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Principal Investigator

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霊芝寄生菌の産製する抗真菌活性物質の研究Principal Investigator

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Principal Investigator

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Principal Investigator

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[Journal Article] Preferential cytotoxicity of crude drugs used in Japanese Kampo medicines against human pancreatic cancer PANC-1 and PSN-1 cells2015

Author(s)

TEZUKA Yasuhiro 手塚康弘