Honda Zen-ichiro 本田善一郎

… Alternative Names

Researcher Number	70238814
Other IDs
Affiliation (Current)	2019: お茶の水女子大学, 保健管理センター, 教授
Affiliation (based on the past Project Information) *help	2018 – 2019: お茶の水女子大学, 保健管理センター, 教授 2012 – 2016: お茶の水女子大学, 保健管理センター, 教授 2008 – 2011: 東京大学, 医学部附属病院, 講師 2007: The University of Tokyo, Hospital, Lecturer 2007: The University of Tokyo, 医学部・附属病院, 講師 … More
Review Section/Research Field	Principal Investigator 内科学一般 / 膠原病・アレルギー・感染症内科学 / Biological Sciences / Basic Section 54020:Connective tissue disease and allergy-related Except Principal Investigator Pathological medical chemistry / 内科学一般 / Hematology / Biological Sciences / 膠原病・アレルギー・感染症内科学 / Kidney internal medicine … More
Keywords	Principal Investigator Fc受容体 / 脂質ラフト / PAF / Src型チロシンキナーゼ / Src family kinase / Lyn / Gq / 顆粒分泌 / 貧食 / 遺伝子多型 … More Except Principal Investigator 血小板活性化因子 / 受容体 / 遺伝子発現 / トランスジェニックマウス / Id / PAF受容体 / 全身性エリテマトーデス / 多型 / 遺伝子多型 / 気管支喘息 / 疾患感受性 / Fc受容体 / 脂質ラフト / 白血病 / ヒストン修飾 / ヒストンH3K27 / PAF / 情報伝達 / PLATELET-ACTIVATING FACTOR / microdissection / RT-PCR / Syk / Fcγ受容体IIb / TNFR2 / CD19 / rheumatoid arthritis / FcγRIIb / CD72 / LILR / APRIL / 心筋細胞 / 炎症細胞 / FcεRI / TAM / SSCP / ノックアウトマウス / エンドトキシンショック / I型インターフェロン / STAT4 / IRF5 / HapMap / 発現解析 / インターフェロン / interferon regulatory factor 5 (IRF5) / ハプロタイプ / SLE / バーター症候群 / カルシウム代謝 / 腎機能低下 / 副甲状腺機能低下症 / Ca感知受容体 / 腎電解質異常 / 低Ca血症 / 慢性腎不全 / 骨異栄養症 / 遺伝子治療 / 遺伝子治療3 / カルシウム感知受容体 / 腎電解質代謝 / 低カルシウム血症 / 高カリウム血症 / 高リン血症 / 慢性骨髄性白血病 / トランスポゾン / がん抑制遺伝子 / ヒストン脱メチル化酵素 / Fbxl10 / 造血幹細胞 / Fbx110 / ポリコーム複合体 / EED / コンディショナルノックアウトマウス / 骨髄異形成症候群 / ヒストンメチル化・脱メチル化 / PRC2 / JMJD3, UTX / Jmjd3, Utx / ヒストンH3K27メチル化 / レセプター / エンドトキシン / ホスホリパーゼ / トランホーマンツ / アンタゴニス / 遺伝子 / platelet-activating factor / receptor / inflammation / endotoxin / Receptor / Endotoxin / Phospholipases / Transformants / Antagonists / 生理活性脂質 / ロイコトリエン / 生合成酵素 / 不活性化酵素 / BIOACTIVE LIPIDS / LEUKOTRIENE / SYNTHETIC ENZYME / RECEPTOR / SIGNAL TRANSDUCTION / INACTIVATING ENZYME / MAPキナーゼ / ウオルマニン / 甲状線ホルモン / 脱感作 / 甲状腺ホルモン / リン酸化 / MAP KINASE / WORTMANNIN / THYROID HORMONE / DESENSITIZATION / PHOSPHORYLATION / ホスホリバーゼA_2 / 腎盂炎 / 多臓器不全 / 糖尿病 / 乳癌細胞 / PAFアセチルヒドロラーゼ / 即時型アレルギー / ホスホリパーゼA_2 / 乳ガン細胞 / phospholipases A_2 / nephritis / multi-organ dysfunction / diabetes / breast carcinoma / PAF-acetylhydrolase / immediate allergy / 血小板活性化因子受容体 / トロンボキサン受容体 / ネフロン / メサンギウム細胞 / mRNA / down-regulation / 血小板活性化因子(PAF) / プロスタグランジン / MRT-PCR / micro-perfusion / mRNA定量 / platelet-activating factor receptor / thromboxane A_2 receptor / nephron / mRNA expression / glomerular mesangial cells / homologous down-regulation / 遊走 / 肥満細胞 / 気道粘膜 / 線維芽細胞 / 血管内皮細胞 / CHEMOTAXIS / MAST CELLS / AIRWAY MUCOSA / FIBROBLASTS / VASCULAR ENDOTHELIAL CELLS / マスト細胞 / ヒスタミン遊離 / チロシンキナーゼ / Lyn / bronchial asthma / polymorphisms / 慢性関節リウマチ / Crohn病 / BLyS / NKG2C / CD94 / BCMA / 全身性エリテュトーデス / クローン病 / FLIP / Fcγ受容体IIB / differential display / 滑膜 / TNFα / SNP / ケモカイン受容体 / HLA-DRB1 / systemic lupus ervthematosus / Crohn's disease / plymorphism / expression / Fcy receptor IIb / Fe受容体 / Srcファミリーキナーゼ / SH3ドメイン / FcrRIIb / C末端Srcキナーゼ / Fc receptor / src family kinases / lipid rafts / SH3 domain / 関節リウマチ / Fcγ受容体Ilb / 顕微鏡的多発血管炎 / FCGR2B / LILRB1 / KIR / HLA / スプライシング / 遺伝子間相互作用 / 血管新生 / 強皮症 / Fcγ受容体 / メタアナリシス / NK受容体 / 欠失 / 国際情報交換 / BLyS(BAFF) / ILT2(LIR1) / ID / systemic lupus erythematosus / polymorphism / Fc_γ receptor IIb / 尿酸 / 動脈硬化 / インフラマソーム / うつ病 / 女子大学生 / 社会的要因 / 男女共同参画 / エピジェネティクス / UTX / COMPASS-like complex / UTY / 幹細胞 / 老化 / 抗加齢療法 Less

Functional analyses of enzymatic activity- and complex formation-dependent roles of UTX in the regulation of hematopoietic stem cells and development of hematopoietic diseasesOngoing
- Principal Investigator
  
  本田浩章
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Women's Medical University
Elucidation of mechanisms underlying stem cell aging induced by deregulation of histone modifications and development of anti-aging therapies by maintaining their functionsOngoing
- Principal Investigator
  
  本田浩章
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Tokyo Women's Medical University
A novel functional antigen receptor TMD module identified as an SLE-associating SNP-related structurePrincipal InvestigatorOngoing
- Principal Investigator
  
  本田善一郎
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Ochanomizu University
痛風における動脈硬化促進の分子機序の解明Ongoing
- Principal Investigator
  
  河野肇
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Teikyo University
女子大学生のうつ病の発症に影響する社会的要因の研究－男女共同参画社会に向けて－Ongoing
- Principal Investigator
  
  布施泰子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Ibaraki University
Analysis of pathogenic mechanisms of myelodysplastic syndrome by deregulation of histone H3K27
- Principal Investigator
  
  Honda Hiroaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Analysis of leukemogenic mechanisms by deregulated expression of histone demethylase Fbxl10
- Principal Investigator
  
  HONDA Hiroaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Analysis of the novel FcgR transmembrane interface motif displaying a polymorphism associate with human SLE susceptibilityPrincipal Investigator
- Principal Investigator
  
  HONDA Zen-ichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Ochanomizu University
  The University of Tokyo
Isolation of novel anti-oncogenes using transposon in model mice for chronic myelogenous leukemia
- Principal Investigator
  
  HONDA Hiroaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Where is the cause of Bartter's syndrome in the kidney?
- Principal Investigator
  
  WATANABE Sumiyo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
全身性エリテマトーデスの遺伝素因における荘型インターフェロン制御系分子群の役割
- Principal Investigator
  
  TSUCHIYA Naoyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
ヒトSLE関連遺伝子異常マウスの病態形成における脂質メディエーターの役割の解明
- Principal Investigator
  
  鈴木毅
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Patho-physiological analysis of collagen vascular disease development results from dysfunction of the membrane microdomain, lipid raftsPrincipal Investigator
- Principal Investigator
  
  HONDA Zen-ichiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Defective immuno-surveillance owing to the disorganization of lipid rafts and its roles in the pathogenesis of autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  HONDA Zen-ichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
EVH1結合配列を持つSrcファミリーキナーゼ特異的新規ユビキチンリガーゼPrincipal Investigator
- Principal Investigator
  
  本田善一郎
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Genomic studies on the rheumatic disease-related genes and their clinical implications
- Principal Investigator
  
  YSUCHIYA Naoyuki
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Analysis of the components of lipid rafts and the possible alteration their pattern in SLEPrincipal Investigator
- Principal Investigator
  
  HONDA Zem-ichiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
脂質ラフトを場とするFc受容体シグナル発信機構の解析Principal Investigator
- Principal Investigator
  
  本田善一郎
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Fc receptor signal initiation mechanisms at lipid rafts
- Principal Investigator
  
  SUZUKI Takeshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
STudies on subceptibility genes to autoimmune diseases using genomic approach
- Principal Investigator
  
  TSUCHIYA Naoyuki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  The University of Tokyo
Specific roles of Src family kinases in inflammatory signaling pathwaysPrincipal Investigator
- Principal Investigator
  
  HONDA Zenichire
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  University of Tokyo
三量体G蛋白質を介する神経分化機構の解析Principal Investigator
- Principal Investigator
  
  本田善一郎
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
The association of polymorphisms of tyrosine kinases with atopic diseases
- Principal Investigator
  
  MORITA Yutaka
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Analysis of a nglammetroumechanisms mediated by GproteinPrincipal Investigator
- Principal Investigator
  
  HONDA Zenichiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
心筋細胞におけるPAF受容体機能の解析
- Principal Investigator
  
  和泉孝志
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
脂質ホルモンによる関節リウマチ滑膜・増殖機構の解析とその制御Principal Investigator
- Principal Investigator
  
  本田善一郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
AIRWAY MUCOSA CELLS PRODUCE CHEMOTACTIC FACTOR(S) FOR MAST CELLS.
- Principal Investigator
  
  SHOJI Shunsuke
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The UNIVERSITY OF TOKYO
トランスジェニックマウスを用いた心筋細胞におけるPAF受容体の解析
- Principal Investigator
  
  和泉孝志
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
エンドトキシンショックにおける脂質伝達物質の役割に関する研究Principal Investigator
- Principal Investigator
  
  本田善一郎
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
気管支喘息における遺伝子多型の研究-高親和性Ige受容体を介するシグナル伝達に関与する機能分子について
- Principal Investigator
  
  森田寛
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Abnormal expression of phospholipases A_2 and human diseases
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Showa University
MOLECULAR MECHANISMS OF ACTION AND PHYSIOLOGICAL ROLES OF LIPID AUTACOIDS IN THE NEPHRON
- Principal Investigator
  
  WATANABE Tsuyoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  UNIVERSITY OF TOKYO
Gタンパク質を介する神経細胞死モデルを用いた情報伝達分子の解析Principal Investigator
- Principal Investigator
  
  本田善一郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
トランスジェニックマウスを用いた心筋細胞におけるPAF受容体の解析
- Principal Investigator
  
  IZUMI Takashi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
炎症細胞における血小板活性化因子(PAF)受容体の発現と作用
- Principal Investigator
  
  和泉孝志
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
サブトラクション/エクスプレッション法を用いた顆粒球機能分子の同走Principal Investigator
- Principal Investigator
  
  本田善一郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
情報伝達分子の相互作用に着目したPAF,エイコサノイド受容体の機能解析Principal Investigator
- Principal Investigator
  
  本田善一郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
STUDIES ON PHYSIOLOGICAL FUNCTION OF PLATELET-ACTIVATING FACTOR
- Principal Investigator
  
  SHIMIZU Takao
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  THE UNIVERSITY OF TOKYO
血小板活性化因子(PAF)、エイコサノイド受容体とG蛋白質の脱共役Principal Investigator
- Principal Investigator
  
  本田善一郎
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
THE MECHANISM AND BIOSYNTHESIS OF BIOACTIVE LIPIDS
- Principal Investigator
  
  IZUMI Takashi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Screening and Development of New Immnomodulatory Drugs using PAF Receptor Gene as a Probe
- Principal Investigator
  
  SHIMIZU Takao
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] dentification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia.2016
- Author(s)
  Sera Y, Yamasaki N, Oda H, Nagamachi A, Wolff L, Inukai T, Inaba T, Honda H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 107 Pages: 890-8
- DOI
  10.1111/cas.12945
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-15K09645, KAKENHI-PROJECT-16K19575
[Journal Article] ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.2016
- Author(s)
  Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda ZI, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H.
- Journal Title
  
  Oncogene
  
  Volume: 無 Pages: 4447-4458
- DOI
  10.1038/onc.2015.519
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-25460416, KAKENHI-PROJECT-15K14384, KAKENHI-PROJECT-26670493, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-26293242, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-16K08691
[Journal Article] Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.2016
- Author(s)
  Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Matsui H, Honda ZI, Oda H, Wolff L, Inaba T, Honda H.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 113(37) Pages: 10370-10375
- DOI
  10.1073/pnas.1600070113
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K19575
[Journal Article] Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency.2016
- Author(s)
  Ikeda K-I, Ueda T, Yamasaki N, Nakata Y, Sera Y, Nagamachi A, Miyama T, Kobayashi H, TakuboK, Kanai A, Oda H, Wolff l, Honda Z-1, Ichinohe T, Matsubara A, Suda T, Inaba T, Honda H
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Pages: 29454-29454
- DOI
  10.1038/srep29454
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-16K19575
[Journal Article] －7/7q－ syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity.2015
- Author(s)
  Honda H, Nagamachi A, Inaba T.
- Journal Title
  
  Oncogene
  
  Volume: 34 Pages: 2413-2425
- DOI
  10.1038/onc.2014.196
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860735, KAKENHI-PROJECT-26293227
[Journal Article] Overexpression of the shortest isoform of histone demethylase LSD1 primes hematopoietic stem/progenitor cells for malignant transformation.2015
- Author(s)
  Wada T, Koyama D, Kikuchi J, Honda H, Furukawa Y.
- Journal Title
  
  Blood
  
  Volume: 125 Pages: 3731-3746
- DOI
  10.1182/blood-2014-11-610907
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461430, KAKENHI-PROJECT-15K19557, KAKENHI-PROJECT-26293227
[Journal Article] Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg22015
- Author(s)
  Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood.
  
  Volume: 125 Pages: 3437-3446
- DOI
  10.1182/blood-2014-03-562694
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26860735, KAKENHI-PROJECT-26293227
[Journal Article] CIZ1, a p21^<Cip1/Waf1>-interacting protein, functions as a tumor suppressor in vivo2014
- Author(s)
  Nishibe R, Watanabe W, Ueda T, Yamasaki N, Koller R, Wolff L, Honda Z, Ohtsubo M, Honda H.
- Journal Title
  
  FEBS Lett
  
  Volume: 587 Pages: 1529-1535
- DOI
  10.1016/j.febslet.2013.03.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591459
[Journal Article] Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function2014
- Author(s)
  Nagamachi A, Nakata Y, Ueda T, Yamasaki N, Ebihara Y, Tsuji K, Honda Zi, Takubo K, Suda T, Oda H, Inaba T, Honda H
- Journal Title
  
  PLoS One.
  
  Volume: 9 Pages: 1-10
- DOI
  10.1371/journal.pone.0087425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390252, KAKENHI-PROJECT-23591459, KAKENHI-PROJECT-23689049, KAKENHI-PROJECT-24390272, KAKENHI-PUBLICLY-25118724, KAKENHI-PROJECT-25640065, KAKENHI-PROJECT-25670489, KAKENHI-PROJECT-26293243, KAKENHI-PROJECT-26670511
[Journal Article] The IL-2/CD25 Axis Maintains Distinct Subsets of Chronic Myeloid Leukemia–Initiating Cells.2014
- Author(s)
  Kobayashi CI, Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, Suda T
- Journal Title
  
  Blood
  
  Volume: 123 Pages: 2540-2549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] Haploinsufficiency of SAMD9L, an endosome fusion facilitator, in mice induces the development of myeloid malignancies mimicking human diseases with monosomy 7.2014
- Author(s)
  Nagamachi A
- Journal Title
  
  Cancer Cell.
  
  Volume: 24 Pages: 305-17
- DOI
  10.1016/j.ccr.2013.08.011
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130004, KAKENHI-PROJECT-23240125, KAKENHI-PROJECT-23249053, KAKENHI-PROJECT-23390252, KAKENHI-PROJECT-23689049, KAKENHI-PROJECT-24591397, KAKENHI-PUBLICLY-25118724, KAKENHI-PROJECT-25550030, KAKENHI-PROJECT-25640065
[Journal Article] A long lasting puzzle for －7/7q－ syndrome.2014
- Author(s)
  Honda H, Inaba T
- Journal Title
  
  Oncotarget
  
  Volume: 5 Pages: 7-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] CIZ1, a p21 Cip1 /Waf1-interacting protein, functions as a tumor suppressor in vivo2013
- Author(s)
  Nishibe R, Watanabe W, Ueda T, Yamasaki N, Koller R, Wolff L, Honda Z-i, Ohtsubo M, Honda H
- Journal Title
  
  FEBS Lett
  
  Volume: 587 Pages: 1529-1535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors2013
- Author(s)
  Nagamatsu G. Kosaka T, Saito S, Honda H, Takubo K, Kinoshita T, Akiyama H, Sudo T, Horimoto K, Oya M, Suda T
- Journal Title
  
  Stem Cells
  
  Volume: 31 Pages: 479-487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] p130Cas plays important roles in osteoclastic bone resorption2013
- Author(s)
  Nagai Y, Osawa K, Fukushima H, Tamura Y, Aoki K, Ohya K, Yasuda H, Hikiji H, Seta Y, Seo S, Kurokawa M, Kato S, Honda H, Nakamura I, Maki K, Jimi E
- Journal Title
  
  J Bone Miner Res
  
  Volume: 28(12) Pages: 2449-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] Skeletal muscle adaptation 1 in response to mechanical stress in p130Cas-/- mice2013
- Author(s)
  Akimoto T, Okuhira K, Aizawa K, Wada S, Honda H, Fukubayashi T, Uchida T
- Journal Title
  
  Am J Physiol Cell Physiol
  
  Volume: 304
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms2012
- Author(s)
  Ueda T, Sanada M, Matsui H, Yamasaki N, Honda ZI, Shih LY, Mori H, Inaba T, Ogawa S, Honda H.
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 2557-2560
- DOI
  10.1038/leu.2012.146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591459, KAKENHI-PROJECT-24390242, KAKENHI-PROJECT-24659458
[Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor2012
- Author(s)
  Sugihara E, Shimizu T, Kojima K, Ohishi N, Kai K, Ishizawa J, Nagata K, Hashimoto N, Honda H, Kanno M, Miwa M, Okada S, Andreeff M, Saya H
- Journal Title
  
  Oncogene
  
  Volume: 31 Pages: 2849-2861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] Mouse Samd9l is not a functional paralogue of the human SAMD9, the gene mutated in normophosphataemic familial tumoral calcinosis2012
- Author(s)
  Li Q, Guo H, Matsui H, Honda H, Inaba T, Sundberg JP, Sprecher E, Uitto J
- Journal Title
  
  Exp Dermatol
  
  Volume: 21 Pages: 554-556
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation2012
- Author(s)
  Ozaki Y, Matsui H, Asou H, Nagamachi A, Aki D, Honda H, Yasunaga S, Takihara Y, Yamamoto T, Izumi S, Ohsugi M, Inaba T
- Journal Title
  
  Mol Cell
  
  Volume: 47 Pages: 694-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms2012
- Author(s)
  Ueda T, Sanada M, Matsui H, Yamasaki N, Honda Zi, Shih LY, Mori H, Inaba T, Ogawa S, Honda H
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 2557-2560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors2012
- Author(s)
  Zhang X, Kinuko Hirose K, Akahane K, Kuroda I, Honna H, Kagami K, Goi K, Nakamura K, Kobayashi M, Yagita H, Kurosawa H, Look AT, Honda H, Inaba T, Nakazawa S, Sugita K, Endo M, Inukai T
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 2483-2493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic resticulum.2012
- Author(s)
  Hitomi Y, et al.
- Journal Title
  
  BMC Immunol.
  
  Volume: 13 Pages: 72-72
- DOI
  10.1186/1471-2172-13-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390199, KAKENHI-PROJECT-23390063, KAKENHI-PROJECT-23591459, KAKENHI-PROJECT-24590575
[Journal Article] Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation.2011
- Author(s)
  Honda H, Takubo K, Oda H, Kosaki K, Tazaki T, Yamasaki N, Miyazaki K, Moore KA, Honda Zi, Suda T, Lemischka IR.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 108 Pages: 2468-2473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation2011
- Author(s)
  Honda H, Takubo K, Oda H, Kosaki K, Tazaki T, Yamasaki N, Miyazaki K, Moore KA, Honda Zi, Suda T, Lemischka IR
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 108 Pages: 2468-2473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation.2011
- Author(s)
  Honda H, Takubo K, Oda H, Kosaki K, Tazaki T, Yamasaki N, Miyazaki K, Moore KA, Honda ZI, Suda T, Lemischka IR.
- Journal Title
  
  Proc Natl Acad Sci USA 108(6)
  
  Pages: 2468-2473
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl2011
- Author(s)
  Seo S, Nakamoto T, Takeshita M, Lu J, Sato T, Suzuki T, Kamikubo Y, Ichikawa M, Noda M, Ogawa S, Honda H, Oda H, Kurokawa M
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 2109-2117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation2011
- Author(s)
  Honda H(他10名 )
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 108 Pages: 2468-2473
- DOI
  10.1073/pnas.1003403108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249053, KAKENHI-PROJECT-23591459
[Journal Article] The Samd9L gene : transcriptional regulation and tissue-specific expression in mouse development2011
- Author(s)
  Jiang Q, Quaynor B, Sun A, Li Q, Matsui H, Honda H, Inaba T, Sprecher E, Uitto J
- Journal Title
  
  J Invest Dermatol
  
  Volume: 131 Pages: 1428-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] pl30Cas plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration.2010
- Author(s)
  Tazaki T, Sasaki, Uto K, Yamasaki N, Tashiro S, Sakai R, Tanaka M, Oda H, HondaZi, Honda H.
- Journal Title
  
  Hepatology
  
  Volume: 52 Pages: 1089-1099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells.2010
- Author(s)
  Miyazaki K, Miyazaki M, Guo Y, Yamasaki N, Kanno M, Honda Zi, Oda H, Kawamoto H, Honda H.
- Journal Title
  
  Journal of Immunology
  
  Volume: 385 Pages: 7330-7339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model.2010
- Author(s)
  Nagamachi A, Htun PW, Ma F, Miyazaki K, Yamasaki N, Kanno M, Inaba T, Honda Zi, Okuda T, Oda H, Tsuji K, Honda H.
- Journal Title
  
  Dev Biol 345
  
  Pages: 226-236
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.2010
- Author(s)
  Yamasaki N, Miyazaki K, Nagamachi A, Koller R, Oda H, Miyazaki M, Sasaki T, Honda Zi, Wolff L, Inaba T, Honda H.
- Journal Title
  
  Oncogene 29
  
  Pages: 1963-1975
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells.2010
- Author(s)
  Miyazaki K, Miyazaki M, Guo Y, Yamasaki N, Kanno M, Honda Zi, Oda H, Kawamoto H, Honda H.
- Journal Title
  
  J Immunol 385(12)
  
  Pages: 7330-7339
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] p130Cas plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration.2010
- Author(s)
  Tazaki T, Sasaki T, Uto K, Yamasaki N, Tashiro S, Sakai R, Tanaka M, Oda H, Honda Zi, Honda H.
- Journal Title
  
  Hepatology 52
  
  Pages: 1089-1099
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model.2010
- Author(s)
  Nagamachi A, Htun P W, Ma F, Miyazaki K, Yamasaki N, Kanno M, Inaba T, Honda Zi, Okuda T, Oda H, Tsuji K, Honda H.
- Journal Title
  
  Developmental Biology
  
  Volume: 345 Pages: 226-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.2010
- Author(s)
  Yamasaki N, Miyazaki K, Nagamachi A, Koller R, Oda H, Miyazaki M, Sasaki T, Honda Zi, Wolff L, Inaba T, Honda H.
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 1963-1975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.2009
- Author(s)
  Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
- Journal Title
  
  Nature 460
  
  Pages: 904-908
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Haploinsufficiency and acquired loss of Bcl11b and H2AX induced blast crisis of chronic myelogenous leukemia in a transgenic mouse model.2009
- Author(s)
  Nagamachi A, 7名, Honda H.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 1219-1226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Elevated intraocular pressure, optic nerve atrophy, and impaired retinal development in ODAG transgenic mice.2009
- Author(s)
  Sasaki T, Watanabe W, Muranishi Y, Kanamoto T, Aihara M, Miyazaki K, Tamura H, Saeki T, Oda H, Souchelnytskyi N, Souchelnytskyi S, Hirohiko A, Honda Zi, Furukawa T, Mishima HK, Kiuchi Y, Honda H.
- Journal Title
  
  Invest Ophthalmol Vis Sci 50
  
  Pages: 242-248
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.2009
- Author(s)
  Miyazaki K, 13名, Honda H.
- Journal Title
  
  Blood 27
  
  Pages: 4702-4710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Haploinsufficiency and acquired loss of Bcl11b and H2AX induced blast crisis of chronic myelogenous leukemia in a transgenic mouse model.2009
- Author(s)
  Nagamachi A, Yamasaki N, Miyazaki K, Oda H, Miyazaki M, Honda Zi, Kominami R, Inaba T, Honda H.
- Journal Title
  
  Cancer Sci 100
  
  Pages: 1219-1226
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.2009
- Author(s)
  Miyazaki K, Yamasaki N, Oda H, Kuwata T, Kanno Y, Miyazaki M, Komeno Y, Kitaura J, Honda Zi, Warming S, Jenkins NA, Copeland NG, Kitamura T, Nakamura T, Honda H.
- Journal Title
  
  Blood 113
  
  Pages: 4702-4710
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Overexpression of ocular development-associated gene (ODAG) in the eye induced elevated intraocular pressure, optic nerve atrophy, and impaired retinal development.2009
- Author(s)
  Sasaki T, Watanabe W, Muranishi Y, Kanamoto T, Aihara M, Miyazaki K, Tamura H, Saeki T, Oda H, Souchelnytskyi N, Souchelnytskyi S, Hirohiko A, Honda Z-i, Furukawa T, Mishima HK, Kiuchi Y, Honda H
- Journal Title
  
  Invest Ophthalmol Vis Sci. 50
  
  Pages: 242-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Identification of CENP-V as a novel microtubule-associating molecule that activates Src family kinases through SH3 domain interaction.2009
- Author(s)
  Honda Zi, Suzuki T, Honda H.
- Journal Title
  
  Genes Cells 14
  
  Pages: 1383-1394
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.2009
- Author(s)
  Sanada M, 6名, Honda H, 20名, Ogawa S.
- Journal Title
  
  Nature 100
  
  Pages: 904-908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.2008
- Author(s)
  Mizuno T, Yamasaki N, Miyazaki K, Tazaki T, Koller R, Oda H, Honda Zi, Ochi M, Wolff L, Honda H.
- Journal Title
  
  Oncogene 27
  
  Pages: 3465-3474
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fib roblasts derived from exon 2-specific knockout mice.2008
- Author(s)
  Tazaki T, Honda Z, 他
- Journal Title
  
  Genes Cells. 13
  
  Pages: 145-57
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch 1 induced acute leukemia in p210BCR/ABL transgenic mice.2008
- Author(s)
  Mizuno T, Honda Z 他
- Journal Title
  
  Oncogene in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notchl induced acute leukemia in p210BCR/ABL transgenic mice2008
- Author(s)
  Mizuno T, Honda Z, et. al.
- Journal Title
  
  Oncogene
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Overexpression / enhanced kinase activity of BCR / ABL and altered expression of Notchl induced acute leukemia in p210BCR / ABL ransgenic mice.2008
- Author(s)
  Mizuno T, Honda Z, 他
- Journal Title
  
  Oncogene (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Successful treatment with infliximab of refractory rheumatoid arthritis in a male with ‘GDF5 brachydactyly'.2008
- Author(s)
  Suzuki T, Honda Z.
- Journal Title
  
  Rheumatol Int. 28
  
  Pages: 201-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Pre-TCR-induced thymocyte proliferation is epigenetically maintained through BMI-1-mediated p19Arf repression.2008
- Author(s)
  Miyazaki M, Miyazaki K, Itoi M, Katoh Y, Guo Y, Kanno R, Katoh-Fukui Y, Honda H, Amagai T, van Lohuizen M, Kawamoto H, Kanno M.
- Journal Title
  
  Immunity 28
  
  Pages: 231-245
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Successful treatment with infliximab of refractory rheumatoid arthritis in amale with'GDF5 brachydactyly'.2008
- Author(s)
  Suzuki T, Honda Z.
- Journal Title
  
  Rheumatology Int 28
  
  Pages: 201-3
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Functional analysis of Src homology 3-encoding exon(exon 2) of p 130Cas in primary fibroblasts derived from exon 2-specific knockout mice2008
- Author(s)
  Takaki T, Honda Z, et. al.
- Journal Title
  
  Genes Cells 13(2)
  
  Pages: 145-57
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice.2008
- Author(s)
  Tazaki T, Miyazaki K, Hiyama E, Nakamoto T, Sakai R, Yamasaki N, Honda Zi, Noda M, Miyasaka N, Sueda T, Honda H.
- Journal Title
  
  Genes Cells 13
  
  Pages: 145-157
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notchl induced acute leukemia in p210BCR/ABL transgenic mice.2008
- Author(s)
  Mizuno T, Yamasaki N, Miyazaki K, Tazaki T, Koller R, Oda H, Honda Z-i, Ochi M, Wolff L, Honda H.
- Journal Title
  
  Oncogene 27
  
  Pages: 3465-3474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591126
[Journal Article] Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice.2008
- Author(s)
  Tazaki T, Honda Z 他
- Journal Title
  
  Genes Cells. 13
  
  Pages: 145-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Successful treatment with infliximab of refractory rheumatoid arthritis in a male with 'GDF5 brachydactyly'2007
- Author(s)
  Suzuki T Honda Z
- Journal Title
  
  Rheumatol Int 28(2)
  
  Pages: 201-3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Role of B cell inhibitory receptor polymorphisms in systemic lupus erythematosus : a negative times a negative makes a positive.2006
- Author(s)
  土屋尚之, 本田善一郎他
- Journal Title
  
  Journal of Human Genetics 51
  
  Pages: 741-750
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Fcepsilon-and Fcgamma-receptor signaling in diseases.2006
- Author(s)
  本田善一郎
- Journal Title
  
  Springer Seminar in Immunopathology 28
  
  Pages: 365-375
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Role of B cell inhibitory receptor polymorphisms in systemic lupus erythematosus : a negative times a negative makes a positive2006
- Author(s)
  Tsuchiya N, Honda Z
- Journal Title
  
  J Hum Genet 51(9)
  
  Pages: 741-50
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Fcepsilon- and Fcgamma-receptor signaling in diseases2006
- Author(s)
  Honda Z
- Journal Title
  
  Springer Semin Immunopathol 28(4)
  
  Pages: 365-75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591101
[Journal Article] Fc gamma RIIB Ile232Thr transmembrane polymorphism -----2005
- Author(s)
  Kono H., -----., *Honda Z.
- Journal Title
  
  Human Molecular Genetics 14(19)
  
  Pages: 2881-2892
- Data Source
  KAKENHI-PROJECT-16590976
[Journal Article] Fc gamma RIIB Ile232Thr transmembrane polymorphism-----2005
- Author(s)
  Kono H., -----., *Honda Z.
- Journal Title
  
  Human Molecular Genetics 14(19)
  
  Pages: 2881-2892
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590976
[Journal Article] CD72 polymorphisms associated with alternative---2004
- Author(s)
  Hitomi Y., ----Honda Z, Tolunaga K.
- Journal Title
  
  Human Molecular Genetics 13(23)
  
  Pages: 2907-2917
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590976
[Journal Article] CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B2004
- Author(s)
  Hitomi Y, Honda, Z他
- Journal Title
  
  Hum.Mol.Genet. 13・23
  
  Pages: 2907-2917
- Data Source
  KAKENHI-PROJECT-16590976
[Journal Article] 「研究成果報告書概要(欧文)」より2004
- Author(s)
  Hitomi Y, ----, Z.Honda, K Tokunaga.
- Journal Title
  
  Human Molecular Genetics 13(23)
  
  Pages: 2907-2917
- Data Source
  KAKENHI-PROJECT-16590976
[Presentation] Analysis of pathogenic mechanisms and development of therapeutic approaches using mouse cancer models2016
- Author(s)
  Hiroaki Honda
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-26293227
[Presentation] Jmjd3コンディショナルノックインマウスにおける白血病感受性亢進機構の解析2016
- Author(s)
  池田健一郎、上田健、長町安希子、山崎憲政、中田雄一郎、世良康如、小畠浩平、稲葉俊哉、本田浩章
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-26293227
[Presentation] AMLの分子機構2016
- Author(s)
  本田浩章
- Organizer
  第78回日本血液学学会総会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-26293227
[Presentation] Haploinsufficiency of Eed enhances to tumor susceptibility and develop leukemia with overexpression of Evi12015
- Author(s)
  Kenichiro Ikeda, Takeshi Ueda, Akiko Nagamachi, Norimasa Yamasaki, Yuichiro Nakata, Toshiya Inaba, Hiroaki Honda
- Organizer
  The 74th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2015-09-29
- Data Source
  KAKENHI-PROJECT-26293227
[Presentation] Functional analysis of UTX, a histone demethylase for H3K27, in normal hematopoiesis and hematologic malignancies2015
- Author(s)
  Yasuyuki Sera, Takeshi Ueda, Yuichiro Nakata, Ken-ichiro Ikeda, Norimasa Yamasaki, Hideaki Oda, Zen-ichiro Honda and Hiroaki Honda
- Organizer
  The 77th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Kanazawa
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26293227
[Presentation] Role of disease-related EED Ile363Met mutant in embryonic development and tumorigenesis2014
- Author(s)
  Takeshi Ueda, Masashi Sanada, Hirotaka Matsui, Norimasa Yamasaki, Zen-ichiro Honda, Lee-Yung Shih, Hiraku Mori, Toshiya Inaba, Seishi Ogawa, and Hiroaki Honda
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] Analysis of leukemogenic mechanisms by deregulated methylation of histone H3K272014
- Author(s)
  Honda H
- Organizer
  The 73rd Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Tokyo
- Year and Date
  2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-26293227
[Presentation] ヒストン脱メチル化酵素Fbxl10の脱制御による白血病発症機構の解析2013
- Author(s)
  本田浩章
- Organizer
  新学術領域がん支援冬期シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] MDSで同定されたポリコローム複合体構成因子EEDの機能欠失型変異体の解析2012
- Author(s)
  上田健, 真田晶, 松井啓隆, 山崎憲政, 本田善一郎, 森啓, LEE-YUNG SHIH 稲葉俊哉, 小川誠司, 本田浩章
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] MDSで同定されたポリコローム複合体構成因子EEDの機能欠失型変異体の解析2012
- Author(s)
  上田健,真田晶,松井啓隆,山崎憲政,本田善一郎,森啓, LEE-YUNG SHIH稲葉俊哉,小川誠司,本田浩章
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-23591459
[Presentation] 骨髄異形成症候群におけるポリコローム複合体PRC構成因子EDDの機構欠失型変異2011
- Author(s)
  上田健, 真田晶, 松井啓隆, 山崎憲政, 本田善一郎, 森啓, LEE-YUNG SHIH, 稲葉俊哉, 小川誠司, 本田浩章
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] Eed mutations impairing polycomb repressive complex 2 function in myelodysplastic syndrome2011
- Author(s)
  上田健、真田昌、松井啓隆、山崎憲政、本田善一郎、Lee-Yung Shih、森啓、稲葉俊哉、小川誠司、本田浩章
- Organizer
  日本血液学
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] Different mechanisms through which Samd9L, a-7/7q-responsible gene, contributes to leukemogenesis2011
- Author(s)
  長町安希子、松井啓隆、尾崎佑子、山崎憲政、小田秀明、稲葉俊哉、本田浩章
- Organizer
  日本血液学
- Place of Presentation
  名古屋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] Analysis of leukemogenic mechanisms induced by deregulation of a histone demethylase, Fbx1102011
- Author(s)
  本田浩章
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] 横断性脊髄炎を呈した全身性エリテマトーデスの一例2011
- Author(s)
  津久井大輔,岡本明子,大久保麻衣,浅子来美,本田善一郎,河野肇,滝川一
- Organizer
  第599回日本内科学会関東地方会
- Place of Presentation
  東京
- Year and Date
  2011-04-14
- Data Source
  KAKENHI-PROJECT-23591459
[Presentation] -7/7q-責任遺伝子候補 Samd9L2011
- Author(s)
  長町安希子, 松井啓隆, 尾崎裕子, 山崎憲政, 小田秀明 , 稲葉俊哉 , 本田浩章
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] Deregulated expression of Fbxl10, a histone demethylase, contributes to leukemia development.2010
- Author(s)
  Ueda T, Inagaki M, Nagamachi A, Yamasaki N, Matsui H, Takubo K, Konuma T, Suda T, Iwama A, Inaba T, Honda H
- Organizer
  第72回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20591126
[Presentation] 造血細胞におけるWnt5aの欠失はp210BCR/ABLによって引き起こされるCMLを増悪させる2010
- Author(s)
  稲垣舞子、小山浩史、菊池章、本田浩章
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-20591126
[Presentation] Unique Gain-of-Function of Mutated c-CBL Tumor Suppresor in Myeloid Neoplasms.2009
- Author(s)
  Sanada M, 5名本田浩章, 14名, Ogawa S.
- Organizer
  51th Annual Meeting of American Society of Hematology
- Place of Presentation
  New Orleans, USA
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-20591126
[Presentation] ヒストン脱メチル化酵素Fbxl10の7q- AML/MDS発症過程への関与2009
- Author(s)
  長町安希子, 8名, 本田浩章
- Organizer
  日本血液学会年会
- Place of Presentation
  京都
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20591126
[Presentation] bHLH型転写因子Dec1の発現調節はT 細胞の胸腺内セレクションと分化に必要である2008
- Author(s)
  宮崎和子, 宮崎正輝, 山崎憲政, 菅野雅元, 本田浩章
- Organizer
  日本血液学会年会
- Place of Presentation
  京都
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20591126

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Honda Zen-ichiro 本田 善一郎

本田 善一郎 ホンダ ゼンイチロウ

HONDA Zenitiro 本田 善一郎

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Functional analyses of enzymatic activity- and complex formation-dependent roles of UTX in the regulation of hematopoietic stem cells and development of hematopoietic diseasesOngoing

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Elucidation of mechanisms underlying stem cell aging induced by deregulation of histone modifications and development of anti-aging therapies by maintaining their functionsOngoing

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A novel functional antigen receptor TMD module identified as an SLE-associating SNP-related structurePrincipal InvestigatorOngoing

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痛風における動脈硬化促進の分子機序の解明Ongoing

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女子大学生のうつ病の発症に影響する社会的要因の研究－男女共同参画社会に向けて－Ongoing

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Analysis of the novel FcgR transmembrane interface motif displaying a polymorphism associate with human SLE susceptibilityPrincipal Investigator

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Patho-physiological analysis of collagen vascular disease development results from dysfunction of the membrane microdomain, lipid raftsPrincipal Investigator

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Defective immuno-surveillance owing to the disorganization of lipid rafts and its roles in the pathogenesis of autoimmune diseasesPrincipal Investigator

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Honda Zen-ichiro 本田善一郎

本田善一郎ホンダゼンイチロウ

HONDA Zenitiro 本田善一郎