Koya Daisuke 古家大祐

… Alternative Names

KOYA Daisuke 古家大祐

古屋大祐コヤダイスケ

古家大祐コヤダイスケ

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Researcher Number	70242980
Other IDs
Affiliation (Current)	2025: 金沢医科大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 金沢医科大学, 医学部, 客員教授 2009 – 2020: Kanazawa Medical University, 医学部, 教授 2005 – 2006: 金沢医科大学, 医学部, 教授 2004 – 2005: SHIGA UNIVERSITY OF MEDICAL SCIENCE, ASSISTANT PROFESSOR, 医学部, 講師 1997 – 2003: 滋賀医科大学, 医学部, 助手 1993: 滋賀医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Kidney internal medicine / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Metabolomics / Kidney internal medicine / Eating habits / 内分泌・代謝学 Except Principal Investigator Biological Sciences / Metabolomics / Kidney internal medicine … More / Basic Section 53040:Nephrology-related / Basic Section 58060:Clinical nursing-related / Ophthalmology / 内分泌・代謝学 / Metabolomics / Kidney internal medicine Less
Keywords	Principal Investigator PKC / 糖尿病 / オートファジー / 糖尿病性腎症 / 酸化ストレス / 内皮細胞 / diabetic nephropathy / Ac-SDKP / db / DIABETIC NEPHROPATHY … More / 腎線維化 / IL-6 / 内皮・間葉転化 / SIRT1 / 線維化 / カロリー制限 / 糖尿病腎症 / メサンギウム細胞 / DAG / MGAT / SGLT-２阻害薬 / 糖尿病性腎臓病 / HK細胞 / MAPK / シングルセル解析 / MGAT2 / 血管内皮細胞 / 上皮間葉転化 / 内皮間葉転化 / 内皮 / 膵島 / 心線維化 / 内皮・間葉化 / 内皮間葉化 / 心臓 / 腎臓 / 高脂肪食負荷 / smad 7 / TGF-beta / oxidative stress / apoptosis / sitr1 / kidney diseaes / H2O2 / プロテオミクス / アポトーシス / p53 / Smad7 / smad / db mouse / mesangial cell / Smad / TGF-β / mesangial expansion / albuminuria / 血清クレアチニン / ANTIOXIDANTS / OXIDATIVE STRESS / DIACYLGILYCEROL KINASE / DGK / 抗酸化薬 / Diacylglycerol Kinase / GLOMERULOSCLEROSIS / PKC INHIBITOR / URINARY ALBUMIN / メサンギウム領域 / PKC阻害剤 / 糸球体硬化 / PKCβ阻害剤 / 尿中アルブミン / メトフォルミン / マイクロRNA / miRNA / AcSDKP / microRNA / mTOR / 代謝 / 骨格筋 / ケト原性アミノ酸 / ポドサイト / 腎障害 / 代謝異常 / メチオニン / たんぱく質 / ケイ原性アミノ酸 / たんぱく質制限 / Mn-SOD / 加齢腎 / ミトコンドリア / プロテオーム解析 / レスベラトロール / 糖代謝異常 / エネルギー / cGMP / 可溶性グアニル酸シクラーゼ / ブラジキニン / 内皮由来弛緩因子 … More Except Principal Investigator 糖尿病性腎症 / 糖尿病 / TGF-β / オートファジー / メサンギウム細胞 / 糖尿病合併症 / 遺伝子多型 / fibronectin / 糖尿病腎症 / 白血球DNA / 家系図 / 糖尿病性腎臓病 / NADPH oxidase / PKC-β / 酸化ストレス / mesangial cells / AP-1 / Ac-SDKP / Smad / 細胞外基質 / cAMP / cGMP / 周期的伸展刺激 / 糸球体高血圧 / サーチュイン / 炎症 / ミトコンドリア / システイニルロイコトリエン受容体1 / 腎尿細管間質 / 尿細管間質障害 / プランルカスト / システイニルロイコトリエン受容体1 / 糖尿病関連腎臓病 / 高齢糖尿病患者 / 医療の標準化 / 疾病負荷 / 安全性 / 自立支援 / 家族 / 自己管理 / 慢性腎臓病 / 高齢者 / EQ-5D-5L / 新型コロナウイルス感染症 / 認知症 / 医療依存度 / 糖尿病ディストレス / QOL / 医療経済 / 介護 / 自己管理能力 / 併存疾患 / 重症化予防 / 糖尿病重症化予防 / 認知機能 / 加齢変化 / 橋渡し研究 / 動機づけ面接 / 生活習慣改善 / アクセプタビリティ / 糖尿病自己管理 / 糖尿病発症・重症化予防 / 老年症候群 / 高齢者糖尿病 / mTOR1 / グリシンNメチルトランスフェラーゼ / S-アデノシルメチオニン / メチオニン / 低蛋白質食 / 2型糖尿病ラット / ﾐﾄｺﾝﾄﾞﾘｱ / カロリー制限 / CD38 / Sirt3 / 網膜血管細胞死 / 糖尿病網膜症 / diabetic nephropathy / oxidative stress / heme oxygenase-1 / 腎糸球体 / PKC / 糸球体 / HO-1 / NADPHオキシダーゼ / pioglitazone / MAPKs / ピオグリタゾン / extracellular matrix protein / extracellular signal-regulated kinase (ERK) / Stretch stress / Mesangial cells / Diabetic nephropathy / ブドウ糖過剰 / MAP kinase / extracellular signal-regulated kinase(ERK) / 高糖濃度 / Gene expression / Cyclic stretch / Glomerular hypertension / Mesangial cell / Diabetic nephoropathy / 遺伝子発現 / β細胞増殖 / 迷走神経シグナル / インクレチン効果 / 食行動 / 迷走神経 / グルコース / インスリン分泌 / インクレチン / GLP-1 / たんぱく質制限食 / 栄養応答シグナル / ｵｰﾄﾌｧｼﾞｰ / 尿細管 / たんぱく質制限 / mTOR / 低たんぱく質食 / ゲノム / 遺伝子 / 家計図 / PKC beta / Cox-2 / NFAT / Calcineurin / 糸球体硬化 / 候補遺伝子 Less

Elucidation of the role of cysteinyl leukotriene receptor1 on advanced diabetic kidney disease
- Principal Investigator
  
  Munehiro Kitada
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Wakayama Medical University
  Kanazawa Medical University
New therapeutic strategy for diabetic kidney disease by inhibiting MGATPrincipal Investigator
- Principal Investigator
  
  古家大祐
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kanazawa Medical University
Translational research for ensuring acceptability of lifestyle management of older people with diabetes
- Principal Investigator
  
  Morikawa Hiroko
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58060:Clinical nursing-related
- Research Institution
  Kyoto University
  Komatsu University
Elucidation of role of changing S-adenosylmethionine (SAM) metabolism for the pathogenesis of diabetic kidney disease
- Principal Investigator
  
  KITADA Munehiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kanazawa Medical University
Endothelial autophagy deficiency induces interleukin 6-dependent endothelial mesenchymal transition and organ fibrosisPrincipal Investigator
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kanazawa Medical University
The role of neural mechanism generated by intraportal GLP-1 in the physiological insulin secretion
- Principal Investigator
  
  NISHIZAWA Makoto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa Medical University
Investigation of autophagy-regulated mechanism of vascular cell death in early diabetic retinopathy
- Principal Investigator
  
  Takagi Hitoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  St. Marianna University School of Medicine
The role of Sirtuin on diabetic nephropatfunctionhy based on maintaining mitochondrial
- Principal Investigator
  
  WATANABE Ai
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kanazawa Medical University
Alteration in nutrient sensing and metabolic diseasesPrincipal Investigator
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits
- Research Institution
  Kanazawa Medical University
New therapeutic strategy for diabetic nephropathy via autophagy regulationPrincipal Investigator
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kanazawa Medical University
Elucidation of mechanism by which low protein diet suppresses progression of diabetic nephropathy through activation of autophagy in tubular cells
- Principal Investigator
  
  KITADA Munehiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kanazawa Medical University
New therapeutic strategy for diabetic nephropathyPrincipal Investigator
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa Medical University
ゲノム疫学研究・薬理ゲノミクスに基づく新たな糖尿病合併症治療戦略の開発
- Principal Investigator
  
  柏木厚典
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
The role of SIRT1 in mediating renal cells apoptosis and its therapeutic perspectivePrincipal Investigator
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa Medical University
糖尿病合併症・糖尿病薬剤感受性遺伝子の同定と新たな治療戦略への展開
- Principal Investigator
  
  柏木厚典
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
糖尿病合併症家系図の構築と糖尿病合併症候補遺伝子の検索
- Principal Investigator
  
  柏木厚典
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Effect of N-acetyl seryl-aspartyl-lysyl-proline on renal insufficiency and mesangial matrix expansion in diabetic db/db micePrincipal Investigator
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
糖尿病合併症家系図の構築と糖尿病合併症候補遺伝子の検索
- Principal Investigator
  
  柏木厚典
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
糖尿病合併症家系図の構築と糖尿病合併症候補遺伝子に検索
- Principal Investigator
  
  柏木厚典
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Mechanism of glomerular abnormality by oxidative stress in diabetic nephropathy
- Principal Investigator
  
  HANEDA Masakazu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Shiga University of Medical Science
糖尿病合併症家系図の構築と糖尿病合併症候補遺伝子の探索
- Principal Investigator
  
  KIKKAWA Ryuichi
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
腎糸球体硬化におけるCalcineurin-NFAT経路の重要性とその分子機構
- Principal Investigator
  
  MAEDA Shiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Shiga University of Medical Science
Development of the treatment of diabetic nephropathy by targeting the TGF-β signaling
- Principal Investigator
  
  KIKKAWA Ryuichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Shiga University of Medical Science
Molecular Mechanism in the development of diabetic nephropathy-the role of diacylglycerol kinase in regulating protein kinase C activity-Principal Investigator
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
ROLE OF DIABETES-INDUCED GLOMERULAR PKC-MAPK ACTIVATION ON DIABETIC GLOMERULOSCLEROSISPrincipal Investigator
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
MOLECULAR MECHANISM OF MESANGIAL CELL DYSFUNCTION DUE TO HYPERGLYCEMIA AND GLOMERULAR HYPERTENSION
- Principal Investigator
  
  HANEDA Masakazu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
The molecular mechanism of increase of TGF-β expression in diabetic glomeruli
- Principal Investigator
  
  KIKKAWA Ryuichi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Shiga University of Medical Science
糖尿病性腎症の発症機構における系球体内皮細胞とメサンギウム細胞の相互作用Principal Investigator
- Principal Investigator
  
  古家大祐
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Shiga University of Medical Science

[Journal Article] 糖尿病性腎臓病の診断と治療　up date2023
- Author(s)
  古家大祐
- Journal Title
  
  糖尿病
  
  Volume: 66
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research2023
- Author(s)
  Kitada Munehiro、Araki Shin-ichi、Koya Daisuke
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 4 Pages: 595-595
- DOI
  10.3390/cells12040595
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08290
[Journal Article] Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis2023
- Author(s)
  Adhikari J, Hirai T, Kawakita E, Iwai K, Koya D, Kanasaki K.
- Journal Title
  
  J Diabetes Invetstig
  
  Volume: Online ahead of print. Issue: 7 Pages: 844-855
- DOI
  10.1111/jdi.14017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773, KAKENHI-PROJECT-22K08330
[Journal Article] 糖尿病性腎症病期分類2023の策定2023
- Author(s)
  古家大祐・他
- Journal Title
  
  糖尿病
  
  Volume: 66（11）
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] 糖尿病性腎臓病の治療に希望の光が2022
- Author(s)
  古家大祐
- Journal Title
  
  滋賀医学
  
  Volume: 44 Pages: 5-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] Adenosine/adenosine type?1 receptor signaling pathway did not play dominant roles on the influence of sodium?glucose cotransporter?2 inhibitor in the kidney of bovine serum albumin‐overloaded streptozotocin‐induced diabetic mice2022
- Author(s)
  Shimada Keiji、Kanasaki Keizo、Kato Makoto、Ogura Yoshio、Takagaki Yuta、Monno Itaru、Hirai Taro、Kitada Munehiro、Koya Daisuke
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: Online ahead of print Issue: 6 Pages: 955-964
- DOI
  10.1111/jdi.13760
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773, KAKENHI-PROJECT-22K08330
[Journal Article] Novel PKD2 Missense Mutation p.Ile424Ser in an Individual with Multiple Hepatic Cysts: A Case Report2022
- Author(s)
  Miura S, Niida Y, Hashizume C, Fujii A, Takagaki Y, Kusama K, Akazawa S, Minami T, Mukai T, Furuichi K, Tsuchishima M, Ueda N, Takamura H, Koya D, Ito T.
- Journal Title
  
  Medicines (Basel)
  
  Volume: 9 Issue: 4 Pages: 25-25
- DOI
  10.3390/medicines9040025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Rationale, design and baseline characteristics of the effect of canagliflozin in patients with type 2 diabetes and microalbuminuria in the Japanese population: The CANPIONE study2022
- Author(s)
  Miyamoto S, Heerspink HJL, de Zeeuw D, Toyoda M, Suzuki D, Hatanaka T, Nakamura T, Kamei S, Murao S, Hida K, Ando S, Akai H, Takahashi Y, Koya D, Kitada M, Sugano H, Nunoue T, Nakamura A, Sasaki M, Nakatou T, Fujimoto K, Kawanami D, Wada T, Miyatake N, Yoshida M, Shikata K; CANPIONE study Investigators.
- Journal Title
  
  Diabetes Obes Metab
  
  Volume: 24 Issue: 8 Pages: 1429-1438
- DOI
  10.1111/dom.14731
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] 糖尿病性腎臓病を視野に入れた糖尿病治療薬の選択2022
- Author(s)
  北田宗弘・古家大祐
- Journal Title
  
  腎臓内科
  
  Volume: 15 Pages: 55-63
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity2022
- Author(s)
  Tsuneki Hiroshi、Maeda Takahiro、Takata Shinjiro、Sugiyama Masanori、Otsuka Koyuki、Ishizuka Hinako、Onogi Yasuhiro、Tokai Emi、Koshida Chiaki、Kon Kanta、Takasaki Ichiro、Hamashima Takeru、Sasahara Masakiyo、Rudich Assaf、Koya Daisuke et al.
- Journal Title
  
  Cell Reports
  
  Volume: 41 Issue: 3 Pages: 111497-111497
- DOI
  10.1016/j.celrep.2022.111497
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06574, KAKENHI-PROJECT-22H04918, KAKENHI-PROJECT-21H02713, KAKENHI-PROJECT-20K21773, KAKENHI-PROJECT-21K19287, KAKENHI-PROJECT-21K19704, KAKENHI-PROJECT-23K24763, KAKENHI-PROJECT-21H05036
[Journal Article] Effects of SGLT2 Inhibitors on Atherosclerosis: Lessons from Cardiovascular Clinical Outcomes in Type 2 Diabetic Patients and Basic Researches2021
- Author(s)
  Xu J, Hirai T, Koya D, Kitada M.
- Journal Title
  
  J Clin Med.
  
  Volume: 11 Issue: 1 Pages: 137-137
- DOI
  10.3390/jcm11010137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08290, KAKENHI-PROJECT-20K21773
[Journal Article] NAD+ Homeostasis in Diabetic Kidney Disease.2021
- Author(s)
  Xu J, Kitada M, Koya D.
- Journal Title
  
  Front Med (Lausanne).
  
  Volume: 8 Pages: 703076-703076
- DOI
  10.3389/fmed.2021.703076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08290, KAKENHI-PROJECT-20K21773
[Journal Article] Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis2021
- Author(s)
  Xu J, Kitada M, Ogura Y, Koya D.
- Journal Title
  
  Front Cell Dev Biol.
  
  Volume: 9 Pages: 641852-641852
- DOI
  10.3389/fcell.2021.641852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08290, KAKENHI-PROJECT-20K21773
[Journal Article] 糖尿病性腎症（DKD)の治療　食事療法（保存期）2021
- Author(s)
  北田宗弘・古家大祐
- Journal Title
  
  腎と透析
  
  Volume: 91 Pages: 638-642
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] CD26/DPP-4: Type 2 Diabetes Drug Target with Potential Influence on Cancer Biology2021
- Author(s)
  Kawakita Emi、Koya Daisuke、Kanasaki Keizo
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 9 Pages: 2191-2191
- DOI
  10.3390/cancers13092191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats.2021
- Author(s)
  Monno I, Ogura Y, Xu J, Koya D, Kitada M.
- Journal Title
  
  Antioxidants
  
  Volume: 10 Issue: 11 Pages: 1754-1754
- DOI
  10.3390/antiox10111754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08290, KAKENHI-PROJECT-20K21773
[Journal Article] Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy.2021
- Author(s)
  Srivastava SP, Zhou H, Setia O, Liu B, Kanasaki K, Koya D, Dardik A, Fernandez-Hernando C, Goodwin J.
- Journal Title
  
  Nat Commun.
  
  Volume: 12 Issue: 1 Pages: 2368-2368
- DOI
  10.1038/s41467-021-22617-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys.2021
- Author(s)
  Srivastava SP, Li J, Takagaki Y, Kitada M, Goodwin JE, Kanasaki K, Koya D.
- Journal Title
  
  iScience
  
  Volume: - Issue: 5 Pages: 102390-102390
- DOI
  10.1016/j.isci.2021.102390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Autophagy in metabolic disease and ageing.2021
- Author(s)
  Kitada M, Koya D.
- Journal Title
  
  Nat Rev Endocrinol.
  
  Volume: 11 Issue: 11 Pages: 647-461
- DOI
  10.1038/s41574-021-00551-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08290, KAKENHI-PROJECT-20K21773
[Journal Article] Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)2021
- Author(s)
  Urushihara M, Sato H, Shimizu A, Sugiyama H, Yokoyama H, Hataya H, Matsuoka K, Okamoto T, Ogino D, Miura K, Hamada R, Hibino S, Shima Y, Yamamura T, Kitamoto K, Ishihara M, Konomoto T, Hattori M; the Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology.
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: 25 Issue: 9 Pages: 1018-1026
- DOI
  10.1007/s10157-021-02077-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07799, KAKENHI-PROJECT-19K08679, KAKENHI-PROJECT-20K21773
[Journal Article] Randomized trial of an intensified, multifactorial intervention in patients with advanced-stage diabetic kidney disease: Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan)2021
- Author(s)
  Shikata K, Haneda M, Ninomiya T, Koya D, Suzuki Y, Suzuki D, Ishida H, Akai H, Tomino Y, Uzu T, Nishimura M, Maeda S, Ogawa D, Miyamoto S, Makino H; Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan) collaborative group.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 12 Issue: 2 Pages: 207-216
- DOI
  10.1111/jdi.13339
- NAID
  120006880216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773, KAKENHI-PROJECT-17K09698
[Journal Article] Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity2021
- Author(s)
  Kumagai Asako、Takeda Satoru、Sohara Eisei、Uchida Shinichi、Iijima Hiroshi、Itakura Astuo、Koya Daisuke、Kanasaki Keizo
- Journal Title
  
  Hypertension
  
  Volume: - Issue: 1 Pages: 138-150
- DOI
  10.1161/hypertensionaha.120.16377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18175, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease2021
- Author(s)
  Srivastava Swayam Prakash、Goodwin Julie E.、Tripathi Pratima、Kanasaki Keizo、Koya Daisuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 11 Pages: 6027-6027
- DOI
  10.3390/ijms22116027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Dapagliflozin Restores Impaired Autophagy and Suppresses Inflammation in High Glucose-Treated HK-2 Cells2021
- Author(s)
  Xu J, Kitada M, Ogura Y, Liu H, Koya D.
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 6 Pages: 1457-1457
- DOI
  10.3390/cells10061457
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08290, KAKENHI-PROJECT-20K21773
[Journal Article] 糖尿病から腎臓を守る”くすり”の話2021
- Author(s)
  北田宗弘・古家大祐
- Journal Title
  
  さかえ：月刊糖尿病ライフ
  
  Volume: 61 Pages: 5-10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] 糖尿病性腎臓病に対する内因性保護的因子としてのオーとファジーの役割2021
- Author(s)
  北田宗弘、古家大祐
- Journal Title
  
  医学のあゆみ
  
  Volume: 276 Pages: 468-473
- Open Access
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] Anterior pituitary function in Rathke’s cleft cysts <i>versus</i> nonfunctioning pituitary adenomas2021
- Author(s)
  Fujii M, Nakagawa A, Tachibana O, Iizuka H, Koya D.
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 8 Pages: 943-952
- DOI
  10.1507/endocrj.EJ21-0050
- NAID
  130008079314
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773, KAKENHI-PROJECT-20K09358
[Journal Article] Sodium-glucose cotransporter 2 inhibitors in type 2 diabetes patients with renal function impairment slow the annual renal function decline, in a real clinical practice2021
- Author(s)
  Hirai T, Kitada M, Monno I, Oda E, Hayashi Y, Shimada K, Takagaki Y, Ogura Y, Fujii M, Konishi K, Sakurai M, Nakagawa A, Koya D.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 12 Issue: 9 Pages: 1577-1585
- DOI
  10.1111/jdi.13502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress.2021
- Author(s)
  Kitada M, Ogura Y, Monno I, Xu J, Koya D.
- Journal Title
  
  Biomedicines.
  
  Volume: - Issue: 2 Pages: 130-130
- DOI
  10.3390/biomedicines9020130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Sirtuins and Renal Oxidative Stress.2021
- Author(s)
  Ogura Y, Kitada M, Koya D.
- Journal Title
  
  Antioxidants
  
  Volume: 10 Issue: 8 Pages: 1198-1198
- DOI
  10.3390/antiox10081198
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08290, KAKENHI-PROJECT-20K21773
[Journal Article] The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1α accumulation.2021
- Author(s)
  Liu H, Takagaki Y, Kumagai A, Kanasaki K, Koya D.
- Journal Title
  
  J Diabetes Investig
  
  Volume: 12 Issue: 5 Pages: 697-709
- DOI
  10.1111/jdi.13478
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Medical nutrition therapy and dietary counseling for patients with diabetes-energy, carbohydrates, protein intake and dietary counseling2020
- Author(s)
  Yamauchi Toshimasa、Kamiya Hideki、Utsunomiya Kazunori、Watada Hirotaka、Kawanami Daiji、Sato Junko、Kitada Munehiro、Koya Daisuke、Harada Norio、Shide Kenichiro、Joo Erina、Suzuki Ryo、Bouchi Ryotaro、Ohta Yasuharu、Kondo Tatsuya
- Journal Title
  
  Diabetology International
  
  Volume: 11 Issue: 3 Pages: 224-239
- DOI
  10.1007/s13340-020-00437-7
- NAID
  130007821841
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08714, KAKENHI-PROJECT-19K09006, KAKENHI-PROJECT-20K21773
[Journal Article] CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD +/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats2020
- Author(s)
  Ogura Y, Kitada M, Xu J, Monno I, Koya D.
- Journal Title
  
  Aging (Albany NY) .
  
  Volume: 12 Issue: 12 Pages: 11325-11336
- DOI
  10.18632/aging.103410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Manganese Superoxide Dismutase Dysfunction and the Pathogenesis of Kidney Disease2020
- Author(s)
  Kitada M, Xu J, Ogura Y, Monno I, Koya D.
- Journal Title
  
  Front Physiol .
  
  Volume: 11 Pages: 755-755
- DOI
  10.3389/fphys.2020.00755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways2020
- Author(s)
  Dorotea D, Koya D, Ha H.
- Journal Title
  
  Front Pharmacol .
  
  Volume: 11 Pages: 265-265
- DOI
  10.3389/fphar.2020.00265
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] 糖尿病性腎臓病に対するSGLT2阻害薬の臨床的重要性2020
- Author(s)
  北田宗弘、古家大祐
- Journal Title
  
  Progress in Medicine
  
  Volume: 40 Pages: 117-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity2020
- Author(s)
  Watanabe E, Wada T, Okekawa A, Kitamura F, Komatsu G, Onogi Y, Yamamoto S, Sasahara M, Kitada M, Koya D, Tsuneki H, Sasaoka T.
- Journal Title
  
  Angiogenesis .
  
  Volume: 23 Issue: 4 Pages: 667-684
- DOI
  10.1007/s10456-020-09738-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-18K08469
[Journal Article] 「糖尿病ガイドライン2019」改訂のポイント、糖尿病性腎症の食事療法　糖尿病性腎症重症化予防に向けて2020
- Author(s)
  北田宗弘、古家大祐
- Journal Title
  
  臨床栄養
  
  Volume: 136 Pages: 460-464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules2020
- Author(s)
  Li J, Liu H, Takagi S, Nitta K, Kitada M, Srivastava SP, Kanasaki K et al.
- Journal Title
  
  JCI Insight.
  
  Volume: 5 Issue: 6 Pages: 6-6
- DOI
  10.1172/jci.insight.129034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling2020
- Author(s)
  Kawakita Emi、Yang Fan、Kumagai Asako、Takagaki Yuta、Kitada Munehiro、Yoshitomi Yasuo、Ikeda Takayuki、Nakamura Yuka、Ishigaki Yasuhito、Kanasaki Keizo、Koya Daisuke
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 19 Issue: 1 Pages: 61-73
- DOI
  10.1158/1541-7786.mcr-20-0115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07407, KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-21K09031, KAKENHI-PROJECT-20K21773
[Journal Article] The impact of mitochondrial quality control by Sirtuins on the treatment of type 2 diabetes and diabetic kidney disease2020
- Author(s)
  Xu J, Kitada M, Koya D.
- Journal Title
  
  Biochim Biophys Acta Mol Basis Dis
  
  Volume: 1866 Issue: 6 Pages: 165756-165756
- DOI
  10.1016/j.bbadis.2020.165756
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Prevalence of albuminuria and renal dysfunction, and related clinical factors in Japanese patients with diabetes: The Japan Diabetes Complication and its Prevention prospective study 52020
- Author(s)
  Shikata K, Kodera R, Utsunomiya K, Koya D, Nishimura R, Miyamoto S, Tajima N; JDCP study group.
- Journal Title
  
  J Diabetes Investig .
  
  Volume: 11 Issue: 2 Pages: 325-332
- DOI
  10.1111/jdi.13116
- NAID
  120007004813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773, KAKENHI-PROJECT-17K09698
[Journal Article] Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis.2020
- Author(s)
  Takagaki Y, Lee SM, Dongqing Z, Kitada M, Kanasaki K, Koya D
- Journal Title
  
  Autophagy.
  
  Volume: - Issue: 10 Pages: 1-10
- DOI
  10.1080/15548627.2020.1713641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans2020
- Author(s)
  Kitada M, Ogura Y, Monno I, Koya D.
- Journal Title
  
  Nutrients .
  
  Volume: 12 Issue: 10 Pages: 3108-3108
- DOI
  10.3390/nu12103108
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Case report of superior mesenteric artery syndrome that developed in a lean type 2 diabetes patient and was associated with rapid body weight loss after sodium-glucose cotransporter 2 inhibitor administration2020
- Author(s)
  Hirai T, Kitada M, Hayashi Y, Monno I, Takagaki Y, Shimada K, Ogura Y, Fujii M, Konishi K, Nakagawa A, Koya D.
- Journal Title
  
  J Diabetes Investig .
  
  Volume: 11 Issue: 5 Pages: 1359-1362
- DOI
  10.1111/jdi.13228
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Endothelial FGFR1 (Fibroblast Growth Factor Receptor 1) Deficiency Contributes Differential Fibrogenic Effects in Kidney and Heart of Diabetic Mice2020
- Author(s)
  Li J, Liu H, Srivastava SP, Hu Q, Gao R, Li S, Kitada M, Wu G, Koya D, Kanasaki K.
- Journal Title
  
  Hypertension .
  
  Volume: 76 Issue: 6 Pages: 1935-1944
- DOI
  10.1161/hypertensionaha.120.15587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Metabolic reprogramming by N-acetyl-seryl-aspartyl-lysyl-proline protects against diabetic kidney disease2020
- Author(s)
  Srivastava SP, Goodwin JE, Kanasaki K, Koya D.
- Journal Title
  
  Br J Pharmacol.
  
  Volume: - Issue: 16 Pages: 3691-3711
- DOI
  10.1111/bph.15087
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Significance of SGLT2 inhibitors: lessons from renal clinical outcomes in patients with type 2 diabetes and basic researches2020
- Author(s)
  Kitada M, Hirai T, Koya D.
- Journal Title
  
  Diabetol Int.
  
  Volume: 11 Issue: 3 Pages: 245-251
- DOI
  10.1007/s13340-020-00444-8
- NAID
  40022307347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine2020
- Author(s)
  Kitada M, Xu J, Ogura Y, Monno I, Koya D.
- Journal Title
  
  Front Cell Dev Biol .
  
  Volume: 8 Pages: 715-715
- DOI
  10.3389/fcell.2020.00715
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21773
[Journal Article] Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs2020
- Author(s)
  Srivastava SP, Goodwin JE, Kanasaki K, Koya D.
- Journal Title
  
  Genes
  
  Volume: 11 Issue: 2 Pages: 2-2
- DOI
  10.3390/genes11020211
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Methionine Abrogates the Renoprotective Effect of a Low-Protein Diet Against Diabetic Kidney Disease in Obese Rats With Type 2 Diabetes2020
- Author(s)
  Kitada M, Ogura Y, Monno I, Xu J, Koya D.
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 12 Issue: 5 Pages: 4489-4505
- DOI
  10.18632/aging.102902
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09718, KAKENHI-PROJECT-20K21773
[Journal Article] CD‐1db/db mice: a novel type 2 diabetic mouse model with progressive kidney fibrosis2020
- Author(s)
  Mizunuma Yuiko、Kanasaki Keizo、Nitta Kyoko、Nakamura Yuka、Ishigaki Yasuhito、Takagaki Yuta、Kitada Munehiro、Li Shaolan、Liu Haijie、Li Jinpeng、Usui Isao、Aso Yoshimasa、Koya Daisuke
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 10.1111/jdi.13311 Issue: 6 Pages: 1-23
- DOI
  10.1111/jdi.13311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18015, KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance through the CXCL12/CXCR4/mTOR/TGFbeta Signaling Pathway in Breast Cancer Cells.2020
- Author(s)
  Li S, Fan Y, Kumagai A, Kawakita E, Kitada M, Kanasaki K, et al.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21 Issue: 3 Pages: 3-3
- DOI
  10.3390/ijms21030805
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity2020
- Author(s)
  Onogi Yasuhiro、Wada Tsutomu、Okekawa Akira、Matsuzawa Takatoshi、Watanabe Eri、Ikeda Keisuke、Nakano Minoru、Kitada Munehiro、Koya Daisuke、Tsuneki Hiroshi、Sasaoka Toshiyasu
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 670-670
- DOI
  10.1038/s41598-019-57368-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08469, KAKENHI-PROJECT-17H02941, KAKENHI-PROJECT-20K21773
[Journal Article] 合併症や併存症を見据えた最適医療　最新のエビデンスに基づく糖尿病患者の慢性腎臓病の治療戦略2020
- Author(s)
  北田宗弘、古家大祐
- Journal Title
  
  Medical Practice
  
  Volume: 37 Pages: 1741-1746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] Secular changes in clinical manifestations of kidney disease among Japanese adults with type 2 diabetes from 1996 to 2014.2019
- Author(s)
  Kume S, Araki SI, Ugi S, Morino K, Koya D, Nishio Y, Haneda M, Kashiwagi A, Maegawa H.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: - Issue: 4 Pages: 1032-1040
- DOI
  10.1111/jdi.12977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] 高血糖・低血糖のしくみと治療・ケア　高血糖と慢性合併症の関係2019
- Author(s)
  北田宗弘、古家大祐
- Journal Title
  
  糖尿病ケア
  
  Volume: 16 Pages: 982-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis.2019
- Author(s)
  Srivastava SP, Li J, Kitada M, Fujita H, Yamada Y, Goodwin JE, Kanasaki K, Koya D.
- Journal Title
  
  Cell Death Dis.
  
  Volume: - Issue: 10
- DOI
  10.1038/s41419-018-1057-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] The impact of dietary protein intake on longevity and metabolic health.2019
- Author(s)
  Kitada M, Ogura Y, Monno I, Koya D.
- Journal Title
  
  EBioMedicine.
  
  Volume: - Pages: 632-640
- DOI
  10.1016/j.ebiom.2019.04.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15472, KAKENHI-PROJECT-17K09718
[Journal Article] 蛋白質の摂取量と糖尿病の管理　糖尿病性腎症における低蛋白食を考える2019
- Author(s)
  北田宗弘、古家大祐
- Journal Title
  
  月刊糖尿病
  
  Volume: 11 Pages: 47-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.2019
- Author(s)
  Kumagai A, Itakura A, Koya D, Kanasaki K.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: - Issue: 10 Pages: 3076-3076
- DOI
  10.3390/ijms19103076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] βklotho is essential for the anti-endothelial mesenchymal transition effects of N-acetyl-seryl-aspartyl-lysyl-proline.2019
- Author(s)
  Gao R, Kanasaki K, Li J, Kitada M, Okazaki T, Koya D.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 9 Issue: 5 Pages: 1029-1038
- DOI
  10.1002/2211-5463.12638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15472, KAKENHI-PROJECT-19K08738
[Journal Article] Identification of subgroups of patients with type 2 diabetes with differences in renal function preservation between sglt2 inhibitors and dpp4 inhibitors using a supervised machine learning algorithm (profile study): A Retrospective analysis of a japanese commercial medical database.2019
- Author(s)
  Zhou FL, Watada H, Tajima Y, Berthelot M, Kang D, Esnault C, Shuto Y, Maegawa H, Koya D.
- Journal Title
  
  Diabetes Obes Metab.
  
  Volume: - Issue: 8 Pages: 1925-1934
- DOI
  10.1111/dom.13753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] Effect of switching to teneligliptin from other dipeptidyl peptidase-4 inhibitors on glucose control and renoprotection in type 2 diabetes patients with diabetic kidney disease.2019
- Author(s)
  Kitada M, Ogura Y, Nitta K, Fujii M, Kanasaki K, Konishi K, Iida Y, Nakagawa A, Koya D.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: - Issue: 3 Pages: 706-13
- DOI
  10.1111/jdi.12917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472, KAKENHI-PROJECT-19K08738
[Journal Article] Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function.2019
- Author(s)
  Kitada M, Ogura Y, Monno I, Koya D.
- Journal Title
  
  Front Endocrinol (Lausanne).
  
  Volume: -
- DOI
  10.3389/fendo.2019.00187
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] N-Acetyl-seryl-aspartyl-lysyl-proline is a potential biomarker of renal function in normoalbuminuric diabetic patients with eGFR above 30 ml/min/1.73 m2.2019
- Author(s)
  Nitta K, Nagai T, Mizunuma Y, Kitada M, Nakagawa A, Sakurai M, Toyoda M, Haneda M, Kanasaki K, Koya D.
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: - Issue: 8 Pages: 1004-12
- DOI
  10.1007/s10157-019-01733-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472, KAKENHI-PROJECT-19K08738
[Journal Article] 「陣と栄養・代謝」肥満と腎臓病2019
- Author(s)
  北田宗弘・古家大祐
- Journal Title
  
  腎臓内科・泌尿器科
  
  Volume: ９ Pages: 34-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] 医療の標準化とアクセプタビリティリサーチ2019
- Author(s)
  森川浩子・任和子・北田宗弘・古家大祐
- Journal Title
  
  Bio Clinica
  
  Volume: 34 Pages: 106-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] 糖尿病治療の新たな展開2018
- Author(s)
  古家大祐
- Journal Title
  
  日本透析医会雑誌
  
  Volume: 33 Pages: 398-402
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] Role of dietary amino acid balance in diet restriction-mediated lifespan extension, renoprotection, and muscle weakness in aged mice.2018
- Author(s)
  Yoshida S, Yamahara K, Kume S, Koya D, Yasuda-Yamahara M, Takeda N, Osawa N, Chin-Kanasaki M, Adachi Y, Nagao K, Maegawa H, Araki SI.
- Journal Title
  
  Aging Cell.
  
  Volume: 17 Issue: 4
- DOI
  10.1111/acel.12796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15998, KAKENHI-PROJECT-16K15472
[Journal Article] Ipragliflozin improves mitochondrial abnormalities in renal tubules induced by a high-fat diet.2018
- Author(s)
  Takagi S, Li J, Takagaki Y, Kitada M, Nitta K, Takasu T, Kanasaki K, Koya D.
- Journal Title
  
  J Diabetes Investig
  
  Volume: 9 Issue: 5 Pages: 1025-1032
- DOI
  10.1111/jdi.12802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial?Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis2018
- Author(s)
  Yang Fan、Takagaki Yuta、Yoshitomi Yasuo、Ikeda Takayuki、Li Jinpeng、Kitada Munehiro、Kumagai Asako、Kawakita Emi、Shi Sen、Kanasaki Keizo、Koya Daisuke
- Journal Title
  
  Cancer Research
  
  Volume: 79 Issue: 4 Pages: 735-746
- DOI
  10.1158/0008-5472.can-18-0620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16214, KAKENHI-PROJECT-16K15472, KAKENHI-PROJECT-19K08738
[Journal Article] A Low-Protein Diet for Diabetic Kidney Disease: Its Effect and Molecular Mechanism, an Approach from Animal Studies2018
- Author(s)
  Kitada M, Ogura Y, Monno I, Koya D.
- Journal Title
  
  Nutrients
  
  Volume: 10 Issue: 5 Pages: 544-544
- DOI
  10.3390/nu10050544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] A low-protein diet exerts a beneficial effect on diabetic status and prevents diabetic nephropathy in Wistar fatty rats, an animal model of type 2 diabetes and obesity.2018
- Author(s)
  Kitada M, Ogura Y, Suzuki T, Monno I, Kanasaki K, Watanabe A, Koya D.
- Journal Title
  
  Nutr Metab (Lond).
  
  Volume: - Issue: 1
- DOI
  10.1186/s12986-018-0255-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] 糖尿病性腎症の重症化予防ストラテジー2018
- Author(s)
  植木浩二郎・南学正臣・津下一代・古家大祐
- Journal Title
  
  Diabetes Strategy
  
  Volume: 8 Pages: 133-145
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] A ketogenic amino acid rich diet benefits mitochondrial homeostasis by altering the AKT/4EBP1 and autophagy signaling pathways in the gastrocnemius and soleus.2018
- Author(s)
  Li J, Kanasaki M, Xu L, Kitada M, Nagao K, Adachi Y, Jinzu H, Noguchi Y, Kohno M, Kanasaki K, Koya D
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: S0304-4165 Issue: 7 Pages: 30075-8
- DOI
  10.1016/j.bbagen.2018.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] FGFR1 is essential for N-acetyl-seryl-aspartyl-lysyl-proline regulation of mitochondrial dynamics by upregulating microRNA let-7b-5p2018
- Author(s)
  Hu Q, Li J, Nitta K, Kitada M, Nagai T, Kanasaki K, Koya D.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 495 Issue: 3 Pages: 2214-2220
- DOI
  10.1016/j.bbrc.2017.12.089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats2018
- Author(s)
  Ogura Yoshio、Kitada Munehiro、Monno Itaru、Kanasaki Keizo、Watanabe Ai、Koya Daisuke
- Journal Title
  
  Redox Report
  
  Volume: 23 Issue: 1 Pages: 153-159
- DOI
  10.1080/13510002.2018.1487174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16104, KAKENHI-PROJECT-16K15472
[Journal Article] The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans.2018
- Author(s)
  Kitada M, Ogura Y, Maruki-Uchida H, Sai M, Suzuki T, Kanasaki K, Hara Y, Seto H, Kuroshima Y, Monno I, Koya D
- Journal Title
  
  Nutrients.
  
  Volume: 9 Issue: 10 Pages: 1142-1142
- DOI
  10.3390/nu9101142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] 糖尿病診療の標準化と情報発信2018
- Author(s)
  森川浩子・任和子・北田宗弘・古家大祐
- Journal Title
  
  Bio Clinica
  
  Volume: 33 Pages: 93-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10269
[Journal Article] Impact of empagliflozin on diabetic kidney disease.2017
- Author(s)
  Koya D
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 8 Issue: 5 Pages: 658-660
- DOI
  10.1111/jdi.12615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis.2017
- Author(s)
  Kitada M, Ogura Y, Koya D.
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 8 Issue: 10 Pages: 2290-2307
- DOI
  10.18632/aging.101068
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] Dipeptidyl peptidase-4 inhibition and renoprotection: the role of antifibrotic effects.2017
- Author(s)
  Takagaki Y, Koya D, Kanasaki K.
- Journal Title
  
  Curr Opin Nephrol Hypertens
  
  Volume: 26 Pages: 56-66
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] Catechol-O-methyltransferase deficiency leads to hypersensitivity of the pressor response against angiotensin II2017
- Author(s)
  Norikazu Ueki, Keizo Kanasaki, Megumi Kanasaki, Satoru Takeda, Daisuke Koya
- Journal Title
  
  Hypertension
  
  Volume: In Press Issue: 6 Pages: 1156-1164
- DOI
  10.1161/hypertensionaha.117.09247
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460403, KAKENHI-PROJECT-16K15472
[Journal Article] FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway2017
- Author(s)
  Li J, Shi S, Srivastava SP, Kitada M, Nagai T, Nitta K, Kohno M, Kanasaki K, Koya D
- Journal Title
  
  Cell Death Dis.
  
  Volume: 8 Issue: 8 Pages: e2965-e2965
- DOI
  10.1038/cddis.2017.353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] Cyclic and intermittent very low-protein diet can have beneficial effects against advanced diabetic nephropathy in Wistar fatty (fa/fa) rats, an animal model of type 2 diabetes and obesity.2017
- Author(s)
  Kitada M, Ogura Y, Suzuki T, Monnno I, Kanasaki K, Watanabe A, Koya D.
- Journal Title
  
  Nephrology (Carlton).
  
  Volume: 22 Issue: 12 Pages: 1030-1034
- DOI
  10.1111/nep.13152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance2017
- Author(s)
  Wada T, Ishikawa A, Watanabe E, Nakamura Y, Aruga Y, Hasegawa H, Onogi Y, Honda H, Nagai Y, Takatsu K, Ishii Y, Sasahara M, Koya D, Tsuneki H, Sasaoka T
- Journal Title
  
  J Endocrinol.
  
  Volume: 235 Issue: 3 Pages: 179-191
- DOI
  10.1530/joe-17-0351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-15K07960, KAKENHI-PROJECT-15K08527
[Journal Article] Regulating Autophagy as a Therapeutic Target for Diabetic Nephropathy2017
- Author(s)
  Kitada M, Ogura Y, Monno I, Koya D.
- Journal Title
  
  Curr Diab Rep
  
  Volume: 17 Issue: 7
- DOI
  10.1007/s11892-017-0879-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced Obesity2017
- Author(s)
  Y. Onogi, T. Wada, C. Kamiya, K. Inata, T. Matsuzawa, Y. Inaba, K. Kimura, H. Inoue, S. Yamamoto, Y. Ishii, D. Koya, H. Tsuneki, M. Sasahara, T. Sasaoka
- Journal Title
  
  Diabetes
  
  Volume: 4 Issue: 4 Pages: 1008-1021
- DOI
  10.2337/db16-0881
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05678, KAKENHI-PROJECT-25293093, KAKENHI-PROJECT-15K08396, KAKENHI-PROJECT-16K15472, KAKENHI-PUBLICLY-17H05499, KAKENHI-PROJECT-17H04062
[Journal Article] Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice.2017
- Author(s)
  Kanasaki M, Srivastava SP, Yang F, Xu L, Kudoh S, Kitada M, Ueki N, Kim H, Li J, Takeda S, Kanasaki K, Koya D.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1
- DOI
  10.1038/s41598-017-08513-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] Anagliptin ameliorates albuminuria and urinary liver-type fatty acid-binding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent manner.2017
- Author(s)
  Kitada M, Tsuda SI, Konishi K, Takeda-Watanabe A, Fujii M, Kanasaki K, Nishizawa M, Nakagawa A, Koya D
- Journal Title
  
  BMJ Open Diabetes Res Care.
  
  Volume: 5 Issue: 1 Pages: e000391-e000391
- DOI
  10.1136/bmjdrc-2017-000391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472
[Journal Article] Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis.2016
- Author(s)
  Srivastava SP, Shi S, Kanasaki M, Nagai T, Kitada M, He J, Nakamura Y, Ishigaki Y, Kanasaki K, Koya D.
- Journal Title
  
  Sci Rep
  
  Volume: 18 Issue: 1 Pages: 29884-29884
- DOI
  10.1038/srep29884
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460403, KAKENHI-PROJECT-16K15472
[Journal Article] A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity.2016
- Author(s)
  Kitada M, Ogura Y, Suzuki T, Sen S, Lee SM, Kanasaki K, Kume S, Koya D.
- Journal Title
  
  Diabetologia
  
  Volume: in press Issue: 6 Pages: 1307-17
- DOI
  10.1007/s00125-016-3925-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-26460403
[Journal Article] Linagliptin but not Sitagliptin inhibited transforming growth factor-β2-induced endothelial DPP-4 activity and the endothelial-mesenchymal transition2016
- Author(s)
  Shi S, Kanasaki K, Koya D
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 26 Issue: 1 Pages: 184-190
- DOI
  10.1016/j.bbrc.2016.01.154
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460403, KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-25282028
[Journal Article] Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen2016
- Author(s)
  Nitta K, Shi S, Nagai T, Kanasaki M, Kitada M, Srivastava SP, Haneda M, Kanasaki K, Koya D.
- Journal Title
  
  Biomed Res Int
  
  Volume: 2016:9172157 Pages: 9172157-9172157
- DOI
  10.1155/2016/9172157
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460403, KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-25282028
[Journal Article] MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells.2016
- Author(s)
  Kuwagata S, Kume S, Chin-Kanasaki M, Araki H, Araki S, Nakazawa J, Sugaya T, Koya D, Haneda M, Maegawa H, Uzu T.
- Journal Title
  
  Kidney Int.
  
  Volume: 90 Issue: 6 Pages: 1211-1225
- DOI
  10.1016/j.kint.2016.06.036
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25713033, KAKENHI-PROJECT-16K15472
[Journal Article] Dipeptidyl peptidase-4 and kidney fibrosis in diabetes.2016
- Author(s)
  Shi S, Koya D, Kanasaki K.
- Journal Title
  
  Fibrogenesis Tissue Repair
  
  Volume: 9 Issue: 1 Pages: 1-10
- DOI
  10.1186/s13069-016-0038-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460403, KAKENHI-PROJECT-25670414
[Journal Article] Pituitary apoplexy following gonadotropin-releasing hormone agonist administration with gonadotropin-secreting pituitary adenoma.2015
- Author(s)
  Sasagawa Y, Tachibana O, Nakagawa A, Koya D, Iizuka H.
- Journal Title
  
  J Clin Neurosci
  
  Volume: 22 Issue: 3 Pages: 601-603
- DOI
  10.1016/j.jocn.2014.08.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-15K19981
[Journal Article] Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy.2015
- Author(s)
  Kume S, Koya D.
- Journal Title
  
  Diabetes Metab J.
  
  Volume: 39 Issue: 6 Pages: 451-460
- DOI
  10.4093/dmj.2015.39.6.451
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25713033
[Journal Article] Interactions of DPP-4 and integrin β1 influences endothelial-to mesenchymal transition.2015
- Author(s)
  Shi S, Srivastava SP, Kanasaki M, He J, Kitada M, Nagai T, Nitta K, Takagi S, Kanasaki K, Koya D.
- Journal Title
  
  Kidney Int.
  
  Volume: - Issue: 3 Pages: 479-489
- DOI
  10.1038/ki.2015.103
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790329, KAKENHI-PROJECT-26460403, KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-25282028
[Journal Article] The biological significance of angiotensisn-converting enzyme inhibition to combat kidney fibrosis2015
- Author(s)
  Nagai T, Nitta K, Kanasaki M, Koya D, Kanasaki K.
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: 19 Issue: 1 Pages: 65-74
- DOI
  10.1007/s10157-014-1000-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790329, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-26460403
[Journal Article] Autophagy: emerging therapeutic target for diabetic nephropathy.2014
- Author(s)
  Kume S, Yamahara K, Yasuda M, Maegawa H, Koya D.
- Journal Title
  
  Semin Nephrol.
  
  Volume: 34 Issue: 1 Pages: 9-16
- DOI
  10.1016/j.semnephrol.2013.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-25713033
[Journal Article] N-acetyl-seryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition2014
- Author(s)
  Takako Nagai, Megumi Kanasaki, Swayam Prakash Srivastava, Yuka Nakamura, Yasuhito Ishigaki, Munehiro Kitada, Sen Shi, Keizo Kanasaki, Daisuke Koya
- Journal Title
  
  BioMed Research International
  
  Volume: 2014 Pages: 696475-696475
- DOI
  10.1155/2014/696475
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23790381, KAKENHI-PROJECT-24659264, KAKENHI-PROJECT-24790329, KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-26460403
[Journal Article] N-acetyl-seryl-aspartyl-lysyl-proline: a valuable endogenous anti-fibrotic peptide for combating kidney fibrosis in diabetes.2014
- Author(s)
  Kanasaki K, Nagai T, Nitta K, Kitada M, Koya D.
- Journal Title
  
  Front Pharmacol.
  
  Volume: 2014 Pages: 1-11
- DOI
  10.3389/fphar.2014.00070
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-26460403
[Journal Article] Role of sirtuins in kidney disease.2014
- Author(s)
  Kitada M, Kume S, Koya D.
- Journal Title
  
  Curr Opin Nephrol Hypertens.
  
  Volume: 23 Issue: 1 Pages: 75-79
- DOI
  10.1097/01.mnh.0000437330.85675.ac
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591218, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25670414
[Journal Article] Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes.2014
- Author(s)
  Yasuda M, Tanaka Y, Kume S, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki SI, Koya D, Haneda M, Kashiwagi A, Maegawa H, Uzu T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1842 Issue: 7 Pages: 1097-1108
- DOI
  10.1016/j.bbadis.2014.04.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24890089, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-25713033
[Journal Article] Clinical therapeutic strategies for early stage of diabetic kidney disease.2014
- Author(s)
  Kitada M, Kanasaki K, Koya D
- Journal Title
  
  World J Diabetes.
  
  Volume: 5 Issue: 3 Pages: 342-356
- DOI
  10.4239/wjd.v5.i3.342
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591218, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-26460403
[Journal Article] Linagriptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabeticmice by inhibiting endothelial-to mesenchymal transition in a therapeutic regimen.2014
- Author(s)
  Kanasaki K, Shi S, Kanasaki M, He J, Nagai T, Nakamura Y, Ishigaki Y, Kitada M, Srivastava SP, Koya D.
- Journal Title
  
  Diabetes.
  
  Volume: 63 Issue: 6 Pages: 2120-2131
- DOI
  10.2337/db13-1029
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790329, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-26460403
[Journal Article] Cilostazol attenuates spontaneous microaggregation of platelets in type 2 diabetic patients with insufficient platelet response to aspirin.2013
- Author(s)
  Araki S, Matsuno H, Haneda M, Koya D, Kanno Y, Kume S, Isshiki K, Araki H, Ugi S, Kawai H, Kashiwagi A, Uzu T, Maegawa H.
- Journal Title
  
  Diabetes Care
  
  Volume: 36(7) Issue: 7 Pages: e92-e93
- DOI
  10.2337/dc12-2702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591323, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25460078, KAKENHI-PROJECT-25670414
[Journal Article] SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential.2013
- Author(s)
  Kitada M, Koya D.
- Journal Title
  
  Diabetes Metab J.
  
  Volume: 37(5) Pages: 315-325
- Data Source
  KAKENHI-PROJECT-24591218
[Journal Article] Statin use in patients with diabetes and kidney disease: the Japanese experience.2013
- Author(s)
  Koya D, Campese VM.
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 20 Pages: 407-24
- NAID
  130004444686
- Data Source
  KAKENHI-PROJECT-25282028
[Journal Article] Sirtuins as possible drug targets in type 2 diabetes.2013
- Author(s)
  Kitada M, Kume S, Kanasaki K, Takeda-Watanabe A, Koya D.
- Journal Title
  
  Curr Drug Targets
  
  Volume: 14 Pages: 622-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282028
[Journal Article] Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions.2013
- Author(s)
  Yamahara K, Kume S, Koya D, Tanaka Y, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki S, Haneda M, Matsusaka T, Kashiwagi A, Maegawa H, Uzu T.
- Journal Title
  
  J Am Soc Nephrol.
  
  Volume: 24 Issue: 11 Pages: 1769-81
- DOI
  10.1681/asn.2012111080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25713033
[Journal Article] Renal protective effects of resveratrol.2013
- Author(s)
  Kitada M, Koya D.
- Journal Title
  
  Oxid Med Cell Longev.
  
  Volume: 2013 Pages: 1-7
- DOI
  10.1155/2013/568093
- NAID
  40019560561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591218
[Journal Article] Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy2013
- Author(s)
  Kume S.
- Journal Title
  
  Arch Pharm Res.
  
  Volume: 36(2) Issue: 2 Pages: 230-6
- DOI
  10.1007/s12272-013-0019-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790381, KAKENHI-PROJECT-23890085, KAKENHI-PROJECT-24591218
[Journal Article] Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways.2013
- Author(s)
  Nishizawa M, Nakabayashi H, Uehara K, Nakagawa A, Uchida K, Koya D.
- Journal Title
  
  Am J Physiol Endocrinol Metab.
  
  Volume: 305 Issue: 3 Pages: E376-E387
- DOI
  10.1152/ajpendo.00565.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282028
[Journal Article] Role of the Endothelial-to-mesenchymal Transition in Renal Fibrosis of Chronic Kidney Disease2013
- Author(s)
  Jianhua He, Yong Xu, Daisuke Koya, Keizo Kanasaki
- Journal Title
  
  2013 Clin Exp Nephrol Clin Exp Nephrol
  
  Volume: 17(4) Issue: 4 Pages: 488-497
- DOI
  10.1007/s10157-013-0781-0
- NAID
  10031195312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790381, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25670414
[Journal Article] Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy.2013
- Author(s)
  Araki S, Haneda M, Koya D, Sugaya T, Isshiki K, Kume S, Kashiwagi A, Uzu T, Maegawa H.
- Journal Title
  
  Diabetes Care.
  
  Volume: 36 Issue: 5 Pages: 1248-1253
- DOI
  10.2337/dc12-1298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670414
[Journal Article] Interventions against nutrient-sensing pathways represent an emerging new therapeutic approach for diabetic nephropathy2013
- Author(s)
  Koya D, Kitada M, Kume S, Kanasaki K
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 18(2) Issue: 2 Pages: 210-213
- DOI
  10.1007/s10157-013-0908-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790381, KAKENHI-PROJECT-25670414, KAKENHI-PROJECT-26460403
[Journal Article] Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP1c Tg mice fed high-fat and high-fructose diet2013
- Author(s)
  Wada T, Miyashita Y, Sasaki M, Aruga Y, Nakamura Y, Ishii Y, Sasahara M, Kanasaki K, Kitada M, Koya D, Shimano H, Tsuneki H, Sasaoka
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 305 Issue: 11 Pages: E1415-E1425
- DOI
  10.1152/ajpendo.00419.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790381, KAKENHI-PROJECT-24390230, KAKENHI-PUBLICLY-25126701, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25293093, KAKENHI-PROJECT-25670414
[Journal Article] Statin use in patients with diabetes and kidney disease: the Japanese experience.2013
- Author(s)
  Koya D, Campese VM.
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 20 Pages: 407-424
- NAID
  130004444686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670414
[Journal Article] Sirtuins and renal diseases: relationship with aging and diabetic nephropathy2013
- Author(s)
  Kitada M.
- Journal Title
  
  Clin Sci (Lond)
  
  Volume: 124(3) Issue: 3 Pages: 153-64
- DOI
  10.1042/cs20120190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790381, KAKENHI-PROJECT-23890085, KAKENHI-PROJECT-24591218, KAKENHI-PROJECT-25670414
[Journal Article] The use of calorie restriction mimetics to study aging.2013
- Author(s)
  Kitada M, Koya D.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1048 Pages: 95-107
- DOI
  10.1007/978-1-62703-556-9_8
- ISBN
  9781627035552, 9781627035569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591218, KAKENHI-PROJECT-25670414
[Journal Article] Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage.2013
- Author(s)
  Takeda N, Kume S, Tanaka Y, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki S, Haneda M, Koya D, Kashiwagi A, Maegawa H, Uzu T.
- Journal Title
  
  Am J Pathol.
  
  Volume: 183 Issue: 3 Pages: 774-85
- DOI
  10.1016/j.ajpath.2013.05.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25670414
[Journal Article] Ketogenic essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules.2013
- Author(s)
  Xu L, Kanasaki M, He J, Kitada M, Nagao K, Jinzu H, Noguchi Y, Maegawa H, Kanasaki K, Koya D.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1832(10) Issue: 10 Pages: 1605-1612
- DOI
  10.1016/j.bbadis.2013.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591218, KAKENHI-PROJECT-24790329, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25670414
[Journal Article] irtuins as possible drug targets in type 2 diabetes.2013
- Author(s)
  Kitada M, Kume S, Kanasaki K, Takeda-Watanabe A, Koya D
- Journal Title
  
  Curr Drug Targets.
  
  Volume: 14(6) Pages: 622-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591218
[Journal Article] The biological consequence of obesity on the kidney2013
- Author(s)
  Keizo Kanasaki, Munehiro Kitada, Megumi Kanasaki, Daisuke Koya
- Journal Title
  
  Nephrology Dialysis and Transplantation
  
  Volume: Suppl 4 Issue: suppl 4 Pages: iv1-iv7
- DOI
  10.1093/ndt/gft098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790381, KAKENHI-PROJECT-25282028
[Journal Article] SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential.2013
- Author(s)
  Kitada M, Koya D.
- Journal Title
  
  Diabetes Metab J.
  
  Volume: 37 Pages: 315-325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282028
[Journal Article] Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation.2013
- Author(s)
  Kitada M, Kume S, Takeda-Watanabe A, Tsuda S, Kanasaki K, Koya D.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1830(10) Issue: 10 Pages: 4820-4827
- DOI
  10.1016/j.bbagen.2013.06.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591218, KAKENHI-PROJECT-25282028, KAKENHI-PROJECT-25670414
[Journal Article] Nutrient sensing, autophagy and diabetic nephropathy Diabetes2012
- Author(s)
  Kume S, Thomas MC, Koya D
- Journal Title
  
  Jan
  
  Volume: 61(1) Pages: 23-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] Autophagy as a Therapeutic Target in Diabetic Nephropathy Experimental Diabetes Research2012
- Author(s)
  Tanaka Y, Kume S, Kitada K, Kanasaki K, Uzu T, Maegawa H, Koya D
- Pages
  628978-628978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] Emerging role of autophagy in kidney function, diseases and aging2012
- Author(s)
  Huber TB, Edelstein CL, Hartleben B, Inoki K, Jiang M, Koya D, Kume S, Lieberthal W, Pallet N, Quiroga A, Ravichandran K, Susztak K, Yoshida S, Dong Z
- Journal Title
  
  Autophagy
  
  Volume: 8(7) Pages: 1-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells2011
- Author(s)
  Koyama T, et al
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 51 Pages: 1258-1267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] Biology of obesity : lessons from animal models of obesity2011
- Author(s)
  Kanasaki K, Koya D
- Journal Title
  
  J Biomed Biotechnol
  
  Pages: 197636-197636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway2011
- Author(s)
  Kitada M, Kume S, Imaizumi N, Koya D
- Journal Title
  
  Diabetes
  
  Volume: 60(2) Pages: 634-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in Diabetic Wistar fatty(fa/fa) rats, a model of type 2 diabetes2011
- Author(s)
  Kitada M, Takeda A, Nagai T, Ito H, Kanasaki K, Koya D
- Journal Title
  
  Experimental Diabetes Research
  
  Pages: 908185-908185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells2011
- Author(s)
  Koyama T, Kume S, Koya D, Araki S, Isshiki K, Chin-Kanasaki M, Sugimoto T, Haneda M, Sugaya T, Kashiwagi A, Maegawa H, Uzu T
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 51(6) Pages: 1258-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-prolin e : a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors2011
- Author(s)
  Kanasaki M, Nagai T, Kitada M, Koya D, Kanasaki K
- Journal Title
  
  Fibrogenesis Tissue Repair
  
  Volume: 4 Pages: 25-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] Reversal of redox-dependent inhibition of diacylglycerol kinase by antioxidants in mesangial cells exposed to high glucose2011
- Author(s)
  Atsumi H, Kitada M, Kanasaki K, Koya D
- Journal Title
  
  Mol Med Report
  
  Volume: 4(5) Pages: 923-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney2010
- Author(s)
  Kume S, Uzu T, Horiike K, Chin-Kanasaki M, Isshiki K, Araki S, Sugimoto T, Haneda M, Kashiwagi A, Koya D
- Journal Title
  
  J Clin Invest
  
  Volume: 120(4) Pages: 1043-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article]2010
- Author(s)
  古家大祐
- Journal Title
  
  糖尿病性腎症。専門医のための腎臓病学第2版(医学書院)
  
  Pages: 490-499
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy : a randomised controlled trial.2009
- Author(s)
  Koya D
- Journal Title
  
  Diabetologia. 52
  
  Pages: 2037-2045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591148
[Journal Article] SIRTl inhibits TGFbeta -induced apoptosis in glomerular mesangial cells via Smad7 deacetylation.2007
- Author(s)
  Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki SI, Isshiki K, Isono M, Uzu T, Guarente L, Kashiwagi A, Koya D
- Journal Title
  
  J Biol Chem 282
  
  Pages: 151-8
- Data Source
  KAKENHI-PROJECT-17590925
[Journal Article] SIRT1 inhibits TGFbeta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation.2007
- Author(s)
  Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki SI, Isshiki K, Isono M, Uzu T, Guarente L, Kashiwagi A, Koya D
- Journal Title
  
  J Biol Chem 282
  
  Pages: 151-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590925
[Journal Article] Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation2006
- Author(s)
  Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S-i, Isono M, Isshiki K, Uzu T, Kashiwagi A, Koya D
- Journal Title
  
  Free Radical Biology and Medicine 40
  
  Pages: 2175-2182
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590925
[Journal Article] Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy2005
- Author(s)
  Shimazaki A, Kawamura Y, Kanazawa A, Sekine A, Saito S, Tsunoda T, Koya D, et al.
- Journal Title
  
  Diabetes 54・4
  
  Pages: 1171-1178
- Data Source
  KAKENHI-PROJECT-17019031
[Journal Article] N-acetyl seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice2005
- Author(s)
  Shibuya K, Kanasaki K, Isono M, Sato H, Omata M, Sugimoto T, Araki S, Isshiki K, Kashiwagi A, Haneda M, Koya D.
- Journal Title
  
  Diabetes 54
  
  Pages: 200-208
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590936
[Journal Article] N-acetyl seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice2005
- Author(s)
  Shobuya K, Koya D
- Journal Title
  
  Diabetes 54
  
  Pages: 200-208
- Data Source
  KAKENHI-PROJECT-15590936
[Journal Article] Factors associated with frequent remission of microalbuminuria in patients with type 2 diabetes2005
- Author(s)
  Araki S, Haneda M, Sugimoto T, Isono M, Isshiki K, Kashiwagi A, Koya D.
- Journal Title
  
  Diabetes 54・10
  
  Pages: 2983-2987
- Data Source
  KAKENHI-PROJECT-17019031
[Journal Article] Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.2005
- Author(s)
  Maeda S, Tsukada S, Kanazawa A, Sekine A, Tsunoda T, Koya D, Maegawa H, et al.
- Journal Title
  
  Journal of Human Genetics 50・6
  
  Pages: 283-292
- NAID
  10016605603
- Data Source
  KAKENHI-PROJECT-17019031
[Journal Article] N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice.2005
- Author(s)
  Shibuya K, Kanasaki K, Isono M, Sato H, Omata M, Sugimoto T, Araki S, Isshiki K, Kashiwagi A, Haneda M, Koya D.
- Journal Title
  
  Diabetes 54
  
  Pages: 838-845
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590936
[Journal Article] N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1,expression via inhibition of Smad pathway in human mesangial cells.2003
- Author(s)
  Kanasaki K, Koya D, Sugimoto T, Isono M, Kashiwagi A, Haneda M.
- Journal Title
  
  J Am Soc Nephrol 14
  
  Pages: 863-872
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590936
[Journal Article] N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells.2003
- Author(s)
  Kanasaki K, Koya D, Sugimoto T, Isono M, Kashiwagi A, Haneda M.
- Journal Title
  
  J Am Soc Nephrol. 14
  
  Pages: 863-872
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590936
[Presentation] 代謝調節障害は腎臓の健康と疾患の重要な決定因子である2021
- Author(s)
  Susztak Katalin ・古家大祐
- Organizer
  日本糖尿病合併症学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K10269
[Presentation] 運動負荷は２型糖尿病/肥満ラット腎における炎症を軽減する2021
- Author(s)
  門野　至, 小倉慶雄, 北田宗弘, Jing Xu, 古家大祐
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08290
[Presentation] 糖尿病重症化予防のための地域連携協議会による活動と現状および今後の課題2021
- Author(s)
  小西一典・中野茂・北田宗弘・古家大祐
- Organizer
  日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-18K10269
[Presentation] 体組成計Seca mBCA151を用いた入院当脳病患者における体組成変化に関する検討2021
- Author(s)
  平井太郎・北田宗弘・古家大祐
- Organizer
  日本糖尿病学会
- Data Source
  KAKENHI-PROJECT-18K10269
[Presentation] 糖尿病性腎臓病を有する2型糖尿病患者に対するＳＧＬＴ2阻害薬の追加灯投与はeGFRの年次低下速度を緩和する2020
- Author(s)
  北田宗弘、古家大祐
- Organizer
  第63回日本糖尿病学会年次集会
- Data Source
  KAKENHI-PROJECT-18K10269
[Presentation] Renal protective mechanism of SGLT2 inhibitors2020
- Author(s)
  古家大祐、北田宗弘
- Organizer
  第63回日本糖尿病学会年次集会
- Data Source
  KAKENHI-PROJECT-18K10269
[Presentation] 糖尿病性腎臓病における食事療法を考える　蛋白質の量と質の観点から2020
- Author(s)
  北田宗弘、古家大祐
- Organizer
  第63回日本糖尿病学会年次集会
- Data Source
  KAKENHI-PROJECT-18K10269
[Presentation] 摂取蛋白質の“量”と“質”の観点から糖尿病性腎臓病に対する食事療法を考える2019
- Author(s)
  北田宗弘、古家大祐
- Organizer
  第34回日本糖尿病合併症学会シンポジウム
- Data Source
  KAKENHI-PROJECT-17K09718
[Presentation] 2型糖尿病/肥満ラットにおける腎尿細管Gnmt低下とメチオニン代謝産物SAMの蓄積は糖尿病性腎臓病の病態形成に関与している2019
- Author(s)
  北田宗弘、小倉慶雄、門野至、古家大祐
- Organizer
  第19回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-17K09718
[Presentation] 糖尿病性腎臓病の治療戦略－尿細管間質異常に着目して2019
- Author(s)
  古家大祐
- Organizer
  金沢医科大学雑誌
- Data Source
  KAKENHI-PROJECT-18K10269
[Presentation] 炎症性Diet　メタボリックヘルスと寿命延長における摂取蛋白質の量と質の意義2019
- Author(s)
  北田宗弘、古家大祐
- Organizer
  日本坑加齢医学会
- Data Source
  KAKENHI-PROJECT-18K10269
[Presentation] 糖尿病・循環器ガイドラインに準じた糖尿病食、循環器疾患食・糖質制限食の栄養素量についての分析・評価2019
- Author(s)
  松波俊哉・北田宗弘・古家大祐
- Organizer
  日本病態栄養学会誌
- Data Source
  KAKENHI-PROJECT-18K10269
[Presentation] 腎臓病・糖尿病領域コホート研究の最新知見　日本人2型糖尿病患者における腎症の合併率と反証関連因子　JDCP　Studyの解析結果2018
- Author(s)
  四方賢一・宇都宮一典・古家大祐・小寺亮・西村理明・田嶼尚子
- Organizer
  日本腎臓学会誌
- Data Source
  KAKENHI-PROJECT-18K10269
[Presentation] Sirt3機能低下は糖尿病腎近位尿細管におけるミトコンドリア酸化ストレスの増2017
- Author(s)
  小倉慶雄、北田宗弘、鈴木妙子、門野至、渡邊愛、古家大祐
- Organizer
  第60回日本糖尿病学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2017-05-18
- Data Source
  KAKENHI-PROJECT-26860651
[Presentation] Effectiveness of Calorie restriction on Ameliorating Diabetic Nephropathy possibly through its anti-inflammatory action2010
- Author(s)
  KOYA D
- Organizer
  国際内分泌学会
- Place of Presentation
  京都(京都国際文化会館)
- Data Source
  KAKENHI-PROJECT-21591148
[Presentation] Sirt1による老化腎障害における虚血応答制御2010
- Author(s)
  古家大祐
- Organizer
  第47回日本臨床分子学会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2010-04-10
- Data Source
  KAKENHI-PROJECT-21591148

1. HANEDA Masakazu (60164894)

# of Collaborated Projects: 12 results

# of Collaborated Products: 4 results
2. KITADA Munehiro (40434469)

# of Collaborated Projects: 8 results

# of Collaborated Products: 73 results
3. MAEDA Shiro (50314159)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
4. 柏木厚典 (20127210)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
5. 荒木信一 (80378455)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
6. KIKKAWA Ryuichi (50093406)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. KANASAKI Keizo (60589919)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
8. 前川聡 (00209363)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. KUME Shinji (00452235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. KANASAKI Megumi (50599355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
11. NISHIZAWA Makoto (70278117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Takagi Hitoshi (70283596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKAKURA Nobuyuki (80291954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. WATANABE Ai (70625722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Morikawa Hiroko (10313743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 中川淳 (70262574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 北岡康史 (10367352)

# of Collaborated Projects: 1 results

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18. 宗正泰成 (30440340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 任和子 (40243084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. TAKAGAKI Yuta

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
21. SHIMA Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. MORITA Yoshikata

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. KUWAGATA Shogo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 川浪大治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 安田真子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 川北恵美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. 佐藤杏奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 池田崇之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 吉冨泰央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 稲葉有香

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 小倉慶雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 水沼有威子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 高崎一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 笹岡利安

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 和田努

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koya Daisuke 古家 大祐

KOYA Daisuke 古家 大祐

古屋 大祐 コヤ ダイスケ

古家 大祐 コヤ ダイスケ

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New therapeutic strategy for diabetic kidney disease by inhibiting MGATPrincipal Investigator

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Endothelial autophagy deficiency induces interleukin 6-dependent endothelial mesenchymal transition and organ fibrosisPrincipal Investigator

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Alteration in nutrient sensing and metabolic diseasesPrincipal Investigator

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New therapeutic strategy for diabetic nephropathy via autophagy regulationPrincipal Investigator

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New therapeutic strategy for diabetic nephropathyPrincipal Investigator

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The role of SIRT1 in mediating renal cells apoptosis and its therapeutic perspectivePrincipal Investigator

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Koya Daisuke 古家大祐

KOYA Daisuke 古家大祐

古屋大祐コヤダイスケ

古家大祐コヤダイスケ