UMEHARA Hisanori 梅原久範

Researcher Number	70247881
Other IDs
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Affiliation (based on the past Project Information) *help	2010 – 2015: 金沢医科大学, 医学部, 教授 2004 – 2008: 金沢医科大学, 医学部, 教授 2006 – 2007: 金沢医科大学, 血液免疫制御学, 教授 2001 – 2003: 京都大学, 医学研究科, 助教授 2001 – 2003: 京都大学, 医学部, 助教授 … More 2002: 京都大学, 歯学部, 助教授 1996 – 2000: 大阪歯科大学, 歯学部, 講師 1994 – 1995: 大阪歯科大学, 歯学部, 助手 Less
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / 病態科学系歯学(含放射線系歯学) / Biological Sciences / Periodontal dentistry / Hematology / 内科学一般 Except Principal Investigator 病態科学系歯学(含放射線系歯学) / 膠原病・アレルギー・感染症内科学 / Hematology / Immunology / Conservative dentistry
Keywords	Principal Investigator fractalkine / 血管内皮細胞 / NK細胞 / CD2 / 細胞傷害 / IFN-γ / 細胞接着 / NK cells / スフィンゴミエリン / リピッドラフト … More / フラクタルカイン / ケモカイン / シグナル伝達 / adapter proteins / tyrosine kinase / cytotoxicity / signal pathway / 膠原病学 / 血管傷害 / チロシンキナーゼ / T細胞 / systemic sclerosis / cellular damage / endothelial cell / cell adhesion / NK cell / フラクタルカン / 全身性強皮症 / endothelial cells / adoptive immune therapy / tumor cytotoxicity / chemokine / 頭頸部腫瘍 / 養子免疫療法 / 抗腫瘍殺傷機能 / PI 3-kinase / 単球 / PI3-kinase / PI 3キナーゼ / PI3-キナーゼ / アダプター蛋白 / 抗腫瘍活性 / 炎症学 / DNAマイクロアレイ / 獲得免疫 / 自然免疫 / 自己免疫性膵炎 / ミクリッツ病 / IgG4関連疾患 / IgG4 / コラーゲン誘導関節炎 / サイトカイン / 関節リウマチ / 自己免疫性疾患 / ノックアウトマウス / ZAP-70 / LAT / T細胞レセプター / アポトーシス / 悪性度 / 浸潤 / 転移 / モデルマウス / 血管炎 / 敗血症 / 接着分子 / シェ-グレン症候群 … More Except Principal Investigator Periodontitis / Fractalkine / NK細胞 / Siogren's syndrome / DNA microarray / シェーグレン症候群 / フラクタルカイン / 血管内皮細胞 / RANKL / NK cell / ICAM-1 / IL-2 / T細胞 / 歯周炎 / 細胞接着 / T cell activation / Syk / チロシンリン酸化 / glucocorticoids / IgG Subclass / Autoimmune pancreatitis / Mikulicz's diseae / 間質性腎炎 / 間質性肺炎 / Sjogren症候群 / Mikulicz病 / AMOLPS / リンパ増殖性疾患 / リンバ増殖性疾患 / IgG4 / 自己免疫性膵炎 / ミクリッツ病 / gene expression / salivary island / peripheral blood / IL-1β / インターフェロン / 唾液腺上皮細胞 / ribosomal protein / DNA array / 遺伝子 / 悪性リンパ腫 / 遺伝子発現 / 唾液腺 / 末梢血 / hemochromatosis / anemia / hepcidin / iron metabolism / マス・スペクトロメトリー / 炎症性疾患 / 鉄代謝 / ヘモクロマトーシス / 貧血 / ヘプシジン / 鉄代謝制御 / Chronic Inflammation / Endothelial Cell / Macrophage / Atherosclerosis / 内皮細胞 / 慢性炎症 / マクロファージ / 動脈硬化症 / Vascular endothelial cell / Monocyte / T cell / フィブロネクチン / インテグリン / 慢性辺縁性歯周炎 / CX_3CR1 / THP-1細胞 / 単球 / fractalkine / 辺縁性歯周炎 / Chemokine / Extracellular matrix / Adhesion molecule / Osteoblast / 線維芽細胞E11細胞 / PHA刺激T細胞 / ケモカイン / 細胞外マトリックス蛋白 / 線維芽細胞 / cell adhesion / protooncogene products / adaptors / protein tyrosine phosphatases / protein tyrosine kinase / signal transduction / lymphocytes / T細胞受容体 / 子宮外発生法 / プロトオンコジーン産物 / アダプター / チロシンホスファターゼ / チロシンキナーゼ / シグナル伝達 / リンパ球 / PI3-kinase / CD_3 / CD_2 / Thyrosin phosphorylation / NK cell activation / アダプター蛋白Shc / p125^<FAK> / PI3キナーゼ / CD3 / CD2 / T細胞活性化 / NK細胞活性化 / 歯周病 / Calcium antagonist / Model animal having gingival hyperplasia / Drug-induced gingival hyperplasia / 歯肉増殖症 / Ca拮抗剤 / 歯肉増殖症発症動物モデル / 薬剤誘発歯肉増殖症 / IgG4関連疾患診断基準 / 脂質メディエーター / メタボロミクス / IgG4関連疾患 Less

Metabolomic analysis in IgG4-related disease
- Principal Investigator
  
  IWAO Haruka
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kanazawa Medical University
Analysis of pathogenesis of IgG4-related diseasePrincipal Investigator
- Principal Investigator
  
  UMEHARA Hisanori
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kanazawa Medical University
Study for the pathogenesis of autoimmune diseases using sphingomyeline knock out mousePrincipal Investigator
- Principal Investigator
  
  UMEHARA Hisanori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kanazawa Medical University
Development of the new immuno-suppresant based on the regulation of lipid rafts.Principal Investigator
- Principal Investigator
  
  UMEHARA Hisanori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kanazawa Medical University
新規抗癌剤開発のためのリピッドラフト解析Principal Investigator
- Principal Investigator
  
  梅原久範
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kanazawa Medical University
Significance of the mechanisms of iron homeostasis in malignancies and inflammatory diseases.
- Principal Investigator
  
  KAWABATA Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
Study of gene expression by DNA chip in peripheral blood and salivary epithelial cells from patients with Sjogren's syndrome
- Principal Investigator
  
  OGAWA Noriyoshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Hamamatsu University School of Medicine
  Kanazawa Medical University
Autoimwune multi-tagemlympliopmliferative syndrome (AMOLPS)-propoeal for a new clinical entily
- Principal Investigator
  
  MASAKI Yasufumi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  KANAZAWAMEDICALUNIVERSITY
フラクタルカインおよびレセプター発現と癌の悪性度・転移との関連Principal Investigator
- Principal Investigator
  
  梅原久範
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
The roles of fractalkine in pathogenesis of systemic sclerosisPrincipal Investigator
- Principal Investigator
  
  UMEHARA Hisanori
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  KANAZAWA MEDICAL UNIVERSITY
  Kyoto University
Elucidation of the role of fractalkine in chronic inflammatory diseases -An approach for its clinical application
- Principal Investigator
  
  NAGANO Yutaka
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Osaka Dental University
敗血症ショックに対する抗fractalkine抗体の予防効果Principal Investigator
- Principal Investigator
  
  梅原久範
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
血管炎発症モデルにおけるCX3C-ケモカイン,Fractalkineの関与Principal Investigator
- Principal Investigator
  
  梅原久範
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内科学一般
- Research Institution
  Kyoto University
IMPROVEMENT OF ADOPTIVE IMMUNE THERAPY FOR CERVIAL CANCERPrincipal Investigator
- Principal Investigator
  
  UMEHARA Hisanori
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  KYOTO UNIVERSITY
The roles of interaction between adhesion molecules, chemokines and vascular endothelial cells in the pathogenesis of periodontitis
- Principal Investigator
  
  DOMAE Naochika
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Osaka Dental University
Role of CX_3C-chemokine, fractalkine on pathogenesis of periodontitisPrincipal Investigator
- Principal Investigator
  
  UMEHARA Hisanori
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Periodontal dentistry
- Research Institution
  Osaka Dental University
Functional analyses of roles of tyrosine kinases/phosphatases in lymhpcyte signaling
- Principal Investigator
  
  MINAMI Yasuhiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Immunology
- Research Institution
  Kobe University
The role of adhesion molecules and cytokines in chronic periodontitis
- Principal Investigator
  
  DOMAE Naochika
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Osaka Dental University
CD2-mediated signal pathway in NK cell activationPrincipal Investigator
- Principal Investigator
  
  UMEHARA Hisanori
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Osaka Dental University
The role of adhesion molecules and cytokine in periodontitis
- Principal Investigator
  
  DOMAE Naochika
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Osaka Dental University
シェ-グレン症候群におけるT細胞機能の解析:接着分子を介したシグナル伝達機能Principal Investigator
- Principal Investigator
  
  梅原久範
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Osaka Dental University
Studies on the pathogenesis and the prevention of drug-induced gingival hyperplasia.
- Principal Investigator
  
  DOMAE Naochika
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Osaka Dental University

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All Journal Article Presentation Book Patent

[Book] IgG4関連疾患アトラス2012
- Author(s)
  梅原久範、岡崎和一
- Total Pages
  199
- Publisher
  前田書店、金沢
- Data Source
  KAKENHI-PROJECT-23659503
[Book] IgG4関連疾患アトラス2012
- Author(s)
  梅原久範
- Total Pages
  199
- Publisher
  前田書店
- Data Source
  KAKENHI-PROJECT-23659503
[Book] IgG4関連疾患アトラスーIgG4研究会モノグラフー2012
- Author(s)
  梅原久範、他
- Total Pages
  199
- Publisher
  前田書店
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Isolation of vascular smooth muscle antigen-reactive CD4(+)αβTh1 clones that induce pulmonary vasculitis in MRL/Mp-Fas(+/+) mice.2016
- Author(s)
  Fujita Y, Fujii T, Shimizu H, Sato T, Nakamura T, Iwao H, Nakajima A, Miki M, Sakai T, Kawanami T, Tanaka M, Masaki Y, Fukushima T, Okazaki T, Umehara H, Mimori T.
- Journal Title
  
  Cell Immunol.
  
  Volume: 303 Pages: 50-54
- DOI
  10.1016/j.cellimm.2016.03.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591459, KAKENHI-PROJECT-15K09511, KAKENHI-PROJECT-15K09537
[Journal Article] Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells2014
- Author(s)
  Sugimoto N, Shido O, Matsuzaki K, Katakura M, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
- Journal Title
  
  Cell biochemistry and biophysics
  
  Volume: (in press) Issue: 1 Pages: 301-7
- DOI
  10.1007/s12013-014-9912-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041, KAKENHI-PROJECT-23590278, KAKENHI-PROJECT-24590300, KAKENHI-PROJECT-24659105, KAKENHI-PROJECT-25282021, KAKENHI-PROJECT-25460830, KAKENHI-PROJECT-25670295, KAKENHI-PROJECT-26650173
[Journal Article] Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Fas lpr mice2014
- Author(s)
  Fujita Y, Fujii T, Mimori T, Sato T, Nakamura T, Iwao H, Nakajima A, Miki M, Sakai T, Kawanami T, Tanaka M, Masaki Y, Fukushima T, Okazaki T and Umehara H
- Journal Title
  
  Journal of immunology
  
  Volume: 192 Issue: 3 Pages: 979-984
- DOI
  10.4049/jimmunol.1301685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041, KAKENHI-PROJECT-25461472
[Journal Article] IgG4関連疾患の診断2014
- Author(s)
  梅原久範, 三木美由貴, 岩男　悠, 中島章夫
- Journal Title
  
  神経内科
  
  Volume: 80 Pages: 157-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591459
[Journal Article] Possible Mechanisms of Lymphoma Development in Sjögren's Syndrome2013
- Author(s)
  Dong L, Chen Y, Masaki Y, Okazaki T and Umehara H
- Journal Title
  
  Curr Immunol Rev
  
  Volume: 9 Pages: 13-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041
[Journal Article] Possible Mechanisms of Lymphoma Development in Sjogren's Syndrome2013
- Author(s)
  Dong L, Chen Y, Masaki Y, Okazaki T and Umehara H
- Journal Title
  
  Current Immunology Reviews
  
  Volume: 9 Issue: 1 Pages: 13-22
- DOI
  10.2174/1573395511309010003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041
[Journal Article] Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats2013
- Author(s)
  Sugimoto N, Matsuzaki K, Ishibashi H, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Sekine J, Koizumi S, Yachie A, Umehara H and Shido O
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Issue: 1 Pages: 1763-1763
- DOI
  10.1038/srep01763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041, KAKENHI-PROJECT-23590278, KAKENHI-PROJECT-24591572, KAKENHI-PROJECT-24659105, KAKENHI-PROJECT-24791010, KAKENHI-PROJECT-25282021
[Journal Article] Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease.2013
- Author(s)
  Masaki Y, Kurose N, Yamamoto M, ,Yamada K, Kawano M, ,Eguchi K, Sugai S, Umehara H.
- Journal Title
  
  Int J Rheumatol.
  
  Volume: Epub ahead of print Pages: 580814-580814
- DOI
  10.1155/2012/580814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591460, KAKENHI-PROJECT-23659503, KAKENHI-PROJECT-24591459, KAKENHI-PROJECT-24791010
[Journal Article] Japanese variant of multicentric castleman's disease associated with serositis and thrombocytopenia--a report of two cases: is TAFRO syndrome (Castleman- Kojima disease) a distinct clinicopathological entity?2013
- Author(s)
  Y.Masaki, A.Nakajima, H.Iwao, N.Kurose, T.Sato, T.Nakamura, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara
- Journal Title
  
  J. Clin. Exp. Hematop.
  
  Volume: 53 Pages: 79-85
- NAID
  10031183131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591459
[Journal Article] The role of high mobility group box chromosomal protein 1 in rheumatoid arthritis2013
- Author(s)
  Chen Y, Sun W, Gao R, Su Y, Umehara H, Dong L and Gong F
- Journal Title
  
  Rheumatology (Oxford, England)
  
  Volume: 52 Issue: 10 Pages: 1739-1747
- DOI
  10.1093/rheumatology/ket134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041
[Journal Article] A new clinical entity:IgG4-related disease(IgG4-RD) discovered in the 21st century2012
- Author(s)
  Umehara,H
- Journal Title
  
  Intern Med
  
  Volume: 51(8) Pages: 821-822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Consensus Statementon the Pathology of IgG4-related disease.2012
- Author(s)
  Deshpande,V.,Y.Zen,J.K.C.Chan,E.Yi,Y.Sato,T.Yoshino,Umehara
- Journal Title
  
  Mod.Pathol.
  
  Volume: 2012(1-12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 20112012
- Author(s)
  Umehara, H.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 22 Pages: 21-30
- NAID
  10030206683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details2012
- Author(s)
  Umehara, H.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 22 Pages: 1-14
- NAID
  10030206539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Comprehensive Diagnostic Criteria(CDC criteria) for IgG4-related disease(IgG4-RD)2012
- Author(s)
  Umehara,H.,K.Okazaki,Y.Masaki,M.Kawano,M.Yamamoto,T.Saeki,S.Matsui,T.他 and all Japan IgG4 team
- Journal Title
  
  Mod.Rheum.
  
  Volume: 22(1) Pages: 21-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Cellular heat acclimation regulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells2012
- Author(s)
  Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
- Journal Title
  
  Cell Physiol Biochem
  
  Volume: 30 Pages: 450-457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041
[Journal Article] Research Program for Intractable Diseaseby Ministry of Health,Laborand Welfare (MHLW) Japan G4 team.2012
- Author(s)
  Umehara,H.,K.Okazaki,Y.Masaki,M.Kawano,M.Yamamoto,T.Saeki,S.Matsui,T.Sumida,T.Mimori,Y.Tanaka,K.他andthe
- Journal Title
  
  ModRheum
  
  Volume: 22(1) Pages: 1-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Loss of HITS (FAM107B) expression in cancers of multiple organs : tissue microarray analysis2012
- Author(s)
  Nakajima H, Koizumi K, Tanaka T, Ishigaki Y, Yoshitake Y, Yonekura H, Sakuma T, Fukushima T, Umehara H, Ueno S, Minamoto T and Motoo Y
- Journal Title
  
  International journal of oncology
  
  Volume: 41 Issue: 4 Pages: 1347-1357
- DOI
  10.3892/ijo.2012.1550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041, KAKENHI-PROJECT-22249051, KAKENHI-PROJECT-22590669, KAKENHI-PROJECT-23500427, KAKENHI-PROJECT-23590349, KAKENHI-PROJECT-23590898, KAKENHI-PROJECT-23591955, KAKENHI-PROJECT-23659643
[Journal Article] Prevention of fasting-mediated bone marrow atrophy by leptin administration2012
- Author(s)
  Fujita Y, Yanagida H, Mimori T, Jin ZX, Sakai T, Kawanami T, Sawaki T, Masaki Y, Fukushima T, Okazaki T and Umehara H
- Journal Title
  
  Cellular immunology
  
  Volume: 273 Issue: 1 Pages: 52-58
- DOI
  10.1016/j.cellimm.2011.11.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041, KAKENHI-PROJECT-24791010
[Journal Article] Are Classification Criteria for IgG4-RD Now Possible? The Concept of IgG4-Related Disease and Proposal of Comprehensive Diagnostic Criteria in Japan2012
- Author(s)
  Okazaki, K. and H. Umehara
- Journal Title
  
  IntJRheumatol
  
  Volume: 2012:357071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] A novel clinical entity, IgG4-related disease(IgG4-RD):general concept and details.2012
- Author(s)
  Umehara Hisanori et al.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 22(1) Pages: 1-14
- NAID
  10030206539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Henoch-Schonlein purpura nephritis in a patient with IgG4-related disease Apossible association.2012
- Author(s)
  ItoK,Yamada K,Mizushima I,Aizu M,Fujii H,Mizutomi K,Matsumura M,Hayashi K,Yamagish M,Umehara H,Yamaguchi Y,Nagata M,and Kawano M.
- Journal Title
  
  Clin Nephrol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation2012
- Author(s)
  Nakajima H, Ishigaki Y, Xia QS, Ikeda T, Yoshitake Y, Yonekura H, Nojima T, Tanaka T, Umehara H, Tomosugi N, Takata T, Shimasaki T, Nakaya N, Sato I, Kawakami K, Koizumi K, Minamoto T and Motoo Y
- Journal Title
  
  International journal of oncology
  
  Volume: 37 Pages: 583-593
- URL
  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20664927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041
[Journal Article] Cellular heat acclimation regulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells2012
- Author(s)
  Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
- Journal Title
  
  Cell Physiol Biochem.
  
  Volume: 30 Issue: 2 Pages: 450-457
- DOI
  10.1159/000339038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041, KAKENHI-PROJECT-22659121, KAKENHI-PROJECT-23390160, KAKENHI-PROJECT-23590278, KAKENHI-PROJECT-24500786, KAKENHI-PROJECT-24590300, KAKENHI-PROJECT-24659105, KAKENHI-PROJECT-24791010
[Journal Article] IgG4-Related Disease:Recommendations for the Nomenclature of this Condition and itsI ndividual Organ System Manifestations.2012
- Author(s)
  Stone,J.H.,A.Khosroshahi,V.Deshpande,J.H.Umehara
- Journal Title
  
  Arthritis & Rheumatism.
  
  Volume: 64 Pages: 3061-3067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Regulation of cell migration by sphingomyelin synthases : sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway2012
- Author(s)
  Asano S, Kitatani K, Taniguchi M, Hashimoto M, Zama K, Mitsutake S, Igarashi Y, Takeya H, Kigawa J, Hayashi A, Umehara H and Okazaki T
- Journal Title
  
  Molecular and cellular biology
  
  Volume: 32 Issue: 16 Pages: 3242-3252
- DOI
  10.1128/mcb.00121-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041, KAKENHI-PROJECT-23790366, KAKENHI-PROJECT-24659469
[Journal Article] Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 42012
- Author(s)
  Murakami K, Tanaka M, Usui T, Kawabata D, Shiomi A, Iguchi-Hashimoto M, Shimizu M, Yukawa N, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Umehara H and Mimori T
- Journal Title
  
  FEBS Lett.
  
  Volume: 586 Pages: 319-324
- URL
  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22265692
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041
[Journal Article] CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice2012
- Author(s)
  Dong L, Watanabe K, Itoh M, Huan CR, Tong XP, Nakamura T, Miki M, Iwao H, Nakajima A, Sakai T, Kawanami T, Sawaki T, Masaki Y, Fukushima T, Fujita Y, Tanaka M, Yano M, Okazaki T and Umehara H
- Journal Title
  
  International immunology
  
  Volume: 24 Issue: 5 Pages: 327-337
- DOI
  10.1093/intimm/dxs008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041, KAKENHI-PROJECT-24591459, KAKENHI-PROJECT-24791010
[Journal Article] Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway2012
- Author(s)
  Taniguchi M, Kitatani K, Kondo T, Hashimoto-Nishimura M, Asano S, Hayashi A, Mitsutake S, Igarashi Y, Umehara H, Takeya H, Kigawa J and Okazaki T
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 287 Pages: 39898-39910
- URL
  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=23035115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041
[Journal Article] Comprehensive diagnostic criteria for IgG4-related disease(IgG4-RD).2012
- Author(s)
  Umehara Hisanori et al.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 22(1) Pages: 21-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Skewed production of IL-6 and TGFbeta by cultured salivary gland epithelial cells from patients with Sjogren's syndrome2012
- Author(s)
  Kawanami T, Sawaki T, Sakai T, Miki M, Iwao H, Nakajima A, Nakamura T, Sato T, Fujita Y, Tanaka M, Masaki Y, Fukushima T, Hirose Y, Taniguchi M, Sugimoto N, Okazaki T and Umehara H
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 10 Pages: e45689-e45689
- DOI
  10.1371/journal.pone.0045689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041, KAKENHI-PROJECT-24591459, KAKENHI-PROJECT-24659105, KAKENHI-PROJECT-24791010
[Journal Article] Sphingomyelin synthase 1-generated sphingomyelin plays an important role in transferrin trafficking and cell proliferation2011
- Author(s)
  Abo Bakr Abdel Shakor
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Issue: 41 Pages: 36053-36062
- DOI
  10.1074/jbc.m111.228593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659238, KAKENHI-PROJECT-22249041
[Journal Article] Proposal for diagnosti ccriteria for IgG4-related kidney disease.2011
- Author(s)
  KawanoM,SaekiT,NakashimaH,NishiS,YamaguchiY,HisanoS,UmeharaH
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 15(5) Pages: 615-626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Inhibitory effects of dietary glucosylceramides on squamous cell carcinoma of the head and neck in NOD/SCID mice2011
- Author(s)
  Fujiwara K, Kitatani K, Fukushima K, Yazama H, Umehara H, Kikuchi M, Igarashi Y, Kitano H and Okazaki T
- Journal Title
  
  International journal of clinical oncology / Japan Society of Clinical Oncology
  
  Volume: 16 Pages: 133-140
- NAID
  10029366450
- URL
  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21057846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249041
[Journal Article] Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice2011
- Author(s)
  Yano M., et al
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 5 Pages: 3992-4002
- DOI
  10.1074/jbc.m110.179176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-22249041, KAKENHI-PROJECT-23659797, KAKENHI-PROJECT-23791038
[Journal Article] IgG4-Related Disease (IgG4+MOLPS)-Diagnostic Criteriaand Diagnostic Problems.2011
- Author(s)
  MasakiY,IwaoH,NakajimaA,MikiM,SugaiS,UmeharaH.
- Journal Title
  
  Current Immunology Reviews
  
  Volume: 7 Pages: 172-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659503
[Journal Article] Successful treatment of amegakaryocytic thrombocytopenia with tuximab in a patient with systemic lupus erythematosus.2008
- Author(s)
  Fukushima, T., L. Dong, T. Sakai, T. Sawaki, M. Tanaka, Y. Masaki, M. Kuwana, Y. Hirose, and H. Umehara.
- Journal Title
  
  Lupus 17
  
  Pages: 210-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390276
[Journal Article] Impaired TCR signalingthrough dysfunction of lipid rafts sphingomyelin synthese 1 (SMS1)-nock down T cells Int.2008
- Author(s)
  Jin, Z.-X., C.-R. Huang, S. Goda, L. Dong, T. Kawanami, T. Sawaki, T. Sakai, X.-P. Tong, Y. Masaki, T. Fukushima, M. Tanaka, T. Mimori, H. Tojo, E. T. Bloom, T. Okazaki, and H. Umehara
- Journal Title
  
  Immunology 20
  
  Pages: 1427-1437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390276
[Journal Article] Proposal for a new clinical entity, IgG4-positive multi-organ lymphoproliferative syndrome (IgG4+MOLPS): Analysis of 64 cases of IgG4-related isorders including Mikulicz's disease and autoimmune pancreatitis.2008
- Author(s)
  Masaki, Y., L. Dong, N. Kurose, K. Kitagawa, Y. Morikawa, M. Yamamoto, H. Takahashi, Y. Shinomura, K. Imai, T. Saeki, A. Azumi, S. Nakata, E. Sugiyama, S. Matsui, T. Origuchi, S. Nishiyama, I. Nishimori, T. Nojima, K. Yamada, M. Kawano, Y. Zen, M. Kaneko, K. Miyazaki, K. Tsubota, K. Tomoda, T. Sawaki, T. Kawanami, M. Tanaka, T. Fukushima, S. Sugai, and H. Umehara.
- Journal Title
  
  Ann. Rheum. Dis.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390276
[Journal Article] Efficacy and Safety of Mizoribine for the Treatment of Sjogren's syndrome : A Multicenter Open-label Clinical Trial.2007
- Author(s)
  Nakayamada, S., K. Saito, H. Umehara, N. Ogawa, T. Sumida, S. Ito, S. Minota, H. Nara, H. Kondo, J. Okada, T. Mimori, H. Yoshifuji, H. Sano, N. Hashimoto, S. Sugai, and Y. Tanaka.
- Journal Title
  
  Mod. Rheumatol. 17
  
  Pages: 464-469
- NAID
  10020178053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390276
[Journal Article] Cloning and expression of two human recombinant monoclonal Fab fragments specific for EBV viral capsid antigen.2007
- Author(s)
  Dong, L., Y. Masaki, T. Takegami, T. Kawanami, I. Kunihiko, Z.-X. Jin, C.-R. Huang, X.-P. Tong, T. Fukushima, M. Tanaka, T. Sawaki, T. Sakai, S. Sugai, T. Okazaki, Y. Hirose, and H. Umehara.
- Journal Title
  
  Int. Immunol. 19
  
  Pages: 331-336
- NAID
  10020111440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390276
[Journal Article] Sjogren's syndrome and lymphoma development.2007
- Author(s)
  Dong, L., Y. Masaki, M. Tanaka, T. Fukushima, T. Okazaki, and H. Umehara.
- Journal Title
  
  Clin. Immunol. Rev. 3
  
  Pages: 289-296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390276
[Journal Article] Clonality analysis of lymphoproliferative disorders in lymphocytes infiltration from patients with Sjogren's syndrome (SS)2007
- Author(s)
  Dong, L., Y. Masaki, T. Takegami, Z.-X. Jin, C.-R. Huang, T. Fukushima, T. Sawaki, T. Kawanami, T. Saeki, K. Kitagawa, S. Sugai, T. Okazaki, Y. Hirose, and H. Umehara.
- Journal Title
  
  Clin. Exp. Immunol. 150
  
  Pages: 279-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390276
[Journal Article] Urinary pseudouridine in patients with lymphoma : comparison with other clinical parameters.2006
- Author(s)
  Masaki Y, Itoh K, Sawaki T, et al., Umehara H.
- Journal Title
  
  Clin.Chim.Acta. 371
  
  Pages: 148-151
- Data Source
  KAKENHI-PROJECT-18659287
[Journal Article] Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System.2006
- Author(s)
  Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, Ishikawa I.
- Journal Title
  
  Blood 108(4)
  
  Pages: 1381-1387
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591016
[Journal Article] Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System.2006
- Author(s)
  Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, Ishikawa I.
- Journal Title
  
  Blood. 108
  
  Pages: 1381-1387
- Data Source
  KAKENHI-PROJECT-17591016
[Journal Article] Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System.2006
- Author(s)
  Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, Ishikawa I
- Journal Title
  
  Blood. 108・4
  
  Pages: 1381-1387
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591016
[Journal Article] Fractalkine in rheumatoid arthritis and allied conditions2006
- Author(s)
  Umehara H, Tanaka M, Sawaki T, Jin ZX, Huang CR, Dong L, et al.
- Journal Title
  
  Mod.Rheumatol 16
  
  Pages: 124-130
- NAID
  10017608542
- Data Source
  KAKENHI-PROJECT-18659287
[Journal Article] Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System.2006
- Author(s)
  Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, Ishikawa I
- Journal Title
  
  Blood 108
  
  Pages: 1381-1387
- Data Source
  KAKENHI-PROJECT-18659287
[Journal Article] Successful salvage therapy of continuous low-dose irinotecan for a patient with relapsed and refractory diffuse large B-cell lymphoma2006
- Author(s)
  Masaki Y, Sawaki T, Shimoyama, Umehara H. et al.
- Journal Title
  
  J.Rinsho Retsueki 46
  
  Pages: 1074-1077
- NAID
  130004501017
- Data Source
  KAKENHI-PROJECT-18659287
[Journal Article] Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies.2006
- Author(s)
  Yoshifuji H, Fujii T, Umehara H, et al.
- Journal Title
  
  Autoimmunity 39
  
  Pages: 233-241
- Data Source
  KAKENHI-PROJECT-18659287
[Journal Article] Matrix metalloproteinase-1 produced by human CXCL12-stimulated natural killer cells.2006
- Author(s)
  Goda S, Inoue H, Umehara H, et al.
- Journal Title
  
  Am.J.Pathol 169
  
  Pages: 445-458
- Data Source
  KAKENHI-PROJECT-18659287
[Journal Article] Hepcidin-最近の進歩2005
- Author(s)
  川端浩, 河南崇典, 友杉直久, 石川勲, 梅原久範
- Journal Title
  
  血液・腫瘍科 51
  
  Pages: 174-182
- Data Source
  KAKENHI-PROJECT-17591016
[Journal Article] Fractalkine and vascular biology : from basic research to clinical diseases2004
- Author(s)
  Umehara H, et al.
- Journal Title
  
  Arterio.Thromb.Vasc.Biol. 24
  
  Pages: 34-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390313
[Journal Article] Fractalkine and vascular biology : from basic research to clinical diseases.2004
- Author(s)
  Umehara H, et al.
- Journal Title
  
  Arterio.Thromb.Vasc.Biol.(Review). 24
  
  Pages: 34-40
- Data Source
  KAKENHI-PROJECT-15390313
[Journal Article] Fractalkine and vascular biology : from basic research to clinica diseases.2004
- Author(s)
  Umehara H, et al.
- Journal Title
  
  Arterio. Thromb. Vasc. Biol. (Review). 24
  
  Pages: 34-40
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390313
[Patent] 特許2010
- Inventor(s)
  梅原久範、正木康史、友杉直久、石垣靖人
- Industrial Property Rights Holder
  金沢医科大学
- Industrial Property Number
  2010-194326
- Filing Date
  2010-08-31
- Data Source
  KAKENHI-PROJECT-22249041
[Presentation] IgG4関連疾患包括診断基準2013
- Author(s)
  梅原久範
- Organizer
  第57回日本リウマチ学会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2013-04-20
- Data Source
  KAKENHI-PROJECT-23659503
[Presentation] 「IgG4＋MOLPS(IgG4関連多臓器リンパ増殖症候群)、Castleman病その他の多クローン性高γグロブリン血症の鑑別診断のための他施設共同前方視的臨床研究」の中間報告2013
- Author(s)
  岩男　悠, 正木康史, 佐伯敬子, 松井祥子, 川野充弘, 平田信太郎, 藤川敬太, 折口智樹, 宮下賜一郎, 坪井洋人, 梅原久範
- Organizer
  第57回日本リウマチ学会総会・学術集会／第22回国際リウマチシンポジウム
- Place of Presentation
  国立京都国際会館, 京都府京都市
- Data Source
  KAKENHI-PROJECT-24591459
[Presentation] IgG4関連疾患発見の経緯と概念2013
- Author(s)
  梅原久範
- Organizer
  第86回日本内分泌学会総会、指定シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2013-04-27
- Data Source
  KAKENHI-PROJECT-23659503
[Presentation] IgG4関連疾患診断のための組織　IgG4陽性細胞比率の検討2011
- Author(s)
  梅原久範、他
- Organizer
  第55回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-23659503
[Presentation] IgG4関連疾患における呼吸器病変の検討2011
- Author(s)
  梅原久範、他
- Organizer
  第55回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-23659503
[Presentation] IgG4関連疾患の誕生今、日本から世界にむけて発信!2011
- Author(s)
  梅原久範
- Organizer
  第20回日本シェーグレン学会、
- Place of Presentation
  金沢
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-23659503
[Presentation] Impaired T cell functions in SMS1-knock out mice2010
- Author(s)
  梅原久範
- Organizer
  14th International congress of immunology
- Place of Presentation
  神戸ポートピアホテル(兵庫県)
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-22249041

1. DOMAE Naochika (60115889)

# of Collaborated Projects: 11 results

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2. IMAI Toshiiio

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3. KAWANAMI Takafumi (20350762)

# of Collaborated Projects: 5 results

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4. MASAKI Yasufumi (40238895)

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5. MIMORI Tsuneyo (10157589)

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6. IMAI Hisao (80067024)

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7. NAGANO Yutaka (80228048)

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8. OKAZAKI Toshirou (40233308)

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9. FUKUSHIMA Toshihiro (60251998)

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10. TANAKA Masao (10332719)

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24. MINAMI Yasuhiro (70229772)

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40. 山田和徳

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# of Collaborated Products: 1 results

UMEHARA Hisanori 梅原 久範

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Analysis of pathogenesis of IgG4-related diseasePrincipal Investigator

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Study for the pathogenesis of autoimmune diseases using sphingomyeline knock out mousePrincipal Investigator

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Development of the new immuno-suppresant based on the regulation of lipid rafts.Principal Investigator

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新規抗癌剤開発のためのリピッドラフト解析Principal Investigator

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フラクタルカインおよびレセプター発現と癌の悪性度・転移との関連Principal Investigator

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The roles of fractalkine in pathogenesis of systemic sclerosisPrincipal Investigator

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敗血症ショックに対する抗fractalkine抗体の予防効果Principal Investigator

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血管炎発症モデルにおけるCX3C-ケモカイン,Fractalkineの関与Principal Investigator

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IMPROVEMENT OF ADOPTIVE IMMUNE THERAPY FOR CERVIAL CANCERPrincipal Investigator

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UMEHARA Hisanori 梅原久範