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YAMAMOTO Kazuo  山本 一男

ORCIDConnect your ORCID iD *help
… Alternative Names

山本 一男  ヤマモト カズオ

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Researcher Number 70255123
Other IDs
External Links
Affiliation (Current) 2022: 長崎大学, 医歯薬学総合研究科(医学系), 准教授
Affiliation (based on the past Project Information) *help 2014 – 2021: 長崎大学, 医歯薬学総合研究科(医学系), 准教授
2017: 長崎大学, 医歯(薬)学総合研究科, 准教授
2002 – 2004: 長崎大学, 大学院・医歯薬学総合研究科, 助教授
1999 – 2001: School of Medicine, Nagasaki University Lecturer, 大学院・医学研究科, 講師
1999: 長崎大学, 医学部, 講師
1995: 埼玉医科大学, 医学部, 助手
1993: Saitama Medical School Fac.of Med.Assistant, 医学部, 助手
Review Section/Research Field
Principal Investigator
Molecular biology / Biological Sciences / Tumor biology / Laboratory medicine / Obstetrics and gynecology / Basic Section 50010:Tumor biology-related / Medium-sized Section 50:Oncology and related fields
Except Principal Investigator
General medical chemistry / Experimental pathology / Virology … More / Pathobiological dentistry/Dental radiology / Biomolecular chemistry / Gastroenterology / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related Less
Keywords
Principal Investigator
代謝 / 細胞サイズ / ミトコンドリア / 翻訳制御 / がん / rRNA遺伝子 / プロモーター / 転写制御 / リンパ球 / 転写因子 … More / IRF / 活性調節 / 免疫応答 / インターフェロン / 標的遺伝子 / 至適結合配列 / トランスジェニックマウス / 白血病 / リンパ腫 / プリオン / 早期診断 / プロテオーム / prion / early diagnosis / proteome / 脆弱性X症候群 / Fmr1関連早期卵巣不全 / タンパク質相互作用 / 遺伝子発現 / Largen / FMRP / 神経 / 卵巣 / 遺伝子 / 細胞・組織 / タンパク質合成 / 癌抑制遺伝子 … More
Except Principal Investigator
rDNA / UBF / FM3A / MH134 / RPA40 / PAF53 / 転写因子 / IRF / NF-kappaB / IRF-3 / IFNβ / dsRNA / NDV / HT1080 / atherosclerosis / PPARγ / がん代謝 / 活性酸素種 / エピジェネティクス / efp / エストロゲン受容体 / リングフィンガー / Znフィンガー蛋白 / エストロゲン応答要素 / CpGアイランド・ライブラリー / NMDA受容体2型D / In situ hybrization histochemistry / 成人性白血病 / Fibroleukin / IFN-γ / Fas / RNAポリメラーゼ / 転写制御 / RNAポリメラーゼI(PolI) / PIN / ERCC3 / ペレット転写法 / RNAポリメラーゼI / 核小体 / HMG-box / NLS / 酸性ドメイン / RNA polymerase / Transcriptional Regulation / サイトカイン / インターフェロン / cytokine / interferon / transcription factor / GFP融合タンパク質 / 発現スクリーニング / in vitroリン酸化アッセイ / GFP-fusion protein / expression screening / 電離放射線 / マクロファージ / atheroselerosis / ionizing radiation / macrophage / エピゲノム / 活性酸素腫 / ユビキチン化 / 生体分子 / 癌 / 肝細胞癌 / ワールブルグ効果 / Largen遺伝子 / Largen / ユビキチン修飾 / 翻訳後修飾 Less
  • Research Projects

    (16 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (23 People)
  •  Understanding the correlation between metabolism and cancer via working points of the cell size controlling gene that alters the roles on different tissuesPrincipal Investigator

    • Principal Investigator
      山本 一男
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Nagasaki University
  •  葉酸代謝に関与するアルデヒド脱水素酵素のがん抑制機能の全容解明を目指して

    • Principal Investigator
      佐々木 雅人
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Tohoku Medical and Pharmaceutical University
  •  Exploring a molecular mechanism governing the metabolism to repress cancer progression depending on genetic backgroundsPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuo
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Nagasaki University
  •  Tumorigenesis and tumor progression mechanisms induced by aldehyde dehydrogenases associated NADPH and folate metabolism.

    • Principal Investigator
      Sasaki Masato
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biomolecular chemistry
    • Research Institution
      Tohoku Medical and Pharmaceutical University
  •  The inhibition of hepatocellular carcinoma growth through Warburg effect disruption using cell-size regulating gene

    • Principal Investigator
      Miuma Satoshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagasaki University
  •  Elucidation of the molecular mechanism of Fmr1-associated premature ovarian failure based on novel protein-protein interactionsPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuo
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Nagasaki University
  •  Dissecting the roles of metabolism in the development of cancer by means of the mitochondrial hyperactive model micePrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuo
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor biology
    • Research Institution
      Nagasaki University
  •  リンパ球特異的転写因子IRF4の活性調節による過剰免疫応答の制御Principal Investigator

    • Principal Investigator
      山本 一男
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  Investigation of mechanism on radiation-induced atheroma

    • Principal Investigator
      KATAYAMA Ikuo
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      NAGASAKI UNIVERSITY
  •  Proteome Analysis for Early Diagnosis of Prion DiseasePrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuo
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Nagasaki University
  •  成人T細胞性白血病患者末梢血細胞における細胞外マトリックスの分子生物学的解析

    • Principal Investigator
      KOHNO Tomoko
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nagasaki University
  •  Identification of novel factors related to induction of IFN by viral infection

    • Principal Investigator
      KOHNO Tomoko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Nagasaki University
  •  Role of IFN transcription factors, IRF-1, and IRF-2 in acute hepatic injury model

    • Principal Investigator
      MATSUYAMA Toshifumi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University
  •  エストロゲン応答性転写因子efpの機能とその作用カスケード

    • Principal Investigator
      MURAMATSU Masami
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Saitama Medical University
  •  rRNA遺伝子のプロモーターい結合する新規蛋白質p70の構造と機能Principal Investigator

    • Principal Investigator
      山本 一男
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Molecular biology
    • Research Institution
      Saitama Medical University
  •  Regulation Mechanisms of Ribosomal Gene in Cellular Growth and Differentiation

    • Principal Investigator
      MURAMATSU Masami
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Saitama Medical School

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] 実験医学2016年9月増刊号2016

    • Author(s)
      山本一男
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-26640082
  • [Journal Article] An inhibitor of Kr?ppel-like factor 5 suppresses peritoneal fibrosis in mice2021

    • Author(s)
      Muta K, Nakazawa Y, Obata Y, Inoue H, Torigoe K, Nakazawa M, Abe K, Furusu A, Miyazaki M, Yamamoto K, Koji T, Nishino T
    • Journal Title

      Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis

      Volume: -

    • DOI

      10.1177/0896860820981322

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07246, KAKENHI-PROJECT-18K07235
  • [Journal Article] Geranylgeranylacetone decreases the production of hepatitis B virus‐related antigen by comprehensive downregulation of mRNA transcription activity2021

    • Author(s)
      Haraguchi Masafumi、Miuma Satoshi、Yamamoto Kazuo、Nakao Yasuhiko、Ichikawa Tatsuki、Kanda Yasuko、Sasaki Ryu、Fukushima Masanori、Akazawa Yuko、Miyaaki Hisamitsu、Nakao Kazuhiko
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: - Pages: 1979-1987

    • DOI

      10.1111/jgh.15394

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07235, KAKENHI-PROJECT-18K07975, KAKENHI-PROJECT-21K07916
  • [Journal Article] Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury2020

    • Author(s)
      Torigoe K, Obata Y, Torigoe M, Oka S, Yamamoto K, Koji T, Ueda H, Mukae H, Nishino T
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 24 Pages: 411-419

    • DOI

      10.1007/s10157-019-01843-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07246, KAKENHI-PROJECT-20K17287, KAKENHI-PROJECT-18K07235
  • [Journal Article] Association between FOXP3+ regulatory T-cells and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts2019

    • Author(s)
      Khan KN, Yamamoto K, Fujishita A, Koshiba A, Kuroboshi H, Sakabayashi S, Teramukai S, Nakashima M, Kitawaki J.
    • Journal Title

      Reproductive BioMedicine Online

      Volume: Jan 31 Pages: 857-869

    • DOI

      10.1016/j.rbmo.2019.01.011

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09268, KAKENHI-PROJECT-18K07235
  • [Journal Article] Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis2019

    • Author(s)
      Khan KN, Yamamoto K, Fujishita A, Muto H, Koshiba A, Kuroboshi H, Saito S, Teramukai S, Nakashima M, Kitawaki J.
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism

      Volume: May 1 Pages: 4715-4729

    • DOI

      10.1210/jc.2019-00350

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09268, KAKENHI-PROJECT-18K07235
  • [Journal Article] Intracellular redox status controls spherogenicity, an in vitro cancer stem cell marker, in thyroid cancer cell lines2018

    • Author(s)
      Shimamura M, Yamamoto K, Kurashige T, Nagayama Y
    • Journal Title

      Experimental Cell research

      Volume: 370 Issue: 2 Pages: 699-707

    • DOI

      10.1016/j.yexcr.2018.07.036

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07235, KAKENHI-PROJECT-16K00548, KAKENHI-PROJECT-17K16167, KAKENHI-PROJECT-16H06276
  • [Journal Article] Mechanistic aspects of mammalian cell size control2017

    • Author(s)
      Yamamoto Kazuo、Mak Tak W.
    • Journal Title

      Development, Growth & Differentiation

      Volume: 59 Pages: 33-40

    • DOI

      10.1111/dgd.12334

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15709
  • [Journal Article] 哺乳類の細胞サイズを規定する分子基盤2016

    • Author(s)
      山本一男
    • Journal Title

      実験医学

      Volume: 34 Pages: 217-222

    • Data Source
      KAKENHI-PROJECT-16K15709
  • [Journal Article] Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression2015

    • Author(s)
      Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, Molyneux SD, Mason JM, Li WY, Yamamoto K, Wakeham A, Berman HK, Khokha R, Done SJ, Kavanagh TJ, Lam CW, Mak TW.
    • Journal Title

      Cancer Cell

      Volume: 27 Pages: 211-222

    • DOI

      10.1016/j.ccell.2014.11.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26640082
  • [Journal Article] 細胞の大きさを規定する分子基盤2015

    • Author(s)
      山本一男
    • Journal Title

      化学と生物

      Volume: 53 Pages: 141-142

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26640082
  • [Journal Article] Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio2015

    • Author(s)
      M Itsumi, S Inoue, AJ Elia, K Murakami, M Sasaki, EF Lind, D Brenner, IS Harris, IIC Chio, S Afzal, RA Cairns, DW Cescon, AR Elford, J Ye, PA Lang, WY Li, A Wakeham, GS Duncan, J Haight, A You-Ten, B Snow, K Yamamoto, PS Ohashi, TW Mak
    • Journal Title

      Cell Death & Differentiation

      Volume: 22 Pages: 1837-1845

    • DOI

      10.1038/cdd.2015.38

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20095, KAKENHI-PROJECT-26640082
  • [Presentation] 細胞サイズを規定するエレメントを探して2017

    • Author(s)
      山本一男
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-16K15709
  • [Presentation] A mechanism of cell size regulation and its readout governed by Largen2016

    • Author(s)
      Kazuo Yamamoto
    • Organizer
      EMBO Workshop
    • Place of Presentation
      Joachimsthal, Germany
    • Year and Date
      2016-09-14
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26640082
  • [Presentation] A molecular basis of mammalian cell size control2016

    • Author(s)
      Kazuo Yamamoto, Masato Sasaki, Ivan Topisirovic, Mitsuhiko Ikura, Nahum Sonenberg, Tak W. Mak
    • Organizer
      CDB Symposium 2016
    • Place of Presentation
      理化学研究所多細胞システム形成研究センター(兵庫県・神戸市)
    • Year and Date
      2016-03-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26640082
  • [Presentation] A mechanism of cell size regulation and its readout governed by Largen2016

    • Author(s)
      Kazuo Yamamoto
    • Organizer
      The EMBO Workshop on Cell Size Regulation
    • Place of Presentation
      ヨアヒムシュタール(ドイツ)
    • Year and Date
      2016-09-14
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15709
  • [Presentation] 細胞の大きさを制御する遺伝子ネットワークの抽出2015

    • Author(s)
      山本一男、Susan McCracken、Tak W. Mak
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26640082
  • 1.  MATSUYAMA Toshifumi (30165922)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  KOHNO Tomoko (60284684)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  MURAMATSU Masami (10035454)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  NOGI Yasuhisa (60101937)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  Sasaki Masato (30396527)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  Miuma Satoshi (30437892)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  MAKINO Yasutaka (20240989)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  TAMURA Taka-aki (30112692)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SUZUKI Toshiya (90216416)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KOJIMA Chojiro (50333563)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KATAMINE Shigeru (40161062)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KATAYAMA Ikuo (80295089)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HOTOKEZAKA Yuka (10244089)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NAKAMURA Takashi (30172406)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  奥田 晶彦 (60201993)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  宮田 康好 (60380888)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  KHAN Khaleque
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 18.  NAGAYAMA Yuji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  SHIMAMURA Mika
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 20.  小路 武彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 21.  蔵重 智美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  宮明 寿光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  逸見 百江
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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